Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions
2008
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation
2007
p53 represses c-Myc through induction of the tumor suppressor miR-145
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
lincRNAs: Genomics, Evolution, and Mechanisms
2013 Standout
Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex
2011
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
2012
Sequence requirements for premature termination of transcription in the human c-myc gene
1988
MYC on the Path to Cancer
2012 Standout
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts
2011
The genetic regulation of apoptosis
1995
In vivo dynamics of RNA polymerase II transcription
2007
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
2007 StandoutNobel
A role for c-Myc in the regulation of ribosomal RNA processing
2003
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Chromatin structure and transcriptional regulation of human papillomavirus type 18 DNA in hela cells
1989 StandoutNobel
Targeting MYC Expression through G-Quadruplexes
2010
Histone Ubiquitination: Triggering Gene Activity
2008
c-Myc-regulated microRNAs modulate E2F1 expression
2005 StandoutNature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Tumor surveillance via the ARF–p53 pathway
1998
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules
2008
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
2009 Nature
Cdc25 cell-cycle phosphatase as a target of c-myc
1996 Nature
The Interplay Between MYC and HIF in the Warburg Effect
2008
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
2013 Nature
The Hallmarks of Cancer
2000 Standout
Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression
2000
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
2006 StandoutNobel
Widespread microRNA repression by Myc contributes to tumorigenesis
2007
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Histone H2B ubiquitination and beyond
2010
Direct activation of RNA polymerase III transcription by c-Myc
2003 Nature
Distinct Thresholds Govern Myc's Biological Output In Vivo
2008
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network
2003
Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
2011
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
2010
Chapter 1 Physiological Roles of Ribosomal Protein S6: One of Its Kind
2008
Identification of direct regulatory targets of the transcription factor Sox10 based on function and conservation
2008
The c-Myc target gene network
2006
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
2005
Non-B DNA structure-induced genetic instability
2006
MYC as a regulator of ribosome biogenesis and protein synthesis
2010
E1A signaling to p53 involves the p19ARFtumor suppressor
1998
The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line
2000
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Analysis of Non‐B DNA Structure at Chromosomal Sites in the Mammalian Genome
2006
Sense transcription through the S region is essential for immunoglobulin class switch recombination
2011
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle
2007
Small-molecule perturbation of competing interactions between c-Myc and Max
2008
Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry
2010
PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic β Cells
2008 StandoutNobel
Transcriptional Amplification in Tumor Cells with Elevated c-Myc
2012
The cancerous translation apparatus
2011
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
2002
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
2006
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Myc influences global chromatin structure
2006
Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors
2005
Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase
1996
Therapeutic Targeting of Myc
2010
Transcriptional regulation and transformation by Myc proteins
2005
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
First Exon Length Controls Active Chromatin Signatures and Transcription
2012
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
1988 StandoutNatureNobel
Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization
2003
Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1
2002
Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis
1998
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
2008
In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization
2010
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and modification of the AP-1 transcription complex
1999 StandoutNobel
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
2009 StandoutNature
Stimulation of c‐MYC transcriptional activity and acetylation by recruitment of the cofactor CBP
2003
Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
2003
Regulation of c-fosgene expression in hamster fibroblasts: initiation and elongation of transcription and mRNA degradation
1987
Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G1/S-Regulatory Genes
1995
Life, death, and the pursuit of apoptosis.
1996
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter
1996
Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein.
1996
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
2005
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.
1996
Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression
2003
Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.
1988
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.
1994 StandoutNobel
Mechanisms of nonhomologous recombination in mammalian cells.
1985
Two distinct mechanisms of transcriptional control operate on c-myc during differentiation of HL60 cells.
1988
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells
2000
TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins
2002
Direct Regulation of RNA Polymerase III Transcription by RB, p53 and c-Myc
2003
Targeting MYC-Regulated miRNAs to Combat Cancer
2010
Differential Expression of c- myb mRNA in Murine B Lymphomas by a Block to Transcription Elongation
1987 Science
Cancer Cell Cycles
1996 StandoutScience
Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression
1991
A FOS protein is present in a complex that binds a negative regulator of MYC.
1989 StandoutNobel
The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.
1996 StandoutNobel
Anchorage-Dependent Transcription of the Cyclin A Gene
1996
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt Lymphoma
1987 Science
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene
1986 StandoutNatureNobel
Selective suppression of human papillomavirus transcription in non-tumorigenic cells by 5-azacytidine.
1988 StandoutNobel
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1998
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
2007 StandoutNobel
Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc
2009
Controlling mRNA lifespan
1988 StandoutNatureNobel
DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc.
1989 StandoutNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Global mapping of c-Myc binding sites and target gene networks in human B cells
2006
Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
1997 StandoutNobel
Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo
2000
The Biochemistry of Somatic Hypermutation
2008
Viruses in Human Cancers
1991 StandoutScienceNobel
The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein.
1993
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state
2010
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
1995
Regulation of the cyclin E gene by transcription factor E2F1.
1995
Transient excess of MYC activity can elicit genomic instability and tumorigenesis
1999 Nobel
Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells.
1992 StandoutNobel
The transcriptional cycle of HIV-1 in real-time and live cells
2007
The c-Myc Transactivation Domain Is a Direct Modulator of Apoptotic versus Proliferative Signals
2000
Upstream Stimulatory Factor Regulates Expression of the Cell Cycle-Dependent Cyclin B1 Gene Promoter
1995
Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model
2009
A Highly Conserved Domain of RNA Polymerase II Shares a Functional Element with Acidic Activation Domains of Upstream Transcription Factors
1994
Association of polyomaviruses JC, SV40, and BK with human brain tumors
1987
MYC stimulates EZH2 expression by repression of its negative regulator miR-26a
2008
Abnormal Centrosome Amplification in the Absence of p53
1996 Science
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression.
1995
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Identification of critical cis elements involved in mediating Epstein-Barr virus nuclear antigen 2-dependent activity of an enhancer located upstream of the viral BamHI C promoter
1992
Suppression of the malignant phenotype in somatic cell hybrids between Burkitt's lymphoma cells and Epstein-Barr virus-immortalized lymphoblastoid cells despite deregulated c-myc expression.
1990
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
2010
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
2009
Noncoding Transcription at Enhancers: General Principles and Functional Models
2012
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.
1995
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
2011
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter.
1993
A unique glucose-dependent apoptotic pathway induced by c-Myc
1998
A Matter of Life and Cell Death
1998 Science
Works of Dirk Eick being referenced
Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7
2007 Science
Selective Inhibition of c-Myc/Max Dimerization and DNA Binding by Small Molecules
2006
Cell cycle activation by c-myc in a Burkitt lymphoma model cell line
2000
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters
2011
Rapid conditional knock-down–knock-in system for mammalian cells
2006
Elongation and maturation ofc-mycRNA is inhibited by differentiation inducing agents in HL60 cells
1990
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36
2011
Dynamic long‐range chromatin interactions control Myb proto‐oncogene transcription during erythroid development
2011
Activation of Pausing RNA Polymerases by Nuclear Run-on Experiments
1994
Induction of Apoptosis by the c-Myc Helix-Loop-Helix/Leucine Zipper Domain in Mouse 3T3-L1 Fibroblasts
1995
Conditional Expression of RNA Polymerase II in Mammalian Cells
2000
Control of cell growth by c-Myc in the absence of cell division
1999
Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line
2004
H2B Ubiquitylation Acts as a Barrier to Ctk1 Nucleosomal Recruitment Prior to Removal by Ubp8 within a SAGA-Related Complex
2007
Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles
2001
Nucleosomal Structures of c-myc Promoters with Transcriptionally Engaged RNA Polymerase II
1997
Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1.
1995
Burkitt-like mutations in the c-myc gene locus in prolymphocytic leukemia.
1994
The Proto-Oncogene c- myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2
1999
Identification of CDK4 as a target of c-MYC
2000
Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene
1991
Truncation does not abrogate transcriptional downregulation of the c-myc gene by sodium butyrate in Burkitt's lymphoma cells.
1987
Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo.
1992
Two antisense promoters in the immunoglobulin mu-switch region drive expression of c-myc in the Burkitt's lymphoma cell line BL67.
1992
Mediation of c-Myc-Induced Apoptosis by p53
1994 Science
Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.
1985
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.
1994
Multiple Single-Stranded cis Elements Are Associated with Activated Chromatin of the Human c-myc Gene In Vivo
1996
Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation
2005
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression
1986
On the Mechanism of Recombination Between Adenoviral and Cellular DNAs: The Structure of Junction Sites
1983
Transcriptional Regulation of the Igκ Gene by Promoter-Proximal Pausing of RNA Polymerase II
1999
Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II.
1999
Structure and cell cycle-regulated transcription of the human cyclin A gene.
1994