Standout Papers
Citation Impact
Citing Papers
A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas
2012
Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic Analyses
2007
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells
2006
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
DNA damage checkpoints: from initiation to recovery or adaptation
2007
Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
2006
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
2011
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
2007
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
2006 Nature
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Cellular senescence: when bad things happen to good cells
2007 Standout
p53 — a Jack of all trades but master of none
2009
Tying the loose ends together in DNA double strand break repair with 53BP1.
2006
Cancer Metastasis: Building a Framework
2006 Standout
Cancer despite immunosurveillance: immunoselection and immunosubversion
2006
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
Plant and Animal Pathogen Recognition Receptors Signal through Non-RD Kinases
2006
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Using or abusing: viruses and the cellular DNA damage response
2007
Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study
2007
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
2009 Standout
DNA repair pathways as targets for cancer therapy
2008
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
2006
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
ATR: an essential regulator of genome integrity
2008
MLL1 is essential for the senescence-associated secretory phenotype
2016
Senescent cells: an emerging target for diseases of ageing
2017
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
2006 Nature
TGFβ: the molecular Jekyll and Hyde of cancer
2006
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Characterization of novel markers of senescence and their prognostic potential in cancer
2014
DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy
2007
Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
2008
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
Cellular senescence and DNA repair
2006
KLF4, p21 and context-dependent opposing forces in cancer
2005
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response
2013
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Immunity, Inflammation, and Cancer
2010 Standout
Cellular senescence: putting the paradoxes in perspective
2010
p53 in health and disease
2007 Standout
Divorcing ARF and p53: an unsettled case
2006
The DNA damage response, immunity and cancer
2006
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
2008
Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors
2009
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
γH2AX and cancer
2008
Oncogene-induced senescence: the bright and dark side of the response
2010
NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy
2008
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
2007
Genome instability: a mechanistic view of its causes and consequences
2008
The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells
2007
Non-transcriptional control of DNA replication by c-Myc
2007 Nature
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
2005 Nature
Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice
2001
A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen
2010
Genomic instability — an evolving hallmark of cancer
2010 Standout
The Hallmarks of Aging
2013 Standout
The Causes and Consequences of Polyploidy in Normal Development and Cancer
2011
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
The combined status of ATM and p53 link tumor development with therapeutic response
2009
The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence
2007
DNA Damage Repair and Telomere Length in Normal Breast, Preneoplastic Lesions, and Invasive Cancer
2010
Topoisomerase I inhibitors: camptothecins and beyond
2006 Standout
Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest
2018
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Inflammatory networks during cellular senescence: causes and consequences
2010
p53 and disease: when the guardian angel fails
2006
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
2007
Cellular senescence: hot or what?
2009
The plant immune system
2006 StandoutNature
Cellular senescence: from physiology to pathology
2014 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress
2011
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation
2010
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
2012
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Chromosome Fragile Sites
2007
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Catalytic Enantioselective Conversion of Epoxides to Thiiranes
2016 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
An Oncogene-Induced DNA Damage Model for Cancer Development
2008 Science
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?
2009
Innate Immune Recognition of Cancer
2015
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling
2008
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence
2011
Spontaneous Transformation of Cultured Mouse Bone Marrow–Derived Stromal Cells
2006 StandoutNobel
Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs
2012 StandoutScience
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Surviving the Breakup: The DNA Damage Checkpoint
2006
The chemistry of senescence
2019
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
2008 Standout
DNA Damage Responses: Mechanisms and Roles in Human Disease
2008
An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program
2019
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Works of Dimitris Kletsas being referenced
Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
2007
Robust, universal biomarker assay to detect senescent cells in biological specimens
2016
Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy
2002
The Highly Reducing Sugar 2-Deoxy-d-Ribose Induces Apoptosis in Human Fibroblasts by Reduced Glutathione Depletion and Cytoskeletal Disruption
1998
TGF-β regulates differentially the proliferation of fetal and adult human skin fibroblasts via the activation of PKA and the autocrine action of FGF-2
2005
Senescence in human intervertebral discs
2006
Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives
2003
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
2005 StandoutNature
p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions
2005
STI571 as a potent inhibitor of growth and invasiveness of human epithelial breast cancer cells.
2004
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
2012
Deregulated expression of c-mos in non-small cell lung carcinomas: relationship with p53 status, genomic instability, and tumor kinetics.
2001