Citation Impact
Citing Papers
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein
2012
AMP‐activated protein kinase: a potential player in Alzheimer’s disease
2011
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly
2010
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
2004
Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β
2018
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Transcriptomic profiling of microglia and astrocytes throughout aging
2020
Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease
2008
Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?
2004
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
2001
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation
1999
Substitutions at codon 22 of Alzheimer's A beta peptide induce conformational changes and diverse apoptotic effects in human cerebral endothelial cells
2000
A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway
1997
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
2014
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons
2021
A type III intermediate filament gene is expressed in mature neurons
1988
Variant Alzheimer Disease With Spastic paraparesis: Neuropathological phenotype
2001
Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimerʼs β-amyloid precursor protein
1999
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
2004
Comparison of the aggregation properties, secondary structure and apoptotic effects of wild‐type, Flemish and Dutch N‐terminally truncated amyloid β peptides
2001
Nuclear Signaling: A Common Function of Presenilin Substrates?
2001
Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies
2009
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid
1992 Standout
The role of autophagy in neurodegenerative disease
2013 Standout
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
2004
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model
2012
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
1992 Nature
Rapid induction of Alzheimer A beta amyloid formation by zinc
1994 Science
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
1991 Nature
Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein
2002
The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
2001
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
2015
Exosomes as new diagnostic tools in CNS diseases
2015
Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)
1996
Identification of an Evolutionarily Conserved Heterotrimeric Protein Complex Involved in Protein Targeting
1998
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
Genetic Analysis of Mint/X11 Proteins: Essential Presynaptic Functions of a Neuronal Adaptor Protein Family
2006 StandoutNobel
Low‐density lipoprotein receptor‐related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1
2002
Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments
1991 StandoutNobel
Animal models of human amyloidoses: Are transgenic mice worth the time and trouble?
2009
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc
2002
Mint2/X11‐like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease
1999
Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy
1995
Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-β Peptide
2012
Shedding light on the cell biology of extracellular vesicles
2018 Standout
Synergistic Effects of Munc18a and X11 Proteins on Amyloid Precursor Protein Metabolism
2002
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
2012
Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann–Sträussler–Scheinker Disease
2012
Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein
1998
Autophagy failure in Alzheimer's disease—locating the primary defect
2011
Structural and kinetic features of amyloid β-protein fibrillogenesis
1998
X11α and X11β Interact with Presenilin-1 via Their PDZ Domains
2000
Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins
1991
Autophagy and human disease: emerging themes
2014
Amyloid fibrils in Gerstmann-Sträussler-Scheinker disease (Indiana and Swedish Kindreds) express only PrP peptides encoded by the mutant allele
1994
The influence of the central region containing residues 19−25 on the aggregation properties and secondary structure of Alzheimer's β‐amyloid peptide
1998
APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice
2001 Nobel
“Secretase,” Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific
1991
Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells
1992
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene
1992
Autophagy modulation as a potential therapeutic target for diverse diseases
2012 Standout
Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons
2017
APP Processing and Synaptic Function
2003
Charge Alterations of E22 Enhance the Pathogenic Properties of the Amyloid β‐Protein
2000
Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid β/A4 peptide
1993
Animal models of cerebral β-amyloid angiopathy
1997
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases
2015
Mechanism of Cerebral β-Amyloid Angiopathy: Murine and Cellular Models
2006
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Alzheimer’s amyloid fibrils: structure and assembly
2000
Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy
2011
Ultrastructural localization of mint1 at synapses in mouse hippocampus
2000
Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
1998
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
2010
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease
2016
The Amyloid State of Proteins in Human Diseases
2012 Standout
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Amyloid β-Protein Fibrillogenesis
1997
The X11α Protein Slows Cellular Amyloid Precursor Protein Processing and Reduces Aβ40 and Aβ42 Secretion
1998
Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models
2011
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability
2002 Standout
A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain
1998 StandoutNobel
Impact of lysosome status on extracellular vesicle content and release
2016
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
LIN-10 Is a Shared Component of the Polarized Protein Localization Pathways in Neurons and Epithelia
1998
Identification and characterization of key kinetic intermediates in amyloid β-protein fibrillogenesis11Edited by F. Cohen
2001
The 717Val→Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups
1991
Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane
2001
Molecular genetics of cell death in the nematode Caenorhabditis elegans
1992
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Modulation of Amyloid Precursor Protein Metabolism by X11α/Mint-1
2000
Exosomes: Therapy delivery tools and biomarkers of diseases
2017
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006
Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier
1997
Autophagy and Neuronal Cell Death in Neurological Disorders
2012
Developmental and abnormal cell death in C. Elegans
1992 StandoutNobel
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain
1997
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Mint 3: A ubiquitous mint isoform that does not bind to munc18-1 or -2
1998 StandoutNobel
Flemish and Dutch Mutations in Amyloid β Precursor Protein Have Different Effects on Amyloid β Secretion
1998
The β‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?
2002
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Exosome secretion is a key pathway for clearance of pathological TDP-43
2016
Exosomes, an Unmasked Culprit in Neurodegenerative Diseases
2017
Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein
2001
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
2001
The molecular pathology of Alzheimer's disease
1991 Standout
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
2007
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Substitutions at Codon 22 of Alzheimer's Aβ Peptide Induce Diverse Conformational Changes and Apoptotic Effects in Human Cerebral Endothelial Cells
2000
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
1992 StandoutNature
Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification
2013
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Framing β–amyloid
1992
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
1999
Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1
1999
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif
1997
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
PROTOFIBRILS , PORES , FIBRILS, AND NEURODEGENERATION : Separating the Responsible Protein Aggregates from The Innocent Bystanders
2003
Basolateral Localization of theCaenorhabditis elegansEpidermal Growth Factor Receptor in Epithelial Cells by the PDZ Protein LIN-10
1999
Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population.
1996 StandoutNobel
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
1998
A Century of Alzheimer's Disease
2006 StandoutScience
Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.
1991
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing
2016
Deletion of CASK in mice is lethal and impairs synaptic function
2007 StandoutNobel
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
1996
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease
2012
The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids
1999
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
1997 StandoutScience
Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?
2014
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
2002 StandoutNobel
A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease
1991 Science
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression
2003
Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms
2002 StandoutNobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
1991 StandoutNobel
Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy
2001
Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice
2016
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
2010
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein.
1996
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity
2010
Review
1995
Angiotensin-converting enzyme and male fertility
1998 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Propagating structure of Alzheimer’s β-amyloid (10–35) is parallel β-sheet with residues in exact register
1998
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's β-amyloid precursor protein
1998
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
Characterization of MALS/Velis-1, -2, and -3: a Family of Mammalian LIN-7 Homologs Enriched at Brain Synapses in Association with the Postsynaptic Density-95/NMDA Receptor Postsynaptic Complex
1999
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
1994
The E6 Oncoproteins of High-Risk Papillomaviruses Bind to a Novel Putative GAP Protein, E6TP1, and Target It for Degradation
1999
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Molecular Analysis of the X11–mLin-2/CASK Complex in Brain
1999
Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme
1996
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
1993
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.
1991
feh-1 and apl-1, the Caenorhabditis elegansorthologues of mammalian Fe65 and β-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping
2002
Works of Efrat Levy being referenced
Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities
2017
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers
2010
X11 Interaction with β-Amyloid Precursor Protein Modulates Its Cellular Stabilization and Reduces Amyloid β-Protein Secretion
1998
Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype
1996
Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models
2007
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
2010
Exosomes in the Diseased Brain: First Insights from In vivo Studies
2017
Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease
2009
Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl‐terminal fragments in cerebral neurons in vivo
2007
Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease
2008
Codeposition of Cystatin C with Amyloid-β Protein in the Brain of Alzheimer Disease Patients
2001
β-Amyloid precursor protein gene in squirrel monkeys with cerebral amyloid angiopathy
1995
The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space
2012
Codon 618 variant of alzheimer amyloid gene associated with inherited cerebral hemorrhage
1991
C-Terminal Fragments of α- and β-Tubulin Form Amyloid Fibrilsin Vitroand Associate with Amyloid Deposits of Familial Cerebral Amyloid Angiopathy, British Type
1996
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF
2015
Cystatin C in Alzheimer's disease
2012
Expression of a normal and variant Alzheimer's β-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays
1990
Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation
2004
Cystatin C modulates cerebral β-amyloidosis
2007
The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein
1996
DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)
1991
Cystatin C
1996
P1‐059: Cystatin B deletion in a mouse model of Alzheimer's disease, TgCRND8, ameliorates both autophagic‐lysosomal and amyloid pathologies
2008
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
2011
Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes
2018
Mutation in gelsolin gene in Finnish hereditary amyloidosis.
1990
Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein
1987
Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.
1989
Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type
1990 Science
Cell-Lysate Conversion of Prion Protein into Its Protease-Resistant Isoform Suggests the Participation of a Cellular Chaperone
1999
Cystatin C Mutation in an Elderly Man With Sporadic Amyloid Angiopathy and Intracerebral Hemorrhage
1995