Standout Papers
Citation Impact
Citing Papers
A Small-Molecule Modulator of Poly-α2,8-Sialic Acid Expression on Cultured Neurons and Tumor Cells
2001 StandoutScienceNobel
Neuroprotective Effects of Glutamate Antagonists and Extracellular Acidity
1993 Science
Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
1990
Ca2+–Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration
2000
An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death
1995
Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP
1989 Science
Blockade of Ca2+-Permeable AMPA/Kainate Channels Decreases Oxygen–Glucose Deprivation-Induced Zn2+Accumulation and Neuronal Loss in Hippocampal Pyramidal Neurons
2002
Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells
2000 StandoutNobel
Changes in Extracellular Concentrations of Glutamate, Aspartate, Glycine, Dopamine, Serotonin, and Dopamine Metabolites After Transient Global Ischemia in the Rabbit Brain
1991
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures
1994
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
1989
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
1993 StandoutNobel
Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils
1994
Ion Homeostasis in Rat Brain in vivo: Intra- and Extracellular [Ca2+] and [H+] in the Hippocampus during Recovery from Short-Term, Transient Ischemia
1992
Quinolinate neurotoxicity in cortical cell culture
1987
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia
1988
Caspase Inhibition Selectively Reduces the Apoptotic Component of Oxygen-Glucose Deprivation-Induced Cortical Neuronal Cell Death
1997
Calcium-dependent glutamate cytotoxicity in a neuronal cell line
1988
The elusive transporters with a high affinity for glutamate
1993
Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus
1991
21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures
1990
Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction
2012
Glutamate-Treated Rat Cortical Neuronal Cultures Die in a Way Different from the Classical Apoptosis Induced by Staurosporine
1997
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Hypoxic neuronal injury in vitro depends on extracellular glutamine
1988
AMPA receptor activation potentiates zinc neurotoxicity
1993
The biochemical mechanisms of the excitotoxicity of Kainic acid
1992
Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia
1988
Platelet‐activating factor antagonists reduce excitotoxic damage in cultured neurons from embryonic chick telencephalon and protect the rat hippocampus and neocortex from ischemic injury in vivo
1993
Ischemia‐Induced Translocation of Ca2+/Calmodulin‐Dependent Protein Kinase II: Potential Role in Neuronal Damage
1992
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Acidic Fibroblast Growth Factor Infusion Reduces Ischemic CA1 Hippocampal Damage in the Gerbil
1993
Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents
1994
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors
1994
Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain
1993
A novel neuronal messenger molecule in brain: The free radical, nitric oxide
1992
Models of neuronal injury in AIDS: another role for the NMDA receptor?
1992
Evolving Concepts About the Role of Acidosis in Ischemic Neuropathology
1993
Effect of Noncompetitive Blockade of N‐Methyl‐d‐Aspartate Receptors on the Neurochemical Sequelae of Experimental Brain Injury
1990
Slowly triggered excitotoxicity occurs by necrosis in cortical cultures
1997
Separating dual effects of zinc at recombinant N-methyl-d-aspartate receptors
1996
Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia
1991
The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study
1993
Hydrogen peroxide mediates amyloid β protein toxicity
1994 Standout
Anoxia reduces depolarization induced calcium uptake in the rat hippocampal slice
1994
Mitochondria and neuronal glutamate excitotoxicity
1998
Translocation of zinc may contribute to seizure-induced death of neurons
1989
Changes in Extracellular Amino Acids and Spontaneous Neuronal Activity During Ischemia and Extended Reflow in the CA1 of the Rat Hippocampus
1991
Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischemia
1997
σ-Ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia
1990
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat
1992
Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
1990
Reduction by delayed hypothermia of cerebral infarction following middle cerebral artery occlusion in the rat: a time-course study
1992
Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms
1994
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
Acidic fibroblast growth factor prevents death of hippocampal CA1 pyramidal cells following ischemia
1992
Calcium-activated proteolysis of intracellular domains in the cell adhesion molecules NCAM and N-cadherin
1991
Transient acidosis induces delayed neurotoxicity in cultured hippocampal slices
1995
Food Deprivation Protects the Rat Striatum Against Hypoxia‐Ischemia Despite High Extracellular Glutamate
1994
Regional and Temporal Alterations in Ca2+/Calmodulin‐Dependent Protein Kinase II and Calcineurin in the Hippocampus of Rat Brain After Transient Forebrain Ischemia
1992
N‐Methyl‐d ‐Aspartate Receptor Excitotoxicity Involves Activation of Polyamine Synthesis: Protection by α‐Difluoromethylornithine
1993
Glutamate Neurotoxicity Is Independent of Calpain I Inhibition in Primary Cultures of Cerebellar Granule Cells
1991
The neurobiology of zinc in health and disease
2005 Standout
Potentiation of NMDA receptor currents by arachidonic acid
1992 Nature
Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain
1994
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
1999
The barbiturate thiopental reduces ATP levels during anoxia but improves electrophysiological recovery and ionic homeostasis in the rat hippocampal slice
1992
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Morphinans attenuate cortical neuronal injury induced by glucose deprivation in vitro
1988
Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells
1993
The early events of oxygen and glucose deprivation: setting the scene for neuronal death?
1994
Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation
1995
Differential Sensitivity of RecombinantN-Methyl-d-Aspartate Receptor Subtypes to Zinc Inhibition
1997
Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia
1988
Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells
1992
Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia
1993
An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor
1996 StandoutNobel
Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials
1994
Delayed neurotoxicity of excitatory amino acids In vitro
1987
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses
1993
Neuroprotective effect of mild hypothermia cannot be explained in terms of a reduction of glutamate release during ischemia
1999
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus
1995
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
1995 StandoutNobel
Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders
1993
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Adenosine reduces cortical neuronal injury induced by oxygen or glucose deprivation in vitro
1988
Excitotoxic injury of the neostriatum: a model for Huntington's disease
1990
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins
1990
Mild Hypothermia and MK-801 Have Similar But Not Additive Degrees of Cerebroprotection in the Rat Permanent Focal Ischemia Model
1994
Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced
1988
Alterations of a 200 kDa Neurofilament in the Rat Hippocampus after Forebrain Ischemia
1993
Contributory mechanisms in the causation of neurodegenerative disorders
1993
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+
1990 StandoutNobel
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
1995 StandoutNobel
Extracellular pH modulates N-methyl-d-aspartate receptor-mediated neurotoxicity and calcium accumulation in rat cortical cultures
1992
The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion
1997 StandoutNatureNobel
Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
1991
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine
1995 StandoutNatureNobel
Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance
1994
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
1989 Standout
Effect of potassium channel modulators on the release of glutamate induced by ischaemic-like conditions in rat hippocampal slices
1993
Neuroprotection in Ischemia
2004
Dopamine has inhibitory and accelerating effects on ischemia-induced neuronal cell damage in the rat striatum
1994
Early cellular swelling during cerebral ischemia in vivo is mediated by excitatory amino acids released from nerve terminals
1992
Calcium-dependent glutamate release concomitant with massive potassium flux during cerebral ischemia in vivo
1991
Immunohistochemical distribution of calcium‐activated neutral proteinases and endogenous CANP inhibitor in the rabbit hippocampus
1990
A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex
1995
NMDA Receptor Activation Mediates Copper Homeostasis in Hippocampal Neurons
2005
β-Adrenergic Regulation of Synaptic NMDA Receptors by cAMP-Dependent Protein Kinase
1996
Localization of neuronal and glial glutamate transporters
1994
Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation
1990
Aurintricarboxylic Acid Protects Hippocampal Neurons from NMDA‐and Ischemia‐Induced Toxicity In Vivo
1993
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
1997
Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity
1992
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Excitatory Amino Acid‐Mediated Cytotoxicity and Calcium Homeostasis in Cultured Neurons
1993
Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3
1989
Cellular Mechanisms of Epilepsy and Potential New Treatment Strategies
1989
Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes
1990
Transient glucose hypermetabolism after acute subdural hematoma in the rat
1992
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
Rapid desensitization determines the pharmacology of glutamate neurotoxicity
1994
Calmodulin in ischemic neurotoxicity of rat hippocampus in vitro
1997
Pathophysiology and treatment of focal cerebral ischemia
1992
Membrane-permeant chelators can attenuate Zn2+-induced cortical neuronal death
2003
cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase
1994 StandoutNobel
Excitatory amino acid release from astrocytes during energy failure by reversal of sodium‐dependent uptake
1995
Hypoxia preferentially destroys GABAergic neurons in developing rat neocortex explants in culture
1988
Death‐signalling cascade in mouse cerebellar granule neurons
1998
Chapter 6 Glutamate receptors and the induction of excitotoxic neuronal death
1994
Stargazin modulates AMPA receptor gating and trafficking by distinct domains
2005 Nature
Oxypurinol attenuates hydroxyl radical production during ischemia/reperfusion injury of the rat cerebral cortex: an ESR study
1993
Calcium-related damage in ischemia
1996
An adenosine uptake blocker, propentofylline, reduces glutamate release in gerbil hippocampus following transient forebrain ischemia
1992
Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death
1992
l-Homocysteate is a potent neurotoxin on cultured cortical neurons
1987
The glial cell glutamate uptake carrier countertransports pH-changing anions
1992 Nature
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia
1993
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
2002
The Micromolar Zinc-Binding Domain on the NMDA Receptor Subunit NR2B
2005
Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor
1999
Ischemic brain injury in vitro: protective effects of NMDA receptor antagonists and calmidazolium
1990
Stimulus‐Transcription Coupling in Focal Cerebral Ischemia
1994
Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans
1993
Neurobiology of Zinc and Zinc-Containing Neurons
1989
Glutamate-induced neuron death requires mitochondrial calcium uptake
1998
Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study
1995
Hippocampal slices: glutamate overflow and cellular damage from ischemia are reduced by sodium-channel blockade
1995
Pre- and postischemic effects of the NMDA receptor antagonist dizocilpine maleate (MK-801) on collateral cerebral blood flow
1997
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation
1992 Nature
Blockade of N-methyl-d-aspartate receptors prevents cyanide-induced neuronal injury in primary hippocampal cultures
1992
Glutamate, calcium, and free radicals as mediators of ischemic brain damage
1995
Zn2+ potentiates ATP-activated currents in rat sympathetic neurons
1993
Molecular genetics of cell death in the nematode Caenorhabditis elegans
1992
Acidosis and ischemic brain damage
1988
A potential role for excitotoxins in the pathophysiology of spinal cord injury
1988
Traumatic Brain Injury‐Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model
1993
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
1994 Standout
Excitatory amino acid neurotoxicity and neurodegenerative disease
1990 Standout
BI-1 Regulates an Apoptosis Pathway Linked to Endoplasmic Reticulum Stress
2004 StandoutNobel
Imaging free zinc in synaptic terminals in live hippocampal slices
1997
Brain Cooling During Transient Focal Ischemia Provides Complete Neuroprotection
1997
L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes
1991
Arachidonic acid participates in the anoxia-induced increase in mEPSC frequency in CA1 neurons of the rat hippocampus
1994
Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis
1992
The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses
2000
β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
1990
Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin
1992
Treatment of Traumatic Brain Injury with Moderate Hypothermia
1997 Standout
Failure to prevent selective CA1 neuronal death and reduce cortical infarction following cerebral ischemia with inhibition of nitric oxide synthase
1994
Ion Dependence and Receptor Mediation of Glutamate Toxicity in the Immature Rat Hippocampal Slice
1990
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Responses of CA1 pyramidal neurons in rat hippocampus to transient forebrain ischemia: An in vivo intracellular recording study
1994
Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia
1996
Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2
1994 StandoutNatureNobel
Enhancement of NMDA receptor-mediated neurotoxicity in the hippocampal slice by depolarization and ischemia
1991
Calcium Channel Antagonists in the Prevention of Neurotoxicity
1991
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
Differential Transcription and Translation of Immediate Early Genes in the Gerbil Hippocampus after Transient Global Ischemia
1993
Effect of Cerebral Ischemia on Calcium/Calmodulin-Dependent Protein Kinase II Activity and Phosphorylation
1995
Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro
1995
Glutamate neurotoxicity in spinal cord cell culture
1991
Protective Effect of Hypothermia on Hippocampal Injury After 30 Minutes of Forebrain Ischemia in Rats Is Mediated by Postischemic Recovery of Protein Synthesis
1993
Requirement for Superoxide in Excitotoxic Cell Death
1996
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function
1995 Standout
Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
1992
Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat.
1992
Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor
1997
Threshold of calcium disturbances after focal cerebral ischemia in rats. Implications of the window of therapeutic opportunity.
1993
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Intraischemic Hypothermia Decreases the Release of Glutamate in the Cores of Permanent Focal Cerebral Infarcts
1995
Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
1999
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
1999
Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat
1992
Cl‐ and Na+ homeostasis during anoxia in rat hypoglossal neurons: intracellular and extracellular in vitro studies.
1992
Focal Cerebral Ischemia in the Cat: Pretreatment with a Competitive NMDA Receptor Antagonist, D-CPP-ene
1990
Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia
1992 StandoutScienceNobel
Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase
1988
Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture
1992
Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.
1987
Nitric Oxide Synthase Inhibition and Extracellular Glutamate Concentration After Cerebral Ischemia/Reperfusion
1995
Vicious Cycle Involving Na+Channels, Glutamate Release, and NMDA Receptors Mediates Delayed Neurodegeneration through Nitric Oxide Formation
1996
Calcium/calmodulin-dependent protein kinase II activity in focal ischemia with reperfusion in rats.
1994
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
1988
Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity
1996
Calcium permeability of the neuronal nuclear envelope: evaluation using confocal volumes and intracellular perfusion
1994
Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischemia
1994
Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity
2001
Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor
1992 ScienceNobel
Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity
1989
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
1990 StandoutScience
Nitric Oxide Acutely Inhibits Neuronal Energy Production
1999
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
1991 Standout
The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro
1987
Neurotransmitter regulation of neuronal outgrowth, plasticity and survival
1989
Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.
1993
The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia
1996 Science
Spatial resolution of fodrin proteolysis in postischemic brain.
1993
Altered gene expression in cerebral ischemia.
1993
Cerebroprotective Effect of Lamotrigine After Focal Ischemia in Rats
1995
Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
1993
Direct Correlation Between Ischemic Injury and Extracellular Glycine Concentration in Mice With Genetically Altered Activities of the Glycine Cleavage Multienzyme System
2007
Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
1995
Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo.
1990
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.
1996
Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes
1990 Science
Highly Zinc-Selective Fluorescent Sensor Molecules Suitable for Biological Applications
2000
Beta- N -Methylamino-L-Alanine Neurotoxicity: Requirement for Bicarbonate as a Cofactor
1988 Science
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
1994 StandoutScienceNobel
Imaging synaptic zinc release in living nervous tissue
2001
Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury
1991
Recovery from NMDA-induced intracellular acidification is delayed and dependent on extracellular bicarbonate
1996
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
Mossy fiber Zn2+ spillover modulates heterosynapticN-methyl-d -aspartate receptor activity in hippocampal CA3 circuits
2002
Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators.
1997
NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection
1990
Calcium in Ischemic Cell Death
1998
Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity
1989 Science
Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases
1996
Inositol Trisphosphate, Polyphosphoinositide Turnover, and High-Energy Metabolites in Focal Cerebral Ischemia and Reperfusion
1995
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Ca2 + Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition
1991 Science
Modulation of the N-methyl-D-aspartate channel by extracellular H+.
1990
Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.
1993
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA.
1988
The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats
1991
Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neurons.
1992
The importance of sodium for anoxic transmission damage in rat hippocampal slices: mechanisms of protection by lidocaine.
1995
Mild acidosis delays hypoxic spreading depression and improves neuronal recovery in hippocampal slices
1994
Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake
1990
The Effects of a Competitive NMDA Receptor Antagonist (CGS-19755) on Cerebral Blood Flow and pH in Focal Ischemia
1991
Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention
1993
A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death
1995
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
1988
Acid-induced death in neurons and glia
1991
Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators
1997
Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons
1994
Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure
1996
Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia
1988
The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
1989 Science
Extracellular Acidity Potentiates AMPA Receptor-Mediated Cortical Neuronal Death
1998
Induction of Mossy Fiber→CA3 Long-Term Potentiation Requires Translocation of Synaptically Released Zn2+
2001
Continuous monitoring and regulating of brain temperature in the conscious and freely moving ischemic gerbil: Effect of MK-801 on delayed neuronal death in hippocampal CA1
1997
Differential Susceptibility to Neurotoxicity Mediated by Neurotrophins and Neuronal Nitric Oxide Synthase
1997
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
1993
Delayed Antagonism of Calpain Reduces Excitotoxicity in Cultured Neurons
1995
Lamotrigine Protects Hippocampal CA1 Neurons From Ischemic Damage After Cardiac Arrest
1997
The Role of Brain-derived Neurotrophic Factor in Transient Forebrain Ischemia in the Rat Brain
1994
Ischemic Cell Death in Brain Neurons
1999 Standout
Enhanced Calcium Uptake by CA1 Pyramidal Cell Dendrites in the Postischemic Phase despite Subnormal Evoked Field Potentials: Excitatory Amino Acid Receptor Dependency and Relationship to Neuronal Damage
1992
Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
1994
Systemic approaches to modifying quinolinic acid striatal lesions in rats
1988
Global Ischemia Induces Downregulation of Glur2 mRNA and Increases AMPA Receptor-Mediated Ca2+Influx in Hippocampal CA1 Neurons of Gerbil
1997
Measurement of Intracellular Free Zinc Concentrations Accompanying Zinc-Induced Neuronal Death
1999
Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey
1997
Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation
1996 Science
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
1988 Standout
Zinc alters excitatory amino acid neurotoxicity on cortical neurons
1988
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.
1988
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
Pathogenesis of Substantia Nigra Lesions following Hyperglycemic Ischemia: Changes in Energy Metabolites, Cerebral Blood Flow, and Morphology of Pars Reticulata in a Rat Model of Ischemia
1988
Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene
1997
High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors
1997
Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations
1990
Prevention of Periinfarct Direct Current Shifts with Glutamate Antagonist NBQX following Occlusion of the Middle Cerebral Artery in the Rat
1994
Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
1988
Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice
1996
Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry
1997
Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen following Concussive Brain Injury
1992
Rapid Translocation of Zn2+From Presynaptic Terminals Into Postsynaptic Hippocampal Neurons After Physiological Stimulation
2001
Peptide growth factors protect against ischemia in culture by preventing nitric oxide toxicity
1993
Deep Prepiriform Cortex Modulates Neuronal Cell Death in Global Ischemia
1997
Potentiated Necrosis of Cultured Cortical Neurons by Neurotrophins
1995 Science
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
1993 StandoutScience
Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons
1990 StandoutScienceNobel
Zinspy Sensors with Enhanced Dynamic Range for Imaging Neuronal Cell Zinc Uptake and Mobilization
2006
Inhibition of Tyrosine Phosphorylation Prevents Delayed Neuronal Death following Cerebral Ischemia
1993
Growth factors protect PC12 cells against ischemia by a mechanism that is independent of PKA, PKC, and protein synthesis
1993
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit
1998
Applications of quantitative measurements for assessing glutamate neurotoxicity.
1988
Secondary Elevation of Extracellular Neurotransmitter Amino Acids in the Reperfusion Phase following Focal Cerebral Ischemia
1996
A Selective N-Type Calcium Channel Antagonist Reduces Extracellular Glutamate Release and Infarct Volume in Focal Cerebral Ischemia
1995
Mechanisms and Effects of Intracellular Calcium Buffering on Neuronal Survival in Organotypic Hippocampal Cultures Exposed to Anoxia/Aglycemia or to Excitotoxins
1997
Calcium Movement in Ischemia-Tolerant Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Gerbils
1996
Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles
1994
Excitotoxicity affects membrane potential and calmodulin kinase II activity in cultured rat cortical neurons.
1993
Amelioration of delayed neuronal death in the hippocampus by nerve growth factor
1991
ZnT-3, a putative transporter of zinc into synaptic vesicles
1996
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Major differences in Ca2+i response to anoxia between neonatal and adult rat CA1 neurons: role of Ca2+o and Na+o
1993
Protection from neuronal damage induced by combined oxygen and glucose deprivation in organotypic hippocampal cultures by glutamate receptor antagonists
1995
ZINC AND BRAIN INJURY
1998
A role for Na + ‐dependent Ca 2+ extrusion in protection against neuronal excitotoxicity
1989
Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain
1989
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
1992
Ischemic Flow Threshold for Extracellular Glutamate Increase in Cat Cortex
1989
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
1992 StandoutNobel
Works of DW Choi being referenced
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity
1990 Science
The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death
1990 Standout
Do NMDA Antagonists Prevent Neuronal Injury? Yes.
1992
Glutamate receptor‐mediated currents and toxicity in embryonal carcinoma cells
1993
A693 HIGH CONCENT RATIONS OF BARBITURATES CAN ENHANCE NEURONAL INJURY IN SUBSTRATE-DEPRIVED CORTICAL CELL CULTURES
1990
Intracellular free calcium increases in cultured cortical neurons deprived of oxygen and glucose.
1990
The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity
1990 Science
Glutamate neurotoxicity in cortical cell culture
1987
Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons
1987 Science
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration
1993
Cerebral hypoxia: some new approaches and unanswered questions
1990
Ionic dependence of glutamate neurotoxicity
1987 Standout
Extracellular alkalinity exacerbates injury of cultured cortical neurons.
1992
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists
1988
Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury
1993
Non-NMDA receptor-mediated neurotoxicity in cortical culture
1990
Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons
1990