Citation Impact
Citing Papers
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
1988 StandoutScience
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate
1988 Nature
Proteins regulating Ras and its relatives
1993 StandoutNature
COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes
1998 StandoutNobel
Apoptosis in the nervous system
2000 StandoutNature
mTOR Signaling in Growth Control and Disease
2012 Standout
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
1993 StandoutNature
Oncogenic kinase signalling
2001 StandoutNature
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
1994
Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor
1995
Inositol phosphates and cell signalling
1989 StandoutNature
cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor
1991
Mechanisms of transformation by polyoma virus middle T antigen
1989
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
2004 StandoutNature
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Phosphorylation of middle T by pp60c-src: A switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis
1989
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
1989
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
Phosphatidylinositol-3-OH kinase direct target of Ras
1994 StandoutNature
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor
1989 Nature
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
1991
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Congenital Insensitivity to Pain with Anhidrosis: Novel Mutations in the TRKA (NTRK1) Gene Encoding A High-Affinity Receptor for Nerve Growth Factor
1999
Intracellular Signaling Pathways Activated by Neuropathic Factors
1996
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase
1989 StandoutNobel
C2-domains, Structure and Function of a Universal Ca2+-binding Domain
1998 StandoutNobel
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Phosphatidylinositol 3‐kinase
1994
The Trk family of neurotrophin receptors
1994
Oncogenes and signal transduction
1991 Standout
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
1988 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
CREB: A Major Mediator of Neuronal Neurotrophin Responses
1997
Neurotrophin signal transduction by the Trk receptor
1994
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
1994 StandoutNature
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
1988 Nature
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
1989 StandoutNatureNobel
Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
1992
Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases
1996 StandoutNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Structural and Functional Properties of the TRK Family of Neurotrophin Receptors
1995
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.
1993
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
1995 StandoutNature
Phosphatidylinositol kinase activity associates with viral p60src protein.
1989
Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells
1990
Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
1989 StandoutScience
Characterization of pp85, a target of oncogenes and growth factor receptors.
1990
Acid potentiation of the capsaicin receptor determined by a key extracellular site
2000 StandoutNobel
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.
1990
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.
1993
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.
1990
Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II
1989
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.
1988
Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.
1991
Synaptic Activity and the Construction of Cortical Circuits
1996 StandoutScience
Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.
1990
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen
1990
Expression of human class II major histocompatibility complex antigens using retrovirus vectors.
1987
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets.
1990
Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons
1997
Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase
1997 Science
The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
1992 StandoutScience
An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase
1987
Neurotrophins and Neuronal Plasticity
1995 StandoutScience
Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways
1996
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
1989 StandoutScience
Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.
1994
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit
1993
Metabolic reprogramming and cancer progression
2020 StandoutScience
Mechanism of Activation of Complexed pp60 c-src by the Middle T Antigen of Polyomavirus
1989
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
1987
Purification and characterization of phosphoinositide 3-kinase from rat liver.
1990
A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity
1990
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting
1993 Science
Growth Factors and Cancer
1991 StandoutScience
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
1987
Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.
1990
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation
1987
Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases
1995 StandoutScience
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus.
1988
Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen
1990
Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor
1995 Science
Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.
1988 StandoutNobel
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
1989
A Phosphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine
1991
Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity
1993
A Tightly Associated Serine/Threonine Protein Kinase Regulates Phosphoinositide 3-Kinase Activity
1993
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
1997 StandoutScience
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
2018
Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.
1992
The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.
1988
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
2004 StandoutNobel
CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase
1993 Science
Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain
1989
Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.
1990
Works of Drora Kaplan being referenced
Phosphatidylinositol metabolism and polyoma-mediated transformation.
1986
Oncogenes and Phosphatidylinositol Turnover
1986
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.
1992
Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo.
1986