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Citing Papers

Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
1998 StandoutNature
GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
1995
NORMAL AGEING, IMPAIRED COGNITIVE FUNCTION, AND SENILE DEMENTIA OF THE ALZHEIMER'S TYPE: A CONTINUUM?
1988
Potent amyloidogenicity and pathogenicity of Aβ43
2011
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain
1996
Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
2000
Apoptosis in the nervous system
2000 StandoutNature
Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology
1987
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
2004
Direct Interaction of Alzheimer's Disease-related Presenilin 1 with Armadillo Protein p0071
1999 StandoutNobel
Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer's disease and frontotemporal dementia
1999
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
1994 Standout
Pathology of Parkinson’s disease
1991
The presenilins and Alzheimer's disease
1997
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
Defects in enteric innervation and kidney development in mice lacking GDNF
1996 StandoutNature
Quantitative assessment of cortical synaptic density in Alzheimer's disease
1990
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
1995
The human raphe nuclei and the serotonergic system
2003
Presenilins and Alzheimer's disease
1997
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40
2006
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
1990 Standout
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits
2000
A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia?
1998
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
THE PROGRESSION OF THE PATHOLOGICAL CHANGES OF ALZHEIMER'S DISEASE IN FRONTAL AND TEMPORAL NEOCORTEX EXAMINED BOTH AT BIOPSY AND AT AUTOPSY
1988
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval
2002
The case described by Alois Alzheimer in 1911
1998
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
1998
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
1998
Endogenous Presenilin-1 Targets to Endocytic Rather Than Biosynthetic Compartments
2000
Clinical and Pathological Diagnosis of Frontotemporal Dementia
2001
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Cerebrospinal Fluid β-Amyloid(1-42) in Alzheimer Disease
1999
The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging
1999
Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment
2003
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation
2001
Alzheimer's disease
2006 Standout
Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice
2000
Comparison of Aβ levels in the brain of familial and sporadic Alzheimer's disease
2009
Alpha-2 macroglobulin is genetically associated with Alzheimer disease
1998
What we can do and what we cannot do with fMRI
2008 StandoutNature
The Role of Apolipoprotein E in Alzheimer's Disease
2009
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
1998
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
1991 Standout
Intraneuronal Aβ42 Accumulation in Human Brain
2000
A Drosophila model of Parkinson's disease
2000 StandoutNature
Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
1998
Corticobasal ganglionic degeneration and/or frontotemporal dementia? A report of two overlap cases and review of literature
2000
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
AN ANALYSIS OF THE MORPHOLOGY OF SENILE PLAQUES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES USING IMMUNOCYTOCHEMICAL AND LECTIN HISTOCHEMICAL TECHNIQUES
1989
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
2000 Standout
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
1994
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism
2000
Incorrect Diagnosis of Alzheimer's Disease
1996
Clinical and Pathological Evidence for a Frontal Variant of Alzheimer Disease
1999
Reliability and Validity of NINCDS-ADRDA Criteria for Alzheimer's Disease
1994
Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42
1999
Amyloid, the presenilins and Alzheimer's disease
1997
Renal agenesis and the absence of enteric neurons in mice lacking GDNF
1996 StandoutNature
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
2010
Microglial cells and amyloid ? protein (A?) deposition: association with A?40-plaques
1995
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
Characterization of α2,6-Sialyltransferase Cleavage by Alzheimer's β-Secretase (BACE1)
2003
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Brain angiotensin receptor subtypes in the control of physiological and behavioral responses
1994
Cognitive and Behavioral Differentiation of Frontal Lobe Degeneration of the Non-Alzheimer Type and Alzheimer’s Disease
1998
Localization and Possible Functions of Presenilins in Brain
1998
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
1996
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
2000 StandoutNature
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
Dementia of frontal type and the focal lobar atrophies
1993
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Dementia of frontal lobe type.
1988
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
Neurodegenerative Tauopathies
2001 Standout
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
1996 StandoutScience
Cerebral glucose metabolism in patients with frontotemporal dementia.
1998
A Century of Alzheimer's Disease
2006 StandoutScience
Practice parameter: Management of dementia (an evidence-based review) [RETIRED]
2001 Standout
Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease
1987 ScienceNobel
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Dementia of the frontal type: neuropsychological and [99Tc]-HM-PAO SPET features.
1995
The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type.
1988
Practice parameter: Diagnosis of dementia (an evidence-based review)
2001
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities
1996
Frontal lobe dementia and motor neuron disease.
1990
Exploring the Etiology of Alzheimer Disease Using Molecular Genetics
1997
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Pharmacologic treatment of noncognitive behavioral disturbances in elderly demented patients
1990
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
1997
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Frontotemporal lobar degeneration
1998 Standout
Alzheimer's Disease--Genotypes, Phenotype, and Treatments
1997 Science
The prevalence of frontotemporal dementia
2002 Standout
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience
Genetics and pathology of alpha-secretase site AβPP mutations in the understanding of Alzheimer's disease
2006
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Positron emission tomography for diagnosis of Alzheimer’s disease and vascular dementia
1998
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex
1996
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
1998
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
1992 StandoutScience
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
1987
Validation of clinical diagnostic criteria for Alzheimer's disease
1988
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.
1988 StandoutNobel
The Alzheimer family of diseases: Many etiologies, one pathogenesis?
1997
Is slowly progressive aphasia actually a new clinical entity?
1990
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
1994

Works of D.M.A. Mann being referenced

Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)
1996
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease
2000
Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques
1995
Distortion of Allelic Expression of Apolipoprotein E in Alzheimer's Disease
1997
Frequency oftau mutations in three series of non-Alzheimer's degenerative dementia
1999
Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?
1993
Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders.
1986
The pathology of the human locus ceruleus.
1983
The topographic distribution of brain atrophy in cortical Lewy body disease: comparison with Alzheimer's disease
1995
Cerebral biopsy in the investigation of presenile dementia due to cerebral atrophy.
1986
Relationship between pigment accumulation and age in Alzheimer's disease and Down syndrome
1984
Neuropsychological syndromes in presenile dementia due to cerebral atrophy.
1986
A comparison of nerve cell loss in cortical and subcortical structures in Alzheimer's disease.
1986
Alzheimer's disease: a correlative study.
1986
ALZHEIMER'S PRESENILE DEMENTIA, SENILE DEMENTIA OF ALZHEIMER TYPE AND DOWN'S SYNDROME IN MIDDLE AGE FORM AN AGE RELATED CONTINUUM OF PATHOLOGICAL CHANGES
1984
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