Citation Impact
Citing Papers
Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women
2010 StandoutScience
2012
Selective Cyclooxygenase-2 Inhibition by Nimesulide in Man
1998
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
2004 Standout
Nonsteroidal Anti-inflammatory Drug Use and Acute Myocardial Infarction
2002
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Atopic Dermatitis
2008 Standout
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
1995 StandoutNobel
Spatial Requirements for 15-(R)-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic Acid Synthesis within the Cyclooxygenase Active Site of Murine COX-2
2000
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
2014 Standout
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents
1998
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
2004 StandoutNature
Assembly of the Warfarin-sensitive Vitamin K 2,3-Epoxide Reductase Enzyme Complex in the Endoplasmic Reticulum Membrane
1997
A Randomized Trial of the Efficacy and Tolerability of the COX-2 Inhibitor Rofecoxib vs Ibuprofen in Patients With Osteoarthritis
2000
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc − cystine transporter: a new action for an old drug
2001
Catalytic Arylation of a CH Bond in Pyridine and Related Six‐Membered N‐Heteroarenes Using Organozinc Reagents
2012
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
2000 StandoutNobel
Endometriosis
2009 Standout
Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state
1999
Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis
2000 Standout
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
2005 Standout
The Biochemical, Molecular, and Genomic Aspects of Leukotriene C4 Synthase
1999
Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets
2001
Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate
1999
Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents
1998
The Interaction of Arginine 106 of Human Prostaglandin G/H Synthase-2 with Inhibitors Is Not a Universal Component of Inhibition Mediated by Nonsteroidal Anti-inflammatory Drugs
1997
Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention
2005 Standout
Efficacy of antileukotriene agents in asthma management
2001
c-Kit Ligand Mediates Increased Expression of Cytosolic Phospholipase A2, Prostaglandin Endoperoxide Synthase-1, and Hematopoietic Prostaglandin D2 Synthase and Increased IgE-dependent Prostaglandin D2 Generation in Immature Mouse Mast Cells
1995
Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis
2001
Cyclooxygenase inhibitors – current status and future prospects
2001
In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As an HIV-1 Microbicide
2010
Platelet Activation and Atherothrombosis
2007 Standout
Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: A randomized, controlled trial
1999
Mechanistic Considerations in the Development and Use of Azine, Diazine and Azole N-Oxides in Palladium-Catalyzed Direct Arylation
2009
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Regulation of Mucous Cell Metaplasia in Bronchial Asthma
2008
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions
2013
N‐Cyano Sulfoximines: COX Inhibition, Anticancer Activity, Cellular Toxicity, and Mutagenicity
2012
Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells
1998 Standout
The Role of Arginine 120 of Human Prostaglandin Endoperoxide H Synthase-2 in the Interaction with Fatty Acid Substrates and Inhibitors
1999
The structures of prostaglandin endoperoxide H synthases-1 and -2
2002
Immune surveillance in the skin: mechanisms and clinical consequences
2004
Applications of and alternatives to π-electron-deficient azine organometallics in metal catalyzed cross-coupling reactions
2007
Inhibition of Prostaglandin H2 Synthases by Salicylate Is Dependent on the Oxidative State of the Enzymes
2003
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
1996 Standout
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions
1987
Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
1998
Anti-inflammatory drugs and their mechanism of action
1998 Nobel
Airway Mucus Function and Dysfunction
2010 Standout
Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions☆
1999
Cyclosporine
1989 Standout
The structure and function of lipoxygenase
1994
Mechanism of Acetaminophen Inhibition of Cyclooxygenase Isoforms
2001
Differential binding mode of diverse cyclooxygenase inhibitors
2002
Cyclooxygenase 2 inhibitors: discovery, selectivity and the future
1999
Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin
2001 Standout
The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins
1999
Membrane Fluidity Is a Key Modulator of Membrane Binding, Insertion, and Activity of 5-Lipoxygenase
2005
COX-2 inhibitors
1999 Standout
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
1999
Identification and Characterization of a Novel Microsomal Enzyme with Glutathione-dependent Transferase and Peroxidase Activities
1997
Prostaglandin Endoperoxide H Synthase-1
2001
The N-terminal “β-Barrel” Domain of 5-Lipoxygenase Is Essential for Nuclear Membrane Translocation
2001
Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety
1995
Synthesis of 8‐substituted tetrahydro‐γ‐carbolines
2006
Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis
2008 Standout
3d Transition Metals for C–H Activation
2018 Standout
Direct arylation of azine N-oxides with aryl triflates
2009
Cyclosporine Improves Psoriasis in a Double-blind Study
1986
Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease
2011
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Cyclooxygenases: Structural, Cellular, and Molecular Biology
2000 Standout
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis
2009
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
2011 StandoutNobel
Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs
2013
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
2011 Standout
Inorganic nanoparticles in porous coordination polymers
2016 StandoutNobel
Kinetic basis for selective inhibition of cyclo-oxygenases
1999
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
IL-4 Receptor Signaling in Clara Cells Is Required for Allergen-Induced Mucus Production
2005
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Sustainable Conversion of Carbon Dioxide: An Integrated Review of Catalysis and Life Cycle Assessment
2017 Standout
Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
2014 StandoutNobel
Simulations of the Large Kinetic Isotope Effect and the Temperature Dependence of the Hydrogen Atom Transfer in Lipoxygenase
2004 StandoutNobel
Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates
2004 Standout
Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates
2016 StandoutNobel
CYCLOOXYGENASES 1 AND 2
1998 StandoutNobel
Arachidonic Acid Oxygenation by COX-1 and COX-2
1999
An efficient copper-catalyzed N-arylation of pyridazinones with a structurally well-defined copper complex
2005
Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis
2012
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Sustainable metal-based catalysts for the synthesis of cyclic carbonates containing five-membered rings
2014
Heme-Containing Oxygenases
1996 Standout
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes
2008 StandoutNobel
Comparative In Vitro Sensitivities of Human Immune Cell Lines, Vaginal and Cervical Epithelial Cell Lines, and Primary Cells to Candidate Microbicides Nonoxynol 9, C31G, and Sodium Dodecyl Sulfate
2002
A Direct Approach to the Synthesis of 5-Aryl-4-chloropyridazinone: From Microwave Assisted Catalyst Screen to Room Temperature Regio- and Chemoselective Suzuki Arylation
2004
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
2004 Standout
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
Proton-Coupled Electron Transfer
2012 Standout
Works of Elizabeth Wong being referenced
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells
1996
Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist
2010
Pyridazinones as selective cyclooxygenase-2 inhibitors
2003
5‐lipoxygenase‐activating protein is an arachidonate binding protein
1993
Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells
1997
Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-selective Inhibitors by a Double His513→ Arg and Ile523→ Val Mutation
1997
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors
1999
5‐Lipoxygenase‐activating protein stimulates the utilization of arachidonic acid by 5‐lipoxygenase
1993
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors
1998
Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma
2005
The role of chemo-attractant lipoxygenase products in the pathogenesis of psoriasis
1985
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors
1995
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
1997
The Responses of Normal and Psoriatic Skin to Single and Multiple Topical Applications of Leukotriene B4
1985
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
1997
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle
1996
Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors
1996
A Controlled Trial of Nonoxynol 9 Film to Reduce Male-to-Female Transmission of Sexually Transmitted Diseases
1999