Citation Impact
Citing Papers
Tryptophan 7-Halogenase (PrnA) Structure Suggests a Mechanism for Regioselective Chlorination
2005 Science
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation
2016
A Structure‐Guided Switch in the Regioselectivity of a Tryptophan Halogenase
2016
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Asymmetric Counteranion‐Directed Catalysis: Concept, Definition, and Applications
2012 StandoutNobel
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
Engineering natural products using combinatorial biosynthesis and biocatalysis
2008
Bioactive natural products from marine cyanobacteria for drug discovery
2007
Biosynthesis of polyketide synthase extender units
2008
Pseudilins: Halogenated, Allosteric Inhibitors of the Non‐Mevalonate Pathway Enzyme IspD
2014
PKS and NRPS release mechanisms
2009
Regioselective Arene Halogenation using the FAD‐Dependent Halogenase RebH
2013
Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
2014
Fluoro amino acids: A rarity in nature, yet a prospect for protein engineering
2015
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
2008 Standout
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
2006
Mononuclear non-heme iron enzymes with the 2-His-1-carboxylate facial triad: recent developments in enzymology and modeling studies
2008
Biocatalysts for the formation of three- to six-membered carbo- and heterocycles
2015
Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2
2013 Nature
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids
2016
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Metamorphic enzyme assembly in polyketide diversification
2009 Nature
A convenient enzymatic synthesis of l-halotryptophans
2006
Characterization of SyrC, an Aminoacyltransferase Shuttling Threonyl and Chlorothreonyl Residues in the Syringomycin Biosynthetic Assembly Line
2007
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Protein–Protein Interactions in Multienzyme Megasynthetases
2008
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
2006
Engineering Biofilms for Biocatalysis
2011
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
2011 StandoutNobel
Cyanobacterial peptides — Nature's own combinatorial biosynthesis
2006
DKxanthene Biosynthesis—Understanding the Basis for Diversity-Oriented Synthesis in Myxobacterial Secondary Metabolism
2008
Stalking intermediates in oxygen activation by iron enzymes: Motivation and method
2006
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis
2007 StandoutNobel
Flavoenzymes
2007
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
2010 StandoutNobel
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
2008
An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation
2006
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis
2006 Nature
Exploring protein fitness landscapes by directed evolution
2009 StandoutNobel
Biosynthetic Manipulation of Tryptophan in Bacteria: Pathways and Mechanisms
2015
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives
2006
Metabolites from symbiotic bacteria
2008
Development of fluorescent aryltryptophans by Pd mediated cross-coupling of unprotected halotryptophans in water
2008
Halogenation Strategies In Natural Product Biosynthesis
2008
Oxidative Halogenation with “Green” Oxidants: Oxygen and Hydrogen Peroxide
2009
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions
2011 Standout
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Enzymatic Fluorination and Biotechnological Developments of the Fluorinase
2014
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Use of Bromine and Bromo-Organic Compounds in Organic Synthesis
2016
Enantioselective Halocyclization Using Reagents Tailored for Chiral Anion Phase-Transfer Catalysis
2012
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
Flavin-dependent halogenases involved in secondary metabolism in bacteria
2006
Regiospecific Chlorination of (S)-β-Tyrosyl-S-Carrier Protein Catalyzed by SgcC3 in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027
2007
Halogenation of Unactivated Carbon Centers in Natural Product Biosynthesis: Trichlorination of Leucine during Barbamide Biosynthesis
2006
Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C–H Functionalization
2016
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
Bis- and Trisindolylmethanes (BIMs and TIMs)
2009 Standout
Non-Heme Fe(IV)–Oxo Intermediates
2007 Standout
SyrB2 in syringomycin E biosynthesis is a nonheme Fe II α-ketoglutarate- and O 2 -dependent halogenase
2005
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
C−H Activation for the Construction of C−B Bonds
2009 Standout
Mechanism of Selective Halogenation by SyrB2: A Computational Study
2010
A highly selective Ir-catalyzed borylation of 2-substituted indoles: a new access to 2,7- and 2,4,7-substituted indoles
2006
Functional Enzyme Mimics for Oxidative Halogenation Reactions that Combat Biofilm Formation
2018
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
2011 Standout
Palladium-Catalyzed Transformations of Alkyl C–H Bonds
2016 Standout
Functional Cross-Antagonism between Transcription Factors FLI-1 and EKLF
2003
Selective C–H halogenation over hydroxylation by non-heme iron(iv )-oxo
2018
Development of Halogenase Enzymes for Use in Synthesis
2017
Recent Advances in Polyoxometalate-Catalyzed Reactions
2015 Standout
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase
2006
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
2011
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)
2018 Standout
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3
2007
Halogenation of organic compounds using continuous flow and microreactor technology
2016
Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein
2008
Recent progress in the chemistry and applications of indolocarbazoles
2008
Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology
2012
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
2018
Ultrafast Dynamics of Flavins in Five Redox States
2008 StandoutNobel
Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase
2016 StandoutNobel
Insight into the structure–function relationship of the nonheme iron halogenases involved in the biosynthesis of 4‐chlorothreonine – T hr3 from S treptomyces sp. OH ‐5093 and S yrB 2 from P seudomonas syringae pv. syringae B 301DR
2012 StandoutNobel
Iron-Catalyzed Cascade Carbochloromethylation of Activated Alkenes: Highly Efficient Access to Chloro-Containing Oxindoles
2014
CD and MCD of CytC3 and Taurine Dioxygenase: Role of the Facial Triad in α-KG-Dependent Oxygenases
2007
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Sulfoximine Assisted Pd(II)-Catalyzed Bromination and Chlorination of Primary β-C(sp3)–H Bond
2014
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Conformational switch triggered by α-ketoglutarate in a halogenase of curacin A biosynthesis
2010
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics
2011
Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP
2011
Biosynthetic Characterization and Chemoenzymatic Assembly of the Cryptophycins. Potent Anticancer Agents from Nostoc Cyanobionts
2006
The Halogen Bond
2016 Standout
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Role of the Secondary Coordination Sphere in Metal-Mediated Dioxygen Activation
2010
An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA
2017
Visible‐Light Photocatalysis: Does It Make a Difference in Organic Synthesis?
2018 Standout
Iron(II)-Catalyzed Benzylic Fluorination
2013
Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes
2007
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
2017
TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells
2010
Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2
2009
Modern Transition-Metal-Catalyzed Carbon–Halogen Bond Formation
2016
Proton-Coupled Electron Transfer
2012 Standout
Auxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp3)–H bonds at room temperature
2016
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Vanadium-catalyzed C(sp3)–H fluorination reactions
2014
The Chemical Versatility of Natural-Product Assembly Lines
2007
Works of Ellen Yeh being referenced
Preferential Lower Respiratory Tract Infection in Swine‐Origin 2009 A(H1N1) Influenza
2010
The Prenylated Proteome of Plasmodium falciparum Reveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action
2016
Type II Thioesterase Restores Activity of a NRPS Module Stalled with an Aminoacyl‐S‐enzyme that Cannot Be Elongated
2004
Enhanced Macrocyclizing Activity of the Thioesterase from Tyrocidine Synthetase in Presence of Nonionic Detergent
2004
Enzymatic Generation of the Antimetabolite γ,γ-Dichloroaminobutyrate by NRPS and Mononuclear Iron Halogenase Action in a Streptomycete
2006
Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion
2002
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
2005 Nature
Chlorination by a Long-Lived Intermediate in the Mechanism of Flavin-Dependent Halogenases,
2007
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum
2011
Dichlorination of a pyrrolyl-S-carrier protein by FADH 2 -dependent halogenase PltA during pyoluteorin biosynthesis
2005
Nature's Inventory of Halogenation Catalysts: Oxidative Strategies Predominate
2006
Characterization of the Aminocarboxycyclopropane-Forming Enzyme CmaC
2006
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis
2005
Flavin Redox Chemistry Precedes Substrate Chlorination during the Reaction of the Flavin-Dependent Halogenase RebH
2006