Citation Impact
Citing Papers
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.
1995
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
1996
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.
1996
Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter
1995
Evolutionary History of a Specialized P450 Propane Monooxygenase
2008 StandoutNobel
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
Stereochemistry of the microsomal glutathione S-transferase catalyzed addition of glutathione to chlorotrifluoroethene
1991
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
1995 Standout
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
1998 StandoutNature
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
1991 StandoutNature
Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase
1990
Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by the free acid rather than the acyl‐CoA derivative
1994
Analytical and statistical approaches to metabolomics research
2009
cDNA cloning and characterization of the transcriptional activities of the hamster peroxisome proliferator-activated receptor haPPARγ
1995
Kinetic Analysis of the Mechanism and Specificity of Protein-disulfide Isomerase Using Fluorescence-quenched Peptides
1998 StandoutNobel
Autophagy regulates lipid metabolism
2009 StandoutNature
Expression of the Peroxisome Proliferator-activated Receptor α Gene Is Stimulated by Stress and Follows a Diurnal Rhythm
1996
Xenopus peroxisome proliferator activated receptors: Genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids
1993
Nonalcoholic Fatty Liver Disease
2002 Standout
Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate β-Lyase Pathway
1994
The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation
1996
Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway
1999
The oxidative inactivation of cytochrome P450 in monooxygenase reactions
1994
Structural and metabolic requirements for activators of the peroxisome proliferator-activated receptor
1993
Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators
1994
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
1992 StandoutNature
Odorant signal termination by olfactory UDP glucuronosyl transferase
1991 Nature
Glutathione S-Transferases: Biomedical Applications
1993
PPAR: a mediator of peroxisome proliferator action
1995
The Pathophysiology and Treatment of Hereditary Tyrosinemia Type 1
2001
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
1990 StandoutNature
The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi
1990
Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?
1993
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
1998 Standout
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
2002 StandoutNatureNobel
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
1998 StandoutNature
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.
1995
9-Cis retinoic acid is a direct hepatocyte mitogen in rats
1996
Enzymology of Microsomal Glutathione S-Transferase
1994
How were new medicines discovered?
2011 Standout
The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism (1967 to 1999)
2000
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
2000
Peroxisome proliferating sulphur- and oxy-substituted fatty acid analogues are activated to acyl coenzyme a thioesters
1991
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Induced pluripotent stem cell–derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
2010 StandoutNobel
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
1995 Standout
Exploring protein fitness landscapes by directed evolution
2009 StandoutNobel
Chromosomal Localisation, Inducibility, Tissue‐Specific Expression and Strain Differences in Three Murine Peroxisome‐Proliferator‐Activated‐Receptor Genes
1995
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
1992
The RXR heterodimers and orphan receptors
1995 Standout
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I
1995 Standout
Neurobehavioural effects of developmental toxicity
2014 Standout
Changes in hepatic lipid metabolism associated with lipid accumulation and its reversal in rats given the peroxisome proliferator LY171883
1990
Peroxisome proliferator-activated receptors: finding the orphan a home
1994
Estrogen-induced Production of a Peroxisome Proliferator-activated Receptor (PPAR) Ligand in a PPARγ-expressing Tissue
1998
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
1994 Standout
Nasal Absorption Enhancement of 17β-Estradiol by Dimethyl-β-Cyclodextrin in Rabbits and Rats
1990
Gene regulation by steroid hormones
1989 Standout
Roles of PPARs in health and disease
2000 StandoutNature
Development of a Scintillation Proximity Assay for Peroxisome Proliferator-Activated Receptor γ Ligand Binding Domain
1998
Pmp27 promotes peroxisomal proliferation.
1995
3d Transition Metals for C–H Activation
2018 Standout
Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.
1993
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms.
1986
Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
1994
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
(4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis: The Basis for Ordered Substrate Addition
2003
Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription
1995
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Cyclodextrin Drug Carrier Systems
1998 Standout
Human microsomal glutathione S-transferase. Its involvement in the conjugation of hexachlorobuta-1,3-diene with glutathione
1989
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
1997 Standout
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Cloning of a novel receptor expressed in rat prostate and ovary.
1996 Standout
Identification of the proximate peroxisome proliferator(s) derived from Di(2-ethylhexyl) phthalate
1985
Renal function in tyrosinaemia type I after liver transplantation: A long‐term follow‐up
2005
Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates
2004 Standout
Odorant-selective genes and neurons mediate olfaction in C. elegans
1993 StandoutNobel
Review
1997
Liver Regeneration
1997 StandoutScience
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
1997 Standout
Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K.
2000
Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.
1993
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.
1992
Peroxisome Proliferator Activated Receptor-α Expression in Human Liver
1998
Peroxisome proliferator activated receptor-alpha expression in human liver.
1998
The gut microbiota as an environmental factor that regulates fat storage
2004 Standout
Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor.
1996 StandoutNobel
Evidence for the metabolism of mitozantrone by microsomal glutathione transferases and 3-methylcholanthrene-inducible glucuronosyl transferases
1986
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine
1998
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?
1998
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
1999 Standout
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
1995
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.
1992
Induction and suppression of glutathione transferases by interferon in the mouse.
1987
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
2004 Standout
Structure and Chemistry of Cytochrome P450
2005 Standout
Works of Edward A. Lock being referenced
NADPH: cytochrome P-450 reductase in olfactory epithelium Relevance to cytochrome P-450-dependent reactions
1986
d-Serine-induced nephrotoxicity: a HPLC–TOF/MS-based metabonomics approach
2004
Studies on the Mechanism of Nephrotoxicity and Nephrocarcinogenicity of Halogenated Alkenes
1988
Investigations of the pathways of toxicity of methyl iodide in the rat nasal cavity
1998
Inhibition of 4-Hydroxyphenylpyruvate Dioxygenase by 2-(2-Nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-Chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione
1995
The role of glutathione in L -2-chloropropionic acid induced cerebellar granule cell necrosis in the rat
1996
A mechanism of S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine toxicity to rabbit renal proximal tubules
1987
Biochemical Mechanisms of Induction of Hepatic Peroxisome Proliferation
1989
Pentachlorobutadienyl-l-cysteine uncouples oxidative phosphorylation by dissipating the proton gradient
1989
Strychnine and Glycine Protect Renal Proximal Tubules from Various Nephrotoxicants and Act in the Late Phase of Necrotic Cell Injury
1994
Cysteine conjugate β-lyase of rat kidney cytosol: Characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity
1989
Solvents and Parkinson disease: A systematic review of toxicological and epidemiological evidence
2012
Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450 c
1986
The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity
1984
Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase.
1993
The acute toxic effects of hexachloro-1 : 3-butadiene on the rat kidney
1979
The nephrotoxicity of hexachloro-1:3-butadiene in the rat: Studies of organic anion and cation transport in renal slices and the effect of monooxygenase inducers
1982
Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity.
1984
Characterization of the Interaction of 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-4,4,6,6-tetramethylcyclohexane-1,3,5-trione with Rat Hepatic 4-Hydroxyphenylpyruvate Dioxygenase
1996
Necrosis of the pars recta (S3 segment) of the rat kidney produced by hexachloro 1:3 butadiene
1982
From toxicological problem to therapeutic use: The discovery of the mode of action of 2‐(2‐nitro‐4‐trifluoromethylbenzoyl)‐1,3‐cyclohexanedione (NTBC), its toxicology and development as a drug
1998
Selectivity and Molecular Mechanisms of Toxicity
1987
The metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: In vivo and in vitro dose and time dependency of metabolism
1985
Olfactory cytochrome P-450. Studies with suicide substrates of the haemoprotein
1988