Citation Impact
Citing Papers
Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins
2008 StandoutNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
2009 StandoutNobel
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor
2004
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation
2006
Sorting GPI-anchored proteins
2004
NF-κB signaling in inflammation
2017 Standout
Psoriasis
2009 Standout
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Targeting monocytes/macrophages in the treatment of rheumatoid arthritis
2012
Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis
2008 StandoutNobel
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Trafficking and Proteolytic Processing of APP
2012
Presenilin: Running with Scissors in the Membrane
2007
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
The proteome of lysosomes
2010
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
2014 Standout
Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
2007
TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
2008
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Interleukin-17 and Type 17 Helper T Cells
2009 Standout
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α
2005 StandoutNobel
The ADAM metalloproteinases
2008
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
The ins and outs of hepatitis C virus entry and assembly
2013 StandoutNobel
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
2010
Crystal structure of a rhomboid family intramembrane protease
2006 Nature
Functional mapping and annotation of genetic associations with FUMA
2017 Standout
The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly
2007
Yos9p Detects and Targets Misfolded Glycoproteins for ER-Associated Degradation
2005
The Amyloid State of Proteins in Human Diseases
2012 Standout
Analysis of Notch Function in Presomitic Mesoderm Suggests a γ-Secretase-Independent Role for Presenilins in Somite Differentiation
2005
Signalling hypoxia by HIF hydroxylases
2005 StandoutNobel
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment
2009
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Signal Peptide Peptidase-catalyzed Cleavage of Hepatitis C Virus Core Protein Is Dispensable for Virus Budding but Destabilizes the Viral Capsid
2006
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
2012 Standout
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Maturation of Hepatitis C Virus Core Protein by Signal Peptide Peptidase Is Required for Virus Production
2008
A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci
2008
Structure and function of γ-secretase
2008
Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
2017 StandoutNobel
Transmembrane TNF- : structure, function and interaction with anti-TNF agents
2010
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery
2006
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
Mechanisms of implantation: strategies for successful pregnancy
2012 Standout
Replication of hepatitis C virus
2007 StandoutNobel
Intramembrane Proteolysis
2009
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
2010 StandoutNobel
A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia
2011
Internal Initiation Stimulates Production of p8 Minicore, a Member of a Newly Discovered Family of Hepatitis C Virus Core Protein Isoforms
2009 StandoutNobel
Genetic Analysis of the Carboxy-Terminal Region of the Hepatitis C Virus Core Protein
2009 StandoutNobel
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
2012 StandoutNobel
Hox patterning of the vertebrate rib cage
2007 StandoutNobel
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
IL-17 and Th17 Cells
2009 Standout
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
Intramembrane Proteolysis: Theme and Variations
2004 Science
Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation
2008
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
2004
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
2006 StandoutNobel
Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors
2007
Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
2018 StandoutNobel
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Interleukin-1 Receptor Type 1 Is a Substrate for γ-Secretase-dependent Regulated Intramembrane Proteolysis
2008
Alanine Scanning of the Hepatitis C Virus Core Protein Reveals Numerous Residues Essential for Production of Infectious Virus
2007 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Synthesis of Lipidated Green Fluorescent Protein and Its Incorporation in Supported Lipid Bilayers
2005 StandoutNobel
Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly
2006
Pathophysiology, Clinical Presentation, and Treatment of Psoriasis
2020 Standout
Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1
2006
Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase
2016
Works of Elena Friedmann being referenced
Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins
2004
A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b
2006
A Selective Interaction between OS-9 and the Carboxyl-terminal Tail of Meprin β
2002
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells
2007
Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors
2003
YOS9, the Putative Yeast Homolog of a Gene Amplified in Osteosarcomas, Is Involved in the Endoplasmic Reticulum (ER)-Golgi Transport of GPI-anchored Proteins
2002
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production
2006