Citation Impact
Citing Papers
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Protein structure determination using metagenome sequence data
2017 StandoutScienceNobel
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Peptide-binding specificity of the molecular chaperone BiP
1991 StandoutNatureNobel
Energetics of Pore Opening in a Voltage-Gated K+ Channel
2002 StandoutNobel
Allosteric Communication in Dihydrofolate Reductase: Signaling Network and Pathways for Closed to Occluded Transition and Back
2007
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Identification, classification, and analysis of beta‐bulges in proteins
1993
Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis
1989
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
Insights into Enzyme Function from Studies on Mutants of Dihydrofolate Reductase
1988 Science
Joint X-ray and neutron refinement withphenix.refine
2010
Solvation, Reorganization Energy, and Biological Catalysis
1998
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3
1988 Nature
Complex interactions between the chaperonin 60 molecular chaperone and dihydrofolate reductase
1991
Dynamics of the Dihydrofolate Reductase-Folate Complex: Catalytic Sites and Regions Known To Undergo Conformational Change Exhibit Diverse Dynamical Features
1995
Crystal structures of a double-barrelled fluoride ion channel
2015 Nature
Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
1999 StandoutNatureNobel
Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features
1999
Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding
1989
Weakly Polar Interactions In Proteins
1988
Expanding the Genetic Code
2004
Protein structure prediction by all-atom free-energy refinement
2007
Thermal motions of surface α-helices in the d-galactose chemosensory receptor
1992
High resolution functional analysis of antibody-antigen interactions
1992
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
The three-dimensional structure of the RNA-binding domain of ribosomal protein L2; a protein at the peptidyl transferase center of the ribosome
1999
Why ion pair reversal by protein engineering is unlikely to succeed
1988 StandoutNatureNobel
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Enhanced protein thermostability from designed mutations that interact with α-helix dipoles
1988 Nature
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α
1998 StandoutNobel
Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core
1991 StandoutNatureNobel
Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis
1987
Proteases of enhanced stability: Characteization of a thermostable variant of subtilisin
1986
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
Reshaping Human Antibodies: Grafting an Antilysozyme Activity
1988 StandoutScienceNobel
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
2000 StandoutScienceNobel
β‐Bulges: Extensive structural analyses of β‐sheets irregularities
2013
Dipoles localized at helix termini of proteins stabilize charges.
1991 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Probing the Role of an Active Site Aspartic Acid in Dihydrofolate Reductase
1997
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Computational method to reduce the search space for directed protein evolution
2001 StandoutNobel
Import of an incompletely folded precursor protein into isolated mitochondria requires an energized inner membrane, but no added ATP.
1987
Structural Studies of Mutants of T4 Lysozyme That Alter Hydrophobic Stabilization
1989
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
1984 StandoutNobel
Toward computer-aided site-directed mutagenesis of enzymes.
1986
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Designing substrate specificity by protein engineering of electrostatic interactions.
1987
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
The Mechanism of Irreversible Enzyme Inactivation at 100°C
1985 Science
Mechanisms of Antibody Binding to a Protein
1987 Science
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids
2006 StandoutNobel
Protein Dynamics in Enzymatic Catalysis: Exploration of Dihydrofolate Reductase
1999
The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.
1990 StandoutNobel
Correlated motion and the effect of distal mutations in dihydrofolate reductase
2003
Changing the identity of a transfer RNA
1986 Nature
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
A model of synthetase/transfer RNA interaction as deduced by protein engineering
1986 StandoutNatureNobel
Stabilization of phage T4 lysozyme by engineered disulfide bonds.
1989
Catalytic Reduction of Dinitrogen to Ammonia at a Single Molybdenum Center
2003 StandoutScienceNobel
Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.
1993 StandoutNobel
Probing the salt bridge in the dihydrofolate reductase-methotrexate complex by using the coordinate-coupled free-energy perturbation method.
1988
Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli.
1986
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches
1993 StandoutNobel
Revealing the Architecture of a K + Channel Pore Through Mutant Cycles with a Peptide Inhibitor
1995 StandoutScienceNobel
Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA Gln and ATP at 2.8 Å Resolution
1989 StandoutScienceNobel
PROTON-COUPLED ELECTRON TRANSFER
1998
Structural Basis for Misaminoacylation by Mutant E. coli Glutaminyl-tRNA Synthetase Enzymes
1989 StandoutScienceNobel
Model Substrates for an RNA Enzyme
1987 StandoutScienceNobel
Hydrogen bonding and biological specificity analysed by protein engineering
1985 StandoutNatureNobel
Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
2004
Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.
1985 StandoutNobel
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.
1989 StandoutNobel
[20] Improved oligonucleotide-directed mutagenesis using M13 vectors
1987
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
1990 StandoutNobel
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Structural basis for gating charge movement in the voltage sensor of a sodium channel
2011 StandoutNobel
Construction of two Escherichia coli amber suppressor genes: tRNAPheCUA and tRNACysCUA.
1986
Analysis of Enzyme Structure and Activity by Protein Engineering
1984 StandoutNobel
Works of Elizabeth E. Howell being referenced
A structure—function study of dihydrofolate reductase by protein engineering
1986
How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27 .fwdarw. serine mutation in Escherichia coli dihydrofolate reductase?
1993
Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH
1990
Dynamics of trimethoprim bound to dihydrofolate reductase—a deuterium NMR study
1996
Effects of insertions and deletions in a beta-bulge region of Escherichia coli dihydrofolate reductase
1997
Analysis of hydride transfer and cofactor fluorescence decay in mutants of dihydrofolate reductase: possible evidence for participation of enzyme molecular motions in catalysis
1991
Structure and function of alternative proton-relay mutants of dihydrofolate reductase
1992
Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase
1987
A second-site mutation at phenylalanine-137 that increases catalytic efficiency in the mutant aspartate-27 .fwdarw. serine Escherichia coli dihydrofolate reductase
1990
A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site
1995
Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate
2006
A Survey of Aspartate−Phenylalanine and Glutamate−Phenylalanine Interactions in the Protein Data Bank: Searching for Anion−π Pairs
2011
Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl
1986
Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.
1993
Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH.
1990
Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement
1988
A Preference for Edgewise Interactions between Aromatic Rings and Carboxylate Anions: The Biological Relevance of Anion−Quadrupole Interactions
2007
An engineered disulfide bond in dihydrofolate reductase
1987
Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by Mutagenesis
1986 Science
Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.
1988
Directed Mutagenesis of Dihydrofolate Reductase
1983 Science
The Tail Wagging the Dog: Insights into Catalysis in R67 Dihydrofolate Reductase
2010