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The history, properties, and biological effects of cachectin
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Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
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High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC
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Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
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The Hallmarks of Cancer
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Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development
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Molecular basis of ancestral vertebrate electroreception
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Induction of Germline Transcription in the TCRγ Locus by Stat5
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Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture
1992
Distinct Roles of the Phosphatidylinositol 3-Kinase and STAT5 Pathways in IL-7-Mediated Development of Human Thymocyte Precursors
1999
Interstitial cells of Cajal in human colon and in Hirschsprung's disease
1996
Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count
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Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice
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Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
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The Molecular Architecture of Ribbon Presynaptic Terminals
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Self Renewal of Embryonic Stem Cells in the Absence of Feeder Cells and Exogenous Leukaemia Inhibitory Factor
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The c-kit receptor is involved in the adhesion of mouse primordial germ cells to somatic cells in culture
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Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses
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The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression
1997
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
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Long-term proliferation of mouse primordial germ cells in culture
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Lymphocyte Development from Stem Cells
1992
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling
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Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice
1997
Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice
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Taking dendritic cells into medicine
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Generation of germline-competent induced pluripotent stem cells
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Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
1995
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor
1993
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
Embryonic Germ Cell Lines and Their Derivation from Mouse Primordial Germ Cells
2007
Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
1995
Effects of the steel gene product on mouse primordial germ cells in culture
1991 Nature
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
2011 StandoutNobel
Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice
1997
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
1997 Standout
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
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The c-kit+ Maturation Pathway in Mouse Thymic T Cell Development: Lineages and Selection
1996
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
2005 Nature
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm
1996
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
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Cytokine and Cytokine Receptor Pleiotropy and Redundancy
2002
IL-7 Receptor and VDJ Recombination: Trophic Versus Mechanistic Actions
1997
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Localization of mRNA for c-kit receptor and its ligand in the brain of adult rats: an analysis using in situ hybridization histochemistry
1992
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
1997 StandoutNature
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
2002 Standout
Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
1998 Nature
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
1997 Standout
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
1992
Germ Cells
1999
Development of hematopoietic stem cell activity in the mouse embryo
1994
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation
1997
Unraveling B-1 progenitors
2007
Role of Fibroblast Growth Factors and Their Receptors in Mouse Primordial Germ Cell Growth1
1998
The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution
1989
Mouse hematopoietic stem cells and the interaction ofc‐kirreceptor and steel factor
1991
Multilineage Potential of Adult Human Mesenchymal Stem Cells
1999 StandoutScience
Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.
1993
Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis From Primitive Cells in Normal Human Bone Marrow Transplanted Into Immunodeficient Mice
1997
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
2003 StandoutNobel
Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.
1994
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Interleukin 7 receptor-deficient mice lack gammadelta T cells.
1996
Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF
2000
Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.
1992
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors
1996 StandoutScienceNobel
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
1989
The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development
1999
Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells
1996
Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys
2003
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
1992 StandoutNobel
IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.
1999
Early T Lymphocyte Progenitors
1996
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.
1996
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.
1995
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.
1988 StandoutNobel
Primitive Human Hematopoietic Cells Are Enriched in Cord Blood Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay
1997
Role of leukemia inhibitory factor and its receptor in mouse primordial germ cell growth
1994
Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
1997
Quality Control by DNA Repair
1999 StandoutScienceNobel
Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors
2005
The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid Predendritic Cells Are within the Bone Marrow Hemopoietic Precursors Expressing Flt3
2003
Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
1996
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
1995
Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.
1996
The future of cloning
1999 StandoutNatureNobel
Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: a Kit-KL interaction critical for meiosis
1998
Induction of Germline Transcription in the Human TCRγ Locus by STAT5
2001 StandoutNobel
Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
1994
Expression of Thy-1 on human hematopoietic progenitor cells.
1993
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
2012
Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice
1994
Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors
1998 StandoutScience
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.
1995
IL-7 Induces Immunological Improvement in SIV-Infected Rhesus Macaques under Antiviral Therapy
2006 StandoutNobel
Requirement of Mip-1α for an Inflammatory Response to Viral Infection
1995 StandoutScienceNobel
Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
1991
Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice
1999
Control of T Cell Development In Vivo by Subdomains Within the IL-7 Receptor α-Chain Cytoplasmic Tail
2001
Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype
2002
Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells
1990
Effects of IL-7 on Early Human Thymocyte Progenitor Cells In Vitro and in SCID-hu Thy/Liv Mice
2003
Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3
1995 Science
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- γc-/- mice: functional inactivation of p53 in developing T cells
2004
Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity.
1999
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
FLT3 ligand and not TSLP is the key regulator of IL-7–independent B-1 and B-2 B lymphopoiesis
2008
Role of Bcl-2 in αβ T Cell Development in Mice Deficient in the Common Cytokine Receptor γ-Chain: The Requirement for Bcl-2 Differs Depending on the TCR/MHC Affinity
1999
Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function
1991
Phase I study of recombinant tumor necrosis factor in cancer patients.
1987
Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain
1996
Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo
1993
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Hematopoietic cytokines
2008
Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
1995
The ter mutation responsible for germ cell deficiency but not testicular nor ovarian teratocarcinogenesis in ter / ter congenic mice
1996
The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.
1996
Of Mice and Not Men: Differences between Mouse and Human Immunology
2004 Standout
Transcriptional Control of Early B Cell Development
2004
IL-2Rβ/IL-7Rα Doubly Deficient Mice Recapitulate the Thymic and Intraepithelial Lymphocyte (IEL) Developmental Defects of γc−/− Mice: Roles for Both IL-2 and IL-15 in CD8αα IEL Development
1999
Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor
2000
Expression and function of c-kit in hemopoietic progenitor cells.
1991
Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
2003
The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice
1996
The Common Cytokine Receptor γ Chain Controls Survival of γ/δ T Cells
1997
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia
1996
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility
1998
Derivation of pluripotent stem cells from cultured human primordial germ cells
1998
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Secretory products of macrophages.
1987 Standout
Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.
1995
Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.
1991
IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
2005
Defective Development of γ/δ T Cells in Interleukin 7 Receptor–Deficient Mice Is Due to Impaired Expression of T Cell Receptor γ Genes
1999
Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
1994 StandoutScience
Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines
1994
Genes, pathways and checkpoints in lymphocyte development and homeostasis
2005
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells.
1995
IL-7 Enhances the Survival and Maintains the Size of Naive T Cells
2001
Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7−/− Mice
2001
Soluble receptors for cytokines and growth factors: generation and biological function
1994
Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
1994
Effects of exogenous interleukin-7 on human thymus function
2002
Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
1996
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
2002 StandoutNobel
The effect of in vivo IL-7 deprivation on T cell maturation.
1995
Differential Roles of Cytokine Receptors in the Development of Epidermal γδ T Cells
2001 StandoutNobel
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Complementary Signaling through flt3 and Interleukin-7 Receptor α Is Indispensable for Fetal and Adult B Cell Genesis
2003
Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development
2003
Works of Douglas E. Williams being referenced
Requirement for mast cell growth factor for primordial germ cell survival in culture
1991 Nature
Characterization of thymic stromal‐derived lymphopoietin (TSLP) in murine B cell development in vitro
1996
Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells
1993
Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
1990
Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis
1993
Steel Factor (c-kit Ligand) Stimulates the in Vitro Growth of Immature CD3-/CD4-/CD8- Thymocytes: Synergy with IL-7
1994
The production of myeloid blood cells and their regulation during health and disease
1988
Splice-Site A Choice Targets Plasma-Membrane Ca2+-ATPase Isoform 2 to Hair Bundles
2006
Recombinant murine steel factor stimulates in vitro production of granulocyte–macrophage progenitor cells
1992
Identification of a ligand for the c-kit proto-oncogene
1990
Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony-stimulating factor-1, and recombinant murine granulocyte-macrophage colony-stimulating factor on myelopoiesis in mice.
1987
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
1994
The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma.
1986
Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein.
1991
Leukemia inhibitory factor improves survival of retroviral vector-infected hematopoietic stem cells in vitro, allowing efficient long-term expression of vector-encoded human adenosine deaminase in vivo.
1991
Flt3 Ligand Synergizes With Granulocyte-Macrophage Colony-Stimulating Factor or Granulocyte Colony-Stimulating Factor to Mobilize Hematopoietic Progenitor Cells Into the Peripheral Blood of Mice
1997
The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells.
1991
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
1991
c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas.
1992
Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.
1992
Interactions between purified murine colony-stimulating factors (natural CSF-1, recombinant GM-CSF, and recombinant IL-3) on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells.
1987
Administration of IL-7 to normal mice stimulates B-lymphopoiesis and peripheral lymphadenopathy
1991
A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells.
1994
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.
1991
The Steel/W Transduction Pathway: Kit Autophosphorylation and Its Association with a Unique Subset of Cytoplasmic Signaling Proteins Is Induced by the Steel Factor
1991
Macrophage inflammatory protein (MIP)-1 beta abrogates the capacity of MIP-1 alpha to suppress myeloid progenitor cell growth.
1991
Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor
2000
Cytokine Stimulation of Multilineage Hematopoiesis from Immature Human Cells Engrafted in SCID Mice
1992 Science