Citation Impact
Citing Papers
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay
2004 StandoutNobel
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A
2008 StandoutNobel
CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
2003
Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms
2007 StandoutNobel
Conformationally restricted analog and biotin-labeled probe based on beauveriolide III
2011 StandoutNobel
The Enzymes of Neutral Lipid Synthesis
2001
Acute inhibition of hepatic β-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity
2005
REGULATION OF BILE ACID BIOSYNTHESIS
1999
Isochromophilones III -VI, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216.
1995 StandoutNobel
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
2006 StandoutNature
Epidemiologic Evidence on Coffee and Cancer
2010
Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
2007 Standout
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 3
2013 StandoutNobel
Rescuing drug discovery: in vivo systems pathology and systems pharmacology
2005
Drug penetration in solid tumours
2006 Standout
Increased Hepatic Insulin Sensitivity Together with Decreased Hepatic Triglyceride Stores in Hormone-Sensitive Lipase-Deficient Mice
2003
ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice
2006
Pioglitazone
2000
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
2000 Standout
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
2007 Standout
Effect of bile on the intestinal bile‐acid binding protein (I‐BABP) expression. In vitro and in vivo studies
1996
Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study
2012 Standout
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
Down-regulation of the rat hepatic sterol 27-hydroxylase
1999
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 2
2013 StandoutNobel
Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries
2014 Standout
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 1
2013 StandoutNobel
Selectivity of Microbial Acyl-CoA : cholesterol Acyltransferase Inhibitors toward Isozymes
2007 StandoutNobel
3 ACAT Inhibitors: The Search for a Novel and Effective Treatment of Hypercholesterolemia and Atherosclerosis
2002
Pyripyropenes, novel inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties.
1994 StandoutNobel
ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia
2009
Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7α‐Hydroxylase and Sterol 27‐Hydroxylase
1995
Effect of ACAT Inhibition on the Progression of Coronary Atherosclerosis
2006
An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection
1995 StandoutNobel
Consumption of French‐press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects
2000
Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver
2007
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
1999
Isolation and Identification of Three New 5-Alkenyl-3,3(2H)-furanones from Two Streptomyces species using a Genomic Screening Approach
2006 StandoutNobel
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
2016 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
2004 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Coffee and Health: A Review of Recent Human Research
2006 Standout
Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents
1991
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
2012 Standout
Inhibition of acyl-CoA: Cholesterol acyltransferase activity by cyclodepsiptide antibiotics.
1992 StandoutNobel
Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels.
1993
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Regulation of bile acid synthesis
1998
Chemical modification and structure-activity relationships of pyripyropenes; potent, bioavailable inhibitor of acyl-CoA: Cholesterol O-acyltransferase (ACAT)
1995 StandoutNobel
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
2003
Effect of Low Dose Atorvastatin Versus Diet-Induced Cholesterol Lowering on Atherosclerotic Lesion Progression and Inflammation in Apolipoprotein E*3–Leiden Transgenic Mice
2004
Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol
2003 StandoutNobel
Inhibition of acylcoenzyme A:cholesterol acyltransferase activity in CaCo-2 cells results in intracellular triglyceride accumulation.
1989
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
2003 Standout
Effects of the Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor Avasimibe on Human Atherosclerotic Lesions
2004
Myocardial Fatty Acid Metabolism in Health and Disease
2010 Standout
Hep G2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids
1990
Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
2006
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
2016 Standout
Pyripyropene A, an Acyl–Coenzyme A:Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia
2011 StandoutNobel
Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites
2005 StandoutNobel
Oxysterols: Modulators of Cholesterol Metabolism and Other Processes
2000
Mechanisms of Plaque Formation and Rupture
2014 Standout
ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver
2004 StandoutNobel
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
2016 Standout
Fungal Isobisvertinol, a New Inhibitor of Lipid Droplet Accumulation in Mouse Macrophages
2007 StandoutNobel
Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages
2004
New Analogs of the Pyripyropene Family of ACAT Inhibitors via α-Pyrone Fragmentation and γ-Acylation/Cyclization
1997 StandoutNobel
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
1999 StandoutScience
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
1996 StandoutScience
Relative and Absolute Stereochemistry of Quinadoline B, an Inhibitor of Lipid Droplet Synthesis in Macrophages
2008 StandoutNobel
The effect of inhibition of acyl coenzyme A-cholesterol acyltransferase (ACAT) on exercise performance in patients with peripheral arterial disease
2004
Chicken Oocytes and Fibroblasts Express Different Apolipoproteins-B-Specific Receptors
1989
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
2019 Standout
Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate
2002
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
2016 Standout
Fibrates Suppress Bile Acid Synthesis via Peroxisome Proliferator–Activated Receptor-α–Mediated Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Expression
2001
Lipoprotein(a): resurrected by genetics
2012
Selective uptake of high-density lipoprotein-associated cholesteryl esters by human hepatocytes in primary culture
1994
Efficient Total Synthesis of Novel Bioactive Microbial Metabolites
2008 StandoutNobel
Cholesterol Synthesis Inhibition Elicits an Integrated Molecular Response in Human Livers Including Decreased ACAT2
2008 StandoutNobel
Coffee Oil Consumption Increases Plasma Levels of 7α-Hydroxy-4-cholesten-3-one in Humans
2005
Total synthesis of pyripyropene A
2011 StandoutNobel
Enhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker Rats
2004
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives
2011 Standout
Prescribed drugs containing nitrogen heterocycles: an overview
2020 Standout
Works of E.C.M. de Wit being referenced
Rosuvastatin Reduces Plasma Lipids by Inhibiting VLDL Production and Enhancing Hepatobiliary Lipid Excretion in ApoE*3-Leiden Mice
2004
Butyrate stimulates the secretion of apolipoprotein B-100-containing lipoproteins from HepG2 cells by inhibiting the intracellular degradation
1994
Insulin suppresses apolipoprotein(a) synthesis by primary cultures of cynomolgus monkey hepatocytes (Short Communication)
1999
Acyl-CoA:Cholesterol Acyltransferase Inhibitor Avasimibe Reduces Atherosclerosis in Addition to Its Cholesterol-Lowering Effect in ApoE*3-Leiden Mice
2001
Cafestol, the Cholesterol-Raising Factor in Boiled Coffee, Suppresses Bile Acid Synthesis by Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase in Rat Hepatocytes
1997
Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity
1987
Stimulation of the LDL receptor activity in the human hepatoma cell line Hep G2 by high-density serum fractions
1986
Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes
1995