Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes
2009
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
2003 StandoutScienceNobel
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor β/δ and Protects Against Fatty Acid–Induced Oxidative Stress
2010
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
2014
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
FoxOs Function Synergistically to Promote Glucose Production
2010
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Impaired Regulation of Hepatic Glucose Production in Mice Lacking the Forkhead Transcription Factor Foxo1 in Liver
2007
Angiopoietin-like protein 4: health effects, modulating agents and structure–function relationships
2012
Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production
2016
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production
2008
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
2018
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Signaling at the Slit Diaphragm
2004
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Synaptic adhesion molecules
2003
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
2008
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
1999 Standout
Molecular basis of the functionalpodocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains
2003
Direct control of the Forkhead transcription factor AFX by protein kinase B
1999 Nature
Negative Regulation of the Forkhead Transcription Factor FKHR by Akt
1999
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
2012
A Human Gene Encoding a Putative Basic Helix–Loop–Helix Phosphoprotein Whose mRNA Increases Rapidly in Cycloheximide-Treated Blood Mononuclear Cells
1994
Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome
2006
Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways
2001 StandoutNobel
Dissociating fatty liver and diabetes
2012
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
2001
Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
2008
Cellular survival: a play in three Akts
1999 Standout
Podocin Localizes in the Kidney to the Slit Diaphragm Area
2002
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span
1998
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
2000 StandoutNatureNobel
Uterine Insulin-Like Growth Factor-1: Regulation of Expression and Its Role in Estrogen-Induced Uterine Proliferation*
1990
Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence
1999
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation
2007 StandoutNobel
Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence
1998
Unraveling the Regulation of Hepatic Metabolism by Insulin
2017
Insulin action and resistance in obesity and type 2 diabetes
2017
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Cytosolic Phosphoenolpyruvate Carboxykinase Does Not Solely Control the Rate of Hepatic Gluconeogenesis in the Intact Mouse Liver
2007
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
2001 StandoutNobel
Hypoxic gene expression and metastasis
2004
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Decreased expression of hepatic glucokinase in type 2 diabetes
2014
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
2012
Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin
2000
Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR
2000
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
1999 StandoutNobel
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization
2015
Genomic Structure and Insulin-mediated Repression of the Aquaporin Adipose (AQPap), Adipose-specific Glycerol Channel
2001
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
2008 Nature
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
2003 Nature
Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling
2017
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene
2011
Regulation of triglyceride metabolism by Angiopoietin-like proteins
2011
Liver-Specific Overexpression of the Insulin-like Growth Factor-I Enhances Somatic Growth and Partially Prevents the Effects of Growth Hormone Deficiency
2006
Molecular evolution of FOXP2, a gene involved in speech and language
2002 StandoutNatureNobel
Insulin signaling to hepatic lipid metabolism in health and disease
2011
Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4
2013 StandoutNobel
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
2001
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
1993 StandoutNobel
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
2000 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Biosynthesis of the Caenorhabditis elegans dauer pheromone
2009 StandoutNobel
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
On the interaction of caffeine with nucleic acids
1980
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum
2000 StandoutNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.
1999 StandoutNobel
The Genetics of Aging
2001 StandoutNobel
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Molecular mechanisms of DNA repair inhibition by caffeine.
1990 StandoutNobel
Angiopoietin-like 4: a decade of research
2011
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
2005 StandoutNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
2003 StandoutNobel
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes
2001 Nobel
Expression of hypoxia-inducible factor 1? in brain tumors
2000 StandoutNobel
Works of D.R. Powell being referenced
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice
2007
FoxO1 Regulates Multiple Metabolic Pathways in the Liver
2006
Multiple proteins bind the insulin response element in the human IGFBP-1 promoter
1995
Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)
2009
Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions
1997
The 25-KiloDalton Insulin-Like Growth Factor (IGF)-Binding Protein Inhibits both Basal and IGF-I-Mediated Growth of Chick Embryo Pelvic Cartilagein Vitro
1990
Identification of an insulin-responsive element in the promoter of the human gene for insulin-like growth factor binding protein-1
1993
Glucocorticoids and insulin regulate expression of the human gene for insulin-like growth factor-binding protein-1 through proximal promoter elements.
1994
Hepatic Nuclear Factor 3- and Hormone-Regulated Expression of the Phosphoenolpyruvate Carboxykinase and Insulin-Like Growth Factor-Binding Protein 1 Genes
1995
Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.
1999
Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia
1998
Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity.
1990
Identification of a promoter element which participates in cAMP-stimulated expression of human insulin-like growth factor-binding protein-1
1993
Phenotypic Manifestations of Insulin-Like Growth Factor-Binding Protein-3 Overexpression in Transgenic Mice*
2001
Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN
2001
Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1.
1991
Hepatic Nuclear Factor 3 and High Mobility Group I/Y Proteins Bind the Insulin Response Element of the Insulin-Like Growth Factor-Binding Protein-1 Promoter*
1997
Analysis of various indefinite self-associations
1977
FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter*
1999