Citation Impact
Citing Papers
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
2013 Science
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol
2011 Standout
Bisphosphonate nanoclay edge-site interactions facilitate hydrogel self-assembly and sustained growth factor localization
2020
Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples
2006
Adverse Drug Reaction Prediction Using Scores Produced by Large-Scale Drug-Protein Target Docking on High-Performance Computing Machines
2014
β-arrestins: traffic cops of cell signaling
2004 StandoutNobel
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
Mechanically evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1, P2Y2, and P2Y4 receptors
2003
Activity, assay and target data curation and quality in the ChEMBL database
2015
Quantitative assessment of tactile allodynia in the rat paw
1994 Standout
Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack
2013
Bowel Disorders
2016 Standout
Sjögren's syndrome
2005 Standout
A comprehensive map of molecular drug targets
2016 Standout
Chronic inflammation in the etiology of disease across the life span
2019 Standout
In Silico Target Prediction for Small Molecules
2018
STRING v10: protein–protein interaction networks, integrated over the tree of life
2014 Standout
Target deconvolution techniques in modern phenotypic profiling
2013
Tools for in silico target fishing
2014
Trends in GPCR drug discovery: new agents, targets and indications
2017 Standout
Computational prediction of immune cell cytotoxicity
2017
WITHDRAWN—a resource for withdrawn and discontinued drugs
2015
Machine learning for molecular and materials science
2018 StandoutNature
Aetiopathogenesis and Management of Impotence in Diabetic Males: Four Years Experience from a Combined Clinic
1995
What is the Likelihood of an Active Compound to Be Promiscuous? Systematic Assessment of Compound Promiscuity on the Basis of PubChem Confirmatory Bioassay Data
2013
Computational Methods in Drug Discovery
2014
eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences
2015 Standout
Ischemic Colitis and Complications of Constipation Associated With the Use of Alosetron Under a Risk Management Plan: Clinical Characteristics, Outcomes, and Incidences
2010
The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders
2007 Standout
Nano based drug delivery systems: recent developments and future prospects
2018 Standout
Acute Pancreatitis
2016 Standout
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
2006 Standout
Target identification and mechanism of action in chemical biology and drug discovery
2013
Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves
2004
Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine
2006
Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology
2017
The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes
2015 Standout
Drug repurposing: progress, challenges and recommendations
2018 Standout
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
2014
Chemical Biology Strategies for Posttranslational Control of Protein Function
2014
PubChem Substance and Compound databases
2015 Standout
Components of variance for vibratory and thermal threshold testing in normal and diabetic subjects
1995
Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective
2016
A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population
1993
SwissTargetPrediction: a web server for target prediction of bioactive small molecules
2014
STITCH 4: integration of protein–chemical interactions with user data
2013
A Pilot Study on the Influence of a Corticotropin (4-9) Analogue on Vinca Alkaloid--Induced Neuropathy
1992
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
Quantitative measurement of cutaneous perception in diabetic neuropathy
1995
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
2011
In silico methods to address polypharmacology: current status, applications and future perspectives
2015
ProTox: a web server for the in silico prediction of rodent oral toxicity
2014
Expression and Regulation of the Na+‐K+‐2Cl− Cotransporter NKCC1 in the Normal and CFTR‐Deficient Murine Colon
2003 StandoutNobel
The Physiology of Glucagon-like Peptide 1
2007 Standout
The ChEMBL database in 2017
2016 Standout
Counting on natural products for drug design
2016
Quantitative sensory tests in patients with neuralgia 11 to 25 years after injury
1992
Applications of machine learning in drug discovery and development
2019 Standout
Hydrogen Sulfide Is a Novel Prosecretory Neuromodulator in the Guinea-Pig and Human Colon
2006
A large-scale crop protection bioassay data set
2015
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide
2010
The vagus is inhibitory of the late postprandial insulin secretion in conscious pigs
2002
Preventing Foot Ulcers in Patients With Diabetes
2005 Standout
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
2009 Standout
The ChEMBL bioactivity database: an update
2013
NCCN Task Force Report: Update on the Management of Patients with Gastrointestinal Stromal Tumors
2010 Standout
Discovery and resupply of pharmacologically active plant-derived natural products: A review
2015 Standout
Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea‐pig
2005
Use of the Gottingen Minipig as a Model of Diabetes, with Special Focus on Type 1 Diabetes Research
2004
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
2012
Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
2006 Standout
Nanoparticles for bioimaging
2006
An analysis of the attrition of drug candidates from four major pharmaceutical companies
2015 Standout
The Relationship Between Sural Nerve Morphometric Findings and Measures of Peripheral Nerve Function in Mild Diabetic Neuropathy
1991
Computational Drug Repositioning: From Data to Therapeutics
2013
The determination and interpretation of the therapeutic index in drug development
2012
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
2017 Standout
Structural Bioinformatics of the Interactome
2014
Evaluation of thermal and pain sensitivity in type I diabetic patients.
1991
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
2012 Standout
A publicly available crystallisation data set and its application in machine learning
2017
Artificial intelligence in drug discovery and development
2020 Standout
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies
2019
Cilansetron: a new serotonergic agent for the irritable bowel syndrome with diarrhoea
2005
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Recent applications of deep learning and machine intelligence on in silico drug discovery: methods, tools and databases
2018
Osteopenia, Neurological Dysfunction, and the Development of Charcot Neuroarthropathy
1995
Contributions of Molecular Properties to Drug Promiscuity
2013
ProTox-II: a webserver for the prediction of toxicity of chemicals
2018 Standout
Heterologous regulation of trafficking and signaling of G protein-coupled receptors: β-Arrestin-dependent interactions between neurokinin receptors
2002
Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline
2014 Standout
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
2019 Standout
Molecular Docking: Shifting Paradigms in Drug Discovery
2019 Standout
Computational design of environmental sensors for the potent opioid fentanyl
2017 StandoutNobel
Chimeric Antigen Receptor Therapy
2018 Standout
“The Force Be with You”: ATP in Gut Mechanosensory Transduction
2003
Shaping the interaction landscape of bioactive molecules
2013
Involvement of the peripheral nervous system in primary Sjögren's syndrome
2001
Similarity-based machine learning methods for predicting drug–target interactions: a brief review
2013
Diabetic Somatic Neuropathies
2004 Standout
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Polypharmacology: Challenges and Opportunities in Drug Discovery
2014
Diabetic Neuropathy: A Position Statement by the American Diabetes Association
2016 Standout
Diabetic Autonomic Neuropathy
2003 Standout
Protein homology reveals new targets for bioactive small molecules
2015
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
The scoring bias in reverse docking and the score normalization strategy to improve success rate of target fishing
2017
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
The Recognition of Identical Ligands by Unrelated Proteins
2015
Chloride Secretion by the Intestinal Epithelium: Molecular Basis and Regulatory Aspects
2000
Prediction Errors of Molecular Machine Learning Models Lower than Hybrid DFT Error
2017
Evaluation of thermal, pain, and vibration sensation thresholds in newly diagnosed type 1 diabetic patients.
1988
Works of Eckhard Weber being referenced
Different tachykinin receptors mediate chloride secretion in the distal colon through activation of submucosal neurones
1999
Effects of enteral feedback inhibition on motility, luminal flow, and absorption of nutrients in proximal gut of minipigs
1995
Neural components of distension‐evoked secretory responses in the guinea‐pig distal colon
2001
Relationships Between Gastric Emptying and Intestinal Absorption of Nutrients and Energy in Mini Pigs
1998
Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib
2009
Large-scale prediction and testing of drug activity on side-effect targets
2012 Nature
Optimal Timing of Oral Refeeding in Mild Acute Pancreatitis
2010
Thermal discrimination thresholds in normal subjects and in patients with diabetic neuropathy.
1985
Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs
2018
Noninvasive Assessment of Gastric Emptying by Near-Infrared Fluorescence Ref lectance Imaging in Mice: Pharmacological Validation with Tegaserod, Cisapride, and Clonidine
2004
5-HT3 receptor antagonists, alosetron and cilansetron, impair mesenteric blood flow in rats
2003