Citation Impact
Citing Papers
Reduced Paneth cell α-defensins in ileal Crohn's disease
2005
Discovery of five conserved β-defensin gene clusters using a computational search strategy
2002
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3
2003
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
2012 StandoutScience
Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.
1994
The N-terminal Domain of Drosophila Gram-negative Binding Protein 3 (GNBP3) Defines a Novel Family of Fungal Pattern Recognition Receptors
2009 StandoutNobel
Cationic Bactericidal Peptides
1995
BALB/c Mice Bearing a Transgenic IL-12 Receptor β2 Gene Exhibit a Nonhealing Phenotype to Leishmania major Infection Despite Intact IL-12 Signaling
2001
Cytokine Expression by Murine DX5+ Cells in Response to IL-12, IL-18, or the Combination of IL-12 and IL-18
2001
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
2000
Lessons learnt from studies of the immune characterization of naturally SIV infected Sooty Mangabeys
2003
Human Enteric Defensins
1996
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Nucleotide signalling during inflammation
2014 StandoutNature
Defensins
1994
Innate antimicrobial host defense in small intestinal Crohn's disease
2009
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Paneth Cell Defensins and Innate Immunity of the Small Bowel
2001
The immunology of susceptibility and resistance to Leishmania major in mice
2002 Standout
Expression of human α-defensin 5 (HD5) mRNA in nasal and bronchial epithelial cells
2000
Defensins: antimicrobial peptides of innate immunity
2003 Standout
Defensins in granules of phagocytic and non-phagocytic cells
1995
Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation
1998
Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis
1997
Murine ??-Defensin-3 Is an Inducible Peptide with Limited Tissue Expression and Broad-Spectrum Antimicrobial Activity
2002
Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites
2012
Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator
2001
hBD‐1: a novel β‐defensin from human plasma
1995
Human β-defensins
2006
Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores
1994
A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide
1999
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
Inflammatory Bowel Disease
2009 Standout
Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin
1994 StandoutNobel
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
2007 StandoutNature
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
2003 Nature
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Expression of the antimicrobial peptide α-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice
2010
A Novel Murine β-Defensin Expressed in Tongue, Esophagus, and Trachea
2000
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
2001 StandoutNature
Cloning and Expression of Bovine Neutrophil β-Defensins
1999
Plant Defensins: Novel Antimicrobial Peptides as Components of the Host Defense System
1995
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
The immune response of Drosophila
2003 StandoutNatureNobel
Administration of plasmids expressing interleukin‐4 and interleukin‐10 causes BALB/c mice to induce a T helper 2‐type response despite the expected T helper 1‐type response with a low‐dose infection ofLeishmania major
2002
Mapping of the Gene Encoding Human β-Defensin-2 (DEFB2) to Chromosome Region 8p22–p23.1
1997
A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
1998
The mouse genome encodes a single homolog of the antimicrobial peptide human β‐defensin 1
1997
Discovery of new human β-defensins using a genomics-based approach
2001
Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3
2008 StandoutNobel
The Human β-Defensin-1 and α-Defensins Are Encoded by Adjacent Genes: Two Peptide Families with Differing Disulfide Topology Share a Common Ancestry
1997
Paneth Cell α-Defensin Synthesis and Function
2006
Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.
1998
Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins
1993
Structure–activity studies on magainins and other host defense peptides
1995
Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic
2001
Molecular cloning and tissue expression of porcine β‐defensin‐1
1998
A 450-kb contig of defensin genes on human chromosome 8p23
1999
Isolation of human intestinal defensins from ileal neobladder urine
1998
Expression of Antimicrobial Defensins in the Male Reproductive Tract of Rats, Mice, and Humans1
2003
Primate defensins
2004
NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression
2004
Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
2005 StandoutNobel
CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium
2000
Antimicrobial peptides of multicellular organisms
2002 StandoutNature
Innate Immunity
1996 StandoutNobel
Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid
1996
The Isolation and Characterization of a Novel Corticostatin/Defensin-like Peptide from the Kidney
1996
Structure and dynamics of the neutrophil defensins NP‐2, NP‐5, and HNP‐1: NMR studies of amide hydrogen exchange kinetics
1994
Dermcidin: a novel human antibiotic peptide secreted by sweat glands
2001
Paneth cell trypsin is the processing enzyme for human defensin-5
2002
Inheritance of Unequal Numbers of the Genes Encoding the Human Neutrophil Defensins HP-1 and HP-3
1995
Hypertonic Induction of Aquaporin-5 Expression through an ERK-dependent Pathway
2000 StandoutNobel
Antimicrobial Peptides: An Emerging Concept in Cutaneous Biology
1998
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Mucoid Pseudomonas aeruginosa , TNF- α , and IL-1 β , but Not IL-6, Induce Human β -Defensin-2 in Respiratory Epithelia
2000
Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion
2001
Detection of Cryptdin in Mouse Skin
1999
Leishmania species: models of intracellular parasitism
1999
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
2009 StandoutNobel
Epithelial antibiotic induced in states of disease
1997
In BALB/c Mice, IL-4 Production During the Initial Phase of Infection withLeishmania majorIs Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive Disease
2000
Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells
2000
Expression of β-Defensin Genes in Bovine Alveolar Macrophages
1998
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.
1996 StandoutNobel
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males
2007 StandoutNobel
Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation
2002
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha
1996
Transcriptional Regulation of β-Defensin Gene Expression in Tracheal Epithelial Cells
2000
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Epithelial Antibiotics Induced at Sites of Inflammation
1995 Science
Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium
1999
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Mouse β-Defensin 1 Is a Salt-Sensitive Antimicrobial Peptide Present in Epithelia of the Lung and Urogenital Tract
1998
Commensal Host-Bacterial Relationships in the Gut
2001 StandoutScience
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
2004 StandoutNobel
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
2000 StandoutNobel
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
2004 StandoutNobel
The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting
1995
Production of β-defensins by human airway epithelia
1998
Molecular Cloning and Characterization of Rat Genes Encoding Homologues of Human β-Defensins
1999
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
2005 StandoutScience
The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations
2000
Midgut-specific immune molecules are produced by the blood-sucking insect Stomoxys calcitrans
1997
Peptide Antibiotics and Their Role in Innate Immunity
1995 Standout
The synthesis of antimicrobial peptides in the skin of Rana esculenta is stimulated by microorganisms
2001
IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection
2000
An essential amino acid induces epithelial β-defensin expression
2000
Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial
1997
JNK1 Is Required for T Cell-Mediated Immunity AgainstLeishmania majorInfection
2000
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
1999 StandoutScience
Gallinacin-3, an Inducible Epithelial β-Defensin in the Chicken
2001
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.
1999
Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms
1994
Mechanisms for induction of acquired host immunity by neutrophil peptide defensins
1999
Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
2005 StandoutNobel
Adrenomedullin, a Multifunctional Regulatory Peptide*
2000
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
Peptide Localization and Gene Structure of Cryptdin 4, a Differentially Expressed Mouse Paneth Cell α-Defensin
1999
The structure of neutrophil defensin genes
1993
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
1995 StandoutNobel
Differential Scanning Microcalorimetry Indicates That Human Defensin, HNP-2, Interacts Specifically with Biomembrane Mimetic Systems,
1997
Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.
1998
Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells
1996
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
1998 StandoutNobel
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
Isolation, Characterization, cDNA Cloning, and Antimicrobial Properties of Two Distinct Subfamilies of α-Defensins from Rhesus Macaque Leukocytes
1999
Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.
1996
Works of Douglas E. Jones being referenced
Host susceptibility factors to cutaneous leishmaniasis
1998
Human Enteric Defensin Genes: Chromosomal Map Position and a Model for Possible Evolutionary Relationships
1996
Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel
1993
Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response.
1997
Paneth cells of the human small intestine express an antimicrobial peptide gene
1992
Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene.
1993
Enteric β-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum Infection
1998
Differential Regulation of the Interleukin-12 Receptor during the Innate Immune Response toLeishmania major
1998
MACROPHAGE KILLING OF LEISHMANIA AMAZONENSIS AMASTIGOTES REQUIRES BOTH NITRIC OXIDE AND SUPEROXIDE
2007