Standout Papers
Citation Impact
Citing Papers
Principles of assembly reveal a periodic table of protein complexes
2015 Science
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Origins of coevolution between residues distant in protein 3D structures
2017 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
2020 StandoutNobel
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
Linking Crystallographic Model and Data Quality
2012 Science
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN
2024 StandoutNobel
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
2017
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Macromolecular TLS Refinement in REFMAC at Moderate Resolutions
2003
Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4)
2015
iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM
2011 Standout
Structural Basis of Transcription
2004 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
How good are my data and what is the resolution?
2013 Standout
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
Decision-making in structure solution using Bayesian estimates of map quality: thePHENIX AutoSolwizard
2009
Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design
1996
Portal control of viral prohead expansion and DNA packaging
2009
Ab initio determination of the crystal structure of cytochrome c6 and comparison with plastocyanin
1995
phenix.mr_rosetta: molecular replacement and model rebuilding with Phenix and Rosetta
2012 StandoutNobel
In-house measurement of the sulfur anomalous signal and its use for phasing
2003
Metal ion catalysis in the Tetrahymena ribozyme reaction
1993 NatureNobel
Elucidating the exact role of engineered CRABPII residues for the formation of a retinal protonated Schiff base
2009
Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus
2012
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
2016
Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution
2000 StandoutNobel
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
Assignment of the backbone 1H and 15N NMR resonances and secondary structure characterization of barstar
1993
A functional and structural study of the major metalloprotease secreted by the pathogenic fungusAspergillus fumigatus
2013
A short history ofSHELX
2007 Standout
Towards automated crystallographic structure refinement with phenix.refine
2012 Standout
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
REFMAC5 for the refinement of macromolecular crystal structures
2011 Standout
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
Recent developments inMrBUMP: better search-model preparation, graphical interaction with search models, and solution improvement and assessment
2018
Reaction mechanism of alkaline phosphatase based on crystal structures
1991 Standout
Directed mutagenesis and barnase-barstar recognition
1993
Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy
2013 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Effect of active site residues in barnase on activity and stability
1992
Multiple magnesium ions in the ribonuclease P reaction mechanism
1993
Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18
2012 StandoutNobel
Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus
2010
JLigand: a graphical tool for the CCP4 template-restraint library
2012
STRUCTURE OF WHEAT SERINE CARBOXYPEPTIDASE /II$ AT 3.5-*ANGSTROMS RESOLUTION. A NEW CLASS OF SERINE PROTEINASE
1991
Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum
1991 Nature
Improved low-resolution crystallographic refinement with Phenix and Rosetta
2013 StandoutNobel
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
2011 Nature
Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α
2003 StandoutNobel
The P22 Tail Machine at Subnanometer Resolution Reveals the Architecture of an Infection Conduit
2009
Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
2020
PHENIX: a comprehensive Python-based system for macromolecular structure solution
2010 Standout
Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER
2012
Experimental phasing with SHELXC/D/E: combining chain tracing with density modification
2010
Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy
2012
Structural Insights into Atg10-Mediated Formation of the Autophagy-Essential Atg12-Atg5 Conjugate
2012 StandoutNobel
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
2011
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
2001 StandoutNatureNobel
Structural basis of receptor recognition by SARS-CoV-2
2020 StandoutNature
Low-resolution refinement tools in REFMAC5
2012
Improvement of molecular-replacement models withSculptor
2011
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
2002
Computational design of a leucine-rich repeat protein with a predefined geometry
2014
Collaboration gets the most out of software
2013
Structural patterns in globular proteins
1976 StandoutNatureNobel
Structural Analysis of Major Species Barriers between Humans and Palm Civets for Severe Acute Respiratory Syndrome Coronavirus Infections
2008
Structural Symmetry and Protein Function
2000
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Gene duplications in the structural evolution of chymotrypsin
1979
Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes.
1991
Dipoles localized at helix termini of proteins stabilize charges.
1991 StandoutNobel
Crystal Structures of Protein-Bound Cyclic Peptides
2019
A seven-helix coiled coil
2006
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
Structure of wheat serine carboxypeptidase II at 3.5-A resolution. A new class of serine proteinase.
1990
A general two-metal-ion mechanism for catalytic RNA.
1993 StandoutNobel
Computational design of water-soluble α-helical barrels
2014 Science
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
2020
Quality Control by DNA Repair
1999 StandoutScienceNobel
Structure of bovine pancreatic phospholipase A2 at 1.7 Å resolution
1981
Carp Muscle Calcium-binding Protein
1973 Standout
Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein
1991 StandoutScience
Interfacial Catalysis: the Mechanism of Phospholipase A 2
1990 StandoutScience
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
High thermodynamic stability of parametrically designed helical bundles
2014 StandoutScienceNobel
Structure of horse muscle phosphoglycerate kinase
1974
Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors
2012 Science
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism
2014
How many catalytic RNAs? Ions and the Cheshire cat conjecture.
1993
Structure of human plasma prealbumin at 2.5 A resolution
1974
Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium.
1990
On the conformation of proteins: The handedness of the β-strand-α-helix-β-strand unit
1976
Active site of (A)BC excinuclease. II. Binding, bending, and catalysis mutants of UvrB reveal a direct role in 3‘ and an indirect role in 5‘ incision.
1992 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus
2011 StandoutNobel
Recognition of protein-linked glycans as a determinant of peptidase activity
2017
Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution.
1991
The Reverse Turn as a Polypeptide Conformation in Globular Proteins
1973 StandoutNobel
Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data
1975 Nature
Describing patterns of protein tertiary structure
1985
Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 α2β2 Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA
2015
The Molecular Biology of Axon Guidance
1996 StandoutScience
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
More of the catalytic triad
1990 Nature
Computational design of a pH-sensitive IgG binding protein
2013 StandoutNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Phasercrystallographic software
2007 Standout
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
1990 StandoutNobel
Works of E.J. Dodson being referenced
Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis
2001
X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule
1991
Automated production of small-molecule dictionaries for use in crystallographic refinements
1999
The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement
1997
High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus
1989 Nature
Jolly SAD
2002
Use of iron anomalous scattering with multiple models and data sets to identify and refine a weak molecular replacement solution: structure analysis of cytochromec' from two bacterial species
1995
Efficient anisotropic refinement of macromolecular structures using FFT
1999
A flexible and efficient procedure for the solution and phase refinement of protein structures
2000
Overview of theCCP4 suite and current developments
2011 Standout
A modifiedACORNto solve protein structures at resolutions of 1.7 Å or better
2005
Automatic Solution of Heavy-Atom Substructures
2003
A serine protease triad forms the catalytic centre of a triacylglycerol lipase
1990 Nature
High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-State haemoglobins: T(α-oxy)haemoglobin and T(met)haemoglobin
1992
A graphical user interface to theCCP4 program suite
2003
Does NMR Mean “Not for Molecular Replacement”? Using NMR-Based Search Models to Solve Protein Crystal Structures
2000
Structural framework for DNA translocation via the viral portal protein
2007
Is it jolly SAD?
2003
Structure of the trp RNA-binding attenuation protein, TRAP, bound to RNA
1999 Nature
Structure of Rhombohedral 2 Zinc Insulin Crystals
1969 Nature
The crystal structure of a hydrated gramicidin S–urea complex
1978 Nature
Structural relationships in the two-zinc insulin hexamer
1979
Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals
1971 Nature
X-Ray Analysis and the Structure of Insulin
1971
Crystallographic refinement of the structure of actinidin at 1.7 Å resolution by fast Fourier least-squares methods
1980
Molecular structure of a new family of ribonucleases
1982 Nature
Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.
1994
The determination and refinement of heavy-atom parameters in protein heavy-atom derivatives. Some model calculations using acentric reflexions
1971
Structure of insulin in 4-zinc insulin
1976 Nature
Zinc-free cubic pig insulin: Crystallization and structure determination
1978
The Crystal Structure of Rhombohedral 2 Zinc Insulin
1972
The Structural Basis of Sequence-Independent Peptide Binding by OppA Protein
1994 Science