Citation Impact
Citing Papers
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
2011 Standout
The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase
2005
Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation
2004 StandoutNobel
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
2002
The 2016 revision of the World Health Organization classification of lymphoid neoplasms
2016 Standout
TOR Signaling in Growth and Metabolism
2006 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Soft corrugated channel with synergistic exclusive discrimination gating for CO2 recognition in gas mixture
2023 StandoutNobel
Overcoming Endocrine Therapy Resistance by Signal Transduction Inhibition
2004
Thematic review series: Lipid Posttranslational Modifications. Farnesyl transferase inhibitors
2005
ERBB receptors and cancer: the complexity of targeted inhibitors
2005 Standout
Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway
2005 StandoutNobel
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
MEK1/2 inhibitors in the treatment of gynecologic malignancies
2014
Actin' up: RhoB in cancer and apoptosis
2001
Ras oncogenes: split personalities
2008
Analysis of the genome to personalize therapy for melanoma
2010
Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin α
2004 StandoutNobel
High prevalence of MAP2K1 mutations in variant and IGHV4-34–expressing hairy-cell leukemias
2013
Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop
2012
High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase
2013 StandoutNobel
Searching for the elusive targets of farnesyltransferase inhibitors
2003
Therapeutic Strategies for Targeting Ras Proteins
2011
Farnesyltransferase inhibitors: promises and realities
2002
A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics
2016 StandoutNobel
Detection of Peptides, Proteins, and Drugs That Selectively Interact With Protein Targets
2002 StandoutNobel
Post-prenylation-processing enzymes as new targets in oncogenesis
2005
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
2010 StandoutNature
Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?
1997
Mitochondria: More Than Just a Powerhouse
2006 Standout
A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan
2002
Targeting cancer with small molecule kinase inhibitors
2008 Standout
FoxM1 is required for execution of the mitotic programme and chromosome stability
2005 Standout
The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling
2005
Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation
1996
Peptidomimetic design
1998
Chemotherapy and the war on cancer
2005 Standout
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
2000
Protein Prenyltransferases
1996
The microenvironment of the tumour–host interface
2001 StandoutNature
Targeting RAS signalling pathways in cancer therapy
2003 Standout
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479
2014
Mechanisms of drug combinations: interaction and network perspectives
2009 Standout
Common pitfalls in preclinical cancer target validation
2017 StandoutNobel
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
2007 Standout
Poly(ADP-ribose): novel functions for an old molecule
2006 Standout
Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing
2011
Structure, mechanism and function of prenyltransferases
2002
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Perspectives on farnesyl transferase inhibitors in cancer therapy
2003
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: Implications in prevention of apoptosis
1999
Molecular Recognition in Chemical and Biological Systems
2015
Revealing the world of RNA interference
2004 StandoutNatureNobel
Comprehensive analysis of kinase inhibitor selectivity
2011 Standout
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
2003
Centromere Proteins Cenpa, Cenpb, and Bub3 Interact with Poly(ADP-ribose) Polymerase-1 Protein and Are Poly(ADP-ribosyl)ated
2002
Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity
2004
Farnesyltransferase Inhibitors: Preclinical Development
1999
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
2006 Standout
Biological effects of essential oils – A review
2007 Standout
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
2004
The spindle-assembly checkpoint in space and time
2007 Standout
Copper is required for oncogenic BRAF signalling and tumorigenesis
2014 Nature
Iron Catalysis in Organic Synthesis
2015 Standout
New Synthesis of KT5823 Indolocarbazole Aglycone
2000
Small GTP-Binding Proteins
2001 Standout
Indium-Catalyzed Annulation of 2-Aryl- and 2-Heteroarylindoles with Propargyl Ethers: Concise Synthesis and Photophysical Properties of Diverse Aryl- and Heteroaryl-Annulated[a]carbazoles
2008
Reactions of indole-3-acetic acid derivatives in trifluoroacetic acid
1995
An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.
2000
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Palmitoylation of oncogenic NRAS is essential for leukemogenesis
2010
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
A Molecular View of Kinetochore Assembly and Function
2017
A facile synthesis of staurosporine aglycone
1994
Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles1
1996
Practical Methodologies for the Synthesis of Indoles
2006 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
2005 StandoutNobel
Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development
2022 StandoutNobel
BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors
2007
A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling
2012
Fluorophore Labeling of the Glycine-Rich Loop as a Method of Identifying Inhibitors That Bind to Active and Inactive Kinase Conformations
2010
A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
2006
Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
2017 StandoutNobel
The total synthesis of (±)K252a
1995
Phase II Study of the Farnesyl Transferase Inhibitor R115777 in Patients With Advanced Non–Small-Cell Lung Cancer
2003
Inverse electron-demand Diels–Alder chemistry in the synthesis of a regioselectively protected analogue of the staurosporine aglycone
2001
A Field Guide to Foldamers
2001 Standout
Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis
2002
Metalated Heterocycles and Their Applications in Synthetic Organic Chemistry
2004
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
2003
BindingDB Entry 2025: Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
2007
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
2018
Functional Oligothiophenes: Molecular Design for Multidimensional Nanoarchitectures and Their Applications
2009 Standout
MEK1 mutations confer resistance to MEK and B-RAF inhibition
2009
Regioselective imide reduction : An issue in the total synthesis of staurosporine
1994
Synthesis of the staurosporine aglycone (K-252c) lactam regioisomer
1997
Farnesyl Diphosphate Analogues with ω-Bioorthogonal Azide and Alkyne Functional Groups for Protein Farnesyl Transferase-Catalyzed Ligation Reactions
2007
The Halogen Bond
2016 Standout
Natural Products as Sources of New Drugs from 1981 to 2014
2016 Standout
Molecular mechanisms of resistance of leukemia to imatinib mesylate
2003
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
2004
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Isolation and Synthesis of Biologically Active Carbazole Alkaloids
2002 Standout
Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
2003
Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease
1999
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
2001
Works of Donna Carr being referenced
Novel Tricyclic Inhibitors of Farnesyl Protein Transferase
1995
The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines
2001
Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules
2000
Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5 H -benzo[5,6]-cyclohepta[1,2- b ]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase
1999
Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I
1997
Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors
2009
Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c.
1993
Biological Effects and Mechanism of Action of Farnesyl Transferase Inhibitors
2000