Standout Papers
- Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis (1992)
- Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity (1995)
- A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF (1998)
- Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998)
Citation Impact
Citing Papers
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation
2004 Standout
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels
1997
Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.
2000
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α
2007
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
Induction of ID2 Expression by Hypoxia-inducible Factor-1
2004
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
1997
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
2001
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
2006
Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell Line
1995
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer.
2002
Activation of the HIF pathway in cancer
2001
Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells
2004
Hallmarks of Cancer: The Next Generation
2011 Standout
The Mouse Gene for Hypoxia‐Inducible Factor‐1α
1997
Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
2010 StandoutNobel
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
2003
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
2003
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
2002
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
2000 StandoutNobel
Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
2001
The impact of O2 availability on human cancer
2008
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300
1999
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
2005 StandoutNobel
Hypoxia-inducible Factor-2α (HIF-2α) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia
2001
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
2007
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
Identification of Functional Hypoxia Response Elements in the Promoter Region of the DEC1 and DEC2 Genes
2002
Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
2003
Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts
2004
Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism
2003
Oxygen sensing and response to hypoxia by mammalian cells
1996 StandoutNobel
Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1 in Colorectal Carcinoma
1996
A Novel Role for Vascular Endothelial Growth Factor as an Autocrine Survival Factor for Embryonic Stem Cells during Hypoxia
2004
Angiogenesis inhibition: A review
1994
Suppression of tumor growth through disruption of hypoxia-inducible transcription
2000 StandoutNobel
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway
2002
Resident vascular progenitor cells: An emerging role for non-terminally differentiated vessel-resident cells in vascular biology
2008
Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1
2000 StandoutNobel
Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme
1994
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
2001
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Regulation of Vascular Endothelial Growth Factor by Oxygen in a Model of Retinopathy of Prematurity
1996
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
1994
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes
1988 StandoutNature
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
1999 Standout
Clinical translation of angiogenesis inhibitors
2002 Standout
The Mouse Gene for Vascular Endothelial Growth Factor
1996
How Tumors Become Angiogenic
1996
HIF-1 and tumor progression: pathophysiology and therapeutics
2002 StandoutNobel
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness
2000
Molecular mechanisms of blood vessel growth
2001
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
1998
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
1999
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
2002
Regulation of Human Vascular Endothelial Growth Factor mRNA Stability in Hypoxia by Heterogeneous Nuclear Ribonucleoprotein L
1999
Hypoxic Regulation of Lactate Dehydrogenase A
1995 StandoutNobel
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Tumor angiogenesis: past, present and the near future
2000
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
2004 Standout
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Involvement of endothelial progenitor cells in tumor vascularization
2010
Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival
2001
Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis
1999
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.
1994
Development and Disease in Proteinase-Deficient Mice
1998
Angiostatin induces and sustains dormancy of human primary tumors in mice
1996
VEGF mRNA is Reversibly Stabilized by Hypoxia and Persistently Stabilized in VEGF-Overexpressing Human Tumor Cell Lines
1995
The role of iron in cell cycle progression and the proliferation of neoplastic cells
2002
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
1998 Standout
Anti-angiogenic effect of TGFβ in aqueous humor
1998
Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
1997
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
1997 Nature
Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis
2007
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
2001 Standout
Imaging angiogenesis of genitourinary tumors
2010
Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells
1996
Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.
1995
Pericytes: gatekeepers in tumour cell metastasis?
2007
Angiogenesis in cancer and other diseases
2000 StandoutNature
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis
1999
Cellular abnormalities of blood vessels as targets in cancer
2004
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
2006 StandoutNobel
PR39, a peptide regulator of angiogenesis
2000
VEGF/VPF: The angiogenesis factor found?
1993
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development
2001
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
2000 StandoutNobel
Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis
1998
Tumor Hypoxia and Malignant Progression
2004
Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia
1996
Angiogenesis in health and disease
2003 Standout
Mechanisms of resistance to antiangiogenesis therapy
2010
Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells
1995
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
VEGF Gene Delivery to Muscle
1998
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
2007
Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity
2000 StandoutNobel
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
2003
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
1994 Nature
Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells
1998
HIF‐1α induces cell cycle arrest by functionally counteracting Myc
2004
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
2003
Age‐dependent impairment of HIF‐1α expression in diabetic mice: Correction with electroporation‐facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
2008 StandoutNobel
Role of Hypoxia-Inducible Factor 1 in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation
2004 StandoutNobel
Cell adhesion and angiogenesis.
1997
Prostaglandin E2 Induces Hypoxia-inducible Factor-1α Stabilization and Nuclear Localization in a Human Prostate Cancer Cell Line
2002
Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α)
1998 StandoutNobel
Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
1997
Vascular Endothelial Growth Factor: Molecular and Biological Aspects
1999
Corrupt policemen: inflammatory cells promote tumor angiogenesis
2008
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
2004
An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma
1997
Vascular endothelial growth factor and its receptors
1996
Hypoxia-Inducible Angiopoietin-2 Expression Is Mimicked by Iodonium Compounds and Occurs in the Rat Brain and Skin in Response to Systemic Hypoxia and Tissue Ischemia
2000
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Levels of Hypoxia-Inducible Factor-1 During Breast Carcinogenesis
2001 StandoutNobel
HIF-1alpha is required for solid tumor formation and embryonic vascularization
1998
Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines
1994 StandoutNobel
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression
2001 StandoutNobel
VEGF as a Key Mediator of Angiogenesis in Cancer
2005
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
1999
Tumor Induction of VEGF Promoter Activity in Stromal Cells
1998
Inhibition of Vascular Endothelial Growth Factor Prevents Retinal Ischemia—Associated Iris Neovascularization in a Nonhuman Primate
1996
Purification and Characterization of Hypoxia-inducible Factor 1
1995 StandoutNobel
Clinical Applications of Research on Angiogenesis
1995 Standout
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
2006 StandoutNobel
Hypoxia signalling in cancer and approaches to enforce tumour regression
2006 Nature
The Role of Hypoxia in Development of the Mammalian Embryo
2009
Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders
1994 Standout
‘Accidental’ anti-angiogenic drugs
2000
Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death
1999 StandoutNobel
Intramyocardial injection of naked DNA encoding HIF-1 /VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
2002
Hypoxia-Induced Vascular Endothelial Growth Factor Expression Precedes Neovascularization after Cerebral Ischemia
2000
Regulation of Vascular Endothelial Growth Factor Expression by Advanced Glycation End Products
2001
Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells
1999
Stem cells in tumor angiogenesis
2010
Hypoxic gene expression and metastasis
2004
Molecular biology of erythropoietin
1993 StandoutNobel
Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis
1995
Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability
1995
Molecular regulation of vessel maturation
2003 Standout
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1
1999
Targeting gene expression to hypoxic tumor cells
1997 StandoutNobel
Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia
1995
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
Mechanisms of angiogenesis
1997 StandoutNature
Transcriptional repression of human cad gene by hypoxia inducible factor-1
2005
Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors
2010
Molecular Mechanisms of Developmental and Tumor Angiogenesis
1994
Stimulation and Inhibition of Angiogenesis in Diabetic Retinopathy
2001
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
2007
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
1999
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
1996 StandoutNobel
Clinical applications of angiogenic growth factors and their inhibitors
1999
Vascular endothelial growth factor
1993
Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis
1996 StandoutNobel
Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors
1999
Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
2009
The role of vascular endothelial growth factor in blood vessel formation
1996
Transgenic mouse models in angiogenesis and cardiovascular disease
2000
Angiogenesis in cancer, vascular, rheumatoid and other disease
1995 Standout
Hypoxia and platelet‐derived growth factor‐BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells
1995
The angiogenic switch in carcinogenesis
2009
Mechanisms of angiogenesis and arteriogenesis
2000 Standout
Angiogenic Signalling Pathways
2008
Vascular endothelial growth factor is essential for corpus luteum angiogenesis
1998
Hypoxia Induces Transcription Factor ETS-1 via the Activity of Hypoxia-Inducible Factor-1
2001
Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR
1998
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection
2011 StandoutNobel
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
1996 StandoutNature
Hypoxia, gene expression, and metastasis
2007
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
2001 Standout
Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells
1995
Tissue responses to ischemia: local and remote responses for preserving perfusion of ischemic muscle
2000
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy
2003
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
2002 StandoutNobel
Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development
1999
Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors
2004
The anti-angiogenic basis of metronomic chemotherapy
2004 Standout
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
2017 Standout
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
1995
Hypoxia-inducible Protein Binding to Vascular Endothelial Growth Factor mRNA and Its Modulation by the von Hippel-Lindau Protein
1996
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
1997
Sprouty proteins, masterminds of receptor tyrosine kinase signaling
2008
The Hypoxic Response: Huffing and HIFing
1997
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
2003
Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.
1995
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
2003
Modes of resistance to anti-angiogenic therapy
2008 Standout
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
2001 StandoutNobel
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer
1998 StandoutNobel
Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development
1995
The role of pericytes in blood-vessel formation and maintenance
2005
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
1999 Standout
Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1
1999
Pericytes and vessel maturation during tumor angiogenesis and metastasis
2010
Tumorigenesis and the angiogenic switch
2003 Standout
Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy
1994
Insulin and Insulin-like Growth Factor-I Induce Vascular Endothelial Growth Factor mRNA Expression via Different Signaling Pathways
2000
Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential‐Display PCR
1996 StandoutNobel
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
1998 Standout
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
1993 StandoutNature
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
2000 StandoutNobel
Regulation of Vascular Endothelial Growth Factor in Cardiac Myocytes
1995
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
2000
Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes
1995
Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
1998
Vascular endothelial growth factor and its receptors
1994
Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression
2000
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
2000 StandoutNobel
A systems approach to cancer therapy
1996
Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
2000
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
2000 StandoutNobel
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
2000 StandoutNobel
Endothelial PAS Domain Protein 1 Gene Promotes Angiogenesis Through the Transactivation of Both Vascular Endothelial Growth Factor and Its Receptor, Flt-1
2004
Sequence of retrovirus provirus resembles that of bacterial transposable elements
1980 NatureNobel
Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis
2009
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.
1995
Endothelial receptor tyrosine kinases involved in angiogenesis.
1995
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases
1979 StandoutNobel
Integration of Oxygen Signaling at the Consensus HRE
2005
Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state
1981 StandoutNobel
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.
1996
Molecular Mechanisms of Coronary Collateral Vessel Growth
1996
Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells
2001
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis.
2001
Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.
1994
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
1995
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
1995 Standout
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
1997 StandoutScience
Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase.
1999
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Expression of Concern: Bcl‐2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF‐1mediated transcriptional activity
2002
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.
1997
Hypoxic stress proteins: Survival of the fittest
1996
Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion After Limb Ischemia
2007 StandoutNobel
Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.
1995
von Hippel-Lindau Disease
2006 StandoutNobel
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia
1997 StandoutNobel
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.
2000 StandoutNobel
Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression.
1999 StandoutNobel
Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells
1993
Regulation of Angiopoietin-2 mRNA Levels in Bovine Microvascular Endothelial Cells by Cytokines and Hypoxia
1998
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
1995 StandoutNobel
The bone marrow constitutes a reservoir of pericyte progenitors
2006
Multiple integration sites for Moloney murine leukemia virus in productively infected mouse fibroblasts
1979
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Correlation of high lactate levels in human cervical cancer with incidence of metastasis.
1995
Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors
2004
Fractals and cancer.
2000
Opposing roles for HIF-1α and HIF-2α in the regulation of angiogenesis by mononuclear phagocytes
2010
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
2001 StandoutNobel
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.
1999
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
1999 StandoutScience
The integration sites of endogenous and exogenous Moloney murine leukemia virus
1979
Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy
2002
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.
1999 StandoutNobel
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
1996 Standout
Arrangement of Integrated Avian Sarcoma Virus DNA Sequences Within the Cellular Genomes of Transformed and Revertant Mammalian Cells
1980
Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
1998
Proviruses of mouse mammary tumor virus in normal and neoplastic tissues from GR and C3Hf mouse strains
1980
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
1996
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
2004 StandoutNobel
Inhibition of Prolyl Hydroxylase Domain Proteins Promotes Therapeutic Revascularization
2009
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
1999
Increased Vascularization in Mice Overexpressing Angiopoietin-1
1998 Science
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
2002
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
1993
Angiogenesis: Models and Modulators
1995
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy.
2001
Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
1999 StandoutScience
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
1994
Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations
1994
Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox.
1999
Vascular Endothelial Growth Factor
2009 Standout
Differentiation of endothelium
1995
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
2000
Number and location of mouse mammary tumor virus proviral DNA in mouse DNA of normal tissue and of mammary tumors
1980
Angiogenesis in Ischemic Disease
1999
Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo
1999
Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor
2002
Angiogenesis Ischemic and Neoplastic Disorders
2003 StandoutNobel
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.
1995
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Functional Upregulation of the Vascular Endothelial Growth Factor Receptor KDR by Hypoxia
1996
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.
2000
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.
2003 StandoutNobel
VEGF is required for growth and survival in neonatal mice
1999
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
Distinct effect of hypoxia on endothelial cell proliferation and cycling
1997
Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors
1998
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
env Gene of Chicken RNA Tumor Viruses: Extent of Conservation in Cellular and Viral Genomes
1978 StandoutNobel
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
1996
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
2000
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes
1999
Chemotherapeutic drugs—more really is not better
2000
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.
2003 StandoutNobel
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
1996 StandoutNobel
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
2000 StandoutNobel
Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.
1999
Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells.
1996
Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.
1996
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
2000
An essential role for p300/CBP in the cellular response to hypoxia
1996
Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway
1998
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
1999 StandoutNobel
Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
1997
Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression.
1995
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Angiogenesis in Endocrine Tumors
2003
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells
1995
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.
1995 Standout
Regulation of c-jun Expression during Hypoxic and Low-Glucose Stress
1994
Expression of hypoxia-inducible factor 1? in brain tumors
2000 StandoutNobel
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.
1996 Standout
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
1998 Standout
Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.
2000
Interindividual Heterogeneity in the Hypoxic Regulation of VEGF
1999
Integration of avian sarcoma virus DNA in chicken cells
1981 StandoutNobel
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites
1978 StandoutNobel
Conformation of free and of integrated Moloney leukemia virus proviral DNA in preleukemic and leukemic BALB/Mo mice
1980
Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen
1995
Age-Related Changes in Vascular Endothelial Growth Factor Dependency and Angiopoietin-1-Induced Plasticity of Adult Blood Vessels
2004
Frequent Overexpression of Vascular Endothelial Growth Factor Gene in Human Renal Cell Carcinoma.
1994
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.
1994
Insulin-induced vascular endothelial growth factor expression in retina.
1999
Restriction endonuclease mapping of the DNA of Rous-Associated virus 0 reveals extensive homology in structure and sequence with avian sarcoma virus DNA
1981
The distribution of endogenous chicken retrovirus sequences in the DNA of galliform birds does not coincide with avian phylogenetic relationships
1979
Works of Eli Keshet being referenced
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
2002
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
1992 StandoutNature
Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.
1993
Ischemia-Driven Angiogenesis
1997
VEGF modulates early heart valve formation
2003
Development of the Human Retinal Vasculature: Cellular Relations and VEGF Expression
1997
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Anticancer drug targets: approaching angiogenesis
1999
Making vascular networks in the adult: branching morphogenesis without a roadmap
2003
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
1995 Standout
VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells
2006
VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix
1997
Activated pp60c-Src Leads to Elevated Hypoxia-inducible Factor (HIF)-1α Expression under Normoxia
2002
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
1999
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
1998 Standout
Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis
2002
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
2007
Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes
1995
Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
1997
Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia
1998
Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity.
1996
Loss of ovarian function promotes angiogenesis in human ovarian carcinoma
1997
Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis
1994
Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy.
1996
Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis
2001
Sites of integration of reticuloendotheliosis virus DNA in chicken DNA.
1978 Nobel
In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.
1992
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects
2001
Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
1995
Nucleotide Sequences Derived from Pheasant DNA in the Genome of Recombinant Avian Leukosis Viruses with Subgroup F Specificity
1977 Nobel
DNA of noninfectious and infectious integrated spleen necrosis virus (SNV) is colinear with unintegrated SNV DNA and not grossly abnormal
1979 Nobel
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
1998
Developmental regulation of ovarian-specific Mos expression.
1988
Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.
1995
Vascular endothelial growth factor upregulation in human central retinal vein occlusion11The authors have no proprietary interest in any of the materials used in this study.
1998
Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.
1990
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases.
1995