Citation Impact
Citing Papers
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
2009 Standout
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor
2003 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
2003
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
1998
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Smad7 Inhibits Mesoderm Formation and Promotes Neural Cell Fate inXenopusEmbryos
1998
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes
1998
Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib
2010
Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators
1998
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β
2000
The MSG1 Non-DNA-binding Transactivator Binds to the p300/CBP Coactivators, Enhancing Their Functional Link to the Smad Transcription Factors
2000
Physical and Functional Interaction of Murine and Xenopus Smad7 with Bone Morphogenetic Protein Receptors and Transforming Growth Factor-β Receptors
1998
Smad transcription factors
2005 Standout
A component of the ARC/Mediator complex required for TGFβ/Nodal signalling
2002 Nature
Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
1997
Left–Right Asymmetric Expression of lefty2 and nodal Is Induced by a Signaling Pathway that Includes the Transcription Factor FAST2
2000
Smads and early developmental signaling by the TGFβ superfamily
1998
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
1999
TGFβ signalling in context
2012 Standout
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Pharmacology of imatinib (STI571)
2002
Smad6 as a Transcriptional Corepressor
2000
Activation of Transforming Growth Factor-β Signaling by SUMO-1 Modification of Tumor Suppressor Smad4/DPC4
2003
Synergism between Transcription Factors TFE3 and Smad3 in Transforming Growth Factor-β-induced Transcription of theSmad7 Gene
2000
Lineage dependency and lineage-survival oncogenes in human cancer
2006
E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression
2002
The Human Checkpoint Protein hRad17 Interacts with the PCNA-like Proteins hRad1, hHus1, and hRad9
2000
Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7
1998
The Hallmarks of Cancer
2000 Standout
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
The Role of FAST-1 and Smads in Transcriptional Regulation by Activin during Early Xenopus Embryogenesis
1999
Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to theDrosophila mesoderm
1998
TGF-β signalling pathways in early Xenopus development
2001
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
2000 StandoutNatureNobel
Signaling inputs converge on nuclear effectors in TGF-β signaling
2000
Transcriptional Activators of TGF-β Responses: Smads
1998
Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation
2004
The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
2011
Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes
2000
Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo
1998
TGIF2 Interacts with Histone Deacetylase 1 and Represses Transcription
2001
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
2002
Smad2 role in mesoderm formation, left–right patterning and craniofacial development
1998 Nature
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
2002
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Ubiquitin-dependent degradation of TGF-β-activated Smad2
1999
Alternatively Spliced Variant of Smad2 Lacking Exon 3
1999
Cell Migration: A Physically Integrated Molecular Process
1996 Standout
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain
2000
Serotonin receptors: Subtypes, functional responses and therapeutic relevance
1995
Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex
2001
Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome
2001 Standout
The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway
1997 StandoutNobel
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
2001
ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling
1999
Revealing the world of RNA interference
2004 StandoutNatureNobel
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
1999
Nodal Signaling in Early Vertebrate Embryos
2001
A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras
1999
Physical and Functional Interaction of SMADs and p300/CBP
1998
Determinants of specificity in TGF-β signal transduction
1998
How cells read TGF-β signals
2000 Standout
SMADs: mediators and regulators of TGF-β signaling
1998
The TGFβ Receptor Activation Process
2001
Mads and Smads in TGFβ signalling
1998
Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2
1998
TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300
1998
A Smad Transcriptional Corepressor
1999
SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor
1998
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation
1998
Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ)
2002
NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system
2000 Standout
Crystal Structure of a Smad MH1 Domain Bound to DNA
1998
HRad17 Colocalizes with NHP2L1 in the Nucleolus and Redistributes after UV Irradiation
1999
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
1999
Stoichiometry of Active Smad-Transcription Factor Complexes on DNA
2002
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Controlling TGF-β signaling
2000
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Biosynthesis of the Caenorhabditis elegans dauer pheromone
2009 StandoutNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum
2000 StandoutNobel
Inactivation of a Serotonin-Gated Ion Channel by a Polypeptide Toxin from Marine Snails
1998 StandoutScienceNobel
daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans
1997 Science
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
2000
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors
1998
Inactivation of Smad-Transforming Growth Factor β Signaling by Ca2+-Calmodulin-Dependent Protein Kinase II
2000
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
TGF-β–induced Phosphorylation of Smad3 Regulates Its Interaction with Coactivator p300/CREB-binding Protein
1998
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses
1998
Endogenous patterns of TGFβ superfamily signaling during early Xenopus development
2000
Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator
1998
Homology Modeling of the Serotonin 5-HT1AReceptor Using Automated Docking of Bioactive Compounds with Defined Geometry
2005
High frequency of point mutations clustered within the adenosine triphosphate–binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
2002
Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2
1998
Synthesis of a 10,000-Membered Library of Molecules Resembling Carpanone and Discovery of Vesicular Traffic Inhibitors
2006
Mitochondria and Apoptosis
1998 StandoutScience
BF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners
2000
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3, and Smad proteins
1999
Molecular mechanisms of resistance of leukemia to imatinib mesylate
2003
Drosophila TGIF Proteins Are Transcriptional Activators
2003
Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein
1999 Science
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
A changing morphogen gradient is interpreted by continuous transduction flow
2002 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
2006 StandoutNobel
Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β
1999
Controlling TGF-beta signaling.
2000 Standout
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
2000
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins
1998
Swift Is a Novel BRCT Domain Coactivator of Smad2 in Transforming Growth Factor β Signaling
2001 StandoutNobel
Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus
2000
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
Completely N1-Selective Palladium-Catalyzed Arylation of Unsymmetric Imidazoles: Application to the Synthesis of Nilotinib
2011
Works of Ellen Weisberg being referenced
Effects of PKC412, Nilotinib, and Imatinib Against GIST-Associated PDGFRA Mutants With Differential Imatinib Sensitivity
2006
NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)
1988
A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis
1998
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
2002
AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL
2006
Smad4 and FAST-1 in the assembly of activin-responsive factor
1997 Nature
Tensin: A potential link between the cytoskeleton and signal transduction
1994
Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients
2001
Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML
2004
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL– and mutant FLT3-expressing cells
2008
Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL–transformed hematopoietic cell lines
2000
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
1996
HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.
1999
ARG tyrosine kinase activity is inhibited by STI571
2001