Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis
2006
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
2007
Oxygen-Regulated β 2 -Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL
2009 StandoutNobel
Activation of Hypoxia-Inducible Factor-1 in Bacillary Angiomatosis
2005
Cutting Edge: Essential Role of Hypoxia Inducible Factor-1α in Development of Lipopolysaccharide-Induced Sepsis
2007
Persistent induction of HIF‐1α and ‐2α in cardiomyocytes and stromal cells of ischemic myocardium
2004
Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors
2004
Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors
2009
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
2005 StandoutNobel
Genetic evidence for a tumor suppressor role of HIF-2α
2005
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
2001
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
2009
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
2009 Standout
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
2006
Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury
2010
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
2003 StandoutNobel
Regulation of Angiogenesis by Oxygen and Metabolism
2009
The Transcriptional Activation Function of the HIF-like Factor Requires Phosphorylation at a Conserved Threonine
2002
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR
2014
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein
2000 StandoutNobel
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
2005 StandoutNobel
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer
2012
Increased Prolyl 4-Hydroxylase Domain Proteins Compensate for Decreased Oxygen Levels
2006
Activation of the HIF pathway in cancer
2001
Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells
2004
Hallmarks of Cancer: The Next Generation
2011 Standout
Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates
2006
Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
2010 StandoutNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
2000 StandoutNobel
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2
2006
The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1
2008
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
The Hypoxia-Inducible Factor 2α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo
2007 StandoutNobel
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity
2012
Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
2010
Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression
2010
Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism
2003
Ceramide: an intracellular mediator of apopotosis and growth supression
1996
The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen
2003
Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation
2008
Cleavage of ζPKC but Not λ/ιPKC by Caspase-3 during UV-induced Apoptosis
1999
Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation
2002
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides
2000
Hypoxia and gastrointestinal disease
2007
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes
1999
Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues
2002
Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase
2009 StandoutNobel
Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
2007
Phospholipid signaling
1995
Developmental Changes in HIF Transcription Factor in Carotid Body: Relevance for O2 Sensing by Chemoreceptors
2005
Hypoxia Up-regulates Prolyl Hydroxylase Activity
2003
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1
2007 StandoutNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System
2000 StandoutNobel
Oxygen-Independent Stabilization of Hypoxia Inducible Factor (HIF)-1 during RSV Infection
2008
The Length of Peptide Substrates Has a Marked Effect on Hydroxylation by the Hypoxia-inducible Factor Prolyl 4-Hydroxylases
2006
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
2011 StandoutNobel
Roles of individual prolyl‐4‐hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
2012 StandoutNobel
Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis
2009
Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia
2000 Standout
Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes
1996
Suppression of Hypoxia-inducible Factor 1α (HIF-1α) Transcriptional Activity by the HIF Prolyl Hydroxylase EGLN1
2005
Recent Insights into the Molecular Pathogenesis of Pheochromocytoma and Paraganglioma
2006 StandoutNobel
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
2004 StandoutNobel
Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide
2001
Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells
1999
Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 smallt to promote cell growth and NF-kappa B activation
1997
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1α gene
2002
Molecular Mechanism of Hypoxia-inducible Factor 1α-p300 Interaction
2001
Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia
2010
Hypoxia and Inflammation
2011 Standout
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
p53 Stabilization and Transactivation by a von Hippel-Lindau Protein
2006
Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival
2001
Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates
2006
Reactive oxygen species and cellular oxygen sensing
2007
Ceramide Triggers Meiotic Cell Cycle Progression in Xenopus Oocytes.
1995
HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders
2011
Hypoxia-inducible Factor and Its Biomedical Relevance
2003
Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia
2004 StandoutNobel
Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1
2005
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells
2011
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
2010
Atypical Protein Kinase C ι Protects Human Leukemia Cells against Drug-induced Apoptosis
1997
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
2006
Hypoxia and Hypoxia Signaling in Tissue Repair and Fibrosis
2012
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
2015
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation
2002
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
2005
Oxygen Sensors at the Crossroad of Metabolism
2009
Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
2003
How oxygen makes its presence felt: Figure 1.
2002 StandoutNobel
An Endoplasmic Reticulum Transmembrane Prolyl 4-Hydroxylase Is Induced by Hypoxia and Acts on Hypoxia-inducible Factor α
2007
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
2003
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
2011 StandoutNobel
MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α
1996
Prostaglandin E2 Induces Hypoxia-inducible Factor-1α Stabilization and Nuclear Localization in a Human Prostate Cancer Cell Line
2002
Monoclonal Antibody-Based Screening Assay for Factor Inhibiting Hypoxia-Inducible Factor Inhibitors
2008
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia
2004
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
2003 StandoutNobel
HIF-1 and hypoxic response: the plot thickens
2003
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
2004 StandoutNobel
Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis
2002
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Levels of Hypoxia-Inducible Factor-1 During Breast Carcinogenesis
2001 StandoutNobel
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
2008 Nature
OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α
2005 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C
2001
PHD2 Mutation and Congenital Erythrocytosis with Paraganglioma
2008
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
2002
Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
2009
The p14ARF Tumor Suppressor Protein Facilitates Nucleolar Sequestration of Hypoxia-inducible Factor-1α (HIF-1α) and Inhibits HIF-1-mediated Transcription
2001
Evidence for a Stereoelectronic Effect in Human Oxygen Sensing
2009
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
2008
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
2005
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
2005
Hypoxia signalling in cancer and approaches to enforce tumour regression
2006 Nature
The Role of Hypoxia in Development of the Mammalian Embryo
2009
The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells
2011
The von Hippel-Lindau Gene Product Inhibits Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Renal Cell Carcinoma by Blocking Protein Kinase C Pathways
1997
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
2001 StandoutNobel
Regulation of Vascular Endothelial Growth Factor Expression by Advanced Glycation End Products
2001
Non-hypoxic transcriptional activation of the aryl hydrocarbon receptor nuclear translocator in concert with a novel hypoxia-inducible factor-1alpha isoform
2004
NF-κB and cancer — identifying targets and mechanisms
2008
Hypoxic gene expression and metastasis
2004
Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes
2004 StandoutNobel
Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors
2005
ERK activation upon hypoxia: involvement in HIF‐1 activation
2000
Ceramide Activates the Stress-activated Protein Kinases
1995
MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300
2003
The human oxygen sensing machinery and its manipulation
2008
MAPK and Akt Act Cooperatively but Independently on Hypoxia Inducible Factor-1α in rasV12 Upregulation of VEGF
2001
Hypoxia: A key regulator of angiogenesis in cancer
2007
Hypoxia-driven selection of the metastatic phenotype
2007
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
2007
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF
2002
Evidence for the slow reaction of hypoxia‐inducible factor prolyl hydroxylase 2 with oxygen
2010
HIF-1 as a target for drug development
2003
Hypoxia-induced genetic instability—a calculated mechanism underlying tumor progression
2006
Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis
1997 StandoutNobel
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
Role of elongin-binding domain of von hippel lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma
2005
Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor
2001 StandoutNobel
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
2016
Signalling hypoxia by HIF hydroxylases
2005 StandoutNobel
Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1β and regulates the cellular PDH activity
2014
Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens
2010
Induction of Hypoxia-Inducible-Factor 1 by Nitric Oxide Is Mediated via the PI 3K Pathway
2000
Interdependence of hypoxic and innate immune responses
2009
Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes
2012
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
2007
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
2003
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
2001 StandoutNobel
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
2001 StandoutNobel
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
1999 StandoutNature
Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
2003
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration
2009
MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2
2009
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
1995
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation
2009
Drosophila Cyclin D/Cdk4 Requires Hif-1 Prolyl Hydroxylase to Drive Cell Growth
2004
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
2009 StandoutNobel
Activation of Sp1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor Transcription Requires Specific Interaction with Protein Kinase C ζ
1998
Hypoxia-Independent Activation of HIF-1 by Enterobacteriaceae and Their Siderophores
2008
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
2008 StandoutNobel
Insulin and Insulin-like Growth Factor-I Induce Vascular Endothelial Growth Factor mRNA Expression via Different Signaling Pathways
2000
Hypoxia: an alarm signal during intestinal inflammation
2010
Sphingomyelin‐Derived Lipids Differentially Regulate the Extracellular Signal‐Regulated Kinase 2 (ERK‐2) and c‐Jun N‐Terminal Kinase (JNK) Signal Cascades in Airway Smooth Muscle
1996
HIF and the Lung
2011 StandoutNobel
Bcl-2 interrupts the ceramide-mediated pathway of cell death.
1996
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype
2014 StandoutNobel
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
2007
Life with Oxygen
2007 StandoutScienceNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Adenosine: An Old Drug Newly Discovered
2009
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
2000 StandoutNobel
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
2007 StandoutNobel
Mitochondria and cellular oxygen sensing in the HIF pathway
2007
Expression of Concern: Bcl‐2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF‐1mediated transcriptional activity
2002
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
2005
Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar
2002 StandoutNobel
von Hippel-Lindau Disease
2006 StandoutNobel
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases
2013 StandoutNobel
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation.
2001
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF
2002
Hypoxia-Inducible Factor-1 Is Central to Cardioprotection
2008
Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1α
2005
Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
2014
Normoxic Stabilization of Hypoxia-Inducible Factor-1α by Modulation of the Labile Iron Pool in Differentiating U937 Macrophages: Effect of Natural Resistance–Associated Macrophage Protein 1
2006 StandoutNobel
PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies
2018 StandoutNobel
PROLINE HYDROXYLATION AND GENE EXPRESSION
2005 StandoutNobel
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
2005
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP
2002
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.
1994
The HIF Pathway and Erythrocytosis
2011
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
2001 StandoutNobel
Role of Hypoxia-Inducible Factors in Breast Cancer Metastasis
2013 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Induction of HIF–1α in response to hypoxia is instantaneous
2001
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Defective Brain Development in Mice Lacking the Hif-1α Gene in Neural Cells
2003
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses
2001
A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo
2009 StandoutNobel
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
2004 StandoutNobel
The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α
2006
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
2005
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
2013 StandoutNobel
HIF-1–dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
2008
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
2004 StandoutNobel
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion.
2003
Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation
2008
Gene Expression Profiling of the Hypoxia Signaling Pathway in Hypoxia-Inducible Factor 1α Null Mouse Embryonic Fibroblasts
2003
Induction of HIF-1alpha in response to hypoxia is instantaneous.
2001
prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
1996
Accumulation of HIF-1α under the influence of nitric oxide
2001
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
2007 StandoutNobel
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
2006 StandoutNobel
Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing
2003
The potential for isoenzyme‐selective modulation of protein kinase C
1997
Thrombin and Phenotypic Modulation of the Endothelium
2003
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
2000
The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress
2008
Essential Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis of the Adult Vascular System
2007
Hypoxia. 2. Hypoxia regulates cellular metabolism
2010
Reactive Oxygen Species Activate the HIF-1α Promoter Via a Functional NFκB Site
2007
Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1α in Cancer: Role of Free Radical Formation
2006
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.
1995
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes
2009
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
1997 StandoutScience
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases
2004
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
2007 StandoutNobel
Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α
2003
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.
2001
Requirement for Akt (Protein Kinase B) in Insulin-induced Activation of Glycogen Synthase and Phosphorylation of 4E-BP1 (PHAS-1)
1999
Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species
2002
Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α
2003
Short Hairpin RNA Interference Therapy for Ischemic Heart Disease
2008
Works of Edurne Berra being referenced
The Activation of p38 and Apoptosis by the Inhibition of Erk Is Antagonized by the Phosphoinositide 3-Kinase/Akt Pathway
1998
HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation
2001
Angiogenesis: How a Tumor Adapts to Hypoxia
1999
Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b
2004
Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α
2000
Hypoxia-inducible Factor 1 Transactivates the Human Leptin Gene Promoter
2002
JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress
2004
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1
1999
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia
2003 Standout
Hypoxia: the tumor's gateway to progression along the angiogenic pathway
2001
Signaling angiogenesis via p42/p44 MAP kinase and hypoxia
2000
Stress-activated Protein Kinases (JNK and p38/HOG) Are Essential for Vascular Endothelial Growth Factor mRNA Stability
2000
MAP Kinases and Hypoxia in the Control of VEGF Expression
2000
HIF-1: master and commander of the hypoxic world
2004
Protein kinase C ζ isoform is critical for mitogenic signal transduction
1993
Hypoxia‐inducible factor‐1α (HIF‐1α) escapes O 2 ‐driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm
2001
Hypoxia: the tumor's gateway to progression along the angiogenic pathway
2001
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
2006
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.
1994
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.
1993
Hypoxia-inducible factor 1α is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells
2005
Inhibition of Prolyl Hydroxylase Domain Proteins Promotes Therapeutic Revascularization
2009
A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation
1993
Positioning Atypical Protein Kinase C Isoforms in the UV-Induced Apoptotic Signaling Cascade
1997
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.
1994
Nonhypoxic Pathway Mediates the Induction of Hypoxia-inducible Factor 1α in Vascular Smooth Muscle Cells
2000
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.
1994
HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration
2008
The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling
2006
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.
1995
HIF‐1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome
2007
Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions
2015
Evidence for a Role of Protein Kinase C ζ Subspecies in Maturation of Xenopus laevis Oocytes
1992
PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis
2008
The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1
2004