Citation Impact
Citing Papers
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
2015
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Direct and Catalytic C ‐Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside**
2021 StandoutNobel
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication
2018 StandoutNobel
Evaluation of Sofosbuvir (β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine) as an inhibitor of Dengue virus replication #
2017
Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface
2013
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
2018 StandoutNobel
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
2017 StandoutNobel
The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors
2018
Fluorinated nucleosides: Synthesis and biological implication
2008
Nucleoside Analog Inhibitors of Hepatitis C Virus Replication
2006
Transcript RNA supports precise repair of its own DNA gene
2015
Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond
2018
Murine models of hepatitis C: What can we look forward to?
2014
Hepatocellular carcinoma
2018 Standout
Structure and function of the Zika virus full-length NS5 protein
2017
Generation of improved humanized mouse models for human infectious diseases
2014
Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides
2012
A Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes
2013
The importance of resistance to direct antiviral drugs in HCV infection in clinical practice
2015
Hepatitis C Virus RNA Replication and Assembly: Living on the Fat of the Land
2014
Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure
2013 StandoutNobel
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
2013
Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors
2016
Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir
2016 StandoutNobel
Hepatitis C Virus RNA Replication
2013
Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C
2013
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues
2016
Hepatitis C Virus Proteins: From Structure to Function
2013
Overall survival in response to sorafenib versus radiotherapy in unresectable hepatocellular carcinoma with major portal vein tumor thrombosis: propensity score analysis
2014
Screening of the Pan-African Natural Product Library Identifies Ixoratannin A-2 and Boldine as Novel HIV-1 Inhibitors
2015 StandoutNobel
Next generation sequencing of the hepatitis C virus NS5B gene reveals potential novel S282 drug resistance mutations
2015
Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance
2014
Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC
2017
Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin
2015 StandoutNobel
The ins and outs of hepatitis C virus entry and assembly
2013 StandoutNobel
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism
2017 StandoutNobel
The use of spirocyclic scaffolds in drug discovery
2014 Standout
Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661
2011
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
2013
Antiviral therapy of hepatitis C in 2014: Do we need resistance testing?
2014
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
2020 Standout
New NS5B polymerase inhibitors for hepatitis C
2010
Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure–activity and resistance relationships; different scaffolds and mutations
2012
Studies toward the oxidative and reductive activation of C–S bonds in 2′-S-aryl-2ʹ-thiouridine derivatives
2016
Dancing with chemical formulae of antivirals: A panoramic view (Part 2)
2013
Advances in hepatitis C research and treatment
2016
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
Structure of replicating SARS-CoV-2 polymerase
2020 Nature
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Flavivirus RNA transactions from viral entry to genome replication
2016
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
The FDA-approved drug sofosbuvir inhibits Zika virus infection
2016
miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation
2015
External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline
2021
The way forward in HCV treatment — finding the right path
2007 StandoutNobel
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
2017 StandoutNobel
Hepatocellular carcinoma
2022 Standout
Chronic viral hepatitis and its association with liver cancer
2017
Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells
2016 StandoutNobel
Current race in the development of DAAs (direct-acting antivirals) against HCV
2014
Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
2012
Fluorine in medicinal chemistry
2007 Standout
AASLD guidelines for the treatment of hepatocellular carcinoma
2017 Standout
Identification, Molecular Cloning, and Analysis of Full-Length Hepatitis C Virus Transmitted/Founder Genotypes 1, 3, and 4
2015 StandoutNobel
Evolution of the HCV viral population from a patient with S282T detected at relapse after sofosbuvir monotherapy
2015
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
DNA Polymerase γ in Mitochondrial DNA Replication and Repair
2005
Enhancement of the Replication of Hepatitis C Virus Replicons of Genotypes 1 to 4 by Manipulation of CpG and UpA Dinucleotide Frequencies and Use of Cell Lines Expressing SECL14L2 for Antiviral Resistance Testing
2016
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
The ProTide Prodrug Technology: From the Concept to the Clinic
2017
Mitsunobu and Related Reactions: Advances and Applications
2009
Postprogression survival of patients with advanced hepatocellular carcinoma: Rationale for second-line trial design
2013
Progress In The Development Of Anti-Hepatitis C Virus Nucleoside And Nucleotide Prodrugs
2012
Combinations of 2'-C-Methylcytidine Analogues with Interferon-α2b and Triple Combination with Ribavirin in the Hepatitis C Virus Replicon System
2008
Phosphine Organocatalysis
2018 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir
2014
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor
2014
Visualization of Positive and Negative Sense Viral RNA for Probing the Mechanism of Direct-Acting Antivirals against Hepatitis C Virus
2019 StandoutNobel
Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
2018 StandoutNobel
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications
2015
A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1
2019 StandoutNobel
Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479
2008
Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates
2011
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
2018
Development of a multiplex phenotypic cell-based high throughput screening assay to identify novel hepatitis C virus antivirals
2013 StandoutNobel
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Discovery of 2′-α-C-Methyl-2′-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus
2016
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
2020
Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus
2014 StandoutNobel
Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model
2017 StandoutNobel
Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells
2019 StandoutNobel
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
2018 Standout
Deep Sequencing and Phylogenetic Analysis of Variants Resistant to Interferon-Based Protease Inhibitor Therapy in Chronic Hepatitis Induced by Genotype 1b Hepatitis C Virus
2015
Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2′-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase
2014
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/ nucleotide inhibitors
2009
Discovery of a β-d -2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
2010
Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment
2017 StandoutNobel
In vivo models of hepatitis B and C virus infection
2016
Novel Therapies for Hepatitis C: Insights from the Structure of the Virus
2011
Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections
2014
Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures
2018
Barrier-Independent, Fitness-Associated Differences in Sofosbuvir Efficacy against Hepatitis C Virus
2016 StandoutNobel
Detailed Computational Study of the Active Site of the Hepatitis C Viral RNA Polymerase to Aid Novel Drug Design
2013 StandoutNobel
Works of Eisuke Murakami being referenced
Structural basis for RNA replication by the hepatitis C virus polymerase
2015 Science
Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A
2015
Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977
2010
Characterization of Novel Reverse Transcriptase and Other RNA-associated Catalytic Activities by Human DNA Polymerase γ
2003
Hepatic arterial infusion chemotherapy using 5‐fluorouracil and systemic interferon‐α for advanced hepatocellular carcinoma in combination with or without three‐dimensional conformal radiotherapy to venous tumor thrombosis in hepatic vein or inferior vena cava
2011
Evaluation of the mRECIST and α-Fetoprotein Ratio for Stratification of the Prognosis of Advanced-Hepatocellular-Carcinoma Patients Treated with Sorafenib
2012
Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents
2006
A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections
2013
The Mechanism of Action of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methylcytidine Involves a Second Metabolic Pathway Leading to β- d -2′-Deoxy-2′-Fluoro-2′- C -Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase
2007
Clevudine is Efficiently Phosphorylated to the Active Triphosphate form in Primary Human Hepatocytes
2008
Emergence of resistant variants detected by ultra‐deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1
2014
Nucleoside Analog Inhibitors of Hepatitis C Viral Replication: Recent Advances, Challenges and Trends
2009
Long term persistence of NS5A inhibitor‐resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy
2015
Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design
2013
Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d -2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
2011
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
2012
PSI-7851, a Pronucleotide of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
2010
Mechanism of Activation of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase
2006