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Citing Papers
Active site residues in m‐calpain: identification by site‐directed mutagenesis
1995
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
2012 StandoutScienceNobel
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
Tumour-cell invasion and migration: diversity and escape mechanisms
2003 Standout
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
1990 StandoutNature
Acyl-CoA-binding Protein Is a Potent m-Calpain Activator
2000
Molecular and Functional Properties of a Calpain Activator Protein Specific for μ-Isoforms
1998
Cleavage of the calpain inhibitor, calpastatin, during apoptosis
1998
The Bovine Calpastatin Gene Promoter and a New N-terminal Region of the Protein Are Targets for cAMP-dependent Protein Kinase Activity
1998
Calmodulin-binding proteins as calpain substrates
1989
Regulation of Cell Migration by the Calcium-dependent Protease Calpain
1997
cAMP responsiveness of the bovine calpastatin gene promoter
1998
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
DEFECTIVE KERNEL1 (DEK1) Regulates Cell Walls in the Leaf Epidermis
2016
Immunoaffinity purification of the calpains
2002
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
Properties of calpastatin forms in rat brain
1998
CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis
1990 StandoutNobel
Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation
1999
A new mechanism of methylprednisolone and other corticosteroids action demonstrated in vitro: inhibition of a proteinase (calpain) prevents myelin and cytoskeletal protein degradation
1997
The multicatalytic proteinase complex, a major extralysosomal proteolytic system
1990
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
1988 Standout
Dissociation of m-Calpain Subunits Occurs after Autolysis of the N-Terminus of the Catalytic Subunit, and Is Not Required for Activation
2001
Regulation of cell death: the calcium–apoptosis link
2003 Standout
Are there multiple proteolytic pathways contributing to c-Fos, c-Jun and p53 protein degradation in vivo?
1999
Organization of the Functional Domains in Membrane Cytoskeletal Protein Talin1
1995
Chicken skeletal muscle has three Ca2+-dependent proteinases
1989
Molecular Cloning and Characterization of cDNAs for the μ-Type Large Subunit and the Small Subunit of Chicken Calpain
1997
A novel human small subunit of calpains
2002
Functional Defects of a Muscle-specific Calpain, p94, Caused by Mutations Associated with Limb-Girdle Muscular Dystrophy Type 2A
1998
Bovine skeletal muscle calpastatin: cloning, sequence analysis, and steady-state mRNA expression
1994
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease
1997
Effects of Epinephrine Infusion on Expression of Calpastatin in Porcine Cardiac and Skeletal Muscle
2000
Characterization of a Human Digestive Tract-Specific Calpain, nCL-4, Expressed in the Baculovirus System
1999
Calpain Inhibition Decreases the Growth Rate of Mammalian Cell Colonies
2002
Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes
1997
Immunoaffinity purification of calpastatin and calpastatin constructs
2002
Four Types of Calpastatin Isoforms with Distinct Amino-Terminal Sequences Are Specified by Alternative First Exons and Differentially Expressed in Mouse Tissues
2000
Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis
1995
Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?
1992
Rat brain contains multiple mRNAs for calpastatin1
1998
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts
1996
Cleavage of Doublecortin-like Kinase by Calpain Releases an Active Kinase Fragment from a Microtubule Anchorage Domain
2001
Participation of the conventional calpains in apoptosis
2002
Microinjection of Calpastatin Inhibits Fusion in Myoblasts
1999
Multiple forms of rat calpastatin cDNA in the coding region of functionally unknown amino-terminal domain
1992
Identification of a Novel, Tissue-Specific Calpainhtra-3;a Human Homologue of theCaenorhabditis elegansSex Determination Gene
1997
A New Subfamily of Vertebrate Calpains Lacking a Calmodulin-Like Domain: Implications for Calpain Regulation and Evolution
1997
Localization of the Ca2+‐dependent proteinases and their inhibitor in normal, fasted, and denervated rat skeletal muscle
1992
Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway
2000
Calpain activation is essential for membrane fusion of erythrocytes in the presence of exogenous Ca2+
1992
A Ca2+ Switch Aligns the Active Site of Calpain
2002
Characterization and Expression of Calpain 10
2001
Molecular cloning and sequence analysis of a calcium-activated neutral protease (calpain) from Schistosoma mansoni
1991
Comparison of the Effect of Calpain Inhibitors on Two Extralysosomal Proteinases: The Multicatalytic Proteinase Complex and m‐Calpain
1994
Free calcium and calpain I activity
1991
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
Molecular Cloning and Characterization of a Novel Tissue-Specific Calpain Predominantly Expressed in the Digestive Tract
1998
Subcellular Localization and in VivoSubunit Interactions of Ubiquitous μ-Calpain
2003
Regulation of Cyclin D1 by Calpain Protease
1997
Ca 2+ -induced structural changes in rat m -calpain revealed by partial proteolysis
2001
An endogenous inhibitor of calcium‐activated neutral protease in UMX 7.1 hamster dystrophy
1991
Phosphorylation of rat brain calpastatins by protein kinase C
1999
Calpain inhibition: an overview of its therapeutic potential
1994
Cleavage of Focal Adhesion Kinase by Different Proteases during Src-regulated Transformation and Apoptosis
2001
Regulation of activity of calcium activated neutral protease
1988
Neuronal Nitric Oxide Synthase and Calmodulin‐Dependent Protein Kinase IIα Undergo Neurotoxin‐Induced Proteolysis
1997
Cell-matrix contact structures
2001
Accumulation of non‐erythroid αII‐spectrin and calpain‐cleaved αII‐spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats
2001
On the involvement of calpains in the degradation of the tumor suppressor protein p53
1997 StandoutNobel
Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts
2001
Nanometer Analysis of Cell Spreading on Matrix-Coated Surfaces Reveals Two Distinct Cell States and STEPs
2004
Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
2000
Spectrin: a structural mediator between diverse plasma membrane proteins and the cytoplasm
1990
Calcium‐activated neutral proteinase (CANP; calpain) activity in Schwann cells: Immunofluorescence localization and compartmentation of μ‐ and mCANP
1991
Calpain activation in apoptosis
1994
Mapping of calpastatin and three microsatellites to porcine chromosome 2q2.1-q2.4
1998
Some properties of the millimolar Ca2+-dependent proteinase from bovine cardiac muscle
1988
Binding sites for calcium-activated neutral protease on erythrocyte membranes are not membrane phospholipids
1990
Calpastatin Expression in Porcine Cardiac and Skeletal Muscle and Partial Gene Structure
2001
Comparative studies of Ca2+-dependent proteases (CDP I and CDP II) from Allomyces arbuscula
1999
Autolysis of µ- and m-Calpain from Bovine Skeletal Muscle
2001
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Adhesion receptors of the immune system
1990 StandoutNature
Inhibition of Calpain Blocks Platelet Secretion, Aggregation, and Spreading
1999
Regulation of the mevalonate pathway
1990 StandoutNature
Muscle-Specific Calpain, p94, Interacts with the Extreme C-Terminal Region of Connectin, a Unique Region Flanked by Two Immunoglobulin C2 Motifs
1997
Expression of three calpain isoform genes in human skeletal muscles
1998
Calpains: Intact and active?
1997
Failure to find Ca2+-dependent proteinase (calpain) activity in a plant species,
1989
Autolysis, Ca2+ Requirement, and Heterodimer Stability in m-Calpain
1997
Calpain concentration is elevated although net calcium-dependent proteolysis is suppressed in dystrophin-deficient muscle
1992
Calpain
2002
Cytoskeletal dynamics and nerve growth
1988
Calpastatin Is Up-regulated in Response to Hypoxia and Is a Suicide Substrate to Calpain after Neonatal Cerebral Hypoxia-Ischemia
1999
Generation of spectrin breakdown products in peripheral nerves by addition of M-calpain
1999
The Sequence of Porcine Protein NH2-terminal Asparagine Amidohydrolase
1995
The Endoplasmic Reticulum Chaperone Glycoprotein GRP94 with Ca2+-binding and Antiapoptotic Properties Is a Novel Proteolytic Target of Calpain during Etoposide-induced Apoptosis
1999
Development and Therapeutic Potential of Calpain Inhibitors
1996
Calpains and muscular dystrophies
2000
Calpain Mediates Integrin-induced Signaling at a Point Upstream of Rho Family Members
1999
Calpain cleavage of integrin β cytoplasmic domains
1999
Effect of calpain on the composition and structure of postsynaptic densities
1995
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Calpain activation is upstream of caspases in radiation-induced apoptosis
1998
Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts
1990
Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
2009
Calpain Mutants with Increased Ca2+ Sensitivity and Implications for the Role of the C2-like Domain
2001
Structure of the Calmodulin αII-Spectrin Complex Provides Insight into the Regulation of Cell Plasticity
2006 StandoutNobel
Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Clots
1997
Calpain‐induced proteolysis of β‐spectrins
1999
Purification of Active Calpain by Affinity Chromatography on an Immobilized Peptide Inhibitor
1996
Functional Properties of Recombinant Calpain I and of Mutants Lacking Domains III and IV of the Catalytic Subunit
1997
Characterization of Monoclonal Antibodies to Calpain 3 and Protein Expression in Muscle from Patients with Limb-Girdle Muscular Dystrophy Type 2A
1998
Cutting to the chase: calpain proteases in cell motility
2002
Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain
2001
Changes in calpain during meiosis in the rat egg
1997
Characterization of Ca2+-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni
1993
Evidence for a Calpeptin-sensitive Protein-tyrosine Phosphatase Upstream of the Small GTPase Rho
1999
Partial Purification and Characterization of a Ca2+-Dependent Proteinase fromArabidopsisRoots
1997
A BODIPY Fluorescent Microplate Assay for Measuring Activity of Calpains and Other Proteases
2000
In VitroGeneration of an Active Calmodulin-Independent Phosphodiesterase from Brain Calmodulin-Dependent Phosphodiesterase (PDE1A2) by m-Calpain
1998
Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling
2001
Isolation of Two Novel Genes, Down‐regulated in Gastric Cancer
2000
Calpain Activity in the Rat Brain after Transient Forebrain Ischemia
2001
β1 Integrin-Mediated T Cell Adhesion and Cell Spreading Are Regulated by Calpain
2000
Modulation of rat brain calpastatin efficiency by post‐translational modifications
1997
Imaging Calpain Protease Activity by Multiphoton FRET in Living Mice
2004
Immunocytochemical localization of Ca2+‐dependent protease from Allomyces arbuscula
1994
A gradient of bicoid protein in Drosophila embryos
1988 StandoutNobel
Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis
1996
Caspase-dependent Activation of Calpain during Drug-induced Apoptosis
1999
The Calpain Small Subunit Gene Is Essential: Its Inactivation Results in Embryonic Lethality
2000
A variety of calpain/calpastatin systems in mammalian erythrocytes
1993
Changes in calpain and calpastatin mRNA induced by β‐adrenergic stimulation of bovine skeletal muscle
1992
Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunit
1993
Cross-talk between Calpain and Caspase Proteolytic Systems During Neuronal Apoptosis
2003
Dissociation and Aggregation of Calpain in the Presence of Calcium
2001
The sensitivity of c-Jun and c-Fos proteins to calpains depends on conformational determinants of the monomers and not on formation of dimers
1999
Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated.
1991
Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions.
1991
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
1991 StandoutNobel
Calpain localization changes in coordination with actin-related cytoskeletal changes during early embryonic development of Drosophila.
1994
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.
1996
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
1986 StandoutScience
Site-directed activation of calpain is promoted by a membrane-associated natural activator protein
1993
Decreased susceptibility to calpains of v -FosFBR but not of v -FosFBJ or v -JunASV17 retroviral proteins compared with their cellular counterparts
1997
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Distinct kinetics of subunit autolysis in mammalian m‐calpain activation
1994
The effects of truncations of the small subunit on m-calpain activity and heterodimer formation
1997
Evidence That β3 Integrin-Induced Rac Activation Involves the Calpain-Dependent Formation of Integrin Clusters That Are Distinct from the Focal Complexes and Focal Adhesions That Form as Rac and Rhoa Become Active
2000
Association of calpain (Ca2+-dependent thiol protease) with its endogenous inhibitor calpastatin in myoblasts
1999
CalpA, a Drosophila Calpain Homolog Specifically Expressed in a Small Set of Nerve, Midgut, and Blood Cells
1995
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
1999 StandoutScience
Purification and autolytic degradation of a calpain-like calcium-dependent proteinase from lobster (Homarus americanus) striated muscle
1993
Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death
2002
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis
1996
Structural modifications associated with the change in Ca2+ sensitivity on activation of m‐calpain
1993
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system
1996
Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB
1995
Review
1995
Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.
1986
Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division
2000
Possible role of calpain I and calpain II in differentiating muscle
1986
Role of arginine-tRNA in protein degradation by the ubiquitin pathway
1987 StandoutNatureNobel
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
1996 Standout
The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.
1996
v-Src-Induced Modulation of the Calpain-Calpastatin Proteolytic System Regulates Transformation
2002
Transient ischemia causes a reduction of Mg2+ blockade of NMDA receptors
1994
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Properties of erythrocyte membrane binding and autolytic activation of calcium-activated neutral protease
1989
Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.
1993
Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice.
2000
Spatial resolution of fodrin proteolysis in postischemic brain.
1993
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog
1987 StandoutNobel
Amino-terminal conserved region in proteinase inhibitor domain of calpastatin potentiates its calpain inhibitory activity by interacting with calmodulin-like domain of the proteinase.
1994
Autolysis parallels activation of μ-calpain
1996
Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIa.
1993
Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments
1998
Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells.
1992 StandoutNobel
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain
1996
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.
1985 StandoutNobel
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
2005 StandoutScience
Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.
1993 StandoutNobel
Purification of μ-Calpain, m-Calpain, and Calpastatin from Animal Tissues
2003
Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase.
1990 StandoutNobel
Purification and characterization of a high molecular weight proteinase (macropain) from human erythrocytes
1986
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.
1987 StandoutNobel
A comparison of the intracellular distribution of μ-calpain, m-calpain, and calpastatin in proliferating human A431 cells
1992
Identification and characterization of developmentally regulated mRNP proteins of Dictyostelium discoideum
1986
The Calpain System
2003 Standout
Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and μ-types
1989
Transplanted Long-Term Cultured Pre-Bi Cells Expressing Calpastatin Are Resistant to B Cell Receptor–Induced Apoptosis
2001
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum
1982 StandoutNatureNobel
Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer
2000 Nobel
Calmodulin-binding domain of recombinant erythrocyte beta-adducin.
1993
Active recombinant rat calpain II. Bacterially produced large and small subunits associate both in vivo and in vitro.
1994
Four Ca2+-dependent proteinase activities isolated from crustacean muscle differ in size, net charge, and sensitivity to Ca2+ and inhibitors.
1986
Identification and properties of the 38000‐M, poly(A)‐binding protein of non‐polysomal messenger ribonucleoproteins of cryptobiotic gastrulae of Artemia salina
1984
Differential degradation of myofibrillar proteins by four calcium‐dependent proteinase activities from lobster muscle
1993
Expression and Functional Characteristics of Calpain 3 Isoforms Generated through Tissue-Specific Transcriptional and Posttranscriptional Events
1999
The calcium-dependent proteolytic system calpain-calpastatin in Drosophila melanogaster
1988
Affinity labelling of the Ca2+-activated neutral proteinase (calpain) in intact human platelets
1993
Molecular diversity in amino-terminal domains of human calpastatin by exon skipping.
1992
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Caspase and calpain substrates: Roles in synaptic plasticity and cell death
1999
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).
1992
Proteolysis by Calpains: a Possible Contribution to Degradation of p53
1997
Analysis of calcium-dependent interaction between amino-terminal conserved region of calpastatin functional domain and calmodulin-like domain of mu-calpain large subunit.
1994
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP.
1981
Amoeboid leukocyte crawling through extracellular matrix: lessons from theDictyosteliumparadigm of cell movement
2001
Calcium-activated neutral protease inhibitor from rabbit erythrocytes lacks the N-terminal region of the liver inhibitor but retains three inhibitory units
1987
The translational inhibitor 10 S cytoplasmic ribonucleoprotein of chick embryonic muscle. Dissociation and reassociation.
1981
Roles of Ubiquitinylation in Proteolysis and Cellular Regulation
1995
In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s).
1991
Delayed Antagonism of Calpain Reduces Excitotoxicity in Cultured Neurons
1995
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
Modulation of Synapse Formation by Cyclic Adenosine Monophosphate
1983 Science
Six-Hour Window of Opportunity for Calpain Inhibition in Focal Cerebral Ischemia in Rats
1998
Ischemic Cell Death in Brain Neurons
1999 Standout
Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.
1994
Isolation and sequence analyses of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent protease.
1986
Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability
1997
A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: Domain structure and expression
1986 StandoutNobel
Disruption of the Mouse μ-Calpain Gene Reveals an Essential Role in Platelet Function
2001
Purification of a high-molecular-weight inhibitor of the calcium-activated proteinase
1985
Roles of individual EF-hands in the activation of m-calpain by calcium
2000
The role of autolysis in activity of the Ca2+-dependent proteinases (μ-calpain and m-calpain)
1989
Specific small nuclear RNAs are associated with yeast spliceosomes
1986 StandoutNobel
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
1989
Immunogold electron-microscopic localisation of calpain I in skeletal muscle of rats
1986
Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function
1987
Identification of Major Autolytic Cleavage Sites in the Regulatory Subunit of Vascular Calpain II
1989
Calpain Mediates Eukaryotic Initiation Factor 4G Degradation during Global Brain Ischemia
1998
Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme
1985 StandoutNobel
Site-Directed Mutagenesis of αII Spectrin at Codon 1175 Modulates Its μ-Calpain Susceptibility
1997
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
2000 Nobel
Effect of Ca2+ on binding of the calpains to calpastatin
1989
Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.
1993
Disassembly and reconstitution of signal recognition particle
1983 StandoutNobel
Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.
1990
Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin
1999
An endogenous activator of the Ca2+-dependent proteinase of human neutrophils that increases its affinity for Ca2+.
1988
Stable expression of calpain 3 from a muscle transgene in vivo : Immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation
2002
Cross-Talk between Two Cysteine Protease Families
2000 Standout
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
1995
CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei
2001
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Positive regulation of mu-calpain action by polyphosphoinositides.
1992
Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.
1992
An antisense oligodeoxyribonucleotide to m-calpain mRNA inhibits myoblast fusion
1995
Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors
2004
Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
1994
A ribonuclease-resistant cytoplasmic 10 S ribonucleoprotein of chick embryonic muscle. A potent inhibitor of cell-free protein synthesis.
1981
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Studies of the active site of m-calpain and the interaction with calpastatin
1993
Works of Dorothy E. Croall being referenced
An enzyme related to the high molecular weight multicatalytic proteinase, macropain, participates in a ubiquitin-mediated, ATP-stimulated proteolytic pathway in soluble extracts of BHK 21/C13 fibroblasts
1988
Domain structure of calpain: mapping the binding site for calpastatin
1994
Polyclonal antisera specific for the proenzyme form of each calpain
1992
Hepatocellular carcinoma cells resist necrosis during anoxia by preventing phospholipase-mediated calpain activation
1996
Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion
1987
Proteolysis of the protein inhibitor of calcium-dependent proteases produces lower molecular weight fragments that retain inhibitory activity
1988
Cleavage of caldesmon and calponin by calpain: substrate recognition is not dependent on calmodulin binding domains
1996
Calpains Are Activated in Necrotic Fibers from mdx Dystrophic Mice
1995
The calpains: modular designs and functional diversity
2007
Crystallization and X-ray crystallographic analysis of m-calpain, a Ca2+-dependent protease
1999
Purification of Calpain by Affinity Chromatography on Reactive Red-Agarose or on Casein-Sepharose
2003
m‐Calpain subunits remain associated in the presence of calcium
1998
The calmodulin-binding site in alpha-fodrin is near the calcium-dependent protease-I cleavage site.
1988
Calcium-activated proteases in the bovine parathyroid gland: potential role in degradation of parathyroid hormone to peptide fragments
1995
Purification and characterization of a calcium-dependent protease from rat liver
1983
Calcium‐Dependent Proteases in Neuroblastoma Cells
1982
Purification and characterization of a protein inhibitor of calcium-dependent proteases from rat liver
1984
Calpain Regulates Actin Remodeling during Cell Spreading
1998
Calcium-activated neutral protease (calpain) system: structure, function, and regulation.
1991
Comparison of two calcium-dependent proteinases from bovine heart
1984
Calmodulin Regulates Fodrin Susceptibility to Cleavage by Calciumdependent Protease I
1989
Relative Increase in Polysomal mRNA for R1 cAMP‐Binding Protein in Neuroblastoma Cells Treated with 1,N6‐Dibutyryl‐adenosine 3′,‐5′‐phosphate
1980
Autoproteolysis of the small subunit of calcium-dependent protease II activates and regulates protease activity.
1986
Limited proteolysis of the erythrocyte membrane skeleton by calcium-dependent proteinases
1986
Calcium-dependent affinity purification of transclutaminase from rat liver cytosol
1986
Purification and characterization of calcium-dependent proteases from rat heart.
1983
A model of translational control involving mRNA-associated proteins in chick embryonic muscles
1979
Fractionation and quantification of calcium-dependent proteinase activity from small tissue samples
1986