Standout Papers
Citation Impact
Citing Papers
In Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center
2021
Crystal Structure of a Lipid G Protein–Coupled Receptor
2012 Science
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Biased Signaling Pathways in β 2 -Adrenergic Receptor Characterized by 19 F-NMR
2012 ScienceNobel
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
2003 StandoutNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding
2016
Protein structure determination using metagenome sequence data
2017 StandoutScienceNobel
A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly
2019
Structural basis for nucleotide exchange in heterotrimeric G proteins
2015 ScienceNobel
Assessing the utility of coevolution-based residue–residue contact predictions in a sequence- and structure-rich era
2013 StandoutNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia
2017
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex
2020
Topologically-guided continuous protein crystallization controls bacterial surface layer self-assembly
2019 Nobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Structural insights into µ-opioid receptor activation
2015 NatureNobel
Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities
2024 StandoutNobel
Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery
2017
Recent advances in the structural and molecular biology of type IV secretion systems
2014
From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective
2019
GPCR activation mechanisms across classes and macro/microscales
2021
Protein Conformational Switches: From Nature to Design
2012
Molecular Architecture of the 40S⋅eIF1⋅eIF3 Translation Initiation Complex
2014
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Crystal structure of the human COP9 signalosome
2014 Nature
An inverse correlation between loop length and stability in a four-helix-bundle protein
1997
S-layers: principles and applications
2014
Atomic model of the type III secretion system needle
2012 StandoutNatureNobel
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Chemical Technologies for Probing Glycans
2006 StandoutNobel
Signalling bias in new drug discovery: detection, quantification and therapeutic impact
2012
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
2018
Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors
2018
Structure of the µ-opioid receptor–Gi protein complex
2018 NatureNobel
Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri
2018
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Ligand-Specific Interactions Modulate Kinetic, Energetic, and Mechanical Properties of the Human β2 Adrenergic Receptor
2012 StandoutNobel
Modulation of protein properties in living cells using nanobodies
2009
How Ligands Illuminate GPCR Molecular Pharmacology
2017
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Molecular Dynamics Simulation for All
2018 Standout
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Recent developments in biased agonism
2013 Nobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes
2022
Solution NMR studies of polytopic α-helical membrane proteins
2011
Structure of a type IV secretion system
2014 Nature
Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors
2011
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor
2012 StandoutNobel
Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
2021
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Structure and dynamics of GPCR signaling complexes
2017 Nobel
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations
2016
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Structure of the human κ-opioid receptor in complex with JDTic
2012 Nature
New amphiphiles for membrane protein structural biology
2011
Self-assembled two-dimensional protein arrays in bionanotechnology: from S-layers to designed lattices
2013
Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study
2012 StandoutNobel
A Glimpse of Structural Biology through X-Ray Crystallography
2014
Integrating protein structural dynamics and evolutionary analysis with Bio3D
2014
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Oligosaccharyl transferase: gatekeeper to the secretory pathway
2002
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Diversity in S-layers
2016
Chemistry and Biology of Vision
2011
Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor
2015
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
2012 StandoutNobel
Structural insights into adrenergic receptor function and pharmacology
2011 StandoutNobel
Secretion systems in Gram-negative bacteria: structural and mechanistic insights
2015
A Diversity of Assembly Mechanisms of a Generic Amyloid Fold
2011
Structure of the human histamine H1 receptor complex with doxepin
2011 Nature
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
2012 StandoutNobel
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
2012 Nature
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
2013 Nature
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
X-ray structure of the mammalian GIRK2–βγ G-protein complex
2013 NatureNobel
Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques
2011
Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex
2016
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system
2009 StandoutNobel
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing
2012
Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
2016
GPCRdb: an information system for G protein-coupled receptors
2015
Self-Assembly of “S-Bilayers”, a Step Toward Expanding the Dimensionality of S-Layer Assemblies
2013 StandoutNobel
A Genetic Approach to Mammalian Glycan Function
2003
Structural aspects of M 3 muscarinic acetylcholine receptor dimer formation and activation
2011
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
S-Layer Protein Self-Assembly
2013
Type IV secretion systems: Advances in structure, function, and activation
2020
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Structure of the adenosine A2A receptor bound to an engineered G protein
2016 Nature
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Structural Biology of Bacterial Type IV Secretion Systems
2015
Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures
1999 StandoutNobel
Conformations of macromolecules and their complexes from heterogeneous datasets
2014
Super-Resolution in Solution X-Ray Scattering and Its Applications to Structural Systems Biology
2013
Activation mechanism of theβ2-adrenergic receptor
2011
Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
2017
Trajectories of the ribosome as a Brownian nanomachine
2014 StandoutNobel
Engineering the S-Layer of Caulobacter crescentus as a Foundation for Stable, High-Density, 2D Living Materials
2018
Membrane Protein Structure Determination Using Crystallography and Lipidic Mesophases: Recent Advances and Successes
2012
Structure-Function of the G Protein–Coupled Receptor Superfamily
2012
Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor
2015 Science
Conformational Dynamics of Single G Protein-Coupled Receptors in Solution
2011 StandoutNobel
Design of protein crystals in the development of solid biomaterials
2015
Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor
2012
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces
2015 StandoutScienceNobel
Works of Els Pardon being referenced
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins
2021
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
2016 NatureNobel
Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System
2011
Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family
2015
Activation and allosteric modulation of a muscarinic acetylcholine receptor
2013 NatureNobel
Structure of a bacterial type IV secretion core complex at subnanometre resolution
2013
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13 in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome)
1997
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
A general protocol for the generation of Nanobodies for structural biology
2014 Nobel
Structure, substrate recognition and initiation of hyaluronan synthase
2022 Nature
SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly
2012 Nature
Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody
2009
A Ca2+-binding Chimera of Human Lysozyme and Bovine α-Lactalbumin That Can Form a Molten Globule
1995
GABAA receptor signalling mechanisms revealed by structural pharmacology
2018 Nature
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
2015 Science
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
2014
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
2016 NatureNobel
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant
2011
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Engineering a Camelid Antibody Fragment That Binds to the Active Site of Human Lysozyme and Inhibits Its Conversion into Amyloid Fibrils
2008