Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo
2007
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
EglN2 associates with the NRF 1‐ PGC 1α complex and controls mitochondrial function in breast cancer
2015 StandoutNobel
Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13
2002
Genetic evidence for a tumor suppressor role of HIF-2α
2005
Hypoxia-Inducible Factors, Stem Cells, and Cancer
2007
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
2006
Acute postnatal ablation of Hif-2 α results in anemia
2007
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
2009 StandoutNobel
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer.
2002
HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth
2006
Activation of the HIF pathway in cancer
2001
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
2002
Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates
2006
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
2003
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
2003
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300
1999
Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2
2006
Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis
2009
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Hypoxia-inducible Factor-2α (HIF-2α) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia
2001
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice
2003
Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism
2003
ARNT-Deficient Mice and Placental Differentiation
1997
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues
2002
Hypoxia, HIF1 and glucose metabolism in the solid tumour
2008
The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
2002
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1
2007 StandoutNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Remembrance of things PAS: regulation of development by bHLH–PAS proteins
1999
Molecular mechanisms of blood vessel growth
2001
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
2010
Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia
2000 Standout
The Role of Mitochondria in the Regulation of Hypoxia-inducible Factor 1 Expression during Hypoxia
2000
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
2006
p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription
1998
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
2002
The complexity of p53 modulation: emerging patterns from divergent signals
1998
Oxygen sensing and signaling: impact on the regulation of physiologically important genes
1999
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Molecular Mechanism of Hypoxia-inducible Factor 1α-p300 Interaction
2001
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3
2000
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival
2001
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
The role of iron in cell cycle progression and the proliferation of neoplastic cells
2002
The Hallmarks of Cancer
2000 Standout
Induction of hypoxia‐inducible factor‐1 (HIF‐1) and its target genes following focal ischaemia in rat brain
1999 StandoutNobel
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development
2001
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
2006
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
2003
Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tract
2003
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
2005
Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers
2006
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
2003
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
1998
How oxygen makes its presence felt: Figure 1.
2002 StandoutNobel
Hypoxia and Fetal Heart Development
2010
Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide
1999
Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α)
1998 StandoutNobel
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
HIF-1alpha is required for solid tumor formation and embryonic vascularization
1998
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression
2001 StandoutNobel
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
2005
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
2005
The Role of Hypoxia in Development of the Mammalian Embryo
2009
Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death
1999 StandoutNobel
Intramyocardial injection of naked DNA encoding HIF-1 /VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
2002
Hypoxia-Induced Vascular Endothelial Growth Factor Expression Precedes Neovascularization after Cerebral Ischemia
2000
Hypoxic induction of hypoxia-inducible factor-1α and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells
2002
Expression of hypoxia-inducible factor-1α in oligodendrogliomas
2001
JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress
2004
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1
1999
ERK activation upon hypoxia: involvement in HIF‐1 activation
2000
Hypoxia-inducible factors: central regulators of the tumor phenotype
2007
HIF-1 as a target for drug development
2003
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT
1998
Signalling hypoxia by HIF hydroxylases
2005 StandoutNobel
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
2004
Hypoxia-responsive signaling regulates the apoptosis-dependent remodeling of the embryonic avian cardiac outflow tract
2004
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
1994 Nature
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
2006 StandoutNobel
Oncogenic alterations of metabolism
1999 StandoutNobel
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy
2003
Perspectives on Oxygen Sensing
1999 StandoutNobel
Regulation of the Erythropoietin Gene
1989
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia
2012
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
2010
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
2003
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
2001 StandoutNobel
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
2000 StandoutNobel
Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia
2001 StandoutNobel
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α
2003
Gene–environment interaction demonstrates the vulnerability of the embryonic heart
2014
Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
2014
HIF and the Lung
2011 StandoutNobel
Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima
2005 StandoutNobel
Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases
2013
Role of Hypoxia in the Evolution and Development of the Cardiovascular System
2007
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
2000 StandoutNobel
Oxygen tension modulates β‐globin switching in embryoid bodies
1999
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
2000 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
2000 StandoutNobel
Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans
2000
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
2000 StandoutNobel
Hypoxia affects mesoderm and enhances hemangioblast specification during early development
2004
Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes
1999
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
2003 Science
Vulnerability of the Developing Heart to Oxygen Deprivation as a Cause of Congenital Heart Defects
2014
HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia
2001
Cells depleted of mitochondrial DNA (p0) yield insight into physiological mechanisms
1999
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
2005
Hypoxia-Inducible Factor-1α Mediates Hypoxia-Induced Delayed Neuronal Death That Involves p53
1999
Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar
2002 StandoutNobel
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
2001 StandoutNobel
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
2009
Essential role of B-Raf in ERK activation during extraembryonic development
2006
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.
2000 StandoutNobel
How mitochondria produce reactive oxygen species
2008 Standout
Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression.
1999 StandoutNobel
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
2003
The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development
1997
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
2000
PROLINE HYDROXYLATION AND GENE EXPRESSION
2005 StandoutNobel
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Repression of gene expression by oxidative stress
1999
Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction.
1998
Hypoxia. 5. Hypoxia and hematopoiesis
2011
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
2007 StandoutNobel
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy.
2001
Cellular oxygen sensing by mitochondria: old questions, new insight
2000
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion
2000
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
2007
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.
2000
HIF-2α regulates murine hematopoietic development in an erythropoietin-dependent manner
2004
Regulation of the Erythropoietin Gene
1999
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
HIF and pulmonary vascular responses to hypoxia
2013
The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice
2003
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
2000 Standout
Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.
1999
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
1998 StandoutNobel
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis
2007
Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc.
2002
Mutations in SDHD , a Mitochondrial Complex II Gene, in Hereditary Paraganglioma
2000 StandoutScience
Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia
2002
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.
2000
Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia
2007
Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species
2002
Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro
2006
Works of Emin Maltepe being referenced
Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation
2005
Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse
1998
Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development
1998
HIF-1 is Essential for Multilineage Hematopoiesis in the Embryo
2002
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
1997 Nature
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia
1992
Multilineage embryonic hematopoiesis requires hypoxic ARNT activity
1999
Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care
2010
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
1998 Nature
The Role of ARNT2 in Tumor Angiogenesis and the Neural Response to Hypoxia
2000
Oxygen, Epigenetics and Stem Cell Fate
2005
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
2000
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta
2005
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
1998 Standout