Citation Impact
Citing Papers
Mutations of the Drosophila dDP , dE2F , and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G 1 -S Transition
1998
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
The p16INK4a/CDKN2A tumor suppressor and its relatives
1998
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1995 Nature
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
Recent Insights into the Functions of the Retinoblastoma Susceptibility Gene Product
1997 StandoutNobel
Regulation of cell proliferation by the E2F transcription factors
1998
Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen
2001
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Mutations in Drosophila DP and E2F distinguish G1–S progression from an associated transcriptional program
1997
Preventive and therapeutic vaccines for human papillomavirus-associated cervical cancers
2000
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
2000 Standout
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Human papillomavirus oncoproteins: pathways to transformation
2010 Standout
Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
1997
Papillomavirus infections — a major cause of human cancers
1996 StandoutNobel
c-Myc-regulated microRNAs modulate E2F1 expression
2005 StandoutNature
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
1998 StandoutNobel
Hepatitis B Virus Infection
2008
RB kinases and RB-binding proteins: new points of view
1997
Expression patterns of the E2F family of transcription factors during mouse nervous system development
1997
Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells
1996 StandoutNobel
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.
1996
Oncoprotein Networks
1997
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
E6 and E7 Gene Silencing and Transformed Phenotype of Human Papillomavirus 16-Positive Oropharyngeal Cancer Cells
2009
The Hallmarks of Cancer
2000 Standout
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
The role of the E6-p53 interaction in the molecular pathogenesis of HPV
1999
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
Epstein-Barr Virus Provides a New Paradigm: A Requirement for the Immediate Inhibition of Apoptosis
2005
Global cancer statistics
2011 Standout
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
HPV-associated head and neck cancer: a virus-related cancer epidemic
2010 Standout
The regulation of E2F by pRB-family proteins
1998 Standout
Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
2011
Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.
1997
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice
2010
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
1998
G1 phase progression: Cycling on cue
1994 Standout
Retinoblastoma protein in growth suppression and death protection
1997
Aberrations of the G1- and G1/S-regulating genes in human cancer
1997
Control of cell growth by c-Myc in the absence of cell division
1999
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.
1997
Growth Regulation by the E2F and DP Transcription Factor Families
1998
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Retinoblastoma protein recruits histone deacetylase to repress transcription
1998 Nature
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
Therapeutic Vaccination for HPV Induced Cervical Cancers
2007
Human papillomavirus (HPV) 16 E6 sensitizes cells to atractyloside-induced apoptosis: Role of p53, ICE-like proteases and the mitochondrial permeability transition
1997
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
HPV 16 E6 Blocks TNF-Mediated Apoptosis in Mouse Fibroblast LM Cells
1999
Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression
2001 StandoutNobel
Physical status of the E2 human papilloma virus 16 viral gene in cervical preneoplastic and neoplastic lesions
2001
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
2002 StandoutNobel
Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer
1996
The Roles of E6-AP and MDM2 in p53 Regulation in Human Papillomavirus-Positive Cervical Cancer Cells
2000
E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest
1996
Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6
1997
Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Targeting Antigen to Endosomal/Lysosomal Compartments
2001
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes
1998
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.
1994
Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.
1996
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.
1996
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
1998
Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors
1996 StandoutNobel
Repression of cyclin D1: a novel function of MYC.
1994
Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events
1996
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
1997
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
G1 cyclins control the retinoblastoma gene product growth regulation activity via upstream mechanisms.
1995
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Direct activation of TERT transcription by c-MYC
1999
Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and Senescence
1996
Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage ofMycobacterium tuberculosisHeat Shock Protein 70 Gene to an Antigen Gene
2001 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene.
2000
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
1999
Inhibition of p53-Mediated Growth Arrest by Overexpression of Cyclin-Dependent Kinases
1996
Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle
1996
Anchorage-Dependent Transcription of the Cyclin A Gene
1996
Modulation of type M 2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein
1999
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
2000
Position-Dependent Transcriptional Regulation of the Murine Dihydrofolate Reductase Promoter by the E2F Transactivation Domain
1997
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
2007 StandoutNobel
Repression of p27kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells
1996
Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes
1999 StandoutNobel
A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD
2000
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.
1995
Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein
1998
Global mapping of c-Myc binding sites and target gene networks in human B cells
2006
Cyclin E-induced S phase without activation of the pRb/E2F pathway.
1997
Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
1997 StandoutNobel
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.
1995
Activation of p53 in cervical carcinoma cells by small molecules
2000
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
1995
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
2011 StandoutNobel
Identification of Transcription Complexes that Contain the Double Bromodomain Protein Brd2 and Chromatin Remodeling Machines
2006
A Synthetic E7 Gene of Human Papillomavirus Type 16 That Yields Enhanced Expression of the Protein in Mammalian Cells and Is Useful for DNA Immunization Studies
2003 StandoutNobel
A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex–Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression
2001
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.
1997
Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis
2000
Cyclin D1 Is Dispensable for G1 Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity
1995
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
1996 StandoutNobel
Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6
1995
c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination
2001 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Subunit Composition Determines E2F DNA-Binding Site Specificity
1997
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.
1995
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Assembly of cyclin D-dependent kinase and titration of p27 Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
1998
Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.
1996
Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Herpes Simplex Virus Type 1 VP22 Protein to Antigen
2001
Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16INK4A-Mediated Growth Suppression
1996
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
1994
Different Roles for Cyclins D1 and E in Regulation of the G1-to-S Transition
1995
Induction of apoptosis in cervical carcinoma cells by peptide aptamers that bind to the HPV‐16 E7 oncoprotein
2001
p27KIP1 Blocks Cyclin E-Dependent Transactivation of Cyclin A Gene Expression
1997
Human Cyclin E, a Nuclear Protein Essential for the G1-to-S Phase Transition
1995
Another p53 Doppelgänger?
1998 StandoutScienceNobel
E2F-1 Blocks Terminal Differentiation and Causes Proliferation in Transgenic Megakaryocytes
1996
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1998
Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells
2006
Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins
1997 StandoutNobel
Works of Dimitry Spitkovsky being referenced
Cell cycle activation by c-myc in a Burkitt lymphoma model cell line
2000
Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: Repression ofE6/E7-oncogene expression and induction of apoptosis
1996
The human papillomavirus type 16 E7 protein is associated with the nucleolus in mammalian and yeast cells
1997
Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers
2007
S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase.
1996
Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1.
1994
Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter
1996
B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.
1995
Expression of E1A in Terminally Differentiated Muscle Cells Reactivates the Cell Cycle and Suppresses Tissue-Specific Genes by Separable Mechanisms†
1996
Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions
1994
Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107
1996
Functional p53 protein in human papillomavirus-positive cancer cells.
1995
p53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene.
1996
The role of p53 in coordinated regulation of cyclin D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes.
1995
Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation
1995
Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation
1994
Activity of complex III of the mitochondrial electron transport chain is essential for early heart muscle cell differentiation
2004
DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.
1994
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.
1995
Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
2001