Standout Papers
Citation Impact
Citing Papers
An enumerative algorithm for de novo design of proteins with diverse pocket structures
2020 StandoutNobel
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
Generation of ordered protein assemblies using rigid three-body fusion
2021 StandoutNobel
Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system
2018
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN
2024 StandoutNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
A suite of designed protein cages using machine learning and protein fragment-based protocols
2024
Precisely patterned nanofibres made from extendable protein multiplexes
2023 StandoutNobel
Directing polymorph specific calcium carbonate formation with de novo protein templates
2023 StandoutNobel
Optical control of mammalian endogenous transcription and epigenetic states
2013 Nature
Protein Conformational Switches: From Nature to Design
2012
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Multistate and functional protein design using RoseTTAFold sequence space diffusion
2024 StandoutNobel
A genetically encoded photoactivatable Rac controls the motility of living cells
2009 Nature
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
2011 Standout
Directed evolution improves the catalytic efficiency of TEV protease
2019
Enlightened Enzymes: Strategies to Create Novel Photoresponsive Proteins
2011
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
A photoswitchable DNA-binding protein based on a truncated GCN4-photoactive yellow protein chimera
2010
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil Bacterium Beggiatoa
2010
Protein Design Using Structure-Prediction Networks: AlphaFold and RoseTTAFold as Protein Structure Foundation Models
2024
A Chimeric Fusion Protein Engineered with Disparate Functionalities—Enzymatic Activity and Self–assembly
2009
How to control proteins with light in living systems
2014
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
2016 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Formation of Arabidopsis Cryptochrome 2 Photobodies in Mammalian Nuclei
2013 StandoutNobel
Protein sequence optimization with a pairwise decomposable penalty for buried unsatisfied hydrogen bonds
2021 StandoutNobel
Chemical Biology Strategies for Posttranslational Control of Protein Function
2014
Engineered photoreceptors as novel optogenetic tools
2010
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
2010 Standout
Designing protein structures and complexes with the molecular modeling program Rosetta
2019
From Dusk till Dawn: One-Plasmid Systems for Light-Regulated Gene Expression
2012
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Mechanism of Photosignaling by Drosophila Cryptochrome
2013 StandoutNobel
Optogenetic protein clustering and signaling activation in mammalian cells
2013
Principles and Applications of the Photochemical Control of Cellular Processes
2009
Designing switchable enzymes
2009
Design of multi-scale protein complexes by hierarchical building block fusion
2021 StandoutNobel
Engineering Protein Switches: Sensors, Regulators, and Spare Parts for Biology and Biotechnology
2011
Mapping the life histories of T cells
2010
Light activation as a method of regulating and studying gene expression
2009
Engineering genetically-encoded tools for optogenetic control of protein activity
2017
A LOV2 Domain-Based Optogenetic Tool to Control Protein Degradation and Cellular Function
2013
Mechanism-based tuning of a LOV domain photoreceptor
2009
Recent advances in the photochemical control of protein function
2010
Transcription activator-like effector-mediated regulation of gene expression based on the inducible packaging and delivery via designed extracellular vesicles
2017
Design and Signaling Mechanism of Light-Regulated Histidine Kinases
2008
Allostery in Disease and in Drug Discovery
2013
Photochemistry of flavoprotein light sensors
2014
Photoreceptor engineering
2015
Optogenetics in Neural Systems
2011 Standout
Synthetic protein switches: design principles and applications
2014
Directed Evolution of Gloeobacter violaceus Rhodopsin Spectral Properties
2014 StandoutNobel
Time-tagged ticker tapes for intracellular recordings
2023 StandoutNobel
Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins
2023 Nobel
Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors
2016
Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
2012 Standout
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Wavelength-selective cleavage of photoprotecting groups: strategies and applications in dynamic systems
2015 StandoutNobel
De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity
2024 StandoutNobel
Structure and Function of Plant Photoreceptors
2010
Self-Assembling 2D Arrays with de Novo Protein Building Blocks
2019 StandoutNobel
Protein design: Past, present, and future
2015
Tripping the Light Fantastic: Blue-Light Photoreceptors as Examples of Environmentally Modulated Protein−Protein Interactions
2010
Reaction mechanism of Drosophila cryptochrome
2010 StandoutNobel
LOVely enzymes – towards engineering light‐controllable biocatalysts
2009
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
De novo design of small beta barrel proteins
2023 StandoutNobel
Controlling Allosteric Networks in Proteins
2016
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
Multimerization of an Alcohol Dehydrogenase by Fusion to a Designed Self-Assembling Protein Results in Enhanced Bioelectrocatalytic Operational Stability
2019 StandoutNobel
The Evolution of Flavin-Binding Photoreceptors: An Ancient Chromophore Serving Trendy Blue-Light Sensors
2012
Photo-controlled deactivation of immobilised lipase
2014 StandoutNobel
Reshaping de Novo Protein Switches into Bioresponsive Materials for Biomarker, Toxin, and Viral Detection
2022 StandoutNobel
De novo design of protein homodimers containing tunable symmetric protein pockets
2022 StandoutNobel
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Protein Assembly by Design
2021
Light-Induced Subunit Dissociation by a Light–Oxygen–Voltage Domain Photoreceptor from Rhodobacter sphaeroides
2012
Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins
2014
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Works of Devin Strickland being referenced
Perturbing the energy landscape for improved packing during computational protein design
2020 StandoutNobel
TULIPs: tunable, light-controlled interacting protein tags for cell biology
2012
Rationally improving LOV domain–based photoswitches
2010
Optical Control of Peroxisomal Trafficking
2015
Benchmarking of Optical Dimerizer Systems
2014
Light-activated DNA binding in a designed allosteric protein
2008