Standout Papers
Citation Impact
Citing Papers
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
2008
Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
2021 StandoutScienceNobel
Origins of Specificity in Protein-DNA Recognition
2010
Genomic characterization reveals a simple histone H4 acetylation code
2005
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Identification and Characterization of an IκB Kinase
1997
IκBβ, but Not IκBα, Functions as a Classical Cytoplasmic Inhibitor of NF-κB Dimers by Masking Both NF-κB Nuclear Localization Sequences in Resting Cells
2001
The General Transcription Machinery and General Cofactors
2006
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB
2002
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
SWI/SNF Unwraps, Slides, and Rewraps the Nucleosome
2003
Structure of the NF-κB p50 homodimer bound to DNA
1995 Nature
KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading
2010
Pathophysiology of Progressive Nephropathies
1998 Standout
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38
2001
Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation
2009
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Selective Transcription in Response to an Inflammatory Stimulus
2010
Mapping Global Histone Acetylation Patterns to Gene Expression
2004
The enhanceosome
2008
Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death
2001
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB
1995
A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity
2012 Nobel
Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway
2010
Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system
1993 Nobel
The Swi2/Snf2 Bromodomain Is Required for the Displacement of SAGA and the Octamer Transfer of SAGA-acetylated Nucleosomes
2006
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Structural basis of eukaryotic gene transcription
2004 StandoutNobel
Control of NF- B-dependent Transcriptional Responses by Chromatin Organization
2009
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Targeted Recruitment of Set1 Histone Methylase by Elongating Pol II Provides a Localized Mark and Memory of Recent Transcriptional Activity
2003
Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II
2000
A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling
2009
Removal of Promoter Nucleosomes by Disassembly Rather Than Sliding In Vivo
2004 StandoutNobel
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
The Enhanceosome and Transcriptional Synergy
1998
Characterization of IκBα Nuclear Import Pathway
1999
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
A novel IL-4 responsive element of the Eα MHC class II promoter that binds to an inducible factor
1995
Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells
1995
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection
1999
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain
1999
Missing Pieces in the NF-κB Puzzle
2002 Standout
The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1
2002
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
1995 StandoutNatureNobel
Mechanism of κB DNA binding by Rel/NF-κB dimers
2000
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
2007 Standout
Differential Transcriptional Activation in Vitro by NF-κB/Rel Proteins
1995
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response
2006
Restriction enzymes and their isoschizomers
1990 StandoutNobel
The immune response of Drosophila
2003 StandoutNatureNobel
Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter Nucleosomes
2001
The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation
1998
Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300
1998
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
1995 Standout
Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway
2001
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression
1995
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Transcriptional control of the inflammatory response
2009
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails
2007
The Role of Chromatin during Transcription
2007 Standout
Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA
1998 Nature
A light-entrainment mechanism for the Drosophila circadian clock
1996 StandoutNatureNobel
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
2020 Standout
Geometric analysis and comparison of protein-DNA interfaces: why is there no simple code for recognition? 1 1Edited by R. Ebright
2000
Transcription factors: from enhancer binding to developmental control
2012 Standout
A novel DNA recognition mode by the NF-κB p65 homodimer
1998
Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?
2004
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
2000
The NF-κB Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus
1999
Promoter-Specific Regulation of MyoD Binding and Signal Transduction Cooperate to Pattern Gene Expression
2002
Critical role of Vα14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection
2003
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Transcriptional regulation of the IL-2 gene
1995
TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways
1996 Standout
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
1994 Standout
Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation
1998
Functional Interactions of Transforming Growth Factor β-activated Kinase 1 with IκB Kinases to Stimulate NF-κB Activation
1999
Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice
1999
Transactivation Domain 2 (TA2) of p65 NF-κB
1995
The ubiquitin system
1997
SWI/SNF-dependent chromatin remodeling ofRNR3requires TAFIIs and the general transcription machinery
2003
Regulating protein degradation by ubiquitination
1997
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation
2006
I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity
1997
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
CTCF: Master Weaver of the Genome
2009 Standout
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Inducible NF-κB Activation Is Permitted by Simultaneous Degradation of Nuclear IκBα
2000
Stimulation of c‐MYC transcriptional activity and acetylation by recruitment of the cofactor CBP
2003
Nuclear Localization of IκBα Is Mediated by the Second Ankyrin Repeat: the IκBα Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences
1998
The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex
2002
Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter.
1994
Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12
2000
CD28 Mediates a Potent Costimulatory Signal for Rapid Degradation of IκBβ Which Is Associated with Accelerated Activation of Various NF-κB/Rel Heterodimers
1996
Disentangling the Many Layers of Eukaryotic Transcriptional Regulation
2012
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
1996 Standout
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.
1995
TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40
1995 Science
Two-Step Cross-Linking Method for Identification of NF-κB Gene Network by Chromatin Immunoprecipitation
2005
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase
1999
Structure of NF-κB p50 homodimer bound to a κB site
1995 Nature
STATs and Gene Regulation
1997 StandoutScience
Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB
1993
Structure-based prediction of DNA target sites by regulatory proteins
1999
Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins.
1995
CREB-binding protein/p300 are transcriptional coactivators of p65
1997
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression.
1995
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
1995
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
1996
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
1994 Standout
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.
1994
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
2012 StandoutNobel
The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression
2001
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
1997 Science
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
2013
IRAK: A Kinase Associated with the Interleukin-1 Receptor
1996 Science
Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation
2001 Science
An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation.
1994
Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative
1995
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
UBIQUITIN-DEPENDENT PROTEIN DEGRADATION
1996
Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus
1995
REL/NF-κB/IκB Story
1995
Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins
1996 StandoutScienceNobel
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
1997 Standout
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
1995
Structure of the human NF-kappa B p52 homodimer-DNA complex at 2.1Aresolution
1997
Molecular Interaction and Synergistic Activation of a Promoter by Six, Eya, and Dach Proteins Mediated through CREB Binding Protein
2002
A Myc-Associated Zinc Finger Protein Binding Site Is One of Four Important Functional Regions in the CD4 Promoter
1995
NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
1998
Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins
1995
Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2
1997
TAPping into mRNA Export
2001 StandoutScienceNobel
Chromatin remodeling by nucleosome disassembly in vitro
2006 StandoutNobel
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
1995
Transcriptional Regulatory Elements in the Human Genome
2006
Promoter targeting of chromatin-modifying complexes
2001
Characterization of Elements Determining the Dimerization Properties of RelB and p50
1995
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 Standout
Domain-Wide Displacement of Histones by Activated Heat Shock Factor Occurs Independently of Swi/Snf and Is Not Correlated with RNA Polymerase II Density
2005
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Human Histone Chaperone Nucleophosmin Enhances Acetylation-Dependent Chromatin Transcription
2005
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex
2000 Science
Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the TNF Promoter Region
2000
Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses
1998
Works of Dimitris Thanos being referenced
Coordination of a Transcriptional Switch by HMGI(Y) Acetylation
2001 Science
Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter
2000
Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness
2017
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
1998 Nature
Structure of the NF-κB transcription factor: a holistic interaction with DNA
1995
The MHC class II E-β promoter: a complex arrangement of positive and negative elements determines B cell and interferon-δ (IFN-δ) regulated expression
1993
Modifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture
2002
Virus Infection Induces NF-κB-Dependent Interchromosomal Associations Mediating Monoallelic IFN-β Gene Expression
2008
S‐glutathionylation of IRF3 regulates IRF3–CBP interaction and activation of the IFNβ pathway
2008
The κB DNA Sequence from the HIV Long Terminal Repeat Functions as an Allosteric Regulator of HIV Transcription
2002
Gene Repression by Coactivator Repulsion
2000
Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1
1998
The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene
1992
Nucleosome Sliding via TBP DNA Binding In Vivo
2001
Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)
1995
Isolation and identification of restriction endonuclease BseAI
1989
Epigenetic determination of a cell‐specific gene expression program by ATF‐2 and the histone variant macroH2A
2006
An HMG-like protein that can switch a transcriptional activator to a repressor
1994 Nature
Enhanceosomes
2001
Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription
1998
Deciphering the Transcriptional Histone Acetylation Code for a Human Gene
2002
The High Mobility Group Protein HMG I(Y) Is an Essential Structural Component of a Virus-inducible Enhancer Complex
1993
Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
1995
NF-κB: A lesson in family values
1995
Structure of NF-κB p50/p65 Heterodimer Bound to the PRDII DNA Element from the Interferon-β Promoter
2002
Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure
2002 Nobel
A striking similarity in the organization of the E-selectin and beta interferon gene promoters.
1994
Cloning and functional characterization of mouse IκBɛ
1997
Endothelial Interferon Regulatory Factor 1 Cooperates with NF-κB as a Transcriptional Activator of Vascular Cell Adhesion Molecule 1
1995
Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements
1993
Multiple regulatory regions on the 5' side of the mouse E alpha gene.
1988
Transcriptional Activation by NF-κB Requires Multiple Coactivators
1999
Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene
1995
Cell-Type-Specific Regulation of the Human Tumor Necrosis Factor Alpha Gene in B Cells and T Cells by NFATp and ATF-2/JUN
1996
Distinct Functional Properties of IκBα and IκBβ
1997
Intra- and Intermolecular Cooperative Binding of High-Mobility-Group Protein I(Y) to the Beta-Interferon Promoter
1997
Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.
1995
A Striking Similarity in the Organization of the E-Selectin and Bate Interferon gene Promoters
1994
Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers
1995 Standout