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PAS is a dimerization domain common to Drosophila Period and several transcription factors
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An immunocytochemical analysis of the expression of thyroid hormone receptor α and β proteins during natural and thyroid hormone‐induced metamorphosis in Xenopus
1997
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The C. elegans Glutamate Receptor Subunit NMR-1 Is Required for Slow NMDA-Activated Currents that Regulate Reversal Frequency during Locomotion
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2000
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Transcriptional Regulatory Patterns of the Myelin Basic Protein and Malic Enzyme Genes by the Thyroid Hormone Receptors α1 and β1
1998
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2009
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development
1992 StandoutNobel
Transgenic Targeting of a Dominant Negative Corepressor to Liver Blocks Basal Repression by Thyroid Hormone Receptor and Increases Cell Proliferation
2001
Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems
2000
Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis
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Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms
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Negative Regulation of the Gene for the Preprothyrotropin-releasing Hormone from the Mouse by Thyroid Hormone Requires Additional Factors in Conjunction with Thyroid Hormone Receptors
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The Interaction between Nuclear Receptor Corepressor and Histone Deacetylase 3 Regulates Both Positive and Negative Thyroid Hormone Actionin Vivo
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The Localization of Thyroid Hormone Receptor mRNAs in Human Bone
2000
Deletion of the Thyroid Hormone β1 Receptor Increases Basal and Triiodothyronine-Induced Growth Hormone Messenger Ribonucleic Acid in GH3Cells*
1997
Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions
2011
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
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Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
1996 StandoutNobel
Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
1998
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
1996 Nobel
Selective Pituitary Resistance to Thyroid Hormone Produced by Expression of a Mutant Thyroid Hormone Receptor β Gene in the Pituitary Gland of Transgenic Mice
1998
Mapping Sub-Second Structure in Mouse Behavior
2015
Chicken Ovalbumin Upstream Promoter-Transcription Factor (COUP-TF) Modulates Expression of the Purkinje Cell Protein-2 Gene
1998
Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons
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Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1
1998
Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system
1999
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2011
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2000
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2009
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Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor-β Isoform Specific and Required for Adaptive Thermogenesis
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A Unique Role of the β-2 Thyroid Hormone Receptor Isoform in Negative Regulation by Thyroid Hormone
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Alternative mRNA Splicing of Corepressors Generates Variants That Play Opposing Roles in Adipocyte Differentiation
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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
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Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels
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2002
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2012
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
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Mechanisms of transactivation by retinoic acid receptors
1993
Vascular Development in the Retina and Inner Ear
2004
Spared bone mass in rats treated with thyroid hormone receptor TRβ-selective compound GC-1
2003
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
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2012
MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development
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Thyroid Hormone as a Determinant of Metabolic and Contractile Phenotype of Skeletal Muscle
2008
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2008
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2008
Effects of Thyroid Hormone Analogs on Lipid Metabolism and Thermogenesis
2008
The Nuclear Receptor Signaling Atlas: Catalyzing Understanding of Thyroid Hormone Signaling and Metabolic Control
2008
Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting Nutrition and Metabolism
2008
Differential expression of two Xenopus c-myc proto-oncogenes during development.
1989
Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system
1992
Ubiquitination-Induced Conformational Change within the Deiodinase Dimer Is a Switch Regulating Enzyme Activity
2007
Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes.
1992
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
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Mechanism of Thyroid-Hormone Regulated Expression of the SERCA Genes in Skeletal Muscle: Implications for Thermogenesis
2001
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1999 StandoutNobel
Assignment of the beta-thyroid hormone receptor to 3,5,3'-triiodothyronine-dependent inhibition of transcription from the thyrotropin-releasing hormone promoter in chick hypothalamic neurons.
1992
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
2002 StandoutNobel
A Distinct Thyroid Hormone Response Element Mediates Repression of the Human Cholesterol 7α-Hydroxylase (CYP7A1) Gene Promoter
2002
Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone
2000
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
2008
Altered Cardiac Phenotype in Transgenic Mice Carrying the Δ337 Threonine Thyroid Hormone Receptor β Mutant Derived from the S Family*
1999
Postsynaptic N -methyl- d -aspartate receptor function requires α-neurexins
2004 StandoutNobel
A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.
1992
Circadian oscillations in period gene mRNA levels are transcriptionally regulated.
1992 StandoutNobel
Ligand-Dependent and -Independent Transactivation by Thyroid Hormone Receptor β2 Is Determined by the Structure of the Hormone Response Element
1995
Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases
2002 Standout
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
2003 Standout
Missense Mutations and Gene Interruption in PROSIT240 , a Novel TRAP240 -Like Gene, in Patients With Congenital Heart Defect (Transposition of the Great Arteries)
2003
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo
2008
Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses.
1992
The Thermogenic Effect of Thyroid Hormone and Its Clinical Implications
2003
Long-Term Potentiation--A Decade of Progress?
1999 StandoutScience
Interleukin-10 Deficiency Increases Atherosclerosis, Thrombosis, and Low-density Lipoproteins in Apolipoprotein E Knockout Mice
2003
Physiological regulation of hypothalamic TRH transcription in vivo is T 3 receptor isoform specific
1998
Mitochondrial Fission, Fusion, and Stress
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Glutamate receptor pores
2014
The Thyroid Hormone Receptor-β Gene Mutation R383H Is Associated with Isolated Central Resistance to Thyroid Hormone1
1999
An unliganded thyroid hormone receptor causes severe neurological dysfunction
2001
MOLECULAR GENETIC ANALYSIS OF SYNAPTIC PLASTICITY, ACTIVITY-DEPENDENT NEURAL DEVELOPMENT, LEARNING, AND MEMORY IN THE MAMMALIAN BRAIN
1997 Nobel
Type 2 deiodinase at the crossroads of thyroid hormone action
2011
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
A General Mechanism for Network-Dosage Compensation in Gene Circuits
2010 StandoutScienceNobel
Human-level performance in 3D multiplayer games with population-based reinforcement learning
2019 StandoutScienceNobel
In Vivo Interaction of Steroid Receptor Coactivator (SRC)-1 and the Activation Function-2 Domain of the Thyroid Hormone Receptor (TR) β in TRβ E457A Knock-In and SRC-1 Knockout mice
2009
Neural Science
2000 StandoutNobel
A Thyroid Hormone Analog with Reduced Dependence on the Monocarboxylate Transporter 8 for Tissue Transport
2009
Thyroid Hormone Regulation of Metabolism
2014 Standout
Thyroid hormone receptor isoforms are sequentially expressed in oligodendrocyte lineage cells during rat cerebral development
1998
Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo.
1994
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Targeted Disruption of the Type 1 Selenodeiodinase Gene (Dio1) Results in Marked Changes in Thyroid Hormone Economy in Mice
2005
Thyroid Hormones and the Metabolic Syndrome
2013
The Glutamate Receptor Ion Channels
1999 Standout
Thyroid hormone receptor transcriptional activity is potentially autoregulated by truncated forms of the receptor.
1992
Clinical Phenotype of a New Type of Thyroid Hormone Resistance Caused by a Mutation of the TRα1 Receptor: Consequences of LT4 Treatment
2013
Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)
2011
Health Care–Associated Bloodstream Infections
2003
Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha
2000
Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.
1994
Cardiac Dysfunction Caused by Myocardium-Specific Expression of a Mutant Thyroid Hormone Receptor
2000
Transgenic Mice Bearing a Human Mutant Thyroid Hormone βl Receptor Manifest Thyroid Function Anomalies, Weight Reduction, and Hyperactivity
1997
Different causes of Reduced Sensitivity to Thyroid Hormone: Diagnosis and Clinical management
2013
Thyroid Hormone-Responsive Genes in Developing Cerebellum Include a Novel Synaptotagmin and ahairlessHomolog
1996
A Variant Form of the Nuclear Triiodothyronine Receptor c-ErbAα1 Plays a Direct Role in Regulation of Mitochondrial RNA Synthesis
1999
Oligodendrocyte development and thyroid hormone
1999
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific
2001
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
2011 StandoutNobel
The glutamate receptor ion channels.
1999
Role of the Iodothyronine Deiodinases in the Physiology and Pathophysiology of Thyroid Hormone Action
2012
Immunofluorescence localization of thyroid hormone receptor protein beta 1 and variant alpha 2 in selected tissues: cerebellar Purkinje cells as a model for beta 1 receptor-mediated developmental effects of thyroid hormone in brain.
1991
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice
2003
Thyroid hormone alters the DNA binding properties of chicken thyroid hormone receptors α and β
1992
Molecular Aspects of Thyroid Hormone Actions
2010
In Vivo Activity of the Thyroid Hormone Receptor β- and α-Selective Agonists GC-24 and CO23 on Rat Liver, Heart, and Brain
2011
Reversing cerebellar long-term depression
2003 StandoutNobel
CaV1.3 Channels Are Essential for Development and Presynaptic Activity of Cochlear Inner Hair Cells
2003
Molecular Basis of Thyroid Hormone-Dependent Brain Development*
1997
Thyroid Hormone and the Energetic Cost of Keeping Body Temperature
2005
Thyroid Hormone Reduces Cholesterol via a Non-LDL Receptor-Mediated Pathway
2012
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles
2001
Heterodimeric interaction of the retinoic acid and thyroid hormone receptors in transcriptional regulation on the gamma F-crystallin everted retinoic acid response element.
1994
Genetics of Sensory Mechanotransduction
2002 StandoutNobel
Works of Douglas Forrest being referenced
Retarded Developmental Expression and Patterning of Retinal Cone Opsins in Hypothyroid Mice
2008
Making the gradient: Thyroid hormone regulates cone opsin expression in the developing mouse retina
2006
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin
1999
Beta receptor isoforms are not essential for thyroid hormone-dependent acceleration of PCP-2 and myelin basic protein gene expression in the developing brains of neonatal mice
1998
A thyroid hormone receptor that is required for the development of green cone photoreceptors
2001
International Union of Pharmacology. LIX. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Thyroid Hormone Receptors
2006
An Intron Control Region Differentially Regulates Expression of Thyroid Hormone Receptor β2 in the Cochlea, Pituitary, and Cone Photoreceptors
2007
An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons
2013
Functions of Thyroid Hormone Receptors in Mice
2000
Multigenic control of thyroid hormone functions in the nervous system
2008
Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors
2000
Absence of thyroid hormone receptor β–retinoid X receptor interactions in auditory function and in the pituitary–thyroid axis
1998
Thyrotropin Regulation by Thyroid Hormone in Thyroid Hormone Receptor β-Deficient Mice1
1997
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation
1999
Thyroid Hormone Receptor β-Deficient Mice Show Complete Loss of the Normal Cholesterol 7α-Hydroxylase (CYP7A) Response to Thyroid Hormone but Display Enhanced Resistance to Dietary Cholesterol
2000
Ablation of TRα2 and a Concomitant Overexpression of α1 Yields a Mixed Hypo- and Hyperthyroid Phenotype in Mice
2001
Type 3 Deiodinase, a Thyroid-Hormone-Inactivating Enzyme, Controls Survival and Maturation of Cone Photoreceptors
2010
Thyroid hormone receptor β is essential for development of auditory function
1996
Requirement for Thyroid Hormone Receptor β in T3Regulation of Cholesterol Metabolism in Mice
2002
Developmental expression of thyroid hormone receptor β2 protein in cone photoreceptors in the mouse
2009
Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death
1994
The Thyroid and Metabolism: The Action Continues
2008
Neurodevelopmental control by thyroid hormone receptors
2002
The Thyroid Hormone Receptor β Gene: Structure and Functions in the Brain and Sensory Systems
2003
Functional NMDA Receptors Are Transiently Active and Support the Survival of Purkinje Cells in Culture
1996
N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.
1995
Effects of thyroid hormone receptor gene disruption on myosin isoform expression in mouse skeletal muscles
2000
Thyroid hormone receptors in chick retinal development: differential expression of mRNAs for α and N-terminal variant β receptors
1992
Conservation of the c-myc coding sequence in transduced feline v-myc genes
1986
Retardation of Cochlear Maturation and Impaired Hair Cell Function Caused by Deletion of All Known Thyroid Hormone Receptors
2001
Distinct Tissue-Specific Roles for Thyroid Hormone Receptors β and α1 in Regulation of Type 1 Deiodinase Expression
2001
Cerebellar Abnormalities in Mice Lacking Type 3 Deiodinase and Partial Reversal of Phenotype by Deletion of Thyroid Hormone Receptor α1
2012
TRs Have Common and Isoform-Specific Functions in Regulation of the Cardiac Myosin Heavy Chain Genes
2001
Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing
2000
The erbA/thyroid hormone receptor genes in development of the central nervous system.
1994
Retinoid-related orphan nuclear receptor RORβ is an early-acting factor in rod photoreceptor development
2009
Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.
1990
Developmental and Cell-Specific Expression of Thyroid Hormone Transporters in the Mouse Cochlea
2011
Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-β or both α1 and β
1999
Thyroid hormone receptor β-dependent expression of a potassium conductance in inner hair cells at the onset of hearing
1998
Dysfunctions in Mice by NMDA Receptor Point Mutations NR1(N598Q) and NR1(N598R)
2000
Distinct functions for thyroid hormone receptors alpha and beta in brain development indicated by differential expression of receptor genes.
1991
Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.
1996
Selective Activation of Calcium Permeability by Aspartate in Purkinje Cells
1996 Science
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
2004
Genetic analysis of thyroid hormone receptors in development and disease.
1996
Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes.
1990