Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
2011
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
2011
Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A
1993
Neuropharmacology of AMPA and kainate receptors
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors1The first two authors contributed equally to this work.1
2001
Glutamate receptor ion channels
2005 Standout
A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling
2002
Vertebrate floor-plate specification: variations on common themes
2004
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
1999
Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
2000
PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands
1998
Axon Guidance Molecules in Vascular Patterning
2010
Conservation and divergence of axon guidance mechanisms
1999
Hedgehog Signaling Regulates Nociceptive Sensitization
2011
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Oncogenic kinase signalling
2001 StandoutNature
Rostral growth of commissural axons requires the cell adhesion molecule MDGA2
2011
Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation
2011
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms
2008 StandoutNobel
EphB Forward Signaling Controls Directional Branch Extension and Arborization Required for Dorsal-Ventral Retinotopic Mapping
2002
Noninvasive Imaging beyond the Diffraction Limit of 3D Dynamics in Thickly Fluorescent Specimens
2012 StandoutNobel
Isolation and Characterization of Dek, a Drosophila Eph Receptor Protein Tyrosine Kinase
1999
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
The Ephrin VAB-2/EFN-1 Functions in Neuronal Signaling to Regulate Epidermal Morphogenesis in C. elegans
1999
Eph receptor signalling casts a wide net on cell behaviour
2005
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
1997
Eph receptors and ephrin ligands: embryogenesis to tumorigenesis
2000
Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures
1998
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
Eph receptors and ephrins restrict cell intermingling and communication
1999 Nature
Elementary steps in synaptic transmission revealed by currents through single ion channels
1992 Nobel
The dual role of the ligand UNC-6/Netrin in both axon guidance and synaptogenesis inC. elegans
2009
Neural development: Bidirectional signals establish boundaries
1999
Further tales of the midline
2010
Myasthenia Gravis
1994 Standout
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Neurexin mediates the assembly of presynaptic terminals
2003
Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2
2003
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
2010 Nature
A Novel Family of Adhesion-Like Molecules That Interacts with the NMDA Receptor
2006
Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist
1994
The Expression and Functional Role of Nicotinic Acetylcholine Receptors in Rat Adipocytes
2004
Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses
2000
Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord
2005
Secreted TARSH regulates olfactory mitral cell dendritic complexity
2009
EphrinB Ligands Recruit GRIP Family PDZ Adaptor Proteins into Raft Membrane Microdomains
1999
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
2001
Mechanisms and functions of eph and ephrin signalling
2002 Standout
Assembly of an adult type acetylcholine receptor in a mouse cell line transfected with rat muscle ϵ‐subunit DNA
1990 StandoutNobel
Eph receptors and ephrins in neural development
1999
Eph receptors and ephrins: Regulators of guidance and assembly
2000
Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel
1991 StandoutNobel
Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor
2001
Signaling by Eph receptors and their ephrin ligands
1998
Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway
2009
Signaling molecules and transcription factors involved in the development of the sympathetic nervous system, with special emphasis on the superior cervical ganglion
2014
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
2007
Extracellular Matrix: Functions in the Nervous System
2010
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alpha vbeta 3 and alpha 5beta 1 integrins
1999
A Novel Signaling Intermediate, SHEP1, Directly Couples Eph Receptors to R-Ras and Rap1A
1999
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Crystal structure of an Eph receptor–ephrin complex
2001 Nature
The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif
1999
Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
1999
Mechanisms of Hedgehog gradient formation and interpretation
2005
Sez-6 Proteins Affect Dendritic Arborization Patterns and Excitability of Cortical Pyramidal Neurons
2007
Synaptic structure and development: The neuromuscular junction
1993
Synthetic Multivalent Ligands as Probes of Signal Transduction
2006
Modulation of EphA Receptor Function by Coexpressed EphrinA Ligands on Retinal Ganglion Cell Axons
1999
A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis
2005
Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
1999
Translating Axon Guidance Cues
2002
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development
1999
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
2003 StandoutNature
Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis
2008
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Crystal Structure of an Ephrin Ectodomain
2001
Imprinting of acetylcholine receptor messenger RNA accumulation in mammalian neuromuscular synapses
1990 StandoutNatureNobel
Angiogenic Signalling Pathways
2008
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
Controlling Cell Behavior Electrically: Current Views and Future Potential
2005 Standout
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Multiple roles of eph receptors and ephrins in neural development
2001
Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development
1999
Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila
2001 StandoutNobel
Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production
2009
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
1999
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
2000
Sonic Hedgehog Has a Dual Effect on the Growth of Retinal Ganglion Axons Depending on Its Concentration
2005
Kinase-Dependent and Kinase-Independent Functions of EphA4 Receptors in Major Axon Tract Formation In Vivo
2001
Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites
1999
Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β
1998
Angiogenesis as a therapeutic target
2005 StandoutNature
Differential regulation of MyoD and myogenin mRNA levels by nerve induced muscle activity
1991 StandoutNobel
Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4
1998 Standout
A ring of uncharged polar amino acids as a component of channel constriction in the nicotinic acetylcholine receptor
1991
Topographic Mapping in Dorsoventral Axis of the Xenopus Retinotectal System Depends on Signaling through Ephrin-B Ligands
2002
MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development
2012 StandoutNobel
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Wnt Signaling in Neural Circuit Assembly
2008
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Eph receptors and ephrins: effectors of morphogenesis
1999
The EphA8 Receptor Regulates Integrin Activity through p110γ Phosphatidylinositol-3 Kinase in a Tyrosine Kinase Activity-Independent Manner
2001
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing
1994 Science
Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins
2012 StandoutNobel
Postsynaptic N -methyl- d -aspartate receptor function requires α-neurexins
2004 StandoutNobel
Synthesis of Glycopolymers for Microarray Applications via Ligation of Reducing Sugars to a Poly(acryloyl hydrazide) Scaffold
2010 StandoutNobel
Protein Tyrosine Kinase Structure and Function
2000
Downregulation of the Ras–Mitogen-Activated Protein Kinase Pathway by the EphB2 Receptor Tyrosine Kinase Is Required for Ephrin-Induced Neurite Retraction
2001
Signal transfer by Eph receptors
1999
Multiple in Vivo Tyrosine Phosphorylation Sites in EphB Receptors
1999
A role for the EphA family in the topographic targeting of vomeronasal axons
2001
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
EphB Receptors Interact with NMDA Receptors and Regulate Excitatory Synapse Formation
2000
Oligomeric Structure of the Human EphB2 Receptor SAM Domain
1999 Science
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
Fibroblast Growth Factor Receptor-Mediated Rescue of x-Ephrin B1-Induced Cell Dissociation in XenopusEmbryos
2000
Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation
2000
Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium
2012
Acetylcholine receptor-inducing activity stimulates expression of the epsilon-subunit gene of the muscle acetylcholine receptor.
1991
Establishment of Axon-Dendrite Polarity in Developing Neurons
2009
Netrin-G1: a Novel Glycosyl Phosphatidylinositol-Linked Mammalian Netrin That Is Functionally Divergent from Classical Netrins
2000 StandoutNobel
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
2008
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
2006
Neural factors regulate AChR subunit mRNAs at rat neuromuscular synapses.
1991 StandoutNobel
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor
1998
Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis
2010
A Novel Allosteric Potentiator of AMPA Receptors: 4-[2-(Phenylsulfonylamino)ethylthio]-2,6-Difluoro-Phenoxyacetamide
1997
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping
2003
Antiangiogenic and Antitumor Efficacy of EphA2 Receptor Antagonist
2004
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal
2012 StandoutNobel
Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors
2000
THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT
1998
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
2003 StandoutNobel
Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing
1997 StandoutNobel
Characterization of Grb4, an adapter protein interacting with Bcr-Abl
2000
Molecular Diversity of Glutamate Receptors and Implications for Brain Function
1992 StandoutScience
SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly
2002 StandoutScienceNobel
Works of Elke Stein being referenced
Regulation of Cortical Dendrite Development by Slit-Robo Interactions
2002
Novel Role for Netrins in Regulating Epithelial Behavior during Lung Branching Morphogenesis
2004
Eph Family Receptors and Ligands in Vascular Cell Targeting and Assembly
1997
Nck Recruitment to Eph Receptor, EphB1/ELK, Couples Ligand Activation to c-Jun Kinase
1998
DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1
2008
Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
1998
Primary structure and functional expression of the α‐, β‐, γ‐, δ‐ and ɛ‐subunits of the acetylcholine receptor from rat muscle
1990
The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance
2003
Netrin signaling leading to directed growth cone steering
2007
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation
2002 Nature
Developmental regulation of five subunit specific mRNAs encoding acetylcholine receptor subtypes in rat muscle
1989 StandoutNobel
Plexin-A3 Mediates Semaphorin Signaling and Regulates the Development of Hippocampal Axonal Projections
2001
Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells
1996
A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion
2022
Complex pharmacological properties of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subtypes.
1992