Standout Papers
Citation Impact
Citing Papers
TRP channel activation by reversible covalent modification
2006 StandoutNobel
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
2017 StandoutScienceNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription
2007
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
2007
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
A primer on ankyrin repeat function in TRP channels and beyond
2008
Collapse Precedes Folding in Denaturant-Dependent Assembly of Ubiquitin
2017
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex
2008
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Calorimetric study of a series of designed repeat proteins: Modular structure and modular folding
2010
How Initiation Factors Maximize the Accuracy of tRNA Selection in Initiation of Bacterial Protein Synthesis
2006
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Folding and Unfolding Mechanism of Highly Stable Full-Consensus Ankyrin Repeat Proteins
2007
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Slow formation of aggregation‐resistant β‐sheet folding intermediates
2009
Target Selectivity of Vertebrate Notch Proteins
2005
Designing repeat proteins: a modular approach to protein design
2017
The ankyrin repeat as molecular architecture for protein recognition
2004
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
How, when and why proteins collapse: the relation to folding
2011
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Tandem repeats in proteins: From sequence to structure
2011
Hemoglobin: Structure, Function and Allostery
2020
Compact Intermediate States in Protein Folding
1995
The nature of protein folding pathways: The classical versus the new view
1995
Microsecond Barrier-Limited Chain Collapse Observed by Time-Resolved FRET and SAXS
2014
Principles of protein folding — A perspective from simple exact models
1995
Designing Repeat Proteins: Well-expressed, Soluble and Stable Proteins from Combinatorial Libraries of Consensus Ankyrin Repeat Proteins
2003
Protein folding and misfolding: mechanism and principles
2007
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force
2017
Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex
2006
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli
2011
Engineering and functionalization of large circular tandem repeat protein nanoparticles
2020
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Anchoring Notch Genetics and Biochemistry
2004
Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes
2006
Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding
1995 Standout
Chapter 23 Solvent Denaturation of Proteins and Interpretations of the m Value
2009
Low-N protein engineering with data-efficient deep learning
2021
The barriers in protein folding
1994
Packing interactions in the apomyglobin folding intermediate
1996
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Excess information at bacteriophage T7 genomic promoters detected by a random cloning technique
1989
Role of electrostatic repulsion in the acidic molten globule of cytochrome c
1991
The coming of age of de novo protein design
2016 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Partially Folded States of Proteins: Characterization by X-ray Scattering
1995
A Method to Configure Protein Side-chains from the Main-chain Trace in Homology Modelling
1993
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helixes of myoglobin
1993
Extremely rapid protein folding in the absence of intermediates
1995
Linking folding and binding
2009
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
Overcoming Hysteresis to Attain Reversible Equilibrium Folding for Outer Membrane Phospholipase A in Phospholipid Bilayers
2011
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
2007 StandoutNobel
Structure and stability of the molten globule state of guinea pig .alpha.-lactalbumin: A hydrogen exchange study
1993
Modular peptide binding: From a comparison of natural binders to designed armadillo repeat proteins
2013
Beyond Consensus: Statistical Free Energies Reveal Hidden Interactions in the Design of a TPR Motif
2004
Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA
2006
Design of multi-scale protein complexes by hierarchical building block fusion
2021 StandoutNobel
Designed Armadillo Repeat Proteins: Library Generation, Characterization and Selection of Peptide Binders with High Specificity
2012
Structural and Functional Studies of RegB, a New Member of a Family of Sequence-specific Ribonucleases Involved in mRNA Inactivation on the Ribosome
2006
DARPins and other repeat protein scaffolds: advances in engineering and applications
2011
Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization
2004
Artificial leucine rich repeats as new scaffolds for protein design
2011
Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches
2008
De novo proteins from designed combinatorial libraries
2004
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Intrinsic Stability of Individual α Helices Modulates Structure and Stability of the Apomyoglobulin Molten Globule Form
1995
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Structural basis for messenger RNA movement on the ribosome
2006 Nature
Mutational and Energetic Studies of Notch1 Transcription Complexes
2007
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Designing Repeat Proteins: Modular Leucine-rich Repeat Protein Libraries Based on the Mammalian Ribonuclease Inhibitor Family
2003
Relating sequence encoded information to form and function of intrinsically disordered proteins
2015
Translocation gets a push
1994 StandoutNobel
Protein folding dynamics: The diffusion‐collision model and experimental data
1994
A General Computational Approach for Repeat Protein Design
2014 StandoutNobel
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
De novo protein design by deep network hallucination
2021 StandoutNatureNobel
More complicated than it looks: assembly of Notch pathway transcription complexes
2008
Nanospring behaviour of ankyrin repeats
2006 Nature
Cold Denaturation of the Molten Globule States of Apomyoglobin and a Profile for Protein Folding
1994
Computational design of a leucine-rich repeat protein with a predefined geometry
2014
PROTEIN FOLDING: The Endgame
1997 StandoutNobel
From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display
2013
Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering
2012
Peroxidase Activity of Myoglobin Is Enhanced by Chemical Mutation of Heme-Propionates
1999 StandoutNobel
Initiation of Protein Synthesis in Bacteria
2005
Evolutionary Conservation of Reactions in Translation
2002
Consensus-derived structural determinants of the ankyrin repeat motif
2002
Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase
1990 StandoutScience
Benchmarking all-atom simulations using hydrogen exchange
2014
Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragment
2014
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
THE STEREOCHEMICAL MECHANISM OF THE COOPERATIVE EFFECTS IN HEMOGLOBIN REVISITED
1998
How molten is the molten globule?
1996
Constructing the equilibrium ensemble of folding pathways from short off-equilibrium simulations
2009
Deep penetration of a portion of Escherichia coli SecA protein into model membranes is promoted by anionic phospholipids and by partial unfolding.
1992
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
How Fast-Folding Proteins Fold
2011 Science
Designed Protein Cages as Scaffolds for Building Multienzyme Materials
2020
Side-chain hydrophobicity scale derived from transmembrane protein folding into lipid bilayers
2011
The molten globule state of α‐lactalbumin
1996
Ankyrin Repeat: A Unique Motif Mediating Protein−Protein Interactions
2006
Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel
2012
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
The Protein Folding Problem
2008
Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin
1993 Science
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Works of Doug Barrick being referenced
Consensus sequence design as a general strategy to create hyperstable, biologically active proteins
2019
An experimentally determined protein folding energy landscape
2004
Insertion of Endocellulase Catalytic Domains into Thermostable Consensus Ankyrin Scaffolds: Effects on Stability and Cellulolytic Activity
2013
Synergistic enhancement of cellulase pairs linked by consensus ankyrin repeats: Determination of the roles of spacing, orientation, and enzyme identity
2016
A test of the role of the proximal histidines in the Perutz model for cooperativity in haemoglobin
1997
The Leucine-Rich Repeat Domain of Internalin B Folds along a Polarized N-Terminal Pathway
2008
Structure and Notch Receptor Binding of the Tandem WWE Domain of Deltex
2005
Effect of Multiple Prolyl Isomerization Reactions on the Stability and Folding Kinetics of the Notch Ankyrin Domain: Experiment and Theory
2005
Quantitative analysis of ribosome binding sites in E.coli
1994
A Naturally Occurring Repeat Protein with High Internal Sequence Identity Defines a New Class of TPR-like Proteins
2015
Protein Folding and Stability Using Denaturants
2007
Structure and stability of the ankyrin domain of the Drosophila Notch receptor
2003
Repeat-protein folding: New insights into origins of cooperativity, stability, and topology
2007
Folding thermodynamics and kinetics of the leucine‐rich repeat domain of the virulence factor Internalin B
2007
The Notch Ankyrin Domain Folds via a Discrete, Centralized Pathway
2006
The Tolerance of a Modular Protein to Duplication and Deletion of Internal Repeats
2004
Experimental Characterization of the Folding Kinetics of the Notch Ankyrin Domain
2005
The folding of single domain proteins—have we reached a consensus?
2010
The molten globule intermediate of apomyoglobin and the process of protein folding
1993
Probing the stability of a partly folded apomyoglobin intermediate by site-directed mutagenesis
1991
Measuring the stability of partly folded proteins using TMAO
2003
Three-state analysis of sperm whale apomyoglobin folding
1993
Molecular Mechanisms of Acid Denaturation
1994
The Contribution of Entropy, Enthalpy, and Hydrophobic Desolvation to Cooperativity in Repeat-Protein Folding
2011
Translation initiation in Escherichia coli: sequences within the ribosome‐binding site
1992
Thermodynamics, Kinetics, and Salt dependence of Folding of YopM, a Large Leucine-rich Repeat Protein
2008
Quantitative Dissection of the Notch:CSL Interaction: Insights into the Notch-mediated Transcriptional Switch
2006
Effects of Linker Length and Transient Secondary Structure Elements in the Intrinsically Disordered Notch RAM Region on Notch Signaling
2015
Folding landscapes of ankyrin repeat proteins: experiments meet theory
2008
Enhancing the Stability and Folding Rate of a Repeat Protein through the Addition of Consensus Repeats
2006
Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
2002
Studies of the Ankyrin Repeats of the Drosophila melanogaster Notch Receptor. 2. Solution Stability and Cooperativity of Unfolding
2001
Nonspecific hydrophobic interactions stabilize an equilibrium intermediate of apomyoglobin at a key position within the AGH region
2004
Histidine 82 influences heme orientational isomerism in sperm whale myoglobin. Long-range effect due to mutation of a conserved residue
1992
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
Predicting coupling limits from an experimentally determined energy landscape
2007
Urea unfolding of peptide helices as a model for interpreting protein unfolding.
1995
Studies of the Ankyrin Repeats of the Drosophila melanogaster Notch Receptor. 1. Solution Conformational and Hydrodynamic Properties
2001
The Association Rate Constant for Heme Binding to Globin Is Independent of Protein Structure
1996
The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder
2008
Capping motifs stabilize the leucine‐rich repeat protein PP32 and rigidify adjacent repeats
2014