Citation Impact
Citing Papers
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O 2 activation
2019 StandoutNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
2015 Science
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Membrane curvature regulates the spatial distribution of bulky glycoproteins
2022 StandoutNobel
Activity-independent targeting of mTOR to lysosomes in primary osteoclasts
2017
Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process
2019
Role of extracellular calcium and mitochondrial oxygen species in psychosine-induced oligodendrocyte cell death
2014
Niemann-Pick C1 Functions Independently of Niemann-Pick C2 in the Initial Stage of Retrograde Transport of Membrane-impermeable Lysosomal Cargo
2009
Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases
2010
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
2016 Standout
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
Glycosphingolipidoses: Beyond the enzymatic defect
2004
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
2005 StandoutNobel
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses
2005
Clarifying lysosomal storage diseases
2011
Ion flux and the function of endosomes and lysosomes: pH is just the start
2010
Mechanism and medical implications of mammalian autophagy
2018 Standout
A comparative study on fluorescent cholesterol analogs as versatile cellular reporters
2015
Saturation variant interpretation using CRISPR prime editing
2022
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
The role of autophagy in neurodegenerative disease
2013 Standout
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells
2022 StandoutNobel
Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
2006
Mutations in the Glucocerebrosidase Gene and Parkinson's Disease in Ashkenazi Jews
2004
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Glycosylation in Cellular Mechanisms of Health and Disease
2006 Standout
Mechanisms and consequences of impaired lipid trafficking in Niemann–Pick type C1-deficient mammalian cells
2009
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
2017 Nature
AI in health and medicine
2022 Standout
The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease
2017
O-Pair Search with MetaMorpheus for O-glycopeptide characterization
2020 StandoutNobel
Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Principles of bioactive lipid signalling: lessons from sphingolipids
2008 Standout
ER stress and neurodegenerative diseases
2006
The cellular pathology of lysosomal diseases
2011
Parkinson's disease
2009 Standout
Lysosomal Ion Channels as Decoders of Cellular Signals
2018
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-β Peptide
2012
Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein
2010
Lysosomal storage disorders
2005
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
2011 StandoutNature
Parkinson's disease
2015 Standout
Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages
2013
Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content
2012
Revealing the human mucinome
2022 StandoutNobel
Dynamics and functions of lipid droplets
2018 Standout
Molecular basis of multiple sulfatase deficiency, mucolipidosis II/III and Niemann–Pick C1 disease — Lysosomal storage disorders caused by defects of non-lysosomal proteins
2008
NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system
2018
Gangliosides as apoptotic signals in ER stress response
2006
The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA
2016
ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain
2017
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Glycosylation in health and disease
2019
Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism
2015
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Neuropathology provides clues to the pathophysiology of Gaucher disease
2004
Drosophila TRPML Is Required for TORC1 Activation
2012
TRPM2
2014
Structure and function of ER membrane contact sites with other organelles
2015
Lysosomal disorders: From storage to cellular damage
2008
New strategies for the treatment of lysosomal storage diseases (Review)
2012
The mystery of membrane organization: composition, regulation and roles of lipid rafts
2017 Standout
The role of the unfolded protein response in tumour development: friend or foe?
2004
The cell biology of lysosomal storage disorders
2004
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Chronic Cyclodextrin Treatment of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol and Glycosphingolipid Storage and Disease Progression
2009
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
2011
Niemann-Pick C1 Protein Facilitates the Efflux of the Anticancer Drug Daunorubicin from Cells According to a Novel Vesicle-Mediated Pathway
2005
Endosome maturation
2011 Standout
Mucolipin 1: endocytosis and cation channel—a review
2004
Substrate reduction therapy
2008
Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders
2010
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Lysosomal degradation of membrane lipids
2009
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles
2018
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
2004
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication
2018 Standout
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
2020 Standout
LYSOSOMAL STORAGE DISEASES
1991
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition
2012
Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications
2015 StandoutNobel
Exosomes
2019 Standout
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Metabolic control of cell death
2014 Science
Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition
1998 Standout
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
2011
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis
2020 StandoutNobel
Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease
2012
Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα
2018
Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
2014
Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
2012
Wound Healing: A Cellular Perspective
2018 Standout
The life cycle of phagosomes: formation, maturation, and resolution
2016
mTOR: a pharmacologic target for autophagy regulation
2015 Standout
Cellular uptake of nanoparticles: journey inside the cell
2017 Standout
SNX14 mutations affect endoplasmic reticulum-associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20
2018
TRP Channels
2007 Standout
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Calcium signaling via two-pore channels: local or global, that is the question
2009
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Physiology of Microglia
2011 Standout
Works of Emyr Lloyd‐Evans being referenced
The lysosomal storage disease continuum with ageing-related neurodegenerative disease
2016
Inhibition of Calcium Uptake via the Sarco/Endoplasmic Reticulum Ca2+-ATPase in a Mouse Model of Sandhoff Disease and Prevention by Treatment with N-Butyldeoxynojirimycin
2003
Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
2015
A rapid method for the preparation of ultrapure, functional lysosomes using functionalized superparamagnetic iron oxide nanoparticles
2015
Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport
2004
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
2008
Enhanced calcium release in the acute neuronopathic form of Gaucher disease
2004
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis
2008
Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases
2011
Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease
2010
Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking
2010
Glucosylceramide and Glucosylsphingosine Modulate Calcium Mobilization from Brain Microsomes via Different Mechanisms
2003
Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C
2004
Endolysosomal calcium regulation and disease
2010
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
2011
Disorders of Cholesterol Metabolism and Their Unanticipated Convergent Mechanisms of Disease
2014
Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms
2003