Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA
2004 StandoutNobel
Human Ageing and Telomeres
2007
Hallmarks of Cancer: The Next Generation
2011 Standout
Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression
2001
A telomerase component is defective in the human disease dyskeratosis congenita
1999 Nature
Telomerase activation by the E6 gene product of human papillomavirus type 16
1996 Nature
Hayflick, his limit, and cellular ageing
2000
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Telomeres, the nucleolus and aging
1998
Cancer and aging: a model for the cancer promoting effects of the aging stroma
2002
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
2006
Clonally Derived Human Embryonic Stem Cell Lines Maintain Pluripotency and Proliferative Potential for Prolonged Periods of Culture
2000
Modular regulatory principles of large non-coding RNAs
2012 StandoutNature
Human Telomerase Activation Requires Two Independent Interactions between Telomerase RNA and Telomerase Reverse Transcriptase
2000
Cellular senescence: when bad things happen to good cells
2007 Standout
Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions
1996
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
1997 Standout
Processive Utilization of the Human Telomerase Template
2004 StandoutNobel
Method for Determining RNA 3' Ends and Application to Human Telomerase RNA
1996
Functional requirement of p23 and Hsp90 in telomerase complexes
1999
Oxidative Stress in Neurodegenerative Diseases
1996
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Long-term molecular and cellular stability of human neural stem cell lines
2004
Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process
1999
Telomere states and cell fates
2000 StandoutNatureNobel
Telomere maintenance and disease
2003
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
Functionally interacting telomerase RNAs in the yeast telomerase complex
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
2013
Regulation of cellular senescence by p53
2001
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
Normal human chromosomes have long G-rich telomeric overhangs at one end
1997
Angiogenesis in health and disease
2003 Standout
Telomerase and the maintenance of chromosome ends
1999 Nobel
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Telomerase and ATM/Tel1p Protect Telomeres from Nonhomologous End Joining
2003 StandoutNobel
Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro
2002
Exercise training improves ageing‐induced decrease in eNOS expression of the aorta
2003
The roles of telomeres and telomerase in cell life span
1996
Human telomerase contains two cooperating telomerase RNA molecules
2001
Functional Reconstitution of Human Telomerase Expressed inSaccharomyces cerevisiae
1999
Reconstitution of human telomerase activity in vitro
1998
The mouse telomerase RNA 5'-end lies just upstream of the telomerase template sequence
1998 StandoutNobel
Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
2004
Cdc13 Delivers Separate Complexes to the Telomere for End Protection and Replication
2001
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
2001
Secondary Structure of Vertebrate Telomerase RNA
2000 StandoutNobel
Telomerase in human development and cancer
1997
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
1997
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
2001
Telomeres and senescence: The history, the experiment, the future
1998 StandoutNobel
Senescence and epigenetic dysregulation in cancer
2002
Cancer and ageing: rival demons?
2003
Role of Oxidative and Nitrosative Stress, Longevity Genes and Poly(ADPribose) Polymerase in Cardiovascular Dysfunction Associated with Aging
2005
Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
2001
Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
1996 StandoutNatureNobel
Human telomerase RNA-protein interactions
2001
The essence of senescence: Figure 1.
2010 Standout
Regulation of Telomere Length and Telomerase in T and B Cells
1998
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
1996 StandoutNobel
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Mechanisms of cellular senescence
1997
Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties
1998
Food Restriction Attenuates Age-Related Increase in the Sensitivity of Endothelial Cells to Oxidized Lipids
2004
Nicotine and pathological angiogenesis
2012
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
A survey of telomerase activity in human cancer
1997 Standout
Switching and Signaling at the Telomere
2001 StandoutNobel
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
1998
Oxidative stress shortens telomeres
2002 Standout
Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes
2003
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?
2000
Severe growth defect in mouse cells lacking the telomerase RNA component
1998
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
2002
Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
2012
Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination
1998 StandoutNatureNobel
The role of senescent cells in ageing
2014 StandoutNature
Genetic Control of Telomerase and Replicative Senescence in Human and Rodent Cells
2007
Human telomerase contains evolutionarily conserved catalytic and structural subunits
1997
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
2003
TRF1 promotes parallel pairing of telomeric tracts in vitro
1998
A critical role for telomeres in suppressing and facilitating carcinogenesis
2000
Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro
1998
DNA damage response and cellular senescence in tissues of aging mice
2009
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
2003
A Novel Role for High-Mobility Group A Proteins in Cellular Senescence and Heterochromatin Formation
2006
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
2001
Activation of nuclear factor-kappa B signalling promotes cellular senescence
2011
Specific telomerase RNA residues distant from the template are essential for telomerase function
1998 StandoutNobel
TLP1: A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family
1997
Creation of human tumour cells with defined genetic elements
1999 StandoutNature
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
2001 Nature
Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube
1999
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
1997
Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types
1997
The power and the promise of oncogene-induced senescence markers
2006
Cellular lifespan and senescence signaling in embryonic stem cells
2004
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
2008
Endless quest
1996
Molecular cloning of bovine telomerase RNA
1998
Inhibition of telomerase limits the growth of human cancer cells
1999
Cellular senescence: hot or what?
2009
The telomerase reverse transcriptase: components and regulation
1998
p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions
2005
Control of telomere length by the human telomeric protein TRF1
1997 Nature
Cellular senescence as a tumor-suppressor mechanism
2001
Expression of TERT in early premalignant lesions and a subset of cells in normal tissues
1998
Feedback between p21 and reactive oxygen production is necessary for cell senescence
2010
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
The catalytic subunit of yeast telomerase
1997
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.
1996 StandoutNobel
Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1
2002
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1999 StandoutNobel
Effects of p21Waf1/Cip1/Sdi1on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
2000
Antitumor Activity of Systemically Delivered Ribozymes Targeting Murine Telomerase RNA
2004 StandoutNobel
Aging, Cellular Senescence, and Cancer
2012 Standout
Functional Multimerization of the Human Telomerase Reverse Transcriptase
2001
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Regulated expression of telomerase activity in human T lymphocyte development and activation.
1996
TELOMERES AND THEIR CONTROL
2000 StandoutNobel
Telomerase maintains telomere structure in normal human cells
2006
Telomerase and cancer: revisiting the telomere hypothesis
1996 StandoutNobel
Characterization and developmental patterns of telomerase expression in plants
1996
Cellular senescence controls fibrosis in wound healing
2010
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
2003
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
2003 Standout
The future of cloning
1999 StandoutNatureNobel
Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation
1998
Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA
2000 StandoutNobel
Both Transcriptional and Posttranscriptional Mechanisms Regulate Human Telomerase Template RNA Levels
1999
Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance
1996 Science
Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase
2000
A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End
1999
Senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
1996
Two Inactive Fragments of the Integral RNA Cooperate To Assemble Active Telomerase with the Human Protein Catalytic Subunit (hTERT) In Vitro
1999
A Mammalian Telomerase-Associated Protein
1997 Science
Ciliate Telomerase Biochemistry
1999
Telomerase Activity Is Sufficient To Allow Transformed Cells To Escape from Crisis
1999
Connecting Chromosomes, Crisis, and Cancer
2002 Science
A Human Telomeric Protein
1995 Science
Cellular senescence as a tumor-suppressor mechanism
2001
Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.
1996 StandoutNobel
Processing of Nontelomeric 3′ Ends by Telomerase: Default Template Alignment and Endonucleolytic Cleavage
1996
A novel telomerase template antagonist (GRN163) as a potential anticancer agent.
2003
Three Ever Shorter Telomere ( EST ) genes are dispensable for in vitro yeast telomerase activity
1997 Nobel
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
2001
Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines.
1996
Reprogramming of Telomerase by Expression of Mutant Telomerase RNA Template in Human Cells Leads to Altered Telomeres That Correlate with Reduced Cell Viability
1997
In vivotelomere dynamics of human hematopoietic stem cells
1997
The signals and pathways activating cellular senescence
2004
Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase
1997 ScienceNobel
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
1999
Polymerization Defects within Human Telomerase Are Distinct from Telomerase RNA and TEP1 Binding
2000
Arterial Aging
2005
Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence for Regulation of Telomerase RNA with Cell Proliferation
1996
Telomerase in kinetoplastid parasitic protozoa
1999 StandoutNobel
PML is induced by oncogenicrasand promotes premature senescence
2000
A Single Telomerase RNA Is Sufficient for the Synthesis of Variable Telomeric DNA Repeats in Ciliates of the Genus Paramecium
1996
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
1997 StandoutNobel
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
2001 StandoutNobel
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.
1996 StandoutNobel
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax
1998 Nobel
Expression of mouse telomerase catalytic subunit in embryos and adult tissues
1998
Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow
1996
Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using an in VivoReconstitution System
2001
Template Boundary in a Yeast Telomerase Specified by RNA Structure
2000 StandoutScienceNobel
Telomeres: Beginning to Understand the End
1995 Science
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
2003
Telomerase and DNA End Replication: No Longer a Lagging Strand Problem?
1995 ScienceNobel
A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status
2002
Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation
1997 StandoutScienceNobel
Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells
1997
Photothermal Nanomaterials: A Powerful Light-to-Heat Converter
2023 Standout
Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells
1997
Stem-Loop IV of Tetrahymena Telomerase RNA Stimulates Processivity in trans
2003 StandoutNobel
Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice
1999
Est1 has the properties of a single-stranded telomere end-binding protein.
1996
Telomerase regulation during entry into the cell cycle in normal human T cells.
1996 StandoutNobel
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains
1997 StandoutNobel
Boundary elements of the Tetrahymena telomerase RNA template and alignment domains.
1995 StandoutNobel
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 StandoutScience
Flexible Positioning of the Telomerase-Associated Nuclease Leads to Preferential Elimination of Nontelomeric DNA
1998
Works of Edwin Chang being referenced
Endothelial Progenitor Cells Participate in Nicotine-Mediated Angiogenesis
2006
Aging and Survival of Cutaneous Microvasculature
2002
Microarray analysis of replicative senescence
1999
Human Endothelial Cell Life Extension by Telomerase Expression
1999
Remotely controlled near-infrared-triggered photothermal treatment of brain tumours in freely behaving mice using gold nanostars
2022
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
1999
Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo
1995
Telomere length and replicative aging in human vascular tissues.
1995
Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?
2010
A Central Role for Nicotinic Cholinergic Regulation of Growth Factor–Induced Endothelial Cell Migration
2006
eNOS Activity Is Reduced in Senescent Human Endothelial Cells
2001
ROS and Brain Diseases: The Good, the Bad, and the Ugly
2013
PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2
2015
The RNA Component of Human Telomerase
1995 StandoutScienceNobel