Citation Impact
Citing Papers
Small-molecule activators of RNase L with broad-spectrum antiviral activity
2007
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
2002 StandoutScience
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
A (2′-5′)A n -Dependent Endonuclease: Tissue Distribution in BALB/c Mice and the Effects of IFN-β Treatment and Anti-IFN-α/β Immunoglobulin on the Levels of the Enzyme
1988
Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity.
1994
Role of the Vaccinia Virus E3L and K3L Gene Products in Rescue of VSV and EMCV from the Effects of IFN-α
1998
New Insights into the Role of RNase L in Innate Immunity
2010
Cloning and Characterization of a RNase L Inhibitor.
1995
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Expression of the SV40 promoter in fission yeast: Identification and characterization of an AP-1-like factor
1988 StandoutNobel
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
The Human 2',5'-Oligoadenylate Synthetase Family: Interferon-Induced Proteins with Unique Enzymatic Properties
1999
A Bipartite Model of 2-5A-dependent RNase L
1997
Interferons at age 50: past, current and future impact on biomedicine
2007
mRNA Is an Endogenous Ligand for Toll-like Receptor 3
2004 StandoutNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Chromatin Modifications and Their Function
2007 Standout
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1994 StandoutNature
Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage
1991
Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action
1993
Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing
2008
Expansion and Molecular Evolution of the Interferon-Induced 2′–5′ Oligoadenylate Synthetase Gene Family
2000
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2′,5′-oligoadenylate synthetase from prostate cancer cells
2006
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
1999 StandoutNobel
The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation
1998
Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
2010 StandoutNobel
New advances in our understanding of the “unique” RNase L in host pathogen interaction and immune signaling
2016
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
Deletion Mutants of Poly(ADP-Ribose) Polymerase A Support a Model of Cyclic Association and Dissociation of Enzyme from DNA Ends During DNA Repair
1994
The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function
1997
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes
2015 StandoutNobel
Analysis of the role of the transcription factor ATF in the assembly of a functional preinitiation complex
1988
The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells
2010
Role of poly(ADP-ribose) formation in DNA repair
1992 StandoutNatureNobel
Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD+ ADP-ribosyltransferase requires the DNA binding domain (“zinc fingers”)
1992
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Poly(ADP-ribose): novel functions for an old molecule
2006 Standout
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
(2′‐5′)An‐dependent endoribonuclease: Enzyme levels are regulated by IFNβ, IFNγ, and cell culture conditions
1988
A Convenient and Sensitive Fluorescence Resonance Energy Transfer Assay for RNase L and 2′,5′ Oligoadenylates
2005
2- and 8-Azido photoaffinity probes. 1. Enzymic synthesis, characterization and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins
1988 StandoutNobel
Complementation of Vaccinia Virus Deleted of the E3L Gene by Mutants of E3L
1997
Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1
2000
The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
1993
Two-Dimensional Crystallography of TFIIB– and IIE–RNA Polymerase II Complexes: Implications for Start Site Selection and Initiation Complex Formation
1996 StandoutNobel
Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L
2011 StandoutNobel
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP
2010
Molecular and biochemical features of poly (ADP-ribose) metabolism
1993
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
1990 StandoutNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Cleavage of Oligoribonucleotides by the 2′,5′-Oligoadenylate- dependent Ribonuclease L
1996
Stoichiometry of 2′,5′-Oligoadenylate-induced Dimerization of Ribonuclease L
1996
Activation and evasion of the antiviral 2???-5??? oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA
2002
Interferon-inducible antiviral effectors
2008 Standout
2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A
1995
Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways
1999
The p69/71 2-5A Synthetase Promoter Contains Multiple Regulatory Elements Required for Interferon-α-Induced Expression
1997
A Very Large Metallosupramolecular Capsule with Cube-like 43 Topology Assembled from Twelve Cu(II) Centers and Eight Tri-Bidentate Tri-Anionic Ligands Derived from 2,4,6-Triphenylazo-1,3,5-trihydroxybenzene
1999 StandoutNobel
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System
1997
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation
1989
Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication
2000
The dsRNA binding protein family: critical roles, diverse cellular functions
2003
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.
1993 StandoutNobel
2‘,5‘-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits.
1993
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Isolation of three proteins that bind to mammalian RNA polymerase II.
1985
2-5A synthetase: assay, distribution and variation with growth or hormone status
1979 Nature
Inhibition of vaccinia mRNA methylation by 2',5'-linked oligo(adenylic acid) triphosphate.
1981
Induction of 2′5′-oligoadenylate synthetase activity and a new protein by chick interferon
1979
Inhibition of protein synthesis by double-stranded RNA in reticulocyte lysates: Evidence for activation of an endoribonuclease
1978
Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras
1994 Science
Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts
1978
2',5'-Oligoadenylates and related 2',5'-oligonucleotide analogs. 1. Enzymic synthesis and substrate specificity of the interferon-induced murine 2',5'-oligoadenylate synthetase
1983
Mechanism for discrimination between viral and host mRNA in interferon-treated cells.
1979
Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase.
1994
2'5'Oligo(A) polymerase activity and inhibition of viral RNA synthesis in interferon-treated HeLa cells
1979
Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.
1992
Double-stranded RNA
1980
A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L
2005
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.
1979 StandoutNobel
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Interferon action. Covalent linkage of (2'-5')pppApApA(32P)pCp to (2'-5')(A)n-dependent ribonucleases in cell extracts by ultraviolet irradiation.
1982
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
2011 StandoutNobel
Antiviral Actions of Interferons
2001 Standout
Regulation of cell proliferation and differentiation by interferons
1985
Initiation by Yeast RNA Polymerase II at the Adenoviral Major Late Promoter in Vitro
1989 StandoutScienceNobel
Amino Terminal Sequence of the Major Component of Human Lymphoblastoid Interferon
1980 ScienceNobel
Affinity Labelling and Characterization of the ppp(A2′p)nA‐Dependent Endoribonuclease from Different Mammalian Sources
1982
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
Newcastle Disease Virus (NDV)-Based Assay Demonstrates Interferon-Antagonist Activity for the NDV V Protein and the Nipah Virus V, W, and C Proteins
2002
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.
1987
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
2001 StandoutNobel
Dinucleotide priming of transcription mediated by RNA polymerase II.
1984 StandoutNobel
Synthesis, Characterisation and Biological Significance of (2′‐5′)Oiigoadenylate Derivatives of NAD+, ADP‐Ribose and Adenosine(5′)Tetraphosph0(5′)Adenosine
1982
Human leukocyte interferon: Isolation and characterization of several molecular forms
1981
Interactions between RNA polymerase II, factors, and template leading to accurate transcription.
1984 StandoutNobel
RNase L Mediates the Antiviral Effect of Interferon through a Selective Reduction in Viral RNA during Encephalomyocarditis Virus Infection
1998
Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene
1995
Regulation of lymphocyte mitogenesis by (2′–5′) oligo-isoadenylate
1979 Nature
Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease
1981 Nature
In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.
1996
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
1999 Standout
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
1995
Are double-stranded RNA-directed inhibition of protein synthesis in interferon-treated cells and interferon induction related phenomena?
1979
Cloning, sequencing, and expression of two murine 2‘-5‘-oligoadenylate synthetases. Structure-function relationships
1991
Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro
1985 StandoutScience
RNA Scanning of a Molecular Machine with a Built-in Ruler
2016 StandoutNobel
Heterogeneous nuclear RNA promotes synthesis of (2',5')oligoadenylate and is cleaved by the (2',5')oligoadenylate-activated endoribonuclease.
1982
A mammalian 2-5A system functions as an antiviral pathway in transgenic plants.
1996
Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli.
1989
Ribosomal RNA cleavage, nuclease activation and 2-5A (ppp(A2′p)nA) in interferon-treated cells
1981
Effect of Interferon-α1 from E. coli on Some Cell Functions
1980 StandoutScienceNobel
Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response
2007
Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes
1998
Yeast RNA polymerase II initiation factor e: isolation and identification as the functional counterpart of human transcription factor IIB.
1992 StandoutNobel
Activation of the ppp(A2'p)nA system in interferon-treated, Herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase
1984
Factors involved in specific transcription by human RNA polymerase II: analysis by a rapid and quantitative in vitro assay.
1985
pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.
1978
Immunoquantitation and size determination of intrinsic poly(ADP-ribose) polymerase from acid precipitates. An analysis of the in vivo status in mammalian species and in lower eukaryotes.
1988
Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation.
1992 StandoutNobel
Acid/Azole Complexes as Highly Effective Promoters in the Synthesis of DNA and RNA Oligomers via the Phosphoramidite Method
2001 StandoutNobel
The Ebola virus VP35 protein functions as a type I IFN antagonist
2000
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
NAD(+)-dependent repair of damaged DNA by human cell extracts.
1993 StandoutNobel
Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.
1993
Elongation mechanism and substrate specificity of 2',5'-oligoadenylate synthetase.
1980
Eukaryotic RNA Polymerase
1985
Works of E. Slattery being referenced
Purification of interferon from mouse Ehrlich ascites tumor cells.
1978
Purification and analysis of a factor which suppresses nick-induced transcription by RNA polymerase II and its identity with poly(ADP-ribose) polymerase.
1983
Structural characteristics of interferons from mouse Ehrlich ascites tumor cells.
1979
Interferon, double-stranded RNA, and RNA degradation: activation of an endonuclease by (2'-5')An.
1979
Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease
1981 Science
Interferon, double-stranded RNA and mRNA degradation
1976 Nature
Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.
1987
Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.
1978
Interferon, Double‐Stranded RNA and RNA Degradation
1977