Standout Papers
Citation Impact
Citing Papers
RNA tertiary interactions in the large ribosomal subunit: The A-minor motif
2001 StandoutNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Rapid protein fold determination using unassigned NMR data
2003 StandoutNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors
1993
Similar Structures and Shared Switch Mechanisms of the β2-Adrenoceptor and the Parathyroid Hormone Receptor
1999
Improved molecular replacement by density- and energy-guided protein structure optimization
2011 StandoutNatureNobel
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
A Primer on Vesicle Budding
1999 StandoutNobel
The 2.0 Å crystal structure of a heterotrimeric G protein
1996 Nature
Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ
2013 Standout
Structural studies of elongation and release factors
2008
Locking and Unlocking of Ribosomal Motions
2003 StandoutNobel
Fluorescent BODIPY-GTP Analogs: Real-Time Measurement of Nucleotide Binding to G Proteins
2001
Dynamics of receptor/G protein coupling in living cells
2005
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
1997 Nature
Mapping of Effector Binding Sites of Transducin α-Subunit Using Gαt/Gαil Chimeras
1996
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
1994 StandoutNatureNobel
Insights into G Protein Structure, Function, and Regulation
2003
Complexity and Diversity of Mammalian Adenylyl Cyclases
1996 Nobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form
1995 Nature
Structural determinants of water permeation through aquaporin-1
2000 StandoutNatureNobel
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Structural Basis of Inward Rectification
2002 StandoutNobel
Stimulation of the GTPase Activity of Translation Elongation Factor G by Ribosomal Protein L7/12
2000
Receptor-Mediated Activation of Heterotrimeric G-Proteins: Current Structural Insights
2007
Placement of protein and RNA structures into a 5 Å-resolution map of the 50S ribosomal subunit
1999 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The structure of the G protein heterotrimer Giα1β1γ2
1995 Nobel
Heterotrimeric G proteins
1996
Structural and Functional Analysis of the ARF1–ARFGAP Complex Reveals a Role for Coatomer in GTP Hydrolysis
1999
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins
2006
Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits
1995 Nobel
Catalytic mechanism of F1-ATPase
1997
Heterotrimeric C proteins: Organizers of transmembrane signals
1995
Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin
1996
The Importance of Structural Transitions of the Switch II Region for the Functions of Elongation Factor Tu on the Ribosome
2001
Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue
1998
Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2
1999 Nobel
Heterotrimeric G protein activation by G-protein-coupled receptors
2007
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Structure of the GDP–Pi complex of Gly203→Ala Giα1: a mimic of the ternary product complex of Gα-catalyzed GTP hydrolysis
1996 Nobel
Structure of bovine mitochondrial F1-ATPase inhibited by Mg2+ADP and aluminium fluoride
2000 Nobel
GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4
1994 Nature
New roles for G-protein (βγ-dimers in transmembrane signalling
1993 Nature
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
1996 Nobel
Structural clues in the sequences of the aquaporins
2000
Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis
1997 Nobel
Limited Proteolysis and Amino Acid Replacements in the Effector Region ofThermus thermophilusElongation Factor Tu
1996
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Solution structure of human GAIP (Gα interacting protein): a regulator of G protein signaling
1999
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 StandoutNobel
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
1994 StandoutNobel
Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli
2001 StandoutNobel
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
2009 StandoutNobel
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM
2008 StandoutNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
1997 Science
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Electrostatic origin of the mechanochemical rotary mechanism and the catalytic dwell of F1-ATPase
2011 StandoutNobel
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.
1992
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes
1995
Visualizing tmRNA Entry into a Stalled Ribosome
2003 StandoutScienceNobel
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Sequestration of the G protein βγ subunit complex inhibits receptor-mediated endocytosis
1998 Nobel
G PROTEIN βγ SUBUNITS
1997
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure
2001 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases
1997 StandoutNobel
Visualization of elongation factor G on the Escherichia coli 70S ribosome: The mechanism of translocation
1998 StandoutNobel
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit
2011
Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase
2003 StandoutNobel
Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS
1997 ScienceNobel
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Mechanisms of signaling and related enzymes
1997
GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins
2000
Mechanisms of signaling and related enzymes
1997
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
G proteins, effectors and GAPs: structure and mechanism
1997
Visualizing Signal Transduction: Receptors, G-Proteins, and Adenylate Cyclases
1996 Nobel
Lipid modifications of G proteins: alpha subunits are palmitoylated.
1993 StandoutNobel
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Crystal Structure of the Adenylyl Cyclase Activator G s α
1997 ScienceNobel
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Crystal Structure of the Ternary Complex of Phe-tRNA Phe , EF-Tu, and a GTP Analog
1995 Science
A Detailed View of a Ribosomal Active Site
1999 StandoutNobel
Receptor regulation of G-protein palmitoylation.
1994 StandoutNobel
Works of E Lee being referenced
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Mechanism of GTP hydrolysis by G-protein alpha subunits.
1994 StandoutNobel
The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.
1992 StandoutNobel
Mutations eliminating the protein export function of a membrane-spanning sequence.
1994