Standout Papers
Citation Impact
Citing Papers
Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
2006
Transforming Growth Factor-β Signaling–Deficient Fibroblasts Enhance Hepatocyte Growth Factor Signaling in Mammary Carcinoma Cells to Promote Scattering and Invasion
2008
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Selectivity and proofreading both contribute significantly to the fidelity of RNA polymerase III transcription
2007
Monofunctional Platinum–DNA Adducts Are Strong Inhibitors of Transcription and Substrates for Nucleotide Excision Repair in Live Mammalian Cells
2011
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
Schizosacharomyces pombe RNA polymerase II at 3.6-Å resolution
2009 Nobel
RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription
2010 StandoutNobel
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair
2009 StandoutNobel
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct
2010
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity
2014
The DNA-damage response in human biology and disease
2009 StandoutNature
The path for metal complexes to a DNA target
2013
Inhibition of transcription by platinum antitumor compounds
2009
Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells
2015
Carbon nanotubes for delivery of small molecule drugs
2013
Nucleic acid polymerases use a general acid for nucleotidyl transfer
2009
Bim Protein Degradation Contributes to Cisplatin Resistance
2011
Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin
2013
Liposomes, a promising strategy for clinical application of platinum derivatives
2013
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
Polymeric drug delivery of platinum-based anticancer agents
2008
Structural basis for substrate loading in bacterial RNA polymerase
2007 Nature
Synthesis, characterization, and study on HeLa cells activity of a dinuclear complex [Cu4(phen)4(H2O)2]·(pyri)·3H2O
2011
Structure–activity relationship study of copper(II) complexes with 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (4′-methylbenzoyl) hydrazone: synthesis, structures, DNA and protein interaction studies, antioxidative and cytotoxic activity
2011
Synthesis and in vitro cytotoxicity of cis,cis,trans-diamminedichloridodisuccinatoplatinum(iv)–peptide bioconjugates
2012
Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles
2010
Oncogenic kinase signalling
2001 StandoutNature
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
A texaphyrin–oxaliplatin conjugate that overcomes both pharmacologic and molecular mechanisms of cisplatin resistance in cancer cells
2012
A cross-linked polymeric micellar delivery system for cisplatin(IV) complex
2012
Structural basis for transcription elongation by bacterial RNA polymerase
2007 Nature
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
2011 Nature
The Mediator complex: a central integrator of transcription
2015
Mixed-Ligand Copper(II) Maltolate Complexes: Synthesis, Characterization, DNA Binding and Cleavage, and Cytotoxicity
2009
An Alkyne‐Appended, Click‐Ready PtII Complex with an Unusual Arrangement in the Solid State
2014
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Molecular mechanisms of resistance and toxicity associated with platinating agents
2006 Standout
Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy
2012
Novel Metals and Metal Complexes as Platforms for Cancer Therapy
2010
Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta
2008
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers
2014
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
The multifaceted mismatch-repair system
2006
Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs
2012
Nanocarriers for delivery of platinum anticancer drugs
2013
Role of the RNA polymerase trigger loop in catalysis and pausing
2009
Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?
2012
The crystal structure of oxaliplatin: A case of overlooked pseudo symmetry
2013
Platinum(ii) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity
2010
Polysilsesquioxane Nanoparticles for Targeted Platin‐Based Cancer Chemotherapy by Triggered Release
2011
Thermal ablation of tumours: biological mechanisms and advances in therapy
2014 Standout
Phosphatase-like activity, DNA binding, DNA hydrolysis, anticancer and lactate dehydrogenase inhibition activity promoting by a new bis–phenanthroline dicopper(ii) complex
2011
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Multifunctional Pt(iv ) pro-drug and its micellar platform: to kill two birds with one stone
2012
Molecular Mechanisms of Long Noncoding RNAs
2011 Standout
Pioneer transcription factors: establishing competence for gene expression
2011
Platinum (IV)-coordinate polymers as intracellular reduction-responsive backbone-type conjugates for cancer drug delivery
2011
A distinct molecular profile associated with mucinous epithelial ovarian cancer
2006
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
Syntheses, characterization and antitumor activities of transition metal complexes with isoflavone
2009
Excursions in polynuclear platinum DNA binding
2010
Advances of blood cell-based drug delivery systems
2016
Application of liposomal technologies for delivery of platinum analogs in oncology
2013
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry
2014
Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2
2000
Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy
2014
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
A Central Role of the RNA Polymerase Trigger Loop in Active-Site Rearrangement during Transcriptional Pausing
2007
Transcription bypass of DNA lesions enhances cell survival but attenuates transcription coupled DNA repair
2014
Cisplatin in cancer therapy: Molecular mechanisms of action
2014 Standout
Copper‐Free Click‐Chemistry Platform to Functionalize Cisplatin Prodrugs
2014
Ab Initio Structure Determination from Electron Microscopic Images of Single Molecules Coexisting in Different Functional States
2010
Vitamin E TPGS prodrug micelles for hydrophilic drug delivery with neuroprotective effects
2012
Diameter-dependent release of a cisplatin pro-drug from small and large functionalized carbon nanotubes
2015
DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological investigation
2009
In vitro and in vivo antitumour effects of novel, orally active bile acid-conjugated platinum complexes on rat hepatoma
2006
Alternative transcription and alternative splicing in cancer
2012
The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin
2008 Nobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Enhancer transcripts mark active estrogen receptor binding sites
2013
Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands
2014
A movie of the RNA polymerase nucleotide addition cycle
2009
Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution
2015 StandoutNobel
LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer
2009
Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile
2012
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Interactions of DNA with a New Platinum(IV) Azide Dipyridine Complex Activated by UVA and Visible Light: Relationship to Toxicity in Tumor Cells
2012
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Platinum(II) Complexes with Bioactive Carrier Ligands Having High Affinity for the Translocator Protein
2010
Monofunctional and Higher-Valent Platinum Anticancer Agents
2013
Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles
2013 StandoutNobel
Head and Neck Cancer
2020 Standout
Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
2009
The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy
2007
Organometallic Anticancer Compounds
2010 Standout
Third row transition metals for the treatment of cancer
2015
De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities
2019
Platinum(iv) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal
2012
Activation of Carboplatin by Carbonate
2005
Regulation of Cisplatin Cytotoxicity by Cu Influx Transporters
2010
Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug Design
2007
Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?
2012
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Phosphaplatins, next generation platinum antitumor agents: A paradigm shift in designing and defining molecular targets
2012
Synthesis and Characterization of a Platinum(II) Complex Tethered to a Ligand of the Peripheral Benzodiazepine Receptor
2007
Construction and Application of a Rh–Pt DNA Metalloinsertor Conjugate
2014
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo
2011
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Lipoplatin Formulation Review Article
2011
Encapsulation of Pt(iv ) prodrugs within a Pt(ii ) cage for drug delivery
2014
Understanding Intrinsically Irreversible, Non-Nernstian, Two-Electron Redox Processes: A Combined Experimental and Computational Study of the Electrochemical Activation of Platinum(IV) Antitumor Prodrugs
2014
Circadian Rhythms: Mechanisms and Therapeutic Implications
2007
Convenient detection of metal–DNA, metal–RNA, and metal–protein adducts with a click-modified Pt(ii ) complex
2014
A Potent Glucose–Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells
2016
Control of skin cancer by the circadian rhythm
2011 StandoutNobel
Synthesis, crystal structure and cytotoxicity studies of cis-dichloro(4,5-diazafluoren-9-one)platinum(II)
2014
Non-DNA-binding platinum anticancer agents: Cytotoxic activities of platinum–phosphato complexes towards human ovarian cancer cells
2008
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
Synergistic Cytotoxicity of Irinotecan and Cisplatin in Dual-Drug Targeted Polymeric Nanoparticles
2012
The molecular basis of eukaryotic transcription
2007 Nobel
A dual-targeting, p53-independent, apoptosis-inducing platinum(ii ) anticancer complex, [Pt(BDIQQ)]Cl
2014
Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry
2013
Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery
2014
Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis
2013
Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(iv ) prodrug with unique mode of action
2015
Ratiometric delivery of cisplatin and doxorubicin using tumour-targeting carbon-nanotubes entrapping platinum(iv ) prodrugs
2014
A Monofunctional Platinum Complex Coordinated to a Rhodium Metalloinsertor Selectively Binds Mismatched DNA in the Minor Groove
2015
Surfing the p53 network
2000 StandoutNature
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device
2008
Amino acid-linked platinum(ii ) analogues have altered specificity for RNA compared to cisplatin
2013
Structure of Eukaryotic RNA Polymerases
2008
Structural basis of transcription inhibition by α-amanitin and implications for RNA polymerase II translocation
2008
Conjugated Platinum(IV)−Peptide Complexes for Targeting Angiogenic Tumor Vasculature
2007
Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II
2018
Polymer−Cisplatin Conjugate Nanoparticles for Acid-Responsive Drug Delivery
2009
Antitumor properties of platinum(iv ) prodrug-loaded silk fibroin nanoparticles
2015
Allosteric Regulation of the Rotational Speed in a Light-Driven Molecular Motor
2016 StandoutNobel
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Allosteric cooperation in a de novo-designed two-domain protein
2020
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Helper T‐cell identity and evolution of differential transcriptomes and epigenomes
2013
Direct Cellular Responses to Platinum-Induced DNA Damage
2007
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry
2009
Optimization of cisplatin for the treatment of hormone dependent tumoral diseases
2009
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Understanding and improving platinum anticancer drugs--phenanthriplatin.
2014
Exceedingly small iron oxide nanoparticles as positive MRI contrast agents
2017 StandoutNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage
2014
Nanocapsules of Platinum Anticancer Drugs: Development Towards Therapeutic Use
2009
Effect of N(4)-Phenyl Substitution in 2-Oxo-1,2-dihydroquinoline-3-carbaldehyde Semicarbazones on the Structure, DNA/Protein Interaction, and Antioxidative and Cytotoxic Activity of Cu(II) Complexes
2011
Design and delivery of camplatin to overcome cisplatin drug resistance
2014
Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy
2014
Peptide Targeting of Platinum Anti-Cancer Drugs
2009
Works of Dong Wang being referenced
Sensitive ChIP-DSL technology reveals an extensive estrogen receptor α-binding program on human gene promoters
2007
Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells
2008
IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer
2019
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication
2015
Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase
2003
Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways
1998
5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription
2012
Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential
2003
Cellular processing of platinum anticancer drugs
2005 Standout
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
2011 Nature
Copper Environment in Artificial Metalloproteins Probed by Electron Paramagnetic Resonance Spectroscopy
2015
Synthetic Approaches to Polypyridyl Bridging Ligands with Proximal Multidentate Binding Sites
2005
Prognostic ability of DNA‑binding protein inhibitor ID‑1 expression in patients with oral squamous cell carcinoma
2020
Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma
2015