Citation Impact
Citing Papers
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
2005 Science
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Mutant G-protein-coupled receptors as a cause of human diseases
2004
Whole-genome resequencing reveals loci under selection during chicken domestication
2010 StandoutNature
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
1997 StandoutNature
The Natural Inverse Agonist Agouti-related Protein Induces Arrestin-mediated Endocytosis of Melanocortin-3 and -4 Receptors
2006
Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors
1998
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
1995 Standout
Constitutive Activity in Melanocortin-4 Receptor
2014
Identification and expression cloning of a leptin receptor, OB-R
1995 Standout
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Central nervous system control of food intake and body weight
2006 StandoutNature
Congenital leptin deficiency is associated with severe early-onset obesity in humans
1997 StandoutNature
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2001 StandoutNature
Melanocortin Signalling Mechanisms
2010
Advances in the molecular genetics of obesity
1999
Cyclic analogs of α-melanocyte-stimulating hormone (αMSH) with high agonist potency and selectivity at human melanocortin receptor 1b
2008
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
1995
Interactions of α-Melanotropin and Agouti on B16 Melanoma Cells: Evidence for Inverse Agonism of Agouti
1997
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay
2011
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
2002 Standout
Insights into obesity and diabetes at the intersection of mouse and human genetics
2014
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
1995 StandoutNatureNobel
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
1997 StandoutNature
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
1995 Standout
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
1999
Modulation of murine melanocyte function invitro by agouti signal protein
1997
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
1997 Standout
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
1998 Standout
The melanocortin receptors and their accessory proteins
2013
The Rise and Fall of the Chemoattractant Receptor GPR33
2005 StandoutNobel
Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin
2000
Functional Selectivity of Melanocortin 4 Receptor Peptide and Nonpeptide Agonists: Evidence for Ligand-Specific Conformational States
2005
The adipocyte: Storage depot or node on the energy information superhighway?
1995
Genetic dissection of phenotypic diversity in farm animals
2001
Central nervous system control of food intake
2000 StandoutNature
Physiological roles of the melanocortin MC3 receptor
2011
Inhibition of Drosophila EGF receptor activation by the secreted protein Argos
1995 Nature
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
The Melanocortin-1 Receptor
2001
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
2007
AUTOCRINE AND PARACRINE REGULATION BY CYTOKINES AND GROWTH FACTORS IN MELANOMA
2000
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
2003 StandoutNature
A role for ghrelin in the central regulation of feeding
2001 StandoutNature
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
1998 Standout
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
1999 Standout
Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17
2009
Adipogenesis and Obesity: Rounding Out the Big Picture
1996
Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor
2014
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
2004
Obesity as a medical problem
2000 StandoutNature
Melanocortin-5 Receptor Deficiency in Mice Blocks a Novel Pathway Influencing Pheromone-Induced Aggression
2006
The hormone resistin links obesity to diabetes
2001 StandoutNature
Obesity and the Regulation of Energy Balance
2001 Standout
Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
1998
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior
2000 StandoutNobel
Structure–activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the mouse melanocortin receptors
2003
Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides
1999
Leptin and the regulation of body weight in mammals
1998 StandoutNature
MC4R oligomerizes independently of extracellular cysteine residues
2005
The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R)
2005
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Role of leptin in the neuroendocrine response to fasting
1996 StandoutNature
Potent and Selective Peptide Agonists of α-Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro
2001
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
2011 StandoutNature
Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus
1999
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
1996 Nature
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
2003
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
1999
Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
2014
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.
1997
The structural basis of g-protein-coupled receptor function and dysfunction in human diseases
2007
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
1997 StandoutScience
Authentic Cell-Specific and Developmentally Regulated Expression of Pro-Opiomelanocortin Genomic Fragments in Hypothalamic and Hindbrain Neurons of Transgenic Mice
1998
The Central Melanocortin System and Energy Homeostasis
1999
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice.
1995
A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
2001 StandoutScience
Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.
1995
Minireview: Ghrelin and the Regulation of Energy Balance—A Hypothalamic Perspective
2001
Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields
2014 Standout
Design of cyclized selective melanotropins
2016
Melanocortin Antagonists Define Two Distinct Pathways of Cardiovascular Control by α- and γ-Melanocyte-Stimulating Hormones
1996
Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase
2016 StandoutNobel
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
2010
Mechanisms for the pleiotropic effects of the agouti gene.
1995
Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action
1997
Synthesis of (2S,3S)-β-methyltryptophan
2001
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
1997 StandoutScience
Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity.
1996
Human skin pigmentation: melanocytes modulate skin color in response to stress
2007 Standout
A Solid-Phase Approach to Mouse Melanocortin Receptor Agonists Derived from a Novel Thioether Cyclized Peptidomimetic Scaffold
2002 StandoutNobel
Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice
2002
UV Radiation and the Skin
2013 Standout
Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions☆
2000
Gut hormone PYY3-36 physiologically inhibits food intake
2002 StandoutNature
A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences
2000
Interactions Between the Melanocortin System and Leptin in Control of Sympathetic Nerve Traffic
1999
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
2000 StandoutScience
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
2000
Works of Dongsi Lu being referenced
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
1994 Nature
Identification of common polymorphisms in the coding sequence of the human MSH receptor (MCIR) with possible biological effects
1997
A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes
1997
Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors
1995
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.
1996
A Ligand-Mimetic Model for Constitutive Activation of the Melanocortin-1 Receptor
1998
Molecular and pharmacological characterization of dominant black coat color in sheep
1999