Citation Impact
Citing Papers
Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
2013 Science
Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
2010
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
2014
2014
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Spatially resolved, highly multiplexed RNA profiling in single cells
2015 StandoutScience
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
2013
Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity
2003
Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy
2014
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
2013 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Hydrogen peroxide sensing, signaling and regulation of transcription factors
2014
Remote Control of Gene Function by Local Translation
2014
Cancer Cell Metabolism
2011
The DNA-damage response in human biology and disease
2009 StandoutNature
Small RNA: can RNA interference be exploited for therapy?
2003
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
2011
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
2007 Standout
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B
1999
Thiol chemistry and specificity in redox signaling
2008
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
2013
Oxygen radicals and signaling
1998
Free radicals, metals and antioxidants in oxidative stress-induced cancer
2006 Standout
Reversible Inactivation of the Tumor Suppressor PTEN by H2O2
2002
Oncogenic kinase signalling
2001 StandoutNature
Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling
2007
Oxidative stress and gene regulation
2000
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Ubiquitin is phosphorylated by PINK1 to activate parkin
2014 Nature
Mitochondrial-targeted fluorescent probes for reactive oxygen species
2009
Identification of SUMO-Conjugated Proteins and their SUMO Attachment Sites Using Proteomic Mass Spectrometry
2008
Molecular imaging of hydrogen peroxide produced for cell signaling
2007
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
2003
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Select E2 enzymes differentially regulate parkin activation and mitophagy
2014
Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
1999
Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor
1998
Platelet-derived Growth Factor-induced H2O2 Production Requires the Activation of Phosphatidylinositol 3-Kinase
2000
Parkin and mitochondrial quality control: toward assembling the puzzle
2014
The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO
2013
REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species
2002
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases
2001
Novel homologs of gp91phox
2000
Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase
2004
Nerve Growth Factor-induced Neuronal Differentiation Requires Generation of Rac1-regulated Reactive Oxygen Species
2000
Insulin Signaling Is Inhibited by Micromolar Concentrations of H2O2
1999
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Antioxidant enzymes and human diseases
1999 Standout
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics
2005
SUMO
2005 Standout
Oxidative Stress Induces Protein Kinase D Activation in Intact Cells
2000
Redox characteristics of the eukaryotic cytosol
2007
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
2003 Nature
Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
2014
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Regulation of cancer cell metabolism
2011 Standout
The Inactivation Mechanism of Low Molecular Weight Phosphotyrosine-protein Phosphatase by H2O2
1998
Redox signalling in anchorage-dependent cell growth
2006
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Tyrosine Phosphorylation Regulates H2O2Production in Lung Fibroblasts Stimulated by Transforming Growth Factor β1
1998
Cell transformation by the superoxide-generating oxidase Mox1
1999 Nature
Regulation of protein function by S‐glutathiolation in response to oxidative and nitrosative stress
2000
Reactive Oxygen Species and Antioxidants in Signal Transduction and Gene Expression
2009
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH
2000
Asymmetrical β-actin mRNA translation in growth cones mediates attractive turning to netrin-1
2006
Expansion of the eukaryotic proteome by alternative splicing
2010 StandoutNature
Beyond LDL oxidation: ROS in vascular signal transduction
2003
Redox regulation of PTEN and protein tyrosine phosphatases in H2O2‐mediated cell signaling
2004
Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides
2011
Analysis of glutathione: implication in redox and detoxification
2003
Hydrogen Peroxide Generated during Cellular Insulin Stimulation Is Integral to Activation of the Distal Insulin Signaling Cascade in 3T3-L1 Adipocytes
2001
Regulation of Phosphoinositide-specific Phospholipase C Isozymes
1997
A Nuclear-Localized Fluorescent Hydrogen Peroxide Probe for Monitoring Sirtuin-Mediated Oxidative Stress Responses In Vivo
2011
PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions
2014
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Epidermal growth factor receptors: critical mediators of multiple receptor pathways
1999
Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
2004 StandoutNobel
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS)
2006
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Redox Regulation of Cellular Signalling
1999
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
2013 Nature
Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction
1998
UBE2N, UBE2L3 and UBE2D2/3 ubiquitin-conjugating enzymes are essential for parkin-dependent mitophagy
2014
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
2014
Revealing the world of RNA interference
2004 StandoutNatureNobel
Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo
2002
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins
2005
ZAP-70-dependent and -independent Activation of Erk in Jurkat T Cells
1998
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
2014
Global quantification of mammalian gene expression control
2011 StandoutNature
Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy
2013
Reactive Oxygen Species as Downstream Mediators of Angiogenic Signaling by Vascular Endothelial Growth Factor Receptor-2/KDR
2002
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Protein kinase C signaling and oxidative stress
2000
hnRNP Proteins and Splicing Control
2007
Cellular Regulation by Hydrogen Peroxide
2003
Structure of the human Parkin ligase domain in an autoinhibited state
2013
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling
2010
Functions and Mechanisms of Redox Regulation of Cysteine-Based Phosphatases
2005
Hyperglycemia Potentiates H 2 O 2 Production in Adipocytes and Enhances Insulin Signal Transduction: Potential Role for Oxidative Inhibition of Thiol-Sensitive Protein-Tyrosine Phosphatases
2005
Reactive Species-Mediated Regulation of Cell Signaling and the Cell Cycle: The Role of MAPK
2005
Anchorage-Dependent Cell Growth: Tyrosine Kinases and Phosphatases Meet Redox Regulation
2005
Reactive oxygen species in tumor progression
2005
A Palette of Fluorescent Probes with Varying Emission Colors for Imaging Hydrogen Peroxide Signaling in Living Cells
2010
First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
2010
Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal
2015 StandoutNobel
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
2001
Prolonged Production of Reactive Oxygen Species in Response to B Cell Receptor Stimulation Promotes B Cell Activation and Proliferation
2012
The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway
2004
H2O2-dependent Activation of GCLC-ARE4 Reporter Occurs by Mitogen-activated Protein Kinase Pathways without Oxidation of Cellular Glutathione or Thioredoxin-1
2004
H 2 O 2 , a Necessary Evil for Cell Signaling
2006 StandoutScience
Organellophagy: Eliminating cellular building blocks via selective autophagy
2014
Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation
2012
Intrinsic Human Immunodeficiency Virus Type 1 Resistance of Hematopoietic Stem Cells Despite Coreceptor Expression
1999
Reactive oxygen species in cell signaling
2000 Standout
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction
2004
Signal transduction by reactive oxygen species
2011 Standout
Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism
2000
Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches
2009
Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion
1999
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
2013
Redox Paradox
2005
Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes
2005
Organelle-Targetable Fluorescent Probes for Imaging Hydrogen Peroxide in Living Cells via SNAP-Tag Protein Labeling
2010
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Phosphorylated ubiquitin chain is the genuine Parkin receptor
2015
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
2004
A crucial role for Nox 1 in redox‐dependent regulation of Wnt‐β‐catenin signaling
2012
Metabolic reprogramming and cancer progression
2020 StandoutScience
Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways
1999
Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes
2000
Cancer Genome Landscapes
2013 StandoutScience
Reactive oxygen species are critical for the growth and differentiation of medullary thyroid carcinoma cells.
2000
The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation
2004
Reactive Oxygen Species: A Breath of Life or Death?
2007
Imaging the glycome
2008 StandoutNobel
Rapid Phosphorylation of Heterogeneous Nuclear Ribonucleoprotein C1/C2 in Response to Physiologic Levels of Hydrogen Peroxide in Human Endothelial Cells
2002
Reactive oxygen species, cell signaling, and cell injury
2000
Ras‐dependent and ‐independent regulation of reactive oxygen species by mitogenic growth factors and TGF‐β1
2000
Activation of the JAK-STAT pathway by reactive oxygen species
1998
Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca 2+ /Calmodulin-Dependent Protein Kinase II/Janus Kinase 2–Dependent Pathway
2001
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy
2014
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
2014
Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α
1998
Sumoylation in axons triggers retrograde transport of the RNA-binding protein La
2007
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate
2012
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
2015
Regulation of ROS signal transduction by NADPH oxidase 4 localization
2008
Works of Ephrem Tekle being referenced
Reversible Glutathionylation Regulates Actin Polymerization in A431 Cells
2001
Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide
1997 Standout
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: A proteomic analysis
2004
Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin
2003
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
2013
Reversible Phosphorylation as a Controlling Factor for Sustaining Calcium Oscillations in HeLa Cells: Involvement of Calmodulin-Dependent Kinase II and a Calyculin A-Inhibitable Phosphatase
1996