Citation Impact
Citing Papers
CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells
2012
Reconstituting Organ-Level Lung Functions on a Chip
2010 StandoutScience
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
1999 Standout
Premature Rupture of the Fetal Membranes
1998 Standout
Tadalafil Therapy for Pulmonary Arterial Hypertension
2009 Standout
Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia
2006
ADMET in silico modelling: towards prediction paradise?
2003
Predicting Oral Absorption and Bioavailability
2003
The influence of drug-like concepts on decision-making in medicinal chemistry
2007 Standout
The Clinical Sequelae of Intravascular Hemolysis and Extracellular Plasma Hemoglobin
2005 Standout
Tolerability and pharmacokinetics of avanafil, a phosphodiesterase type 5 inhibitor: A single- and multiple-dose, double-blind, randomized, placebo-controlled, dose-escalation study in healthy Korean male volunteers
2010
Role of transport proteins in drug absorption, distribution and excretion
2001
Visible light photoredox catalysis: applications in organic synthesis
2010 Standout
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
2013
The influence of lipophilicity in drug discovery and design
2012
Exploration of cornea permeable calpain inhibitors as anticataract agents
2003
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
2011
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
2007 Standout
Nucleotide signalling during inflammation
2014 StandoutNature
Rethinking amide bond synthesis
2011 StandoutNature
Purinergic Signaling in the Airways
2012
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
2006 StandoutNature
A rabbit model for ascending infection in pregnancy: Intervention with indomethacin and delayed ampicillin-sulbactam therapy
1993
Maraviroc
2007
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
2005 Standout
The Science of Stroke: Mechanisms in Search of Treatments
2010 Standout
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Fluorine in Medicinal Chemistry
2015
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
2011 Standout
Clinical Pharmacokinetic and Pharmacodynamic Profile of the HIV Integrase Inhibitor Elvitegravir
2011
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
2020 StandoutNobel
Age-related macular degeneration
2012 Standout
A quantitative assessment of hERG liability as a function of lipophilicity
2006
Automation of solid-phase microextraction on a 96-well plate format
2007
Sarcolemma-localized nNOS is required to maintain activity after mild exercise
2008 Nature
Prediction of intestinal permeability
2002
Synthetic peroxides as antimalarials
2004
Calculation of Molecular Lipophilicity: State-of-the-Art and Comparison of LogP Methods on more than 96,000 Compounds
2008
Polyphenols: food sources and bioavailability
2004 Standout
Pyrazole NNRTIs 4: Selection of UK-453,061 (lersivirine) as a Development Candidate
2009
Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors
2012
Emerging therapeutic approaches in the management of retinal angiogenesis and edema
2010
An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk
2010
A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
1995 Standout
Identification of an antimalarial synthetic trioxolane drug development candidate
2004 Nature
The ChEMBL database in 2017
2016 Standout
Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction
2002
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Regulation of cardiac hypertrophy by intracellular signalling pathways
2006 Standout
Human growth hormone expressed in tobacco cells as an arabinogalactan-protein fusion glycoprotein has a prolonged serum life
2010
Synthetic therapeutic peptides: science and market
2009
Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments
2009
Acquired QT interval prolongation and HERG: implications for drug discovery and development
2004
Multicomponent reactions for the synthesis of pyrroles
2010 Standout
The determination and interpretation of the therapeutic index in drug development
2012
Antiproliferative Effects of Phosphodiesterase Type 5 Inhibition in Human Pulmonary Artery Cells
2005
Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets
2015
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Fluorine in medicinal chemistry
2007 Standout
K+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells).
1994
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Generation of gold carbenes in water: efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines
2014
A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
2003
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
2014 Standout
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
2002 Standout
Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success
2012
P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design
2005
Experimental and Computational Screening Models for the Prediction of Intestinal Drug Absorption
2001
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery
2015
Species-Specific Antifungal Susceptibility Patterns of Scedosporium and Pseudallescheria Species
2012
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
2005 Standout
Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
2018 StandoutNobel
Time-Related Differences in the Physical Property Profiles of Oral Drugs
2004
Chimeric Antigen Receptor Therapy
2018 Standout
Worldwide emergence of resistance to antifungal drugs challenges human health and food security
2018 StandoutScience
Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity
2010 StandoutNobel
SuperCYPsPred—a web server for the prediction of cytochrome activity
2020
The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules
2016
Assessing Atropisomer Axial Chirality in Drug Discovery and Development
2011 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Visible‐Light Photocatalysis: Does It Make a Difference in Organic Synthesis?
2018 Standout
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles
2011 Standout
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
2015 Standout
Molecular imprinting: perspectives and applications
2016 Standout
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Don K. Walker being referenced
SPECIES DIFFERENCES IN THE DISPOSITION OF THE CCR5 ANTAGONIST, UK-427,857, A NEW POTENTIAL TREATMENT FOR HIV
2005
The use of Cav rather than AUC in safety assessment
2010
PEGylation of somatropin (recombinant human growth hormone): Impact on its clearance in humans
2008
Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man
2003
The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development
2004
Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease
2008
Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man
1999
Species differences in the multiple-dose pharmacokinetics of the non-nucleoside reverse transcriptase inhibitor (NNRTI) UK-453,061 in animals and man: implications for safety considerations
2009
Comparison of the disposition of two novel combined thromboxane synthase inhibitors/thromboxane A2receptor antagonists in the isolated perfused rat liver
1995
THE DISPOSITION OF VORICONAZOLE IN MOUSE, RAT, RABBIT, GUINEA PIG, DOG, AND HUMAN
2003
Potential role for P-glycoprotein in the nonproportional pharmacokinetics of UK-343,664 in man
2001
Automated 96-well solid phase extraction for the determination of doramectin in cattle plasma
1998
Property-Based Design: Optimization of Drug Absorption and Pharmacokinetics
2001
Thromboxane synthetase inhibitors in septic shock.
1983
Towards a drug concentration effect relationship for QT prolongation and torsades de pointes.
2002
Pharmacokinetic and pharmacodynamic effects of UK‐68,798, a new potential class III antiarrhythmic drug.
1991
The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist
2004