Standout Papers
Citation Impact
Citing Papers
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Evolution of new nonantibody proteins via iterative somatic hypermutation
2004 StandoutNobel
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
2009 StandoutScience
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
2002 StandoutScience
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
2007
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
2011 StandoutScience
Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.
2001
Hallmarks of Cancer: The Next Generation
2011 Standout
Genome-scale DNA methylation maps of pluripotent and differentiated cells
2008 StandoutNature
Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma
2002
Methylation-Induced Repression— Belts, Braces, and Chromatin
1999
A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
2002
DNA hypermethylation in tumorigenesis: epigenetics joins genetics
2000
Epigenetic targets in hematopoietic malignancies
2003
The history of cancer epigenetics
2004 Standout
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
A Nonsimultaneous, Extended, Altruistic-Donor Chain
2009 StandoutNobel
Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells
2000
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
CpG island methylator phenotypes in aging and cancer
1999
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Epigenetic regulation of normal and malignant hematopoiesis
2007
Gilbert’s conjecture: the search for DNA (cytosine-5) demethylases and the emergence of new functions for eukaryotic DNA (cytosine-5) methyltransferases 1 1Edited by J. Karn
2000
Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing
2009
Gene silencing in mammalian cells and the spread of DNA methylation
2002
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
The Epigenomics of Cancer
2007 Standout
Anticancer activities of histone deacetylase inhibitors
2006 Standout
The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion
2001
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
2002
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
2002 StandoutNatureNobel
Cell-free nucleic acids as biomarkers in cancer patients
2011 Standout
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
The development of allergic inflammation
2008 StandoutNature
Transcriptional Regulation of Rat Cyclin D1 Gene by CpG Methylation Status in Promoter Region
1999
Histone deacetylase as a therapeutic target
2001
Chromatin Modification, Leukaemia and Implications for Therapy
2002
The epigenetics of epithelial-mesenchymal plasticity in cancer
2013
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
1999
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
2000
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
2003 Standout
Reactivating the expression of methylation silenced genes in human cancer
2002
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
2004 StandoutNature
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Human Mast Cell Transcriptome Project
2001
Role of DNA Methylation and Histone Acetylation in Steroid Receptor Expression in Breast Cancer
2001
Histone methylation versus histone acetylation: new insights into epigenetic regulation
2001
The Polycomb group protein EZH2 directly controls DNA methylation
2005 StandoutNature
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
2000
Leukaemogenesis: more than mutant genes
2009
Above and Within the Genome: Epigenetics Past and Present
2001
Therapy with azanucleosides for myelodysplastic syndromes
2010
Clonal evolution in cancer
2012 StandoutNature
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
2006 Standout
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
2010 StandoutNature
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans
2001
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
2000 StandoutNature
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
DNA methylation and chromatin modification
1999
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
Human DNA methylomes at base resolution show widespread epigenomic differences
2009 StandoutNature
The fundamental role of epigenetic events in cancer
2002 Standout
Psychosocial Health of Living Kidney Donors: A Systematic Review
2006
DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia
2010
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation
2001
TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers.
2000
Molecular Mechanisms of Gene Silencing Mediated by DNA Methylation
2002
Histone deacetylases (HDACs): characterization of the classical HDAC family
2003 Standout
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
2001
A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies.
2001
Epigenetic Reprogramming in Mammalian Development
2001 StandoutScience
Severe Global DNA Hypomethylation Blocks Differentiation and Induces Histone Hyperacetylation in Embryonic Stem Cells
2004
Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation
2002
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
2003
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.
2001
The Role of DNA Methylation in Mammalian Epigenetics
2001 StandoutScience
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.
2003
Cancer Genome Landscapes
2013 StandoutScience
Translating the Histone Code
2001 StandoutScience
Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line
2001
Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase
2003
DNA cleavage in immunoglobulin somatic hypermutation depends onde novoprotein synthesis but not on uracil DNA glycosylase
2005 StandoutNobel
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
2008 StandoutNobel
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor
2002 Science
Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications
2001
Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia.
2002
Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis.
2001
DNA Methylation and Histone Deacetylation in the Control of Gene Expression: Basic Biochemistry to Human Development and Disease
2001
A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor.
2002
Cancer Epigenetics: Modifications, Screening, and Therapy
2007
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
2002
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells
2003 StandoutNobel
Works of Elizabeth E. Cameron being referenced
Living-Related Kidney Donors: A Multicenter Study of Donor Education, Socioeconomic Adjustment, and Rehabilitation
1986
p15INK4BCpG Island Methylation in Primary Acute Leukemia Is Heterogeneous and Suggests Density as a Critical Factor for Transcriptional Silencing
1999
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
1999 Standout