Citation Impact
Citing Papers
Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells
2003 StandoutNobel
Structural inference of native and partially folded RNA by high-throughput contact mapping
2008 StandoutNobel
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene
2006 StandoutScienceNobel
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Three-dimensional structure of a hammerhead ribozyme
1994 Nature
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Properties of an In vitro Selected Pb2+ Cleavage Motif
1994
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
Solution structure of a metal-binding site in the major groove of RNA complexed with cobalt (III) hexammine
1997
Random mutations to evaluate the role of bases at two important single-stranded regions of genomic HDV ribozyme
1992
Hammerhead-mediated processing of satellite pDo500 family transcripts from Dolichopoda cave crickets
2000
Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism
1993
The self-cleaving domain from the genomic RNA of hepatitis delta virus: sequence requirements and the effects of denaturant
1990
Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity
2003
Analysis of the role of phosphate oxygens in the group I intron from Tetrahymena
1992
Atlantic Salmon ( Salmo salar ) Serum Albumin: cDNA Sequence, Evolution, and Tissue Expression
1990
[5] Phosphorothioate modification of RNA for stereochemical and interference analyses
2000
Marine natural products
1990 Standout
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
1987 Standout
A phosphorothioate at the 3′ splice-site inhibits the second splicing step in a group I intron
1992
A Human Gene Encoding a Putative Basic Helix–Loop–Helix Phosphoprotein Whose mRNA Increases Rapidly in Cycloheximide-Treated Blood Mononuclear Cells
1994
In vitro evolution suggests multiple origins for the hammerhead ribozyme
2001 StandoutNatureNobel
Characterization, primary structure, and evolution of lamprey plasma albumin
1992
Nucleic acid-incorporated azidonucleotides: Probes for studying the interaction of RNA or DNA with proteins and other nucleic acids
1993
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
The hammerhead RNA domain, a model ribozyme
1993
Identification of phosphate oxygens that are important for self-cleavage activity of the HDV ribozyme by phosphorothioate substitution interference analysis
1994
Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding
1992
Hammerhead ribozyme kinetics
1998
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage
1995
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm
1993 StandoutNobel
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Involvement of a Specific Metal Ion in the Transition of the Hammerhead Ribozyme to Its Catalytic Conformation
1997
Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site
1990 Nobel
RNA structure and NMR spectroscopy
1991
Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain
1992
A DNA metalloenzyme with DNA ligase activity
1995 StandoutNatureNobel
Structural principles for the inhibition of the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates
1998 StandoutNobel
Atomic structure and chemistry of human serum albumin
1992 StandoutNature
Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis .delta. virus RNA sequence
1992
Rearrangement of a Stable RNA Secondary Structure during VS Ribozyme Catalysis
2000
The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone
1998
In vitro evolution of new ribozymes with polynucleotide kinase activity
1994 StandoutNatureNobel
Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity
1991 Nobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: similar reactivity toward single- and double-stranded forms
1990 Nobel
Crystal structure of a hepatitis delta virus ribozyme
1998 StandoutNatureNobel
Structurally Complex and Highly Active RNA Ligases Derived from Random RNA Sequences
1995 StandoutScienceNobel
Study of a hammerhead ribozyme containing 2'-modified adenosine residues
1991
Novel guanosine requirement for catalysis by the hairpin ribozyme
1991 Nature
Peripheral regions of natural hammerhead ribozymes greatly increase their self-cleavage activity
2003
The role of a conserved guanosine residue in the hammerhead‐type RNA enzyme
1990
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
2003
Ribozyme catalysis: not different, just worse
2005 StandoutNobel
Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39
1993 StandoutNobel
Recent developments in the hammerhead ribozyme field
1998
A common RNA loop motif as a docking module and its function in the hammerhead ribozyme
1994
Mutations in genetic variants of human serum albumin found in Italy.
1990
The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.
1996 StandoutNobel
Cloning and expression of a widely distributed (type IV) adenylyl cyclase.
1991 StandoutNobel
Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site.
1993
MECHANISTIC ASPECTS OF ENZYMATIC CATALYSIS: Lessons from Comparison of RNA and Protein Enzymes
1997
Identical structural changes in inherited albumin variants from different populations.
1989
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme
1996 ScienceNobel
A general two-metal-ion mechanism for catalytic RNA.
1993 StandoutNobel
Self-cleaving catalytic RNA.
1993
Ribosomal Route to Small-Molecule Diversity
2011
Schistosome Satellite DNA Encodes Active Hammerhead Ribozymes
1998
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
1991 StandoutNobel
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
1990
How Big Is the Universe of Exons?
1990 ScienceNobel
Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae.
1990 StandoutNobel
Initiation by Yeast RNA Polymerase II at the Adenoviral Major Late Promoter in Vitro
1989 StandoutScienceNobel
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.
1994 StandoutNobel
How many catalytic RNAs? Ions and the Cheshire cat conjecture.
1993
Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications.
1992
Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes
1991 Science
Crystallization of ribozymes and small RNA motifs by a sparse matrix approach.
1993 StandoutNobel
Structural diversity of self-cleaving ribozymes
2000
Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.
1991
Informational Complexity and Functional Activity of RNA Structures
2004 StandoutNobel
RNA Catalysis in Model Protocell Vesicles
2005 StandoutNobel
Translocation events in the evolution of aminoacyl-tRNA synthetases.
1996 StandoutNobel
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
1989 StandoutScience
Tissue-specific in vitro transcription from the mouse albumin promoter
1986
Culture-independent discovery of natural products from soil metagenomes
2015
Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations.
1987
Origin and Variation of Tunicate Secondary Metabolites
2012
Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.
1991 StandoutNobel
Catalytic Strategies of Self-Cleaving Ribozymes
2008
Ribozyme Structures and Mechanisms
2000 StandoutNobel
Crystal structure of the ribosomal RNA domain essential for binding elongation factors
1998 StandoutNobel
Single substitutions of phosphorothioates in the HDV ribozyme G73 define regions necessary for optimal self-cleaving activity
1997
Total chemical synthesis of a ribozyme derived from a group I intron.
1995 StandoutNobel
Three-Dimensional Structure of Human Serum Albumin
1989 Science
A structural census of the current population of protein sequences
1997 StandoutNobel
Newt satellite 2 transcripts self-cleave by using an extended hammerhead structure.
1991
A 1.3-Å resolution crystal structure of the HIV-1 trans-activation response region RNA stem reveals a metal ion-dependent bulge conformation
1998 StandoutNobel
A cell nanoinjector based on carbon nanotubes
2007 StandoutNobel
A Detailed View of a Ribosomal Active Site
1999 StandoutNobel
Works of Duane E. Ruffner being referenced
Sequence requirements of the hammerhead RNA self-cleavage reaction
1990
Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction
1990
An ultraviolet crosslink in the hammerhead ribozyme dependent on 2-thiocytidine or 4-thiouridine substitution
1997
Accessing the Hidden Majority of Marine Natural Products through Metagenomics
2011
Studies on the hammerhead RNA self-cleaving domain
1989
Progress in the Delivery of Therapeutic Oligonucleotides: Organ/Cellular Distribution and Targeted Delivery of OligonucleotidesIn Vivo
2003
Delivery of Antisense Oligonucleotides Using HPMA Polymer: Synthesis of A Thiol Polymer and Its Conjugation to Water-Soluble Molecules
1998
Splicing mutation in human hereditary analbuminemia.
1988
Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4.
1986