Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
The open pore conformation of potassium channels
2002 StandoutNatureNobel
Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA
1998
Construction of heme enzymes: four approaches
2002
Crystal structure of yeast Cu,Zn superoxide dismutase
1992
Molecular cloning and functional analysis of a Schizosaccharomyces pombe homologue of Escherichia coli endonuclease III
1996
Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands
2000 Nature
Site-Directed Mutagenesis of the Putative Distal Helix of Peroxygenase Cytochrome P450
2001
Role of methionine 230 in intramolecular electron transfer between the oxyferryl heme and tryptophan 191 in cytochrome c peroxidase compound II
1994
In-house measurement of the sulfur anomalous signal and its use for phasing
2003
Analyzing protein functions in four dimensions.
2000
Eigensystem analysis of the refinement of a small metalloprotein
2000
Perspectives on Non-Heme Iron Protein Chemistry
1991
Proximal ligand control of heme iron coordination structure and reactivity with hydrogen peroxide: investigations of the myoglobin cavity mutant H93G with unnatural oxygen donor proximal ligands
2000
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Unprecedented Molecular Architectures by the Controlled Self‐Assembly of a β‐Peptide Foldamer
2010
Refinement of severely incomplete structures with maximum likelihood inBUSTER–TNT
2004
Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif‐like domain
2006
Structure of the 30S ribosomal subunit
2000 StandoutNatureNobel
Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus
1998 StandoutNobel
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
Structure of viscotoxin A3: disulfide location from weak SAD data
2003
Helix control in polymers
2012
Gated Access to the Pore of a Voltage-Dependent K+ Channel
1997
Non-covalent polymer assembly using arrays of hydrogen-bonds
2007
The Internal Structure of Helical Pores Self‐Assembled from Dendritic Dipeptides is Stereochemically Programmed and Allosterically Regulated
2005
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Structure determination of the O -methyltransferase NovP using the `free lunch algorithm' as implemented in SHELXE
2007
Refined crystal structure of the 2[4Fe-4S] ferredoxin from Clostridium acidurici at 1.84 Å resolution
1994
HOLE: A program for the analysis of the pore dimensions of ion channel structural models
1996
Introducing Branches into a Self‐Assembling Peptide Fiber
2003
Microtubes with Rectangular Cross-Section by Self-Assembly of a Short β-Peptide Foldamer
2012
Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment
2004
Ipso-Substitution by Cytochrome P450 with Conversion of p-Hydroxybenzene Derivatives to Hydroquinone: Evidence for Hydroperoxo-Iron As the Active Oxygen Species
2002
The helix-hairpin-helix DNA-binding motif: a structural basis for non- sequence-specific recognition of DNA
1996
A short history ofSHELX
2007 Standout
Substrate Recognition and Molecular Mechanism of Fatty Acid Hydroxylation by Cytochrome P450 from Bacillus subtilis
2003
Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase
2004
Isolation and Characterization of Endonuclease VIII from Escherichia coli
1994
Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein
1999 StandoutNobel
Tetraanionic Organoborate Squares Glued Together by Cations To Generate Nanotubular Stacks
2005 StandoutNobel
Conformational States of Cytochrome P450cam Revealed by Trapping of Synthetic Molecular Wires
2004
Molecular Modeling of Cytochrome P450 1A1: Enzyme-Substrate Interactions and Substrate Binding Affinities
2002
Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway
1997
TOPOLOGICAL CHANGES IN THE CYP3A4 ACTIVE SITE PROBED WITH PHENYLDIAZENE: EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P450 REDUCTASE AND CYTOCHROME B5 AND OF SITE-DIRECTED MUTAGENESIS
2004
The coming of age of de novo protein design
2016 StandoutNatureNobel
Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy
2013 StandoutNobel
Structural Basis for the Excision Repair of Alkylation-Damaged DNA
1996
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Reducing the Environmental Sensitivity of Yellow Fluorescent Protein
2001 StandoutNobel
Structure and regulation of Kit protein-tyrosine kinase—The stem cell factor receptor
2005
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles
1992
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Design, Activity, and Structure of a Highly Specific Artificial Endonuclease
2002 StandoutNobel
Noncovalent Synthesis Using Hydrogen Bonding
2001
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
1.4 .ANG. Structure of Photoactive Yellow Protein, a Cytosolic Photoreceptor: Unusual Fold, Active Site, and Chromophore
1995
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution
2004
The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2 Å Crystal Structure
2004
P450 BM3: the very model of a modern flavocytochrome
2002
How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways 1 1Edited by J. Thornton
2000
On the role of the axial ligand in heme proteins: a theoretical study
2004
The base excision repair pathway
1995
Crystal structure of human cytochrome P450 2C9 with bound warfarin
2003 Nature
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Structural Evidence for Direct Hydride Transfer from NADH to Cytochrome P450nor
2004
Ab initio solution and refinement of two high-potential iron protein structures at atomic resolution
1999
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
In-house phase determination of the lima bean trypsin inhibitor: a low-resolution sulfur-SAD case
2003
Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis
1994 Science
Self-assembly of amphiphilic dendritic dipeptides into helical pores
2004 Nature
Ab initiostructure determination of the lantibiotic mersacidin
2000
The Antiviral Antibiotic Feglymycin: First Direct‐Methods Solution of a 1000+ Equal‐Atom Structure
2005
Comparative modelling of cytochromes P450
2002
Activation of the Anaerobic Ribonucleotide Reductase fromEscherichia coli
1997
Structure of Human Microsomal Cytochrome P450 2C8
2004
Controlled Bioactive Nanostructures from Self‐Assembly of Peptide Building Blocks
2007
Artificial transmembrane ion channels from self-assembling peptide nanotubes
1994 Nature
Identification of a Porphyrin .pi. Cation Radical in Ascorbate Peroxidase Compound I
1995
Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex
1999 StandoutNobel
Serendipitous SAD phasing of an echinomycin–(ACGTACGT)2bisintercalation complex
2006
Fatty Acid Hydroperoxide Lyase: A Plant Cytochrome P450 Enzyme Involved in Wound Healing and Pest Resistance
2001
Well‐defined secondary structures
2004
Structural Aspects of Metal Liganding to Functional Groups in Proteins
1991
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
2001
Validation of protein models from Cα coordinates alone
1997
Yeast cytochrome c peroxidase: mechanistic studies via protein engineering
2002
The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution
2004
Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.
1992
Conformational Plasticity and Structure/Function Relationships in Cytochromes P450
2010
New supramolecular packing motifs: π-stacked rods encased in triply-helical hydrogen bonded amide strands
1999
Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli.
1996
The Antiviral Antibiotic Feglymycin: First Direct‐Methods Solution of a 1000+ Equal‐Atom Structure
2005
I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
2010 StandoutNobel
Site-directed mutagenesis of Azotobacter vinelandii ferredoxin I: cysteine ligation of the [4Fe-4S] cluster with protein rearrangement is preferred over serine ligation.
1995
Photoactive yellow protein: A structural prototype for the three-dimensional fold of the PAS domain superfamily
1998
Direct Electrochemistry of Immobilized Human Cytochrome P450 2E1
2004
Programming the Internal Structure and Stability of Helical Pores Self-Assembled from Dendritic Dipeptides via the Protective Groups of the Peptide
2005
Structure of Mammalian Cytochrome P450 2C5 Complexed with Diclofenac at 2.1 Å Resolution: Evidence for an Induced Fit Model of Substrate Binding,
2003
HKL2MAP: a graphical user interface for macromolecular phasing withSHELXprograms
2004
Supramolecular Polymerization
2009 Standout
Direct Measurement of the Reduction Potential of Catalytically Active Cytochrome c Peroxidase Compound I: Voltammetric Detection of a Reversible, Cooperative Two-Electron Transfer Reaction
1996
Crystal structure of cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors
2001
Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs),
2001
A Highly Stable, Six-Hydrogen-Bonded Molecular Duplex
2000
Theory and Practice of Electron Transfer within Protein−Protein Complexes: Application to the Multidomain Binding of Cytochromecby CytochromecPeroxidase
1996
Assembly of Supramolecular Nanotubes from Molecular Triangles and 1,2-Dihalohydrocarbons
2014 StandoutNobel
Role of the proximal ligand in peroxidase catalysis. Crystallographic, kinetic, and spectral studies of cytochrome c peroxidase proximal ligand mutants.
1994
Roles of the Proximal Heme Thiolate Ligand in Cytochrome P450cam
2001
Chemical Glycobiology
2001 StandoutScienceNobel
Quality Control by DNA Repair
1999 StandoutScienceNobel
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
The C-Terminal Domain of the Adenine-DNA Glycosylase MutY Confers Specificity for 8-Oxoguanine·Adenine Mispairs and May Have Evolved from MutT, an 8-Oxo-dGTPase
1999
Prominent Gelation and Chiral Aggregation of Alkylamides Derived from trans‐1,2‐Diaminocyclohexane
1996
Trapping of Organic Blockers by Closing of Voltage-dependent K+ Channels
1997
Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography
2002
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Response of a Protein Structure to Cavity-Creating Mutations and Its Relation to the Hydrophobic Effect
1992 Science
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin
2006
Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials
2002 Standout
A Heterocyclic Peptide Nanotube
2003
Crystal Structure of the Aequorea victoria Green Fluorescent Protein
1996 StandoutScienceNobel
Self-Assembling Cyclic β3-Peptide Nanotubes as Artificial Transmembrane Ion Channels
1998
Coot: model-building tools for molecular graphics
2004 Standout
Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity
2001
A Contrivance for a Dynamic Porous Framework: Cooperative Guest Adsorption Based on Square Grids Connected by Amide−Amide Hydrogen Bonds
2004 StandoutNobel
Toward Artificial Ion Channels: A Lipophilic G-Quadruplex
2000
An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.
1994
Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit
2005
Ion Channel Models Based on Self-Assembling Cyclic Peptide Nanotubes
2013
Supramolecular Polymers
2001 Standout
Structure of the S15,S6,S18-rRNA Complex: Assembly of the 30 S Ribosome Central Domain
2000 Science
Hydrogen-Bonded Porous Coordination Polymers: Structural Transformation, Sorption Properties, and Particle Size from Kinetic Studies
2006 StandoutNobel
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
1998 StandoutScienceNobel
Genetic Incorporation of a Metal-Ion Chelating Amino Acid into Proteins as a Biophysical Probe
2009
Homochiral supramolecular polymerization of bowl-shaped chiral macrocycles in solution
2013
Fluorescent Probes for Cytochrome P450 Structural Characterization and Inhibitor Screening
2002
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.
1995
β‐Peptides: Synthesis by Arndt‐Eistert homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X‐ray crystallography. Helical secondary structure of a β‐hexapeptide in solution and its stability towards pepsin
1996
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
2016 Standout
Reversible Photoisomerization of Self-Organized Cylindrical Peptide Assemblies at Air−Water and Solid Interfaces
1999
Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.
1994
DNA glycosylases in the base excision repair of DNA
1997
Self-Assembling Organic Nanotubes
2001
Principles of self-assembly of helical pores from dendritic dipeptides
2006
Foldecture as a Core Material with Anisotropic Surface Characteristics
2015
Protein Control of Redox Potentials of Iron−Sulfur Proteins
1996 StandoutNobel
Introduction of P450, Peroxidase, and Catalase Activities into Myoglobin by Site-Directed Mutagenesis: Diverse Reactivities of Compound I
2003
Engineering Novel Metalloproteins: Design of Metal-Binding Sites into Native Protein Scaffolds
2001
Nanoporous and mesoporous organic structures: new openings for materials research
1999
Helical Rosette Nanotubes: Design, Self-Assembly, and Characterization
2001
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Supramolecular Nanotube Architectures Based on Amphiphilic Molecules
2005
Hydrogen‐bonded pseudopolyrotaxanes
1996 StandoutNobel
Self-Assembling Peptide Nanotubes
1996
Hervorragende Gelbildung durch und chirale Aggregate aus Alkylamiden, die aus trans‐1, 2‐Diaminocyclohexan erhalten wurden
1996
Strong Dimerization of Ureidopyrimidones via Quadruple Hydrogen Bonding
1998
Helical Pores Self-Assembled from Homochiral Dendritic Dipeptides Based on l -Tyr and Nonpolar α-Amino Acids
2007
Physical Organic Chemistry of Supramolecular Polymers
2006
Stereospecific Cyclic Poly(methyl methacrylate) and Its Topology‐Guided Hierarchically Controlled Supramolecular Assemblies
2013
Perspectives on main‐chain hydrogen bonded supramolecular polymers
2007
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages
2004
Encoded Helical Self-Organization and Self-Assembly into Helical Fibers of an Oligoheterocyclic Pyridine - Pyridazine Molecular Strand
2000 Nobel
Protein Radicals in Enzyme Catalysis
1998 Standout
Sulfite Reductase Structure at 1.6 Å: Evolution and Catalysis for Reduction of Inorganic Anions
1995 Science
An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution
2003
Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate
1998 Science
Thermodynamic and Biophysical Characterization of Cytochrome P450 BioI from Bacillus subtilis
2004
Structure of a Substrate Complex of Mammalian Cytochrome P450 2C5 at 2.3 Å Resolution: Evidence for Multiple Substrate Binding Modes,
2003
Mechanistic Studies on Synthetic Fe−S-Based Clusters and Their Relevance to the Action of Nitrogenases
2005 StandoutNobel
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Pulsating Tubules from Noncovalent Macrocycles
2012 Science
Experimental Evidence for Intramolecular Blue-Shifting C−H···O Hydrogen Bonding by Matrix-Isolation Infrared Spectroscopy
2003 StandoutNobel
Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine
2002
Self-Assembled Peptide Architecture with a Tooth Shape: Folding into Shape
2011
Self-Assembling Organic Nanotubes with Precisely Defined, Sub-nanometer Pores: Formation and Mass Transport Characteristics
2013
Structure and Chemistry of Cytochrome P450
2005 Standout
Cooperative Dynamics in Duplexes of Stacked Hydrogen-Bonded Moieties
1999
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Duncan E. McRee being referenced
A ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavity
1996
Self-assembling organic nanotubes based on a cyclic peptide architecture
1993 Nature
CHANGES IN CRYSTALLOGRAPHIC STRUCTURE AND THERMOSTABILITY OF A CU,ZN SUPEROXIDE DISMUTASE MUTANT RESULTING FROM THE REMOVAL OF BURIED CYSTEINE
1990
Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features
2000
Mechanism and Atomic Structure of Superoxide Dismutase
1991
Crystallization and crystallographic characterization of the iron-sulfur-containing DNA-repair enzyme endonuclease III from Escherichia coli
1992
A fully integrated protein crystallization platform for small-molecule drug discovery
2003
Mammalian Microsomal Cytochrome P450 Monooxygenase
2000
Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation
2003
XtalView/Xfit—A Versatile Program for Manipulating Atomic Coordinates and Electron Density
1999 Standout
Structure of Azotobacter vinelandii 7Fe ferredoxin at 1.35 Å resolution and determination of the [Fe-S] bonds with 0.01 Å accuracy
1998
The role of aspartate-235 in the binding of cations to an artificial cavity at the radical site of cytochromecperoxidase
1995
The Asp-His-iron triad of cytochrome c peroxidase controls the reduction potential electronic structure, and coupling of the tryptophan free radical to the heme
1993
The Structural and Thermodynamic Basis for the Formation of Self‐Assembled Peptide Nanotubes
1995
Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography
1997 Science
Strukturelle und thermodynamische Voraussetzungen für die Bildung selbstorganisierter röhrenförmiger Peptid‐Nanostrukturen
1995
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.
1990
Variation in Strength of an Unconventional C−H to O Hydrogen Bond in an Engineered Protein Cavity
1997
Crystallographic structure of a photoreceptor protein at 2.4 A resolution.
1989
Altering Substrate Specificity at the Heme Edge of CytochromecPeroxidase
1996
Cylindrical β-Sheet Peptide Assemblies
1998
Nanoscale Tubular Ensembles with Specified Internal Diameters. Design of a Self-Assembled Nanotube with a 13-.ANG. Pore
1994
Atomic Structure of the DNA Repair [4Fe-4S] Enzyme Endonuclease III
1992 Science
Rational Design of a Functional Metalloenzyme: Introduction of a Site for Manganese Binding and Oxidation into a Heme Peroxidase
1998
Electric Fields in Active Sites: Substrate Switching from Null to Strong Fields in Thiol- and Selenol-Subtilisins
1999
The heme and Fe4S4 cluster in the crystallographic structure of Escherichia coli sulfite reductase.
1986
Crystallographic characterization of a photoactive yellow protein with photochemistry similar to sensory rhodopsin.
1986
Replacement of the Axial Histidine Ligand with Imidazole in Cytochrome c Peroxidase. 1. Effects on Structure,
2001
Construction of a bisaquo heme enzyme and binding by exogenous ligands.
1994
THE ASP-HIS-FE TRIAD OF CYTOCHROME C PEROXIDASE CONTROLS THE REDUCTION POTENTIAL, ELECTRONIC STRUCTURE, AND COUPLING OF THE TRYPTOPHAN FREE-RADICAL TO THE HEME
1993
Small Molecule Binding to an Artificially Created Cavity at the Active Site of Cytochrome c Peroxidase
1994