Citation Impact
Citing Papers
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
EFECTO ANTIPARASITARIO DE INHIBIDORES DE CISTEIN PROTEASAS IN VITRO E IN VIVO EN LA ENFERMEDAD DE CHAGAS EXPERIMENTAL
1999
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
1982
Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants
1988
Regulation of Cell Migration by the Calcium-dependent Protease Calpain
1997
N-peptidyl, O-acyl hydroxamates: comparison of the selective inhibition of serine and cysteine proteinases
1996
Structure–activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors
2000
Nature of papain products resulting from inactivation by a peptidyl O‐acyl hydroxamate
1991
Peptidyl O-acyl hydroxamates: Potent new inactivators of cathepsin B
1988
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Characterisation of the antitrypanosomal activity of peptidyl α-aminoalkyl phosphonate diphenyl esters
2000
Synthetic Inhibitors of Elastase
1994
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
A protein-conducting channel in the endoplasmic reticulum
1991 StandoutNobel
Azetidin-2-one derivatives as inhibitors of thrombin
1995
Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis
2000
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
2001
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Participation of the conventional calpains in apoptosis
2002
Microinjection of Calpastatin Inhibits Fusion in Myoblasts
1999
Crystal Structures of Recombinant Rat Cathepsin B and a Cathepsin B-Inhibitor Complex
1995
Activation of the Heat Shock Factor 1 by Serine Protease Inhibitors
1998
[32] Families of cysteine peptidases
1994
Crystal structure of δ-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
2000
Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases
1991
Engineered Metal-Binding Proteins: Purification to Protein Folding
1991 StandoutScienceNobel
The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships
1992
N-tosyl-l-phenylalanyl-chloromethylketone reduces hypoxic–ischemic brain injury in rat pups
2000
A proteolytic system that compensates for loss of proteasome function
1998 Nature
[48] N,O-Diacyl hydroxamates as selective and irreversible inhibitors of cysteine proteinases
1994
Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
1990 StandoutNatureNobel
2 Inhibitors of Human Leukocyte Elastase
1994
Membrane Fusion
2003 StandoutNobel
Recent Developments in Inhibiting Cysteine and Serine Proteases
1990
Geometry of binding of the benzamidine‐ and arginine‐based inhibitors Nα‐(2‐naphthyl‐sulphonyl‐glycyl)‐dl ‐p‐amidinophenylalanyl‐piperidine (NAPAP) and (2R,4R)‐4‐methyl‐1‐[Nα‐(3‐methyl‐1,2,3,4‐tetrahydro‐8‐quinolinesulphonyl)‐l ‐arginyl]‐2‐piperidine carboxylic acid (MQPA) to human α‐thrombin
1990
Regulation of serine protease activity by an engineered metal switch
1990
Chloroketone Hydrolysis by Chymotrypsin and N-Methylhistidyl-57-chymotrypsin: Implications for the Mechanism of Chymotrypsin Inactivation by Chloroketones
1994
Inhibition of 3C Protease from Human Rhinovirus Strain 1B by Peptidyl Bromomethylketonehydrazides
1999
Geometry of binding of the Nα‐tosylated piperidides of m‐amidino‐, p‐amidino‐ and p‐guanidino phenylalanine to thrombin and trypsin
1991
Expression of functional thrombin receptors in Xenopus oocytes injected with human endothelial cell mRNA
1990
Calpains: Intact and active?
1997
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
2000
Development and Therapeutic Potential of Calpain Inhibitors
1996
Inactivation of Subtilisin Carlsberg by N-((tert-Butoxycarbonyl)alanylprolylphenylalanyl)-O-benzoyl Hydroxylamine: Formation of a Covalent Enzyme-Inhibitor Linkage in the Form of a Carbamate Derivative
1994
Identification of epitope‐like consensus motifs using mRNA display
2002 StandoutNobel
Calpain Mediates Integrin-induced Signaling at a Point Upstream of Rho Family Members
1999
Disruption of 3-Phosphoinositide-dependent Kinase 1 (PDK1) Signaling by the Anti-tumorigenic and Anti-proliferative AgentN-α-tosyl-l-phenylalanyl Chloromethyl Ketone
2001
Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen
2003
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
2000
Evidence for Participation of a Calpain-like Cysteine Protease in Cell Cycle Progression through Late G1Phase
1997
Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes)
1996
Why ion pair reversal by protein engineering is unlikely to succeed
1988 StandoutNatureNobel
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Three-Dimensional Structure of Chymotrypsin Inactivated with (2S)-N-Acetyl-L-alanyl-L-phenylalanyl .alpha.-chloroethane: Implications for the Mechanism of Inactivation of Serine Proteases by Chloroketones
1994
Introduction of a cysteine protease active site into trypsin
1989
Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions
1999
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
1991 Standout
Purification of Active Calpain by Affinity Chromatography on an Immobilized Peptide Inhibitor
1996
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
1991
Novel N-peptidyl-O-acyl hydroxamates: selective inhibitors of cysteine proteinases
1993
Catalytic promiscuity and the evolution of new enzymatic activities
1999
Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction
2001
Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase
1995
Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin
1993
The nematophagous fungus Verticillium chlamydosporium produces a chymoelastase-like protease which hydrolyses host nematode proteins in situ
1994
β1 Integrin-Mediated T Cell Adhesion and Cell Spreading Are Regulated by Calpain
2000
Chapter 11 Proteinase families and their inhibitors
2001
Peptide Diazomethyl Ketones are Inhibitors of Subtilisin-Type Serine Proteases
1990
Rates of thrombin acylation and deacylation upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylating agents
1995
Comparison of the structures of the cyclotheonamide a complexes of human α‐thrombin and bovine β‐trypsin
1996
The Calpain Small Subunit Gene Is Essential: Its Inactivation Results in Embryonic Lethality
2000
Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death
1995
Reaction of Dipeptidylpeptidase IV with Substrate-Analogous Azapeptides
1991
A player of many parts: The spotlight falls on thrombin's structure
1993
The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B
1988
A Noncleavable Retro-Binding Peptide That Spans the Substrate Binding Cleft of Serine Proteases. Atomic Structure of Nazumamide A: Human Thrombin
1996
Kinetic studies of the urokinase-catalysed conversion of NH2-terminal glutamic acid plasminogen to plasmin
1977
Mechanism-Based Profiling of Enzyme Families
2006
Characterization of a continuous fluorogenic assay for calpain I. Kinetic evaluation of peptide aldehydes, halomethyl ketones and (acyloxy)methyl ketones as inhibitors of the enzyme
1995
Structural patterns in globular proteins
1976 StandoutNatureNobel
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
1989
Monocyte Chemotaxis: Stimulation by Specific Exosite Region in Thrombin
1983 Science
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
The topography of the purple membrane
1979 StandoutNatureNobel
E64 [trans-epoxysuccinyl-l -leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions
1994
Mechanism of cysteine protease inactivation by peptidyl epoxides
1997
Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin
1969 Nature
Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase
1983 StandoutNobel
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Antibodies to “Alcalase” after Industrial Exposure
1971 StandoutNobel
Review
1995
Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains
1993
Affinity Labelling of Antibodies with Aryl Nitrene as Reactive Group
1969 StandoutNatureNobel
The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
1989 Nobel
Synthesis and properties of Cbz-Phe-Arg-CHN2 (benzyloxycarbonylphenylalanylarginyldiazomethane) as a proteinase inhibitor
1988
Serine protease selectivity of the thrombin inhibitor D-Phe-Pro-Agmatine and its homologs
1995
Modification of a Methionine Residue near the Active Site of Chymotrypsin by p-Nitrophenyl Bromoacetyl-α-aminoisobutyrate*
1965
v-Src-Induced Modulation of the Calpain-Calpastatin Proteolytic System Regulates Transformation
2002
Identity of the tryptic and α-chymotrypic reactive sites on soybean trypsin inhibitor (Kunitz)
1972
Cysteine Proteases and Their Inhibitors
1997
Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
1993
The selective inhibition of thrombin by peptides of boroarginine.
1990
Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway
1997 StandoutNobel
Polypeptide halomethyl ketones bind to serine proteases as analogs of the tetrahedral intermediate. X-ray crystallographic comparison of lysine- and phenylalanine-polypeptide chloromethyl ketone-inhibited subtilisin.
1976
Immunoglobulins: Chemical Typing of Immunoglobulins
1969 StandoutNatureNobel
Synthesis and Evaluation of Diphenyl Phosphonate Esters as Inhibitors of the Trypsin-like Granzymes A and K and Mast Cell Tryptase
1998
Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl flourides
1978
Dipeptidyl peptidase II of bovine dental pulp. Initial demonstration and characterization as a fibroblastic, lysosomal peptidase of the serine class active on collagen-related peptides
1980
Re-examination of the charge relay system in subtilisin comparison with other serine proteases.
1977
Conformational transition from trypsinogen to trypsin
1980 StandoutNobel
Human liver cathepsin L
1985
The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding
1979
Secretion ofSaccharomyces cerevisiaeKiller Toxin: Processing of the Glycosylated Precursor
1983
Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments
1998
Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases
1992
Design of a new selective cysteine protease inactivator and its mechanistic implications
1995
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
2000 StandoutScienceNobel
Chromatin structure as probed by nucleases and proteases: Evidence for the central role of hitones H3 and H4
1976
Hepatitis B virus genes and their expression in E. coli
1979 StandoutNatureNobel
Alkylation of a Histidine Residue at the Active Site of Bovine Pancreatic Deoxyribonuclease
1969 StandoutNobel
Plasminogen: Purification from Human Plasma by Affinity Chromatography
1970 StandoutScience
Structure of Antibody Molecules
1967 StandoutNatureNobel
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver.
1994
Molecular biology: Reverse transcriptase rides again
1985 StandoutNatureNobel
Peptidyl Epoxides: Novel Selective Inactivators of Cysteine Proteases1
1996
Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.
1995
Small synthetic inhibitors of cysteine proteases
1996
Calpain Regulates Actin Remodeling during Cell Spreading
1998
Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin
1987
(p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases
1980
The Calpain System
2003 Standout
Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.
1992
Diethylpyrocarbonate inhibition of estrogen binding to rat alpha-fetoprotein: Evidence that one or more histidine residues regulate estrogen binding
1981
Reaction of proteasomes with peptidylchloromethanes and peptidyldiazomethanes
1993
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
1991
Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus
1977 StandoutNatureNobel
From Poor Substrates to Good Inhibitors: Design of Inhibitors for Serine and Thiol Proteases
1996
Further characterization of intracellular precursor polyproteins of rauscher leukemia virus
1977
Mechanism of inactivation of human leukocyte elastase by a chloromethyl ketone: kinetic and solvent isotope effect studies
1986
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.
1994
Structure of bovine trypsinogen at 1.9 Å resolution
1977
Structure of the binding site of pyridoxal 5'-phosphate to Escherichia coli glutamate decarboxylase
1970 StandoutNobel
Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus
1994
Fluorescence energy-transfer measurements between the calcium binding site and the specificity pocket of bovine trypsin using lanthanide probes
1976
Lasting safe interruption of endarterectomy thrombosis by transiently infused antithrombin peptide D-Phe-Pro-ArgCH2Cl in baboons
1993
Strategy and tactics in protein chemistry
1970 Standout
NS3-4A of hepatitis C virus is a chymotrypsin-like protease
1995
Studies on the Conformational Changes of Plasminogen Induced during Activation to Plasmin and by 6‐Aminohexanoic Acid
1973
Alkyl isocyanates as active-site-specific reagents for serine proteases. Reaction properties
1973
Pancreatic Enzymes of the Spiny Pacific Dogfish. I. Cationic Chymotrypsinogen and Chymotrypsin*
1966
Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.
1987
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
2000 Standout
Potent and selective inactivation of cysteine proteinases with N-peptidyl-O-acyl hydroxylamines
1989
Affinity labelling of the Ca2+-activated neutral proteinase (calpain) in intact human platelets
1993
A joint product of the genes gag and pol of Avian Sarcoma Virus: a possible precursor of reverse transcriptase
1977 StandoutNobel
Variations on a theme
1991 StandoutNatureNobel
Antibody Active Sites and Immunoglobulin Molecules
1966 Science
The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B
1987
Inactivation of α-chymotrypsin by new bifunctional reagents : halomethylated derivatives of dihydrocoumarins
1977
Control of programmed cyclin destruction in a cell-free system.
1989
Polypeptide Chains of Immunoglobulins from the Smooth Dogfish ( Mustelus canis )
1966 StandoutScienceNobel
Replication Strategies of the Single Stranded RNA Viruses of Eukaryotes
1983
Reversible Chemical Modification of the Scrapie Agent
1981 StandoutScienceNobel
The Binding of Thrombin to the Surface of Human Platelets
1974
Characterization of an Extremely Large, Ligand-Induced Conformational Change in Plasminogen
1990 StandoutScienceNobel
Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors
2000
Kinetics of the thrombin-induced release of calcium(II) by platelets
1973
Disulphide Bridges of Immunoglobin G1 Heavy Chains
1967 StandoutNatureNobel
Chymotrypsin: Molecular and catalytic properties
1986
Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors
1991
α-Chymotrypsin: A Case Study of Substituent Constants and Regression Analysis in Enzymic Structure—Activity Relationships
1970
Peptidyl sulfonium salts. A new class of protease inhibitors.
1988
New Peptidic Cysteine Protease Inhibitors Derived from the Electrophilic α-Amino Acid Aziridine-2,3-dicarboxylic Acid
1999
Induction of the bovine trypsinogen—trypsin transition by peptides sequentially similar to the N‐terminus of trypsin
1976 StandoutNobel
Protease Inhibitors: Current Status and Future Prospects
2000
Somatic Translocation of Antibody Genes
1970 StandoutNatureNobel
The use of sodium dodecylsulphate-acrylamide-gel electrophoresis to analyse trypsin preparations
1976
Affinity Labeling of the Active Site of Staphylococcal Nuclease
1969 StandoutNobel
Synthesis and properties of peptidyl derivatives of arginylfluoromethanes
1988
Clathrin: A Role in the Intracellular Retention of a Golgi Membrane Protein
1989 StandoutScienceNobel
Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin.
1983
Studies on the Guinea Pig Pancreas
1974 StandoutNobel
Structure of nucleosome core particles of chromatin
1977 StandoutNatureNobel
Chromatography of Trypsin and Its Derivatives
1968
Inhibition of trypsin-like serine proteinases by tripeptide arginyl and lysyl chloromethylketones
1984
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors
1985
The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases
1986
Location of the calcium ion binding site in bovine α-trypsin and β-trypsin using lanthanide ion probes
1975
The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding
1978 StandoutNobel
Evolution of Structure and Function of Proteases
1967 Science
Synthesis and Biological Activity of a Series of Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I
1997
Structure of Subtilisin BPN′ at 2.5 Å Resolution
1969 Nature
[16] Reaction of serine proteases with halomethyl ketones
1977
The Mechanism of Activation of Trypsinogen. The Role of the Four N-Terminal Aspartyl Residues
1969
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments
1979 StandoutNatureNobel
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor
1984 StandoutNobel
The Complete Amino Acid Sequence of Two Types of Subtilisin, BPN' and Carlsberg
1966
Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA
1992
Affinity Labeling—a General Method for Labeling the Active Sites of Antibody and Enzyme Molecules*
1962
Brain aminoacyl arylamidase. Further purification of the soluble bovine enzyme and studies on substrate specificity and possible active-site residues
1970
The Photolysis of Diazoacetylchymotrypsin
1962
Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin
1981
Synthesis and characterization of a new fluorogenic active-site titrant of serine proteases
1981
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Peptidyl epoxides as selective protease inactivators
2000
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L
1996
Structure and specific binding of trypsin: Comparison of inhibited derivatives and a model for substrate binding
1974
Glycosylation and processing of prepro-α-factor through the yeast secretory pathway
1984 StandoutNobel
Structure-function relationships in the interaction of alpha-thrombin with blood platelets.
1977
Chemical modification of papain
1968 Standout
Retrieval of TGN proteins from the cell surface requires endosomal acidification.
1994
Peptidyldiazomethanes. A novel mechanism of interaction with prolyl endopeptidase
1992
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Aziridine‐2‐carboxylic acid A reactive amino acid unit for a new class of cysteine proteinase inhibitors
1992
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
1992
Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B
1985
Affinity Labeling of the Active Sites of Antibodies to the 2,4-Dinitrophenyl Hapten*
1963
Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation
1992
Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection
1998
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.
1995
Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus.
1994
Purification and properties of the deoxyribonucleic acid polymerase induced by vaccinia virus.
1979
Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus
1995
Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.
1988
Biochemical properties of p15-associated protease in an avian RNA tumor virus
1978
Inhibition of elastase and other serine proteases by heterocyclic acylating agents.
1980
Synthesis of lysine-containing sulphonium salts and their properties as proteinase inhibitors
1988
Works of Elliott Shaw being referenced
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis
1991
Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones
1989
Active center differences between cathepsins L and B: The S1 binding region
1988
p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin
1967
Characterisation of a cysteine protease from bloodstream forms of Trypanosoma congolense
1992
The affinity‐labelling of cathepsin s with peptidyl diazomethyl ketones
1993
Inhibition of Growth of Human TE2 and C-33A Cells by the Cell-Permeant Calpain Inhibitor Benzyloxycarbonyl-Leu-Leu-Tyr Diazomethyl Ketone
1994
[46] Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases
1994
Cysteinyl Proteinases and Their Selective Inactivation
1990
Isolation of a Chinese Hamster Ovary Cell Clone Possessing Decreased µ-Calpain Content and a Reduced Proliferative Growth Rate
1996
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60
1992 Nature
Inactivation of calpain by peptidyl fluoromethyl ketones
1992
The properties of peptidyl diazoethanes and chloroethanes as protease inactivators
1989
A prolyl endopeptidase from murine macrophages, its assay and specific inactivation
1983
Aromatic esters which inhibit plasmin or thrombin by formation of relatively stable acyl enzymes
1973
The reactivity of his-57 in chymotrypsin to alkylation
1971
Diazomethyl ketone substrate derivatives as active-site-directed inhibitors of thiol proteases. Papain
1977
An exploration of the primary specificity site of cathepsin B
1983
Studies on the Active Center of Trypsin
1965
Inactivation of trypsin-like proteases by active-site-directed sulfonylation
1976
Inactivation of trypsin-like proteases by depsipeptides of p-guanidinobenzoic acid
1981
Active site mapping of human and rat urinary kallikreins by peptidyl chloromethyl ketones
1980
Active-site-directed alkylation of chymotrypsin by reagents utilizing various departing groups
1976
The Identification of the Histidine Residue at the Active Center of Chymotrypsin
1965
The selective inactivation of thiol proteasesin vitro andin vivo
1984
A comparison of deacylation rates of para-substituted benzoyl-trypsins and chymotrypsins
1972
Further observations on substrate-derived chloromethyl ketones that inactivate trypsin
1970
Rapid inactivation of cathepsin L by Z-Phe-PheCHN2 and Z-Phe-AlaCHN2
1981
Active-site-directed phenacyl halides inhibitory to trypsin
1971
The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor
1989
Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine*
1965
Affinity labelling of proteinases with tryptic specificity by peptides with C-terminal lysine chloromethyl ketone
1974
[63] Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone
1981
Identification of the histidine residue at the active center of trypsin labelled by TLCK
1967
The Purification of Thrombin and Isolation of a Peptide Containing the Active Center Histidine
1971
Inhibition of Cleavage of Large Poliovirus-Specific Precursor Proteins in Infected HeLa Cells by Inhibitors of Proteolytic Enzymes
1972
A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones
1979
The inhibition of crotalase, a thrombin-like snake venom enzyme, by several peptide chloromethyl ketone derivatives
1981
[58] Site-specific reagents for chymotrypsin, trypsin, and other serine proteases
1972
Studies on the Active Center of Trypsin
1967
Inactivation of cathepsin B1 by diazomethyl ketones
1977
Differences in active center reactivity of trypsin homologs
1974
An Active Center Histidine Peptide of α-Chymotrypsin
1964
Inactivation of trypsin-like proteases by sulfonylation. Variation of positively charged group and inhibitor length
1978
Synthesis of peptides of arginine chloromethyl ketone. Selective inactivation of human plasma kallikrein
1978
[2] Some sensitive methods for the assay of trypsinlike enzymes
1976
Thiobenzyl benzyloxycarbonyl-l-lysinate, substrate for a sensitive colorimetric assay for trypsin-like enzymes
1979
Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes
1969
Direct Evidence for the Presence of Histidine in the Active Center of Chymotrypsin*
1963
D-PHE-PRO-ARGCH2Cl-A selective affinity label for thrombin
1979
A new method for labelling the active center of chymotrypsin
1962
The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketone
1981
[62] Inactivation of thiol proteases with peptidyl diazomethyl ketones
1981
Lysis of trypanosomes by peptidyl fluoromethyl ketones
1990