Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
2016 StandoutScience
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Structure of the Quaternary Complex of Interleukin-2 with Its α, ß, and γ c Receptors
2005 Science
Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression
2014 StandoutNobel
Crystal Structure of the Entire Ectodomain of gp130
2010
Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling
2013
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
Accurate de novo design of heterochiral protein–protein interactions
2024 StandoutNobel
The effects of IL-6 on CD4 T cell responses
2008
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases
2014
Acute Oxygen-Sensing Mechanisms
2005
Interleukin-6 and its receptor: from bench to bedside
2006
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
2012 Standout
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Acquiring signalling specificity from the cytokine receptor gp130
2003
Control of repeat-protein curvature by computational protein design
2015 StandoutNobel
Structure and function of interleukin-17 family cytokines
2011
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain
2010
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
2005
Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism
2014
The pro- and anti-inflammatory properties of the cytokine interleukin-6
2011 Standout
GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor
2003
Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods
2012 StandoutNobel
The rational designed antagonist derived from the complex structure of interleukin-6 and its receptor affectively blocking interleukin-6 might be a promising treatment in multiple myeloma
2006
A cytokine-mediated link between innate immunity, inflammation, and cancer
2007 Standout
The Structure of the Interleukin-15α Receptor and Its Implications for Ligand Binding
2005
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor
2004
Improving de novo protein binder design with deep learning
2023 StandoutNobel
Compensatory Energetic Mechanisms Mediating the Assembly of Signaling Complexes Between Interleukin-2 and its α, β, and γc Receptors
2004
Discovery and characterization of olokizumab
2014
Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases
2012
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
2007
IL-6 as a keystone cytokine in health and disease
2015 Standout
Engineering interferons and interleukins for cancer immunotherapy
2022
Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor
2011
Interpretation of BMP signaling in early Xenopus development
2007 StandoutNobel
Two common structural motifs for TCR recognition by staphylococcal enterotoxins
2016 StandoutNobel
Phylogeny and evolution of class-I helical cytokines
2006
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans
2012
IL-6 in Inflammation, Immunity, and Disease
2014 Standout
A Novel Channelopathy in Pulmonary Arterial Hypertension
2013
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
2009
Genetics and Genomics of Pulmonary Arterial Hypertension
2009
Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands
2015
The IL-10R2 Binding Hot Spot on IL-22 is Located on the N-terminal Helix and is Dependent on N-linked Glycosylation
2004
Molecular Biology of Chronic Thromboembolic Pulmonary Hypertension
2006
The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution
2010
Updated Clinical Classification of Pulmonary Hypertension
2013 Standout
Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane
2005
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
2009 StandoutNobel
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
Development of an IL-6 Inhibitor Based on the Functional Analysis of Murine IL-6Rα1
2009
The Class II cytokine receptor (CRF2) family: overview and patterns of receptor–ligand interactions
2004
Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination
2016 StandoutNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Genetics and Genomics of Pulmonary Arterial Hypertension
2013
Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
2006 StandoutNobel
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
2008 Nature
Molecular recognition of BMP-2 and BMP receptor IA
2004
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
2014 Standout
A High-Affinity Protein Binder that Blocks the IL-6/STAT3 Signaling Pathway Effectively Suppresses Non–Small Cell Lung Cancer
2014
Convergent Mechanisms for Recognition of Divergent Cytokines by the Shared Signaling Receptor gp130
2003 StandoutNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila
2005 StandoutNobel
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
2008 StandoutNobel
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Conformational Changes Mediate Interleukin-10 Receptor 2 (IL-10R2) Binding to IL-10 and Assembly of the Signaling Complex
2006
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
gp130 dimerization in the absence of ligand: Preformed cytokine receptor complexes
2006
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
Inflammation in obesity, diabetes, and related disorders
2022 Standout
Adipose Tissue as an Endocrine Organ
2004 Standout
Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret
2006
Mechanisms of implantation: strategies for successful pregnancy
2012 Standout
Evidence for heterodimeric association of leukemia inhibitory factor (LIF) receptor and gp130 in the mouse uterus for LIF signaling during blastocyst implantation
2006
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells
2008
Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis
2012
JAK2 activation by growth hormone and other cytokines
2015
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins
2012 StandoutNobel
Current concepts in the diagnosis and management of cytokine release syndrome
2014 Standout
Follicular Helper CD4 T Cells (TFH)
2011 Standout
Pulmonary Arterial Hypertension
2006
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension
2011 Standout
Forced Homo- and Heterodimerization of All gp130-Type Receptor Complexes Leads to Constitutive Ligand-independent Signaling and Cytokine-independent Growth
2010
Therapeutic Targeting of the Interleukin-6 Receptor
2011
Hypoxia. 4. Hypoxia and ion channel function
2010
Oxygen sensing by ion channels
2007
Uterine Msx-1 and Wnt4 Signaling Becomes Aberrant in Mice with the Loss of Leukemia Inhibitory Factor or Hoxa-10: Evidence for a Novel Cytokine-Homeobox-Wnt Signaling in Implantation
2004
Pluripotency and nuclear reprogramming
2008 StandoutNobel
Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells
2006
The Structure of Interleukin-2 Complexed with Its Alpha Receptor
2005 Science
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension
2009 Standout
Circumventing the Problems Caused by Protein Diversity in Microarrays: Implications for Protein Interaction Networks
2006
Interleukin-6 and Diabetes
2005
Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells
2005
Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)–Induced Pulmonary Hypertension
2015 StandoutNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Stability of 100 Homo and Heterotypic Coiled−Coil a−a‘ Pairs for Ten Amino Acids (A, L, I, V, N, K, S, T, E, and R)
2006
gp130 at the nexus of inflammation, autoimmunity, and cancer
2010
Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity
2010
Structural Biology of Shared Cytokine Receptors
2007
Interleukin-6 blockade in ocular inflammatory diseases
2014
Works of Elena E. Brevnova being referenced
High level secretion of cellobiohydrolases by Saccharomyces cerevisiae
2011
Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells
2005
Molecular Mechanisms for Viral Mimicry of a Human Cytokine: Activation of gp130 by HHV-8 Interleukin-6
2003
Function of Kv1.5 channels and genetic variations ofKCNA5in patients with idiopathic pulmonary arterial hypertension
2007
Overexpression of human KCNA5 increases IK(V) and enhances apoptosis
2004
Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex
2003 Science