Citation Impact
Citing Papers
Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
2008 Standout
Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
2009 Standout
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Factors Predicting Outcome of Total Thyroidectomy in Young Patients with Multiple Endocrine Neoplasia Type 2: A Nationwide Long‐Term Follow‐up Study
2010
Pediatric Graves’ disease: management in the post-propylthiouracil Era
2014
Current approaches to medullary thyroid carcinoma, sporadic and familial
2006
Clinical management of adrenocortical carcinoma
2009
Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells
2011 StandoutNobel
Inherited pancreatic endocrine tumor syndromes: Advances in molecular pathogenesis, diagnosis, management, and controversies
2008
Early or prophylactic thyroidectomy in MEN 2/FMTC gene carriers: results in 71 thyroidectomized patients. The French Calcitonin Tumours Study Group (GETC)
1999
Calcitonin and carcinoembryonic antigen doubling times as prognostic factors in medullary thyroid carcinoma: a structured meta‐analysis
2009
Guidelines for radioiodine therapy of differentiated thyroid cancer
2008
The antioxidant role of selenium and seleno-compounds
2003 Standout
LRP-1 Promotes Cancer Cell Invasion by Supporting ERK and Inhibiting JNK Signaling Pathways
2010
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Everolimus for Advanced Pancreatic Neuroendocrine Tumors
2011 Standout
Thyroid cancer
2016 Standout
Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer
2013
Cushing’s Syndrome: Adrenalectomy and Long-Term Results
2004
Current Approaches to Primary Therapy for Papillary and Follicular Thyroid Cancer
2001 Standout
Completion thyroidectomy in patients with thyroid cancer who initially underwent unilateral operation
2004
Identification of occult metastases of medullary thyroid carcinoma by pentagastrin‐stimulated intravenous calcitonin sampling followed by targeted surgery
2007
Bexarotene increases uptake of radioiodide in metastases of differentiated thyroid carcinoma
2006
Role of metastasectomy in the management of thyroid carcinoma: The NIH experience
2002
Transcutaneous biopsy of adrenocortical carcinoma is rarely helpful in diagnosis, potentially harmful, but does not affect patient outcome
2014
Papillary microcarcinoma of the thyroid—Prognostic significance of lymph node metastasis and multifocality
2003 Standout
Morbidity of prophylactic lymph node dissection in the central neck area in patients with papillary thyroid carcinoma
1998
Impact of Routine Measurement of Serum Calcitonin on the Diagnosis and Outcome of Medullary Thyroid Cancer: Experience in 10,864 Patients with Nodular Thyroid Disorders
2004
Expression of Selenoproteins in Various Rat and Human Tissues and Cell Lines
1997
Minimal-invasives follikuläres Schilddrüsenkarzinom
2010
Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients
2008
A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer
2011
The Thyroid Nodule
2004 Standout
Adrenal pheochromocytoma remains a frequently overlooked diagnosis
2000
Clinical and molecular aspects of adrenocortical tumourigenesis
2003
Individualization of Lymph Node Dissection in RET (Rearranged During Transfection) Carriers at Risk for Medullary Thyroid Cancer
2009
Influence of prophylactic central lymph node dissection on postoperative thyroglobulin levels and radioiodine treatment in papillary thyroid cancer
2010
Association of Extensive Polymorphisms in the SLAM/CD2 Gene Cluster with Murine Lupus
2004
Cushing's syndrome
2015 Standout
A phase II study using retinoids as redifferentiation agents to increase iodine uptake in metastatic thyroid cancer
2004
Phaeochromocytoma
2005 Standout
Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Endocytic Clearance of Tissue Inhibitor of Metalloproteinases-1 and Promotes Its Cytokine-Like Activities
2014 StandoutNobel
Antithrombotic Therapy for VTE Disease
2016 Standout
Nodal yield, morbidity, and recurrence after central neck dissection for papillary thyroid carcinoma
2005
Long-Term Clinical and Biochemical Follow-up in Medullary Thyroid Carcinoma
2007
Retinoic acid in patients with radioiodine non-responsive thyroid carcinoma
2004
Reoperative central compartment dissection for patients with recurrent/persistent papillary thyroid cancer: Efficacy, safety, and the association of the BRAF mutation
2012
Persistence of Increased Cardiovascular Risk in Patients with Cushing’s Disease after Five Years of Successful Cure
1999
Presentation of a kindred with familial medullary thyroid carcinoma and Cys611Phe mutation of the RET proto-oncogene demonstrating low grade malignancy
2001
Prospects of Remission in Medullary Thyroid Carcinoma According to Basal Calcitonin Level
2005
Prevention of VTE in Nonsurgical Patients
2012 Standout
Risk of Malignancy in Nonpalpable Thyroid Nodules: Predictive Value of Ultrasound and Color-Doppler Features
2002 Standout
Extent of Disease and Practice Patterns for Medullary Thyroid Cancer
2005
Impact of Preoperative Ultrasonographic Staging of the Neck in Papillary Thyroid Carcinoma
2007
Estimated Risk of Pheochromocytoma Recurrence After Adrenal-Sparing Surgery in Patients With Multiple Endocrine Neoplasia Type 2A
2006
Papillary Thyroid Carcinoma
1998
Antithrombotic Therapy for VTE Disease
2012 Standout
The C-terminal CD47/IAP-binding domain of thrombospondin-1 prevents camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells
2006
Long-term outcome in 46 gene carriers of hereditary medullary thyroid carcinoma after prophylactic thyroidectomy: impact of individual RET genotype
2006
Appropriate treatment for asymptomatic papillary microcarcinoma of the thyroid
2007
Cancer immunotherapy: moving beyond current vaccines
2004 Standout
Das medulläre Schilddrüsenkarzinom
2015
Primary Aldosteronism
1996
Advances in the management of hereditary medullary thyroid cancer
2004
Laryngeal Recurrent Nerve Injury in Surgery for Benign Thyroid Diseases
2002
Morbidity Following Central Compartment Reoperation for Recurrent or Persistent Thyroid Cancer
2004
Review of surgical management of aldosterone secreting tumours of the adrenal cortex
2003
Prophylactic Central Neck Dissection in Differentiated Thyroid Cancer: An Assessment of the Evidence
2013
Functioning pulmonary metastases of thyroid cancer: does radioiodine influence the prognosis?
2003
Diagnosis and Complications of Cushing’s Syndrome: A Consensus Statement
2003 Standout
When should thyroidectomy be performed in familial medullary thyroid carcinoma gene carriers with non-cysteine RET mutations?
2003
Radioiodine Treatment for Differentiated Thyroid Cancer
2000
Essential hypertension: First reason for persistent hypertension after unilateral adrenalectomy for primary aldosteronism?
1998
RET proto-oncogene mutations affecting codon 790/791: A mild form of multiple endocrine neoplasia type 2A syndrome?
2002
Postoperative Complications After Prophylactic Thyroidectomy for Very Young Patients With Multiple Endocrine Neoplasia Type 2
2015
Apoptosis
2002 Standout
Management of the patient with progressive radioiodine non-responsive disease
1999
Complete surgical lymph node resection does not prevent authentic recurrences of medullary thyroid carcinoma
2001
Effectiveness of retinoic acid treatment for redifferentiation of thyroid cancer in relation to recovery of radioiodine uptake
2009
Indium-111-labelled octreotide scintigraphy in the diagnosis and management of non-iodine avid metastatic carcinoma of the thyroid
2003
Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology
2012 Standout
European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
2006 Standout
Effect of surgical treatment on hypertension in Cushing's syndrome
1996
Lithium as adjuvant to radioiodine therapy in differentiated thyroid carcinoma: clinical and in vitro studies
2006
The role of a more extensive surgical approach in the initial multimodality management of papillary thyroid cancer in children
2005
Use of Recombinant Human Thyrotropin before Radioiodine Therapy in Patients with Advanced Differentiated Thyroid Carcinoma
2000
Contralateral cervical and mediastinal lymph node metastasis in medullary thyroid cancer: Systemic disease?
2005
Predictive Value of Factor V Leiden and Prothrombin G20210A in Adults With Venous Thromboembolism and in Family Members of Those With a Mutation
2009
The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma
2005
Papillary Thyroid Cancer in Children and Adolescents Does Not Differ in Growth Pattern and Metastatic Behavior
2010
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.
2001 Standout
Extent of Surgery Affects Survival for Papillary Thyroid Cancer
2007 Standout
Does radioiodine therapy have disadvantageous effects in non‐iodine accumulating differentiated thyroid carcinoma?
2002
Total Thyroidectomy Plus Neck Dissection in Differentiated Papillary Thyroid Carcinoma Patients
2007 Standout
Management of medullary thyroid carcinoma and MEN2 syndromes in childhood
2011
Cardiovascular Risk Factors and Common Carotid Artery Caliber and Stiffness in Patients with Cushing’s Disease during Active Disease and 1 Year after Disease Remission
2003
The First 1000 Dendritic Cell Vaccinees
2003
Medullary thyroid carcinoma: results of a standardized surgical approach in a contemporary series of 80 consecutive patients
2003
Follicular Thyroid Carcinoma in an Iodine-Replete Endemic Goiter Region
2009
Distribution of lymph node micrometastasis in pN0 well-differentiated thyroid carcinoma
2002
Cushing's syndrome
2006 Standout
Differentiated thyroid carcinoma: Comparison between papillary and follicular carcinoma in a single institute
2002
Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer
2003
Safety of Modified Radical Neck Dissection for Differentiated Thyroid Carcinoma
2004
Medullary thyroid microcarcinoma recommendations for treatment – A single-center experience
2007
Late‐Onset Medullary Carcinoma of the Thyroid: Need for Genetic Testing and Prophylactic Thyroidectomy in Adult Family Members
2006
ROUTINE LEVEL VI LYMPH NODE DISSECTION FOR PAPILLARY THYROID CANCER: SURGICAL TECHNIQUE
2007
Early Malignant Progression of Hereditary Medullary Thyroid Cancer
2003
Management of Well-Differentiated Thyroid Cancer in 2010: Perspectives of a Head and Neck Surgical Oncologist
2010
Germline RET mutation carriers in Japanese patients with apparently sporadic medullary thyroid carcinoma: A single institution experience
2016
Multiple endocrine neoplasia type 2 and the RET protooncogene: From bedside to bench to bedside
2005
Prophylactic thyroidectomy in multiple endocrine neoplasia: the impact of molecular mechanisms of RET proto-oncogene
2003
Medullary thyroid microcarcinoma
2011
Thrombosis of the Cerebral Veins and Sinuses
2005 Standout
Retinoic Acid Redifferentiation Therapy for Thyroid Cancer
2000
Adrenal tumors: How to establish malignancy?
2004
Genotype-Phenotype Correlations in Hereditary Medullary Thyroid Carcinoma: Oncological Features and Biochemical Properties1
2001
Multiple Endocrine Neoplasia Type 2
2003
Defining CD95 as a tumor suppressor gene
2000
Outcomes analysis in patients undergoing laparoscopic adrenalectomy for hormonally active adrenal tumors
2001
Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma
2015 Standout
Outcomes and Prognostic Factors of 251 Patients with Minimally Invasive Follicular Thyroid Carcinoma
2012
Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce
2006 Standout
Performing Contralateral Central Lymph Node Dissection in Papillary Thyroid Carcinoma: A Decision Approach
2011
Medullary Thyroid Cancer: Management Guidelines of the American Thyroid Association
2009 Standout
Sequential Follow-up of Serum Thyroglobulin and Whole Body Scan in Thyroid Cancer Patients without Initial Metastasis
2006
Graves' Disease with Moderate–Severe Endocrine Ophthalmopathy–Long Term Results of a Prospective, Randomized Study of Total or Subtotal Thyroid Resection
2005
American Thyroid Association Consensus Review and Statement Regarding the Anatomy, Terminology, and Rationale for Lateral Neck Dissection in Differentiated Thyroid Cancer
2012
Clinical Risk Factors Associated with Cervical Lymph Node Recurrence in Papillary Thyroid Carcinoma
2009
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis
2016 Standout
Patient Age Is Significantly Related to the Progression of Papillary Microcarcinoma of the Thyroid Under Observation
2013 Standout
Papillary Thyroid Carcinoma in Patients with RET Proto-Oncogene Germline Mutation
2002
Lymph node dissection and medullary thyroid carcinoma
2002
Integrated PET/CT in differentiated thyroid cancer: diagnostic accuracy and impact on patient management.
2006
Fine-needle aspiration cytology of adrenal masses: a re-assessment with histological confirmation.
2012
Is basal ultrasensitive measurement of calcitonin capable of substituting for the pentagastrin‐stimulation test?
2012
RET as a Diagnostic and Therapeutic Target in Sporadic and Hereditary Endocrine Tumors
2006
Pattern of Nodal Metastasis for Primary and Reoperative Thyroid Cancer
2001
Associations of Serum Thyrotropin Concentrations with Recurrence and Death in Differentiated Thyroid Cancer
2007
The MAPK pathway across different malignancies: A new perspective
2014 Standout
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Nuklearmedizinische Therapie und Nachsorge des differenzierten Schilddrüsenkarzinoms: Status quo
2010
High Risk of Malignancy in Patients with Incidentally Discovered Adrenal Masses: Accuracy of Adrenal Imaging and Image-Guided Fine-Needle Aspiration Cytology
2007
Long‐term Follow‐up after Adrenalectomy for Primary Aldosteronism
2005
Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases
2002 Standout
Modified Radical Neck Dissection for Differentiated Thyroid Cancer: Operative Technique
2004
Follicular Helper CD4 T Cells (TFH)
2011 Standout
Risk Factors for Lateral Cervical Lymph Node Involvement in Follicular Thyroid Carcinoma
2008
Central Lymph Node Dissection in Differentiated Thyroid Cancer
2007
Adrenocortical carcinoma: a clinician's update
2011
Therapeutic Strategy for Differentiated Thyroid Carcinoma in Japan Based on a Newly Established Guideline Managed by Japanese Society of Thyroid Surgeons and Japanese Association of Endocrine Surgeons
2010
Nephrolithiasis in Cushing’s Disease: Prevalence, Etiopathogenesis, and Modification after Disease Cure
2003
Adrenocortical cancer: pathophysiology and clinical management
2007
Prospective Outcomes of Selective Lymph Node Dissection for Papillary Thyroid Carcinoma Based on Preoperative Ultrasonography
2008
Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors.
2001
DIAGNOSIS OF ENDOCRINE DISEASE: The diagnostic performance of adrenal biopsy: a systematic review and meta-analysis
2016
Influence of Total Thyroidectomy on Orbital Opthalmopathy and Levels of Antithyroid Antibodies in Patients with Graves' Disease
2007
Value of the Cervical Compartments in the Surgical Treatment of Papillary Thyroid Carcinoma
2004
Preoperative Staging of Papillary Thyroid Carcinoma: Comparison of Ultrasound Imaging and CT
2009
Performance of Preoperative Sonographic Staging of Papillary Thyroid Carcinoma Based on the Sixth Edition of the AJCC/UICC TNM Classification System
2008
Graves Disease in Childhood
2003
Patterns of care for patients with primary differentiated carcinoma of the thyroid gland treated in Germany during 1996
2000
Estimation of Risk of Inherited Medullary Thyroid Carcinoma in Apparent Sporadic Patients
2001
An Observational Trial for Papillary Thyroid Microcarcinoma in Japanese Patients
2009 Standout
Anaplastic Thyroid Carcinoma Survival
1999
Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis.
2007
Factor V Leiden Mutation Is a Risk Factor for Cerebral Venous Thrombosis
1998
Review of Multiple Endocrine Neoplasia Type 2A in Children: Therapeutic Results of Early Thyroidectomy and Prognostic Value of Codon Analysis
2003
De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma
2008
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline
2016 Standout
LRP-1 Silencing Prevents Malignant Cell Invasion despite Increased Pericellular Proteolytic Activities
2008
The evolving role of (131)I for the treatment of differentiated thyroid carcinoma.
2005
Evaluation of Postoperative Radioactive Iodine Scans in Patients who Underwent Prophylactic Central Lymph Node Dissection
2012
Redifferentiation therapy-induced radioiodine uptake in thyroid cancer.
1998
Reoperative Thyroid Surgery
1997
Follicular Adenoma and Carcinoma of the Thyroid Gland
2011
The Role of Radiation Therapy in the Treatment of Medullary Thyroid Cancer
2010
Total thyroidectomy vs bilateral subtotal thyroidectomy in patients with Graves’ diseases: a meta‐analysis of randomized clinical trials
2013
Selective Use of Adrenal Venous Sampling in the Lateralization of Aldosterone‐producing Adenomas
2006
Prognostic Factors for Persistent or Recurrent Disease of Papillary Thyroid Carcinoma with Neck Lymph Node Metastases and/or Tumor Extension beyond the Thyroid Capsule at Initial Diagnosis
2005
Combination of Radioiodine (131I) and Probe-Guided Surgery for Persistent or Recurrent Thyroid Carcinoma
1998
Prophylactic Thyroidectomy in MEN 2A Syndrome: Experience in a Single Center1
2002
Biomarker-Based Risk Stratification for Previously Untreated Medullary Thyroid Cancer
2010
Lateral cervical lymph node metastases in papillary thyroid cancer: a systematic review of imaging‐guided and prophylactic removal of the lateral compartment
2012
Diversity of mutations in theRETproto-oncogene and its oncogenic mechanism in medullary thyroid cancer
2015
Increased Risk of Lymph Node Metastasis in Multifocal Hereditary and Sporadic Medullary Thyroid Cancer
2007
Guidelines for the management of thyroid cancer
2014 Standout
Restoration of Iodide Uptake in Dedifferentiated Thyroid Carcinoma: Relationship to Human Na+/I− Symporter Gene Methylation Status1
1999
Lateral and Mediastinal Lymph Node Dissection in Differentiated Thyroid Carcinoma: Indications, Benefits, and Risks
2007
Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors
2016 Standout
Management of follicular thyroid carcinoma should be individualised based on degree of capsular and vascular invasion
2010
Diagnostic Accuracy of CT and Ultrasonography for Evaluating Metastatic Cervical Lymph Nodes in Patients with Thyroid Cancer
2008
Prognostic Significance of the Number of Metastatic Lymph Nodes to Stratify the Risk of Recurrence
2013
Islet Hyperplasia in Adults: Challenge to Preoperatively Diagnose Non‐Insulinoma Pancreatogenic Hypoglycemia Syndrome
2006
Prognostic Factors and Therapeutic Strategies for Differentiated Carcinomas of the Thyroid
2009
The Clinically Inapparent Adrenal Mass: Update in Diagnosis and Management
2004
Tumortyp- und tumorstadienorientiertes chirurgisches Konzept bei Karzinomen der Schilddrüse
2010
The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline
2008 Standout
Total Thyroidectomy Is Superior to Subtotal Thyroidectomy for Management of Graves’ Disease in the United States
2009
Thyroid carcinoma
2003 Standout
Surgery for lymph node metastases of medullary thyroid carcinoma: A review
2015
Extent of Routine Central Lymph Node Dissection With Small Papillary Thyroid Carcinoma
2007
Evidence‐based Approach to the Management of Sporadic Medullary Thyroid Carcinoma
2007
Pheochromocytoma and Paraganglioma: An Endocrine Society Clinical Practice Guideline
2014 Standout
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
2008 Standout
Works of Dietmar Simon being referenced
Surgical treatment of postoperative, incidentally diagnosed small sporadic C-cell carcinomas of the thyroid
2000
Growth Regulation of Normal Thyroids and Thyroid Tumors in Man
1990
Complete Sequencing and Messenger Ribonucleic Acid Expression Analysis of the MEN I Gene in Adrenal Cancer1
2000
Diagnosis And Clinical Characteristics Of Inherited Activated Protein C Resistance
1996
Dendritic cell immunotherapy in a neuroendocrine pancreas carcinoma
2001
Spezielle diagnostische und therapeutische Aspekte beim Insulinom
1997
High diagnostic accuracy of adrenal core biopsy: Results of the German and Austrian adrenal network multicenter trial in 220 consecutive patients
2003
Increased I-131 Uptake in Local Recurrence and Distant Metastases After Second Treatment With Retinoic Acid
1999
Clinical impact of retinoids in redifferentiation therapy of advanced thyroid cancer: final results of a pilot study
2002
Therapeutic experience of 65 cases with organic hyperinsulinism
2000
Redifferentiation therapy of differentiated thyroid carcinoma with retinoic acid: basics and first clinical results
2009
Functional retinoid and thyroid hormone receptors in human thyroid-carcinoma cell lines and tissues
1998
Involvement of Soluble CD95 in Churg-Strauss Syndrome
1999
Results of selective venous catheterization (SVC) in occult medullary thyroid carcinoma
1997
Is there any consensus in diagnostic and operative strategy with respect to medullary thyroid cancer?
2001
Surgery for pheochromocytoma in MEN II patients— a radical versus a limited approach
1996
Genetic and Biochemical Screening for Endocrine Disease
1998
Reoperative Surgery for Organic Hyperinsulinism: Indications and Operative Strategy
1998
[Guidelines in oncologic surgery--malignant thyroid tumors].
1997
Importance of Lymph Node Metastases in Follicular Thyroid Cancer
2002
Persistent hypertension after successful adrenal operation.
1993
Surgery for Graves' Disease: Total versus Subtotal Thyroidectomy—Results of a Prospective Randomized Trial
2000
Surgical reintervention for differentiated thyroid cancer
1993
Incidence of Regional Recurrence Guiding Radicality in Differentiated Thyroid Carcinoma
1996
Redifferentiation Therapy with Retinoids: Therapeutic Option for Advanced Follicular and Papillary Thyroid Carcinoma
1998
Recurrent nerve palsy and hypocalcemia after surgery of benign thyroid diseases
1996
Prophylactic Thyroidectomy in 75 Children and Adolescents with Hereditary Medullary Thyroid Carcinoma: German and Austrian Experience
1998