Citation Impact
Citing Papers
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Identification of interferon-stimulated genes that attenuate Ebola virus infection
2020 StandoutNobel
Heparin-Protein Interactions
2002 Standout
Two Distinct Urokinase-Serpin Interactions Regulate the Initiation of Cell Surface-associated Plasminogen Activation
1999
Analysis of a Structural Determinant in Thrombin-Protease Nexin 1 Complexes That Mediates Clearance by the Low Density Lipoprotein Receptor-related Protein
1999
Rhodamines NN: A Novel Class of Caged Fluorescent Dyes
2010 StandoutNobel
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin
1997
New Fluorinated Rhodamines for Optical Microscopy and Nanoscopy
2010 StandoutNobel
Interaction of subtilisins with serpins
1996
Importance of the P2 Glycine of Antithrombin in Target Proteinase Specificity, Heparin Activation, and the Efficiency of Proteinase Trapping as Revealed by a P2 Gly → Pro Mutation
1999
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)
2010
Time‐dependent insulin oligomer reaction pathway prior to fibril formation: Cooling and seeding
2009 StandoutNobel
The Axonally Secreted Serine Proteinase Inhibitor, Neuroserpin, Inhibits Plasminogen Activators and Plasmin but Not Thrombin
1998
A robust cell culture system supporting the complete life cycle of hepatitis B virus
2017 StandoutNobel
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family
1995
4‐Trifluoromethyl‐Substituted Coumarins with Large Stokes Shifts: Synthesis, Bioconjugates, and Their Use in Super‐Resolution Fluorescence Microscopy
2013 StandoutNobel
Serpins and other covalent protease inhibitors
2001
Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase
1996
Inhibition of Angiogenesis in Vivo by Plasminogen Activator Inhibitor-1
2001
Interaction between the P14 Residue and Strand 2 of β-Sheet B Is Critical for Reactive Center Loop Insertion in Plasminogen Activator Inhibitor-2
2001
The crystal structure of plasminogen activator inhibitor 2 at 2.0 Å resolution: implications for serpin function
1999
Control of granzymes by serpins
2009
Additivity in Effects of Vitronectin and Monoclonal Antibodies against α-Helix F of Plasminogen Activator Inhibitor-1 on Its Reactions with Target Proteinases
2004
The structural puzzle of how serpin serine proteinase inhibitors work
1996
The structure of active serpin 1K from Manduca sexta
1999
Stopped Flow Fluorescence Energy Transfer Measurement of the Rate Constants Describing the Reversible Formation and the Irreversible Rearrangement of the Elastase-α1-Proteinase Inhibitor Complex
1998
Survey of the year 2004 commercial optical biosensor literature
2005
Antichymotrypsin Interaction with Chymotrypsin
1998
The pH Dependence of Serpin-Proteinase Complex Dissociation Reveals a Mechanism of Complex Stabilization Involving Inactive and Active Conformational States of the Proteinase Which Are Perturbable by Calcium
2001
X-linked IAP is a direct inhibitor of cell-death proteases
1997 StandoutNature
Topology of the Stable Serpin-Protease Complexes Revealed by an Autoantibody That Fails to React with the Monomeric Conformers of Antithrombin
1999
A Urokinase-type Plasminogen Activator-inhibiting Cyclic Peptide with an Unusual P2 Residue and an Extended Protease Binding Surface Demonstrates New Modalities for Enzyme Inhibition
2005
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
2009 StandoutNobel
Whole blood coagulation on protein adsorption-resistant PEG and peptide functionalised PEG-coated titanium surfaces
2004 StandoutNobel
Incorporation of the fluorescent amino acid 7‐azatryptophan into the core domain 1–47 of hirudin as a probe of hirudin folding and thrombin recognition
2004
Protein aggregation and neurodegenerative disease
2004 Standout
Extracellular matrix structure
2015 Standout
Tissue Kallikrein Inhibitors Based on the Sunflower Trypsin Inhibitor Scaffold – A Potential Therapeutic Intervention for Skin Diseases
2016 StandoutNobel
Evidence That Translocation of the Proteinase Precedes Its Acylation in the Serpin Inhibition Pathway
2000
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
2007 Standout
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Tissue Plasminogen Activator Contributes to the Late Phase of LTP and to Synaptic Growth in the Hippocampal Mossy Fiber Pathway
1998 StandoutNobel
Arginine substitutions in the hinge region of antichymotrypsin affect serpin β-sheet rearrangement
1996
Crystal Structure of the Complex of Plasminogen Activator Inhibitor 2 with a Peptide Mimicking the Reactive Center Loop
2001
Role of Arginine 129 in Heparin Binding and Activation of Antithrombin
2000
Lysine 114 of Antithrombin Is of Crucial Importance for the Affinity and Kinetics of Heparin Pentasaccharide Binding
2001
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
Influence of the P5 Residue on α1-Proteinase Inhibitor Mechanism
1998
Vitronectin Functions as a Cofactor for Rapid Inhibition of Activated Protein C by Plasminogen Activator Inhibitor-1
2001
A serpin‐induced extensive proteolytic susceptibility of urokinase‐type plasminogen activator implicates distortion of the proteinase substrate‐binding pocket and oxyanion hole in the serpin inhibitory mechanism
2001
The prophenoloxidase‐activating system in invertebrates
2004 Standout
An Immune-Responsive Serpin Regulates the Melanization Cascade in Drosophila
2002
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
The structure of a serpin–protease complex revealed by intramolecular distance measurements using donor–donor energy migration and mapping of interaction sites
2000
Roles of the Heparin and Low Density Lipid Receptor-related Protein-binding Sites of Protease Nexin 1 (PN1) in Urokinase-PN1 Complex Catabolism
2000
Characterization of a Human α1-Antitrypsin Variant That Is as Stable as Ovalbumin
1998
Survey of the year 2003 commercial optical biosensor literature
2004
Inactivation of Plasminogen Activator Inhibitor-1 by Specific Proteolysis with Stromelysin-1 (MMP-3)
2000
The Reactivity and Oxidation Pathway of Cysteine 232 in Recombinant Human α1-Antitrypsin
2002
Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition
2022
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
1998
Red‐Emitting Rhodamines with Hydroxylated, Sulfonated, and Phosphorylated Dye Residues and Their Use in Fluorescence Nanoscopy
2012 StandoutNobel
Inhibitory conformation of the reactive loop of α1-antitrypsin
1996
The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin
1996 Nature
Squamous Cell Carcinoma Antigen 2 Is a Novel Serpin That Inhibits the Chymotrypsin-like Proteinases Cathepsin G and Mast Cell Chymase
1997
Neuroserpin, a Brain-associated Inhibitor of Tissue Plasminogen Activator Is Localized Primarily in Neurons
1997
Identification of Interferon-Stimulated Genes with Antiretroviral Activity
2016 StandoutNobel
Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor‐1 and the arginine‐specific proteinases trypsin, LMW u‐PA, HMW u‐PA, and t‐PA: Use of site‐specific fluorescent probes of local environment
2002
Serine protease inhibitors (SERPINS): Where mechanism meets medicine
1996
Aggregation-induced emission
2011 Standout
Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein
1998
Mapping the Serpin-Proteinase Complex Using Single Cysteine Variants of α1-Proteinase Inhibitor Pittsburgh
1998
Masked Rhodamine Dyes of Five Principal Colors Revealed by Photolysis of a 2‐Diazo‐1‐Indanone Caging Group: Synthesis, Photophysics, and Light Microscopy Applications
2014 StandoutNobel
Heterologous protein expression in the methylotrophic yeastPichia pastoris
2000 Standout
Tissue‐type plasminogen activator requires a co‐receptor to enhance NMDA receptor function
2008
Apparent Formation of Sodium Dodecyl Sulfate-stable Complexes between Serpins and 3,4-Dichloroisocoumarin-inactivated Proteinases Is Due to Regeneration of Active Proteinase from the Inactivated Enzyme
1997
Neutrophil granule contents in the pathogenesis of lung injury
2005
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
2018 Standout
Red‐Emitting Rhodamine Dyes for Fluorescence Microscopy and Nanoscopy
2009 StandoutNobel
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
2005 StandoutNobel
Major proteinase movement upon stable serpin–proteinase complex formation
1997
The Role of Arg46 and Arg47 of Antithrombin in Heparin Binding
1999
Serpin Structure, Mechanism, and Function
2002 Standout
Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase
2011
Cross-Class Inhibition of the Cysteine Proteinases Cathepsins K, L, and S by the Serpin Squamous Cell Carcinoma Antigen 1: A Kinetic Analysis
1998
Formation of a Noncovalent Serpin-Proteinase Complex Involves No Conformational Change in the Serpin. Use of 1H-15N HSQC NMR as a Sensitive Nonperturbing Monitor of Conformation
2000
Salmon antithrombin has only three carbohydrate side chains, and shows functional similarities to human β‐antithrombin
2000
Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease
1996
Fluorescence Lifetime Measurements and Biological Imaging
2010 Standout
Heterogeneity in Serpin−Protease Complexes As Demonstrated by Differences in the Mechanism of Complex Breakdown
2001
Distortion of the Active Site of Chymotrypsin Complexed with a Serpin
1996
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
2007 Standout
Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases
1998
Inhibitory Mechanism of Serpins: Loop Insertion Forces Acylation of Plasminogen Activator by Plasminogen Activator Inhibitor-1
1998
Contributions of Amino Acid Side Chains to the Kinetics and Thermodynamics of the Bivalent Binding of Protein L to Ig κ Light Chain
2004 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Serpin Conformational Change in Ovalbumin. Enhanced Reactive Center Loop Insertion through Hinge Region Mutations
1997
Carborhodol: A New Hybrid Fluorophore Obtained by Combination of Fluorescein and Carbopyronine Dye Cores
2013 StandoutNobel
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor
1998
Design and Characterization of Stabilized Derivatives of Human CD4D12 and CD4D1
2011 StandoutNobel
Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A
1999
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Regulation of protein function by native metastability
2000
Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives
2011 Standout
The elongation of yeast prion fibers involves separable steps of association and conversion
2004
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
2018 StandoutNobel
Engineering an Anion-Binding Cavity in Antichymotrypsin Modulates the “Spring-Loaded” Serpin−Protease Interaction
1998
Contact System: A Vascular Biology Modulator With Anticoagulant, Profibrinolytic, Antiadhesive, and Proinflammatory Attributes
1997
Pathways of Oxidative Damage
2003 Standout
Structures of Active and Latent PAI-1: A Possible Stabilizing Role for Chloride Ions
2000
Mechanism of Heparin Activation of Antithrombin. Evidence for Reactive Center Loop Preinsertion with Expulsion upon Heparin Binding
1996
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
2003 Standout
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Change in Environment of the P1 Side Chain upon Progression from the Michaelis Complex to the Covalent Serpin−Proteinase Complex
1998
Effects of Serpin Binding on the Target Proteinase: Global Stabilization, Localized Increased Structural Flexibility, and Conserved Hydrogen Bonding at the Active Site
1997
Functions of Cell Surface Heparan Sulfate Proteoglycans
1999 Standout
Polar Red‐Emitting Rhodamine Dyes with Reactive Groups: Synthesis, Photophysical Properties, and Two‐Color STED Nanoscopy Applications
2013 StandoutNobel
Vitronectin binds to the gonococcal adhesin OpaA through a glycosaminoglycan molecular bridge
1998
Ribosomal Synthesis of Unnatural Peptides
2005 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
The Reaction of Serpins with Proteinases Involves Important Enthalpy Changes
2001
Fluorescent Labeling of Biomolecules with Organic Probes
2008
Works of Duane E. Day being referenced
Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates
1995
A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1
1995
Mutants of Plasminogen Activator Inhibitor-1 Designed to Inhibit Neutrophil Elastase and Cathepsin G Are More Effective in Vivo than Their Endogenous Inhibitors
2004
Accelerated Conversion of Human Plasminogen Activator Inhibitor-1 to Its Latent Form by Antibody Binding
1999
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
2000
The Use of Fluorescent Probes to Characterize Conformational Changes in the Interaction between Vitronectin and Plasminogen Activator Inhibitor-1
1997
Resolution of Michaelis Complex, Acylation, and Conformational Change Steps in the Reactions of the Serpin, Plasminogen Activator Inhibitor-1, with Tissue Plasminogen Activator and Trypsin
2001
Surface-independent acceleration of factor XII activation by zinc ions. I. Kinetic characterization of the metal ion rate enhancement
1993
A Concerted Structural Transition in the Plasminogen Activator Inhibitor-1 Mechanism of Inhibition
2002
Surface-independent acceleration of factor XII activation by zinc ions. II. Direct binding and fluorescence studies
1993