Standout Papers
Citation Impact
Citing Papers
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
1993
p53: puzzle and paradigm.
1996 Standout
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
2004 Standout
Attributes of short linear motifs
2011
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
1996
Hallmarks of Cancer: The Next Generation
2011 Standout
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
1994 Nature
Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control
2002
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
1995
From molecular to modular cell biology
1999 StandoutNatureNobel
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
2000
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
The RB and p53 pathways in cancer
2002 Standout
A Complex of the Srb8, -9, -10, and -11 Transcriptional Regulatory Proteins from Yeast
2002 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
1995
The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
1999 Nature
The Petinoblastoma Tumor Suppressor Protein
1994
The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae
1994
Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation
2009
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Assembly of a Mediator/TFIID/TFIIA Complex Bypasses the Need for an Activator
2003
Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice
1999
Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II
1996
CDK-Independent Activation of Estrogen Receptor by Cyclin D1
1997
The Spliceosome: Design Principles of a Dynamic RNP Machine
2009 Standout
Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer
1995
Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway
1998
Cdk inhibitors: on the threshold of checkpoints and development
1994
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
A Novel Histone Acetyltransferase Is an Integral Subunit of Elongating RNA Polymerase II Holoenzyme
1999
Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II
1998
Dynamic regulation of pol II transcription by the mammalian Mediator complex
2005
Physical interaction of the retinoblastoma protein with human D cyclins
1993
A kinase–cyclin pair in the RNA polymerase II holoenzyme
1995 Nature
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
1994 Standout
Interactions between subunits of Drosophila Mediator and activator proteins
2005
Cyclins and cyclin-dependent kinases: take your partners
1993
TGF-β-receptor-mediated signaling
1994
A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site
2001
Mediator and the mechanism of transcriptional activation
2005 StandoutNobel
Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases
1998
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
Cyclins and oncogenesis
1993
Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators
1999
Radiation-induced cell cycle arrest compromised by p21 deficiency
1995 Nature
Regulation of G1 Phase
1998
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
1993
Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen
1994 Science
Tumor suppressor genes
1994
Composite co-activator ARC mediates chromatin-directed transcriptional activation
1999 Nature
The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited
1995
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
1993 Standout
Role of Ceramide in Cellular Senescence
1995
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
1994 Nature
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
1999 Nature
The cell cycle and the retinoblastoma protein family
1994
DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control
1994
pl9skp1 and p45skp2 are essential elements of the cyclin A-CDK2 S phase kinase
1995
Biochemical properties and biological effects of p53
1995
Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5
2000 StandoutNobel
PP1/PP2A Phosphatases Are Required for the Second Step of Pre-mRNA Splicing and Target Specific snRNP Proteins
2006
Protein complexes in nucleotide excision repair
1999
Genetic analysis of cellular senescence
1995
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Origins of G1 arrest in senescent human fibroblasts
1995
Fibrillar Collagen Inhibits Arterial Smooth Muscle Proliferation through Regulation of Cdk2 Inhibitors
1996
G1 phase progression: Cycling on cue
1994 Standout
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
TFIIH is negatively regulated by cdk8-containing mediator complexes
2000 Nature
Crystal structure of cyclin-dependent kinase 2
1993 Nature
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Frequent Amplification of the Cyclin E Gene in Human Gastric Carcinomas
1995
A Novel Human SRB/MED-Containing Cofactor Complex, SMCC, Involved in Transcription Regulation
1999
Mediator as a General Transcription Factor
2005 StandoutNobel
Principles of CDK regulation
1995 StandoutNature
Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM
1995
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1
1997
The mammalian Mediator complex and its role in transcriptional regulation
2005
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
1994
The Yeast HRS1 Gene Is Involved in Positive and Negative Regulation of Transcription and Shows Genetic Characteristics Similar to SIN4 and GAL11
1997
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
A Multiprotein Complex That Interacts with RNA Polymerase II Elongator
2001 StandoutNobel
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1999 StandoutNobel
Elongation by RNA polymerase II: the short and long of it
2004
Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts
1996
Characterization of CAF4 and CAF16 Reveals a Functional Connection between the CCR4-NOT Complex and a Subset of SRB Proteins of the RNA Polymerase II Holoenzyme
2001
The retinoblastoma protein as a transcriptional repressor
1993
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest
1993
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis
2002
Role of Intrinsic Flexibility in Signal Transduction Mediated by the Cell Cycle Regulator, p27Kip1
2008
Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)
2008
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
1993 Nature
Dissecting the Regulatory Circuitry of a Eukaryotic Genome
1998 Standout
Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
1994
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
1993 StandoutNature
An Activator Target in the RNA Polymerase II Holoenzyme
1998
Phosphorylation-dependent Interaction between the Splicing Factors SAP155 and NIPP1
2002
Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
2000
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
1994 Standout
Mammalian G1 cyclins
1993 Standout
The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression
1999
Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions
2006
Overexpression of the E2F-1 transcription factor gene mediates cell transformation.
1995
The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors
1993
Structural organization of yeast and mammalian mediator complexes
2000 StandoutNobel
Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G1/S-Regulatory Genes
1995
Purification of transcription cofactor complex CRSP
1999
Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.
1994
ATP-Dependent Chromatin-Remodeling Complexes
2000
Rescue of defective mitogenic signaling by D-type cyclins.
1995
Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.
1993
Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter
1996
Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.
1994
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.
1993
Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.
1996
Function of a human cyclin gene as an oncogene.
1994
Yeast Nuclear Extract Contains Two Major Forms of RNA Polymerase II Mediator Complexes
2001
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.
1996
Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors
1996 StandoutNobel
Repression of cyclin D1: a novel function of MYC.
1994
Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo
1997
Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events
1996
Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control
1993 Science
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
1997 StandoutNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
1994
Absence of WAF1 mutations in a variety of human malignancies
1994
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.
1993
Transcription Elongation and Human Disease
1999
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
1993 StandoutNobel
p21-containing cyclin kinases exist in both active and inactive states.
1994
Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
2002 Science
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.
1993
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent
1996
Quality Control by DNA Repair
1999 StandoutScienceNobel
GENETICS OF TRANSCRIPTIONAL REGULATION IN YEAST: Connections to the RNA Polymerase II CTD
1997
Amplification of cyclin genes in colorectal carcinomas.
1993
An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.
1993
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1994
Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and Senescence
1996
Cyclin E-CDK2 is a regulator of p27Kip1.
1997
Activation of Cyclin-Dependent Kinase 4 (cdk4) by Mouse MO15-Associated Kinase
1994
Cancer Cell Cycles
1996 StandoutScience
Cdc25A is a novel phosphatase functioning early in the cell cycle.
1994
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.
1993
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
The Organization of Replication and Transcription
1999 Science
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
1999
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
1998 StandoutNobel
Cell cycle controls: potential targets for chemical carcinogens?
1993
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
The retinoblastoma protein binds to a family of E2F transcription factors.
1993
Cyclin D1 expression is regulated by the retinoblastoma protein.
1994
Cyclin-Binding Motifs Are Essential for the Function of p21CIP1
1996
Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
1994
Anchorage-Dependent Transcription of the Cyclin A Gene
1996
Cyclins and cyclin-dependent kinases: a biochemical view
1995
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
1994
Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.
1993
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
1996
Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD
1995 Science
Redundant cyclin overexpression and gene amplification in breast cancer cells.
1993
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.
1993 StandoutNobel
Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter
1994 StandoutNobel
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Cloning, chromosomal location, and characterization of mouse E2F1.
1994 StandoutNobel
Repression of p27kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells
1996
Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.
1996
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
1994
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
1993
Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.
1995
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 Standout
The retinoblastoma protein and cell cycle control
1995 Standout
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.
1993
E2F-4, a new member of the E2F transcription factor family, interacts with p107.
1994
Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression
1993
Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.
1993
Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.
1996
Cyclin A/CDK2 Binds Directly to E2F-1 and Inhibits the DNA-Binding Activity of E2F-1/DP-1 by Phosphorylation
1994
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.
1994
Altered Cell Cycle Kinetics, Gene Expression, and G1 Restriction Point Regulation in Rb-Deficient Fibroblasts
1996
Effects of Phosphorylation by CAK on Cyclin Binding by CDC2 and CDK2
1995
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
Interplay of Positive and Negative Regulators in Transcription Initiation by RNA Polymerase II Holoenzyme
1998
Increased activity of p53 in senescing fibroblasts.
1995
Acceleration of the G1/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System
1994
Cyclin-Dependent Regulation of G 1 in Mammalian Fibroblasts
1993 Science
Regulation of Cell Division by Intrinsically Unstructured Proteins: Intrinsic Flexibility, Modularity, and Signaling Conduits
2008
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
1992 Standout
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.
1993
Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
2001
PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner
1999
Nuclear localization of vertebrate cyclin a correlates with its ability to form complexes with cdk catalytic subunits
1993
Requirement of TRAP/Mediator for Both Activator-Independent and Activator-Dependent Transcription in Conjunction with TFIID-Associated TAFIIs
2002
Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle.
1994 StandoutNobel
Inhibition of cyclin-dependent kinases by p21.
1995
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.
1995
Chromatin modification by DNA tracking
1999
TRANSCRIPTION OF EUKARYOTIC PROTEIN-CODING GENES
2000
Long-distance transcriptional enhancement by the histone acetyltransferase PCAF
1998
Mediator of Transcriptional Regulation
2000 StandoutNobel
E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.
1994
Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development
2001
Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†
1997
Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.
1993
Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.
1995
CRYO-ELECTRON MICROSCOPY OF SPLICEOSOMAL COMPONENTS
2006
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.
1994
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.
1994
Allosteric Cascade of Spliceosome Activation
2002
A Transcriptional Mediator Protein That Is Required for Activation of Many RNA Polymerase II Promoters and Is Conserved from Yeast to Humans
1997
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
1998
Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.
1995
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
1995
Virus-encoded cyclin.
1994
Mediator protein mutations that selectively abolish activated transcription
1999 StandoutNobel
Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.
1994
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition.
1994
DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.
1994
Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity.
1996
Nerve Growth Factor-induced Growth Arrest and Induction of p21 in NIH-3T3 Cells Expressing TrkA
1995
D-type cyclin-dependent kinase activity in mammalian cells.
1994
A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes.
1993
Tat Modifies the Activity of CDK9 To Phosphorylate Serine 5 of the RNA Polymerase II Carboxyl-Terminal Domain during Human Immunodeficiency Virus Type 1 Transcription
2000
Human DNA Repair Genes
2001 StandoutScienceNobel
Cyclin D1 Is Dispensable for G1 Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity
1995
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.
1993
The N-Terminal Domain of p73 Interacts with the CH1 Domain of p300/CREB Binding Protein and Mediates Transcriptional Activation and Apoptosis
2000
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.
1994
Translational Control of p27 Kip1 Accumulation During the Cell Cycle
1996 Science
Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
1993
Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.
1995 StandoutNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β
1993 Science
Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.
1994
Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells.
1994
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
1996
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.
1995
Cyclin E, a Potential Prognostic Marker in Breast Cancer.
1997
A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression
1993 Science
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.
1993
Molecular Architecture of the Multiprotein Splicing Factor SF3b
2003 Science
Activator-Specific Requirement of Yeast Mediator Proteins for RNA Polymerase II Transcriptional Activation
1999
p53-Independent Expression of p21 Cip1 in Muscle and Other Terminally Differentiating Cells
1995 Science
Alternative splicing of human cyclin E
1994
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
1992 Science
Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage
1996
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
1994
Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.
1994
Telomerase regulation during entry into the cell cycle in normal human T cells.
1996 StandoutNobel
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.
1995
A Potential Role for U2AF-SAP 155 Interactions in Recruiting U2 snRNP to the Branch Site
1998
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.
1993
Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.
1995
Human Cyclin E, a Nuclear Protein Essential for the G1-to-S Phase Transition
1995
Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.
1996
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
1994 Standout
Works of Emma Lees being referenced
Cyclin dependent kinase regulation
1995
Three RNA Polymerase II Carboxyl-terminal Domain Kinases Display Distinct Substrate Preferences
2001
Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis
1998
Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
1998
A human RNA polymerase II complex associated with SRB and DNA-repair proteins
1996 Nature
Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases
1999
NAT, a Human Complex Containing Srb Polypeptides that Functions as a Negative Regulator of Activated Transcription
1998
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
1994 Nature
Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
1999 Nature
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
1994 Standout
Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1
1997
Sequences Within the Conserved Cyclin Box of Human Cyclin A are Sufficient for Binding to and Activation of cdc2 Kinase
1993
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
1992
The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2
1993
Cyclin E Associates with Components of the Pre-mRNA Splicing Machinery in Mammalian Cells
1998
A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure
1998
Association of human cyclin E with a periodic G1-S phase protein kinase
1992 Science
Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.
1993
Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.
1996
Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest
1999
The cdk2 kinase is required for the G1-to-S transition in mammalian cells.
1993
Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation
1994
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.
1992
Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation
2001
A cell cycle-regulated inhibitor of cyclin-dependent kinases.
1994
Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors
1999
Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.
1993