Standout Papers
Citation Impact
Citing Papers
Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells
2005
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
2011
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
2009 Nature
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development
2008
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
2003 Science
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Essential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53
2000
Hallmarks of Cancer: The Next Generation
2011 Standout
Bim is a suppressor of Myc-induced mouse B cell leukemia
2004
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
2006
Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis
2005
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
2003
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells
2005
How the Bcl-2 family of proteins interact to regulate apoptosis
2006
BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
2001
Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs
2002
Hypoxia-inducible factors and hypoxic cell death in tumour physiology
2004
Mutational analysis of Noxa gene in human cancers
2003
Regulation of the type I IFN induction: a current view
2005
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
2008
Granzyme B Induces BID-mediated Cytochrome c Release and Mitochondrial Permeability Transition
2001
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
1998
IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein
2001
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Chemotherapy: targeting the mitochondrial cell death pathway
2002
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
2008
Noxa in colorectal cancer: a study on DNA, mRNA and protein expression
2003
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?
2003
A matter of life and death
2002 Standout
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
2001 Standout
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
2002
Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter
1999
Pharmacological manipulation of Bcl-2 family members to control cell death
2005
p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
2001
Apoptosis regulators and their role in tumorigenesis
2001
Release of Cytochrome c from Isolated Mitochondria by Etoposide
2005
BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization
2003
Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR
1999
Endoplasmic reticulum BIK initiates DRP1‐regulated remodelling of mitochondrial cristae during apoptosis
2005
BCL-2 family antagonists for cancer therapy
2008
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
The Bcl2 family: regulators of the cellular life-or-death switch
2002 Standout
Cell Death
2004 Standout
Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress
2003
Regulation and function of the p53 tumor suppressor protein
2001
DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes
2002
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates Apoptosis
2004
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
2005
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
2001
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
p53
2000
BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death
2000
Cell cycle checkpoint signaling:
2002
p53 Has a Direct Apoptogenic Role at the Mitochondria
2003
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteins
2005
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Apoptosis-based therapies
2002
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
2006
Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3
2005
Apoptosis and toxicology—what relevance?
2002
Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway
2001
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
2004 Standout
BID regulation by p53 contributes to chemosensitivity
2002
Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks
2003
PACT, a Double-Stranded RNA Binding Protein Acts as a Positive Regulator for Type I Interferon Gene Induced by Newcastle Disease Virus
2001
Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
2011
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage
2004
Regulation of apoptosis by endoplasmic reticulum pathways
2003
Live or let die: the cell's response to p53
2002 Standout
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Role of DNA mismatch repair in apoptotic responses to therapeutic agents
2004
Direct Involvement of CREB-binding Protein/p300 in Sequence-specific DNA Binding of Virus-activated Interferon Regulatory Factor-3 Holocomplex
2002
Death and anti-death: tumour resistance to apoptosis
2002 Standout
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
2009
Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K
2005
Apoptosis in the development and maintenance of the immune system
2003
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis
2004
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin
2002
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance
2007
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
2002 Nature
DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa
2012
Dysregulation of apoptosis genes in hematopoietic malignancies
2002
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Ten Strategies of Interferon Evasion by Viruses
2017
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
Adenovirus‐mediated p53AIP1 gene transfer as a new strategy for treatment of p53‐resistant tumors
2004
The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest
2007
p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53
2000
Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways
2001
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
2000
The Hallmarks of Aging
2013 Standout
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
2006
The role of BH3-only proteins in the immune system
2005
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
2004
Caspase-Dependent Cytosolic Release of Cytochrome c and Membrane Translocation of Bax in p53-Induced Apoptosis
2001
Life in the balance: how BH3-only proteins induce apoptosis
2005
Negative regulation of bcl-2 expression by p53 in hematopoietic cells
2001
PUMA in head and neck cancer
2003
Identification of Ser-386 of Interferon Regulatory Factor 3 as Critical Target for Inducible Phosphorylation That Determines Activation
2004
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells
2005
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
2002
Control of apoptosis by p53
2003
Apoptotic and necrotic cell death induced by death domain receptors
2001
Mechanisms of Action of Bcl-2 Family Proteins
2013
Methylation-induced silencing of ASC and the effect of expressed ASC on p53-mediated chemosensitivity in colorectal cancer
2005
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Endoplasmic Reticulum Stress-induced Apoptosis
2006
The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death
2003
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase
2002
Pathogen Recognition and Innate Immunity
2006 Standout
Life-or-death decisions by the Bcl-2 protein family
2001
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
2007
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis
2001
p53AIP1 regulates the mitochondrial apoptotic pathway.
2002
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis
2008
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
Generation and Characterization of Smac/DIABLO-Deficient Mice
2002
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
Apoptosis: A Review of Programmed Cell Death
2007 Standout
IRF Family of Transcription Factors as Regulators of Host Defense
2001
mtCLIC/CLIC4, an Organellular Chloride Channel Protein, Is Increased by DNA Damage and Participates in the Apoptotic Response to p53
2002
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
2006 StandoutNature
Elimination of Hepatic Metastases of Colon Cancer Cells via p53-Independent Cross-Talk between Irinotecan and Apo2 Ligand/TRAIL
2004
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
2001
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase
2003 Nobel
Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock
2003
Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
2001 Science
BH3-only Protein Noxa Is a Mediator of Hypoxic Cell Death Induced by Hypoxia-inducible Factor 1α
2003
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
2001
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane
2002
Cellular Responses to DNA Damage
2001
Activation and activities of the p53 tumour suppressor protein
2001
Antiviral Actions of Interferons
2001 Standout
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling
2006
PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53
2005 Science
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
PUMA Overexpression Induces Reactive Oxygen Species Generation and Proteasome-Mediated Stathmin Degradation in Colorectal Cancer Cells
2005
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
2001 StandoutNobel
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands
2004
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Protein–Protein Interactions Mediated by Helical Tertiary Structure Motifs
2015
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
2008
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo
2005
RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice
2016
Surfing the p53 network
2000 StandoutNature
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Expression of bbc3 , a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
2001
Impairment of Interferon-Induced IRF-7 Gene Expression due to Inhibition of ISGF3 Formation by Trichostatin A
2003
WormBook
2008
p53 Translocation to Mitochondria Precedes Its Nuclear Translocation and Targets Mitochondrial Oxidative Defense Protein-Manganese Superoxide Dismutase
2005
Apoptosis - the p53 network
2003
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
2003
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
2006
Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes
1998
p53-Mediated Apoptosis and Genomic Instability Diseases
2001
The von Hippel-Lindau Tumor Suppressor Gene Product Interacts with Sp1 To Repress Vascular Endothelial Growth Factor Promoter Activity
1997
The expanding role of mitochondria in apoptosis.
2001 Standout
Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
2003
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
2007
Cellular stress response and apoptosis in cancer therapy
2001
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
2010
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
2007
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
2010
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
2004 StandoutScience
Works of Eri Oda being referenced
Reprimo, a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase
2000
Functionally inactivating point mutation in the tumor-suppressorIRF-1 gene identified in human gastric cancer
1998
Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene
1998
Type I interferons are essential mediators of apoptotic death in virally infected cells
1998
Integral role of Noxa in p53-mediated apoptotic response
2003
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
G10BP, an E1A-Inducible Negative Regulator of Sp1, Represses Transcription of the Rat Fibronectin Gene
1995