Standout Papers

Short-chain fatty acids in control of body weight and insulin sensitivity 2015 2026 2018 2022 1.6k
  1. Short-chain fatty acids in control of body weight and insulin sensitivity (2015)
    Emanuel E. Canfora, Johan W. E. Jocken et al. Nature Reviews Endocrinology

Citation Impact

Citing Papers

Nonshivering thermogenesis and its adequate measurement in metabolic studies
2010
Cold-Activated Brown Adipose Tissue in Healthy Men
2009 Standout
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
2011
Increase in clinically recorded type 2 diabetes after colectomy
2018
Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease
2016
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
2014
WGCNA: an R package for weighted correlation network analysis
2008 Standout
DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism
2017
Sirtuins as regulators of metabolism and healthspan
2012 Standout
SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling
2014
The role of physical activity in the management of impaired glucose tolerance: a systematic review
2007
Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens
2017
Linking mitochondrial bioenergetics to insulin resistance via redox biology
2012
The adipose organ
2005
Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
2013
Targeting autophagy in obesity: from pathophysiology to management
2018
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
2016 Standout
Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease
2007
Genetic effects on gene expression across human tissues
2017 StandoutNature
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
2013
Human Skeletal Muscle Mitochondrial Uncoupling Is Associated with Cold Induced Adaptive Thermogenesis
2008
Respiratory Quotient Is Inversely Associated with Muscle Sympathetic Nerve Activity
1998
Identification and Importance of Brown Adipose Tissue in Adult Humans
2009 Standout
Lipolysis and lipid mobilization in human adipose tissue
2009
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue
2007
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
2016
Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women
2009
Human fat cell lipolysis: Biochemistry, regulation and clinical role
2005
RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance
2014
The adipose tissue renin-angiotensin system and metabolic disorders: a review of molecular mechanisms
2012
Targeting inflammation in the treatment of type 2 diabetes: time to start
2014
Lipolysis Response to Endoplasmic Reticulum Stress in Adipose Cells
2012
The metabolic syndrome
2010 Standout
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
Regulation of hepatic glucose metabolism in health and disease
2017
Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology
2015
Hallmarks of aging: An expanding universe
2023 Standout
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
2017 Standout
Fibrosis and Adipose Tissue Dysfunction
2013 Standout
Dysbiosis and the immune system
2017
The Human Intestinal Microbiome in Health and Disease
2016 Standout
Metabolic Control of Longevity
2016
Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
2013
Overexpression of Fto leads to increased food intake and results in obesity
2010
Local adipose tissue renin-angiotensin system
2008
The changing landscape of atherosclerosis
2021 StandoutNature
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
2013
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
Axis of ageing: telomeres, p53 and mitochondria
2012
What causes the insulin resistance underlying obesity?
2012
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Gut-Brain Cross-Talk in Metabolic Control
2017
Gut microbiome and health: mechanistic insights
2022 Standout
Obesity, Weight Gain, and the Risk of Kidney Stones
2005 Standout
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes
2009
Ghrelin induces adiposity in rodents
2000 StandoutNature
Sympathetic System Activity in Obesity and Metabolic Syndrome
2006
Gut–brain axis: how the microbiome influences anxiety and depression
2013 Standout
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
2015 Standout
A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives
1997
Insulin Receptor Signaling in Normal and Insulin-Resistant States
2014
Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
2007 Standout
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
2012 Standout
An Integrated View of Immunometabolism
2018
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Probiotics and prebiotics in intestinal health and disease: from biology to the clinic
2019
A dose–response relation between aerobic exercise and visceral fat reduction: systematic review of clinical trials
2007
Body composition and mortality in chronic obstructive pulmonary disease
2005
Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism
2015
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function
2017 Standout
Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle
2018
Elucidating the Role of Gonadal Hormones in Sexually Dimorphic Gene Coexpression Networks
2008
The Discovery and Development of Liraglutide and Semaglutide
2019
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
2007
Differential Distribution of β-Adrenergic Receptor Subtypes in Blood Vessels of Knockout Mice Lacking β1-or β2-Adrenergic Receptors
2001 StandoutNobel
The metabolic syndrome—a new worldwide definition
2005 Standout
Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are important factors
2016
Mechanisms and Functions of Inflammasomes
2014 Standout
Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
2020
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Caloric restriction mimetics: towards a molecular definition
2014
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
The Hallmarks of Aging
2013 Standout
Adipose tissue and the insulin resistance syndrome
2001
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
2009
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance
2012
DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling
2015
Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes
2014
Adipose Tissue as an Endocrine Organ
2004 Standout
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
2005
Gut microbiota in human metabolic health and disease
2020 Standout
Sympathetic and sensory innervation of brown adipose tissue
2010
Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans
2012
The genetics of obesity: FTO leads the way
2010
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2012 Standout
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
1999
Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity
2017
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
2013
Antibiotic effects on gut microbiota and metabolism are host dependent
2016
Increasing skeletal muscle carnitine content in older individuals increases whole‐body fat oxidation during moderate‐intensity exercise
2021
Adipose Tissue-Derived Factors: Impact on Health and Disease
2006
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes.
2017 Standout
Adipose Tissue Free Fatty Acid Storage In Vivo: Effects of Insulin Versus Niacin as a Control for Suppression of Lipolysis
2015
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
2002 Standout
Revisiting the diacylglycerol‐induced insulin resistance hypothesis
2012
Biological Action of Leptin as an Angiogenic Factor
1998 StandoutScience
Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation
2011
American Association of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines For Medical Care of Patients with Obesity
2016
Once-Weekly Semaglutide in Adults with Overweight or Obesity
2021 Standout
Spermidine in health and disease
2018 StandoutScience
Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity
2010
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
2002
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
2014
The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans
2019
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature
2019 StandoutNobel
Hypoxia and Adipose Tissue Function and Dysfunction in Obesity
2013
“Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance
2013
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
2014
Metabolic Effects of Fructose and the Worldwide Increase in Obesity
2010
The Metabolic Syndrome
2008 Standout
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
2004 StandoutScience
A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor-α)-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity
2005
Semaglutide 2.4 mg for the Treatment of Obesity: Key Elements of the STEP Trials 1 to 5
2020
Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes
2015
The Genetic Landscape of Type 2 Diabetes in Mice
2007
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
2022
Solvent-Dependent Metabolite Distribution, Clustering, and Protein Extraction for Serum Profiling with Mass Spectrometry
2005
The Finnish Diabetes Prevention Study (DPS)
2003
Vascular rarefaction mediates whitening of brown fat in obesity
2014
Molecular Origin of Blood‐Based Infrared Spectroscopic Fingerprints**
2021 StandoutNobel
Obesity: global epidemiology and pathogenesis
2019 Standout
Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes
2001
Metabolic Signatures of Human Adipose Tissue Hypoxia in Obesity
2012
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
2003 StandoutScience
Hypoxemia in patients with COPD: cause, effects, and disease progression
2011
Exploring the therapeutic space around NAD+
2012
Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men
2002
Adiposity, Type 2 Diabetes, and Alzheimer's Disease
2009

Works of Ellen E. Blaak being referenced

Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults
2013
Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans
2012
Lipolytic and nutritive blood flow response to β-adrenoceptor stimulation in situ in subcutaneous abdominal adipose tissue in obese men
2003
The ABCD of Obesity: An EASO Position Statement on a Diagnostic Term with Clinical and Scientific Implications
2019
β-Adrenergically mediated thermogenic and heart rate responses: Effect of obesity and weight loss
1995
Reduced oxidation of dietary fat after a short term high-carbohydrate diet
2008
Substrate Source Use in Older, Trained Males after Decades of Endurance Training
2007
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study
2009
Lifestyle Intervention According to General Recommendations Improves Glucose Tolerance
2003
Does interference with the renin–angiotensin system protect against diabetes? Evidence and mechanisms
2012
A Proposal of the European Association for the Study of Obesity to Improve the ICD-11 Diagnostic Criteria for Obesity Based on the Three Dimensions Etiology, Degree of Adiposity and Health Risk
2017
Gut microbial metabolites in obesity, NAFLD and T2DM
2019
Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance
2013
Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation
2006
Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men
2007
Adipose tissue oxygen tension
2012
Skeletal Muscle Lipase Content and Activity in Obesity and Type 2 Diabetes
2010
Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM): preliminary results after one year
2003
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1interact with plasma saturated fatty acids to modulate insulin resistance
2009
Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial
2016
Adipose Tissue Dysfunction and Impaired Metabolic Health in Human Obesity: A Matter of Oxygen?
2015
Postprandial Interleukin-6 Release from Skeletal Muscle in Men with Impaired Glucose Tolerance Can Be Reduced by Weight Loss
2005
Substrate source utilisation in long-term diagnosed type 2 diabetes patients at rest, and during exercise and subsequent recovery
2006
Do nutrient–gut–microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
2010
Gender differences in fat metabolism
2001
The insulin receptor substrate‐1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population‐based studies
2004
Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle
2009
The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects
2000
Angiotensin II: a hormone that affects lipid metabolism in adipose tissue
2006
Fatty acid metabolism in obesity and type 2 diabetes mellitus
2003
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis
2007
Adipose tissue fatty acid metabolism in insulin-resistant men
2008
Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans
2006
The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
2013
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
2011
Postprandial thermogenesis and substrate utilization after ingestion of different dietary carbohydrates
1996
Short-chain fatty acids in control of body weight and insulin sensitivity
2015 Standout
Weight Reduction and the Impaired Plasma-Derived Free Fatty Acid Oxidation in Type 2 Diabetic Subjects1
2001
β-adrenergic stimulation and abdominal subcutaneous fat blood flow in lean, obese, and reduced-obese subjects
1995
Obesity and the lung: 5 {middle dot} Obesity and COPD
2008
Skeletal Muscle Fatty Acid Handling in Insulin Resistant Men
2011
Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study
2015
Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance
2006
Impact of 3‐year lifestyle intervention on postprandial glucose metabolism: the SLIM study
2008
Total Forearm Blood Flow as an Indicator of Skeletal Muscle Blood Flow: Effect of Subcutaneous Adipose Tissue Blood Flow
1994
β-Adrenoceptor-mediated thermogenesis and lipolysis in patients with chronic obstructive pulmonary disease
2001
Microdialysis assessment of local adipose tissue lipolysis during β-adrenergic stimulation in upper-body-obese subjects with type II diabetes
1999
beta-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men
1994
Reduced Skeletal Muscle Uncoupling Protein-3 Content in Prediabetic Subjects and Type 2 Diabetic Patients: Restoration by Rosiglitazone Treatment
2006
Possible involvement of the adipose tissue renin‐angiotensin system in the pathophysiology of obesity and obesity‐related disorders
2003
Preferential Uptake of Dietary Fatty Acids in Adipose Tissue and Muscle in the Postprandial Period
2006
Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
2001
Short chain fatty acids in human gut and metabolic health
2020
Adipose Triglyceride Lipase and Hormone-Sensitive Lipase Protein Expression Is Decreased in the Obese Insulin-Resistant State
2007
Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation
2011
Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men
2016
Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle
2000
Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.
2000
Plasma Free Fatty Acid Uptake and Oxidation Are Already Diminished in Subjects at High Risk for Developing Type 2 Diabetes
2001
The Fate of [U-13C]Palmitate Extracted by Skeletal Muscle in Subjects With Type 2 Diabetes and Control Subjects
2002
Adrenoceptor subtypes mediating catecholamine-induced thermogenesis in man.
1993
Targeting fatty acid metabolism to improve glucose metabolism
2015
Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity
2018
Endocrine Role of the Renin-Angiotensin System in Human Adipose Tissue and Muscle
2007
Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men
1994
Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects
2008
Quantifying intermediary metabolites in whole blood after a simple deproteinization step with sulfosalicylic acid
1991
Rankless by CCL
2026