Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Reversal of the TCR Stop Signal by CTLA-4
2006 Science
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
2011 Science
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer
2007 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
2005 Standout
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
2015
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function
2005
CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation
1999 StandoutNobel
Cytolytic T Lymphocyte-Associated Antigen-4 and the TCRζ/CD3 Complex, But Not CD28, Interact with Clathrin Adaptor Complexes AP-1 and AP-2
1999
Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation
2012
Confusing signals: Recent progress in CTLA-4 biology
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
2001 Nature
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Modulation of tryptophan catabolism by regulatory T cells
2003
The Medium Subunits of Adaptor Complexes Recognize Distinct but Overlapping Sets of Tyrosine-based Sorting Signals
1998
The reverse stop-signal model for CTLA4 function
2008
Comparison of the Intracellular Trafficking Itinerary of CTLA-4 Orthologues
2013
Oxidative stress and gene regulation
2000
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells
1998 StandoutNobel
Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor
2003
CD28-mediated co-stimulation: a quantitative support for TCR signalling
2003
Regulatory T Cells
2000 StandoutNobel
CTLA-4 -- The Costimulatory Molecule That Doesn't: Regulation of T-cell Responses by Inhibition
1999 StandoutNobel
Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4
1999
Co-stimulation in T cell responses
1997 StandoutNobel
CTLA-4: new insights into its biological function and use in tumor immunotherapy
2002 StandoutNobel
Involvement of endothelial progenitor cells in tumor vascularization
2010
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
CTLA-4 Regulates Induction of Anergy In Vivo
2001
Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation
2010
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
2006 Standout
In vivo overexpression of CTLA‐4 suppresses lymphoproliferative diseases and thymic negative selection
2005
Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
2011 StandoutNobel
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
2019
Two Distinct Raf Domains Mediate Interaction with Ras
1995
The Interaction Properties of Costimulatory Molecules Revisited
2002
Structural mechanisms of costimulation
2002
The Emerging Role of CTLA-4 as an Immune Attenuator
1997 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Structure and Dimerization of a Soluble Form of B7-1
2000
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
2002 StandoutNobel
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
2011
The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts
2011
Src Family Tyrosine Kinases Associate with and Phosphorylate CTLA-4 (CD152)
1998
Strategies for designing and optimizing new generation vaccines
2001
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue
1995 Nature
The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity
2001
B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
2000 Standout
Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
2004
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
2014 StandoutNobel
Microtubule-binding agents: a dynamic field of cancer therapeutics
2010 Standout
Checkpoint Blockade in Cancer Immunotherapy
2006 StandoutNobel
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
T-cell regulation by CD28 and CTLA-4
2001
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
2001 Nature
Costimulatory regulation of T cell function
1999 StandoutNobel
T-cell-antigen recognition and the immunological synapse
2003
Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength
2002 StandoutNobel
B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity
2003
Tyrosine Phosphatase SHP-2 Binding to CTLA-4: Absence of Direct YVKM/YFIP Motif Recognition
2000
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
A guide to cancer immunotherapy: from T cell basic science to clinical practice
2020 Standout
GRAIL
2003
Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells
1997 StandoutNobel
Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation
1998
Enhanced selection of FoxP3 + T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease
2009
Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation
2000
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal
2012
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
1998
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo
1999
Cutting Edge: Tyrosine-Independent Transmission of Inhibitory Signals by CTLA-4
2000
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
1999
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
2000 StandoutNobel
A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION
2005
B7x: A widely expressed B7 family member that inhibits T cell activation
2003 StandoutNobel
The lymphoproliferative defect in CTLA-4–deficient mice is ameliorated by an inhibitory NK cell receptor
2002 StandoutNobel
Differential expression of CTLA-4 among T cell subsets
2004
Absence of CTLA-4 Lowers the Activation Threshold of Primed CD8+ TCR-Transgenic T Cells: Lack of Correlation with Src Homology Domain 2-Containing Protein Tyrosine Phosphatase
2001
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression
2000
Blockade of T Cell Activation Using a Surface-Linked Single-Chain Antibody to CTLA-4 (CD152)
2000
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation
2004
Regulation of Cell Surface Expression of CTLA-4 by Secretion of CTLA-4-Containing Lysosomes Upon Activation of CD4+ T Cells
2000
Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3–mediated Depletion of Thymocytes
1998
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation
2000
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
2001 StandoutNobel
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous
1999
Tyrosine 201 of the cytoplasmic tail of CTLA ‐4 critically affects T regulatory cell suppressive function
2014
The Biology of Interleukin-2
2007
Re-establishing Peripheral Tolerance in the Absence of CTLA-4: Complementation by Wild-Type T Cells Points to an Indirect Role for CTLA-4
2002
Activated Self-MHC-Reactive T Cells Have the Cytokine Phenotype of Th3/T Regulatory Cell 1 T Cells
2000
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Regulation of the Small GTPase Rap1 and Extracellular Signal-Regulated Kinases by the Costimulatory Molecule CTLA-4
2005
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
Defective CTLA-4 cycling pathway in Chediak–Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation
1999
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
2012
Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
2001
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
2000 Standout
Combining Radiation and Immunotherapy: A New Systemic Therapy for Solid Tumors?
2014 StandoutNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism
2006 StandoutNobel
Induction of T Cell Anergy in the Absence of CTLA-4/B7 Interaction
2000
The future of immune checkpoint therapy
2015 StandoutScienceNobel
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
2007 StandoutNobel
Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
2001
CTLA-4 Gene Polymorphism at Position 49 in Exon 1 Reduces the Inhibitory Function of CTLA-4 and Contributes to the Pathogenesis of Graves’ Disease
2000
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
2001
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Surface Cytotoxic T Lymphocyte–associated Antigen 4 Partitions Within Lipid Rafts and Relocates to the Immunological Synapse under Conditions of Inhibition of T Cell Activation
2002
Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani
1998
Costimulatory Receptors in a Teleost Fish: Typical CD28, Elusive CTLA4
2006
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
2001 StandoutNobel
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells
2006
Expression and Function of CTLA-4 in Th1 and Th2 Cells
1998
Phase I/II Study of Ipilimumab for Patients With Metastatic Melanoma
2008
Structure of Murine CTLA-4 and Its Role in Modulating T Cell Responsiveness
2000 Science
B7-Independent Inhibition of T Cells by CTLA-4
2005
Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4
2000
Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered
2001
Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail
1999
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28
1998
Murine B7-H3 Is a Negative Regulator of T Cells
2004
Works of Ellen Chuang being referenced
Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer
2007
The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A
2000
Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.
1994
Transgenic Expression of CTLA-4 Controls Lymphoproliferation in IL-2-Deficient Mice
2004
Molecular Basis of T Cell Inactivation by CTLA-4
1998 Science
Structural Analysis of CTLA-4 Function In Vivo
2000
Phase II Study of Eribulin Mesylate, a Halichondrin B Analog, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane
2009
Regulation of surface and intracellular expression of CTLA4 on mouse T cells.
1996
Identification of the sites of interaction between c-Raf-1 and Ras-GTP.
1995
Regulation of Cytotoxic T Lymphocyte-Associated Molecule-4 by Src Kinases
1999
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
1997